Analysis of Antarctic Ice-Sheet Mass Balance from ICESat Measurements

If protoplanets formed from 10 to 20 kilometer diameter planetesimals in a runaway accretion process prior to their oligarchic growth into the terrestrial planets, it is only logical to ask where these planetesimals may have formed in order to assess the initial composition of the Earth. We have used Weidenschilling's model for the formation of comets (1997) to calculate an efficiency factor for the formation of planetesimals from the solar nebula, then used this factor to calculate the feeding zones that contribute to material contained within 10, 15 and 20 kilometer diameter planetesimals at 1 A.V. as a function of nebular mass. We find that for all reasonable nebular masses, these planetesimals contain a minimum of 3% water as ice by mass. The fraction of ice increases as the planetesimals increase in size and as the nebular mass decreases, since both factors increase the feeding zones from which solids in the final planetesimals are drawn. Is there really a problem with the current accretion scenario that makes the Earth too dry, or is it possible that the nascent Earth lost significant quantities of water in the final stages of accretion

Thickening and Thinning of Antarctic Ice Shelves and Tongues and Mass Balance Estimates

Previous analysis of elevation changes for 1992 to 2002 obtained from measurements by radar altimeters on ERS-l and 2 showed that the shelves in the Antarctic Peninsula (AP) and along the coast of West Antarctica (WA), including the eastern part of the Ross Ice Shelf, were mostly thinning and losing mass whereas the Ronne Ice shelf also in WA was mostly thickening. The estimated total mass loss for the floating ice shelves and ice tongues from ice draining WA and the AP was 95 Gt/a. In contrast, the floating ice shelves and ice tongues from ice draining East Antarctica (EA), including the Filchner, Fimbul, Amery, and Western Ross, were mostly thickening with a total estimated mass gain of 142 Gt/a. Data from ICESat laser altimetry for 2003-2008 gives new surface elevation changes (dH/dt) with some similar values for the earlier and latter periods, including -27.6 and -26.9 cm a-Ion the West Getz ice shelf and -42.4 and - 27.2 cm/a on the East Getz ice shelf, and some values that indicate more thinning in the latter period, including -17.9 and -36.2 cm/a on the Larsen C ice shelf, -35.5 and -76.0 cm/a on the Pine Island Glacier floating, -60.5 and -125.7 .cm/a on the Smith Glacier floating, and -34.4 and -108.9 cm/a on the Thwaites Glacier floating. Maps of measured dH/dt and estimated thickness change are produced along with mass change estimates for 2003 - 2008

Mass Gains of the Antarctic Ice Sheet Exceed Losses

During 2003 to 2008, the mass gain of the Antarctic ice sheet from snow accumulation exceeded the mass loss from ice discharge by 49 Gt/yr (2.5% of input), as derived from ICESat laser measurements of elevation change. The net gain (86 Gt/yr) over the West Antarctic (WA) and East Antarctic ice sheets (WA and EA) is essentially unchanged from revised results for 1992 to 2001 from ERS radar altimetry. Imbalances in individual drainage systems (DS) are large (-68% to +103% of input), as are temporal changes (-39% to +44%). The recent 90 Gt/yr loss from three DS (Pine Island, Thwaites-Smith, and Marie-Bryd Coast) of WA exceeds the earlier 61 Gt/yr loss, consistent with reports of accelerating ice flow and dynamic thinning. Similarly, the recent 24 Gt/yr loss from three DS in the Antarctic Peninsula (AP) is consistent with glacier accelerations following breakup of the Larsen B and other ice shelves. In contrast, net increases in the five other DS of WA and AP and three of the 16 DS in East Antarctica (EA) exceed the increased losses. Alternate interpretations of the mass changes driven by accumulation variations are given using results from atmospheric-model re-analysis and a parameterization based on 5% change in accumulation per degree of observed surface temperature change. A slow increase in snowfall with climate waRMing, consistent with model predictions, may be offsetting increased dynamic losses

Treatment and Disposal of Potato Wastewater by Irrigation

Irrigation with potato processing waste water was studied for 3 years at five locations in southern Idaho. Three of the potato processors surface irrigated and two sprinkled land planted to perennial grasses. The processing season began in October and continued into the following summer. Samples of 24-hour composited waste water and soil water, extracted from depths of 15 to 150 cm, were obtained monthly throughout the year. Analyses were made on all water samples of sufficient volume for chemical oxygen demand (COD), NO3 , total N, total P, ortho P, hydrolyzable P, K, Na, Ca, Mg, Cl, HCO3 , SO4 , electrical conductivity, and pH. Water applications ranged from 160 to 490 cm per year, total N from 1,000 to 2,200 kg, P from 150 to 630 kg, and K from 2,250 to 6,700 kg K/hectare year. COD decreased 95 to 100 percent after passage of the water through 150 cm of soil because of biological activity and filtration. Nitrates were low in one field with a shallow water table because of denitrification that resulted from low redox potentials. Phosphorus concentrations increased 50 to 100 parts per million in the surface 30 cm of soil but not measurably below that depth. K, Na, Ca, and Mg changed in proportion to the amounts applied in the waste water. Irrigation with potato processing waste water provides a means of utilizing part of the nutrients that. would otherwise be wasted and solves a difficult environmental pollution problem

Comparison of Surface Elevation Changes of the Greenland and Antarctic Ice Sheets from Radar and Laser Altimetry

A primary purpose of satellite altimeter measurements is determination of the mass balances of the Greenland and Antarctic ice sheets and changes with time by measurement of changes in the surface elevations. Since the early 1990's, important measurements for this purpose have been made by radar altimeters on ERS-l and 2, Envisat, and CryoSat and a laser altimeter on ICESat. One principal factor limiting direct comparisons between radar and laser measurements is the variable penetration depth of the radar signal and the corresponding location of the effective depth of the radar-measured elevation beneath the surface, in contrast to the laser-measured surface elevation. Although the radar penetration depth varies significantly both spatially and temporally, empirical corrections have been developed to account for this effect. Another limiting factor in direct comparisons is caused by differences in the size of the laser and radar footprints and their respective horizontal locations on the surface. Nevertheless, derived changes in elevation, dHldt, and time-series of elevation, H(t), have been shown to be comparable. For comparisons at different times, corrections for elevation changes caused by variations in the rate offrrn compaction have also been developed. Comparisons between the H(t) and the average dH/dt at some specific locations, such as the Vostok region of East Antarctic, show good agreement among results from ERS-l and 2, Envisat, and ICESat. However, Greenland maps of dHidt from Envisat and ICESat for the same time periods (2003-2008) show some areas of significant differences as well as areas of good agreement. Possible causes of residual differences are investigated and described

Antarctic Ice-Shelf Front Dynamics from ICESat

Time variable elevation profiles from ICESat Laser Altimetry over the period 2003-2009 provide a means to quantitatively detect and track topographic features on polar ice surfaces. The results of this study provide a measure of the horizontal motion of ice-shelf fronts. We examine the time histories of elevation profiles crossing the ice fronts of the Ross, Ronne, Filchner, Riiser-Larson and Fimbul shelves. This provides a basis for estimating dynamics in two dimensions, i.e. in elevation and horizontally in the along-track direction. Ice front velocities, corrected for ground-track intersection angle, range from nearly static to 1.1 km/yr. In many examples, a decrease in elevation up to 1 m/yr near the shelf frontis also detectable. Examples of tabular calving along shelf fronts are seen in some elevation profiles and are confirmed by corresponding MODIS imagery

Greenland Ice Sheet Mass Balance: Distribution of Increased Mass Loss with Climate Warming; 2003-07 Versus 1992-2002

We derive mass changes of the Greenland ice sheet (GIS) for 2003-07 from ICESat laser altimetry and compare them with results for 1992-2002 from ERS radar and airborne laser altimetry. The GIS continued to grow inland and thin at the margins during 2003 07, but surface melting and accelerated flow significantly increased the marginal thinning compared with the 1990s. The net balance changed from a small loss of 7 plus or minus 3 Gt a 1(sup -1) in the 1990s to 171 plus or minus 4 Gt a (sup -1) for 2003-07, contributing 0.5 mm a(sup -1) to recent global sea-level rise. We divide the derived mass changes into two components: (1) from changes in melting and ice dynamics and (2) from changes in precipitation and accumulation rate. We use our firn compaction model to calculate the elevation changes driven by changes in both temperature and accumulation rate and to calculate the appropriate density to convert the accumulation-driven changes to mass changes. Increased losses from melting and ice dynamics (17-206 Gt a(sup-1) are over seven times larger than increased gains from precipitation (10 35 Gt a(sup-1) during a warming period of approximately 2 K (10 a)(sup -1) over the GIS. Above 2000m elevation, the rate of gain decreased from 44 to 28 Gt a(sup-1), while below 2000m the rate of loss increased from 51 to 198 Gt a(sup-1). Enhanced thinning below the equilibrium line on outlet glaciers indicates that increased melting has a significant impact on outlet glaciers, as well as accelerating ice flow. Increased thinning at higher elevations appears to be induced by dynamic coupling to thinning at the margins on decadal timescales

Cellular Immune Responses and Viral Diversity in Individuals Treated during Acute and Early HIV-1 Infection

Immune responses induced during the early stages of chronic viral infections are thought to influence disease outcome. Using HIV as a model, we examined virus-specific cytotoxic T lymphocytes (CTLs), T helper cells, and viral genetic diversity in relation to duration of infection and subsequent response to antiviral therapy. Individuals with acute HIV-1 infection treated before seroconversion had weaker CTL responses directed at fewer epitopes than persons who were treated after seroconversion. However, treatment-induced control of viremia was associated with the development of strong T helper cell responses in both groups. After 1 yr of antiviral treatment initiated in acute or early infection, all epitope-specific CTL responses persisted despite undetectable viral loads. The breadth and magnitude of CTL responses remained significantly less in treated acute infection than in treated chronic infection, but viral diversity was also significantly less with immediate therapy. We conclude that early treatment of acute HIV infection leads to a more narrowly directed CTL response, stronger T helper cell responses, and a less diverse virus population. Given the need for T helper cells to maintain effective CTL responses and the ability of virus diversification to accommodate immune escape, we hypothesize that early therapy of primary infection may be beneficial despite induction of less robust CTL responses. These data also provide rationale for therapeutic immunization aimed at broadening CTL responses in treated primary HIV infection

The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance

It has long been considered that the important biological effects of ionizing radiation are a direct consequence of unrepaired or misrepaired DNA damage occurring in the irradiated cells. It was presumed that no effect would occur in cells in the population that receive no direct radiation exposure. However, in vitro evidence generated over the past two decades has indicated that non-targeted cells in irradiated cell cultures also experience significant biochemical and phenotypic changes that are often similar to those observed in the targeted cells. Further, nontargeted tissues in partial body-irradiated rodents also experienced stressful effects, including oxidative and oncogenic effects. This phenomenon, termed the “bystander response,” has been postulated to impact both the estimation of health risks of exposure to low doses/low fluences of ionizing radiation and the induction of second primary cancers following radiotherapy. Several mechanisms involving secreted soluble factors, oxidative metabolism, gap-junction intercellular communication, and DNA repair, have been proposed to regulate radiation-induced bystander effects. The latter mechanisms are major mediators of the system responses to ionizing radiation exposure, and our knowledge of the biochemical and molecular events involved in these processes is reviewed in this chapter

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, spatial transcriptomics and cellular imaging. Subpopulations of tumor cells exhibited signatures of proliferation, KRAS signaling, cell stress and epithelial-to-mesenchymal transition. Mapping mutations and copy number events distinguished tumor populations from normal and transitional cells, including acinar-to-ductal metaplasia and pancreatic intraepithelial neoplasia. Pathology-assisted deconvolution of spatial transcriptomic data identified tumor and transitional subpopulations with distinct histological features. We showed coordinated expression of TIGIT in exhausted and regulatory T cells and Nectin in tumor cells. Chemo-resistant samples contain a threefold enrichment of inflammatory cancer-associated fibroblasts that upregulate metallothioneins. Our study reveals a deeper understanding of the intricate substructure of pancreatic ductal adenocarcinoma tumors that could help improve therapy for patients with this disease