Piomiositis no traumática recurrente en un jugador de fútbol profesional

La piomiositis representa una importante infección del músculo esquelético causada principalmente por Staphylococcus aureus. En este artículo se presenta el caso clínico de un futbolista de élite con antecedentes de foliculitis de repetición y portador crónico de S. aureus que presenta en un período de 6 meses dos episodios de piomiositis muscular no traumática que, tras las pruebas complementarias adecuadas, el cultivo del microorganismo y el tratamiento antibiótico correcto, se resolvieron sin complicación alguna

Piomiositis no traumàtica recurrent en un jugador de futbol professional

La piomiositis representa una important infecció del múscul esquelètic causada principalment per Staphylococcus aureus. En aquest article es presenta el cas clínic d’un futbolista d’elit amb antecedents de fol·liculitis de repetició i portador crònic de S. aureus que presenta en un període de 6 mesos dos episodis de piomiositis muscular no traumàtica que després de les proves complementàries adequades, el cultiu del microorganisme i el tractament antibiòtic correcte es van resoldre sense complicació

Sap flow, leaf-level gas exchange and spectral responses to drought in Pinus sylvestris, Pinus pinea and Pinus halepensis

In a climate change scenario, Mediterranean forest species such as pines may be endangered by rising temperatures and reduced precipitation, thus calling for studies on the transpiration and water balance in pines. In this paper, the response of young plants of Pinus sylvestris L., Pinus pinea L. and Pinus halepensis Mill. to different irrigation treatments has been studied. Significant differences were found in water potential, sap flow, leaf-level gas exchange and spectral variables. P. sylvestris had higher pre-dawn and midday water potentials, sap flow rates and leaf-level gas exchange rates compared to the other two species in well-watered conditions. Vapor pressure gradient correlated with stomatal conductance, net assimilation and transpiration, but the association between stomatal conductance and sap flow was weak. The environmental variables more strongly associated with sap flow were solar radiation and reference evapo-transpiration, especially in the well-watered plants, but those associations were weaker in the stressed plants. All three pine species showed the isohydric, drought-avoiding strategy common in the genus Pinus, maintaining relatively high water potentials in dry conditions. Nevertheless, P. halepensis showed a water-saving strategy, with a stomatal closure behavior under drought. Stomatal regulation was less strict in P. sylvestris, closer to a water-spending pattern, while P. pinea showed an intermediate behavior. Significant differences were recorded among species in spectral reflectance in the visible and infra-red regions. Photochemical Reflectance Index, Normalized Difference Vegetation Index and combinations of other ratios permitted the discrimination among the three pine species. These spectral variables showed association with sap flow rate, water potential and leaflevel gas exchange variables. Both cluster analysis and k-means classification discriminated Scots pine and Aleppo pine in two different groups. On the other hand, Stone pine showed differences in spectral behavior depending on the hydric status of the plants. Well-watered Stone pine plants had the same spectral behavior as Scots pine, while the plants subjected to drought stress were closer to Aleppo pine plants in spectral response. These findings may help to quantify the impacts of early and mid-summer water deficit on Mediterranean pines in future climate regimes

Prediction of Neurological Enzyme Targets for Known and New Compounds with a Model using Galvez's Topological Indices

The 18th International Electronic Conference on Synthetic Organic Chemistry session Computational ChemistryAlzheimer's Disease (AD), Parkinson, and other neurodegenerative diseases are a major health problem nowadays. In this sense, the discovery of new drugs for neurodiseases treatment is a goal of the major importance. Public databases, like ChEMBL, contain a large amount of data about multiplexing assays of inhibitors of a group of enzymes with special relevance in central nervous system. Mono Amino Oxidases (MAOs), Acetyl Cholinesterase (AChE), Glycogen Synthase Kinase-3 (GSK-3), AChE (AChE), and 5α-reductases (5αRs). This data conform an important information source for the application of multi-target computational models. However, almost all the computational models known focus in only one target. In this work, we developed mt-QSAR for inhibitors of 8 different enzymes promising in the treatment of different neurodiseases. In so doing, we combined by the first time the software DRAGON with Moving Average parameters with this objective. The best DRAGON model found predict with very high accuracy, specificity, and sensitivity >90% a very large data set >10000 cases in training and validation series. We also report experimental results about the assay of several 7

Gestión de información universitaria a través de una revista digital basada en plataforma web responsiva

Este artículo forma parte de un trabajo de conclusión de carrera de ingeniería en informática; propone la implementación de una revista digital como medio de información didáctica, de uso fácil y rápido acceso, destinada a una institución de educación superior. En la actualidad, las mismas se han convertido en una alternativa de espacios de actualización para que la universidad pueda mantenerse informada. Los contenidos están dirigidos a la comunidad educativa y se centran en artículos relevantes y pertinentes a distintas carreras. La solución está basada en plataforma web responsiva. Como principal resultado, la función de la revista digital universitaria está ligada a la gestión de la información de las carreras, de modo a que se constituyen como fuente de toma de decisión

Occupational exposure to wood dust and risk of lung cancer in two population-based case-control studies in Montreal, Canada

BACKGROUND: Wood dust is one of the oldest and one of the most common occupational exposures in the world. The present analyses examine the effect of lifetime exposure to wood dust in diverse occupational settings on lung cancer risk. METHODS: We conducted two population-based case-control studies in Montreal: Study I (1979-1986) included 857 cases and two sets of controls (533 population and 1349 cancer controls), and Study II (1996-2001) comprised 736 cases and 894 population controls. Detailed job histories were obtained by interview and each job was evaluated by expert chemist-hygienists to estimate the likelihood and level of exposure to many substances, one of which was wood dust. Odds ratios (ORs) were computed in relation to different indices of exposure to wood dust, adjusting for several covariates including smoking. Three datasets were analysed: Study I with population controls, Study I with cancer controls, and Study II. RESULTS: The most frequently exposed occupations in our study population were in construction, timber and furniture making industries. We found increased risks of lung cancer for substantial cumulative exposure to wood dust in Study I with cancer controls, (OR = 1.4: 95% confidence interval 1.0;-2.0) and in Study II (OR = 1.7: 95% confidence interval 1.1-2.7). There were no excess risks of lung cancer in any of the three datasets among workers whose cumulative exposure was not substantial. These tendencies held equally within strata of low smokers and heavy smokers. CONCLUSION: There was evidence of increased risk of lung cancer among workers with substantial cumulative exposure to wood dust

Influence of the Carbon Fiber Length Distribution in Polymer Matrix Composites for Large Format Additive Manufacturing via Fused Granular Fabrication

Many studies assess the suitability of fiber-reinforced polymer composites in additive manufacturing. However, the influence of the fiber length distribution on the mechanical and functional properties of printed parts using these technologies has not been addressed so far. Hence, in this work we compare different composites based on Acrylonitrile Styrene Acrylate (ASA) and carbon fiber (CF) suitable for large format additive manufacturing (LFAM) technologies based on fused granular fabrication (FGF). We study in detail the influence of the CF size on the processing and final properties of these materials. Better reinforcements were achieved with longer CF, reaching Young’s modulus and tensile strength values of 7500 MPa and 75 MPa, respectively, for printed specimens. However, the longer CF also worsened the interlayer adhesion of ASA to a greater extent. The composites also exhibited electrical properties characteristic of electrostatic dissipative (ESD) materials (105–1010 Ω/sq) and low coefficients of thermal expansion below 15 µm/m·°C. These properties are governed by the CF length distribution, so this variable may be used to tune these values. These composites are promising candidates for the design of elements with enhanced mechanical and functional properties for ESD protection elements or molds, so the products can be manufactured on demand.Ministerio de Ciencia, Innovación y Universidades (España) Junta de Andalucía (España)13 página

The risk of lung cancer related to dietary intake of flavonoids

It has been hypothesized that flavonoids in foods and beverages may reduce cancer risk through antioxidation, inhibition of inflammation, and other antimutagenic and antiproliferative properties. We examined associations between intake of five flavonoid subclasses (anthocyanidins, flavan-3-ols, flavones, flavonols, flavanones) and lung cancer risk in a population-based case-control study in Montreal, Canada (1,061 cases and 1,425 controls). Flavonoid intake was estimated from a food frequency questionnaire that assessed diet two years prior to diagnosis (cases) or interview (controls). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Overall, total flavonoid intake was not associated with lung cancer risk, the effect being similar regardless of sex and smoking level. However, low flavonoid intake from food, but not from beverages, was associated with an increased risk. The adjusted ORs (95% CIs) comparing the highest versus the lowest quartiles of intake were 0.63 (0.47-0.85) for total flavonoids, 0.82 (0.61-1.11) for anthocyanidins, 0.67 (0.50-0.90) for flavan-3-ols, 0.68 (0.50-0.93) for flavones, 0.62 (0.45-0.84) for flavonols, and 0.70 (0.53-0.94) for flavanones. An inverse association with total flavone and flavanone intake was observed for squamous cell carcinoma but not adenocarcinoma. In conclusion, low flavonoid intake from food may increase lung cancer risk

Exposure to welding fumes increases lung cancer risk among light smokers but not among heavy smokers: evidence from two case-control studies in Montreal.

We investigated relationships between occupational exposure to gas and arc welding fumes and the risk of lung cancer among workers exposed to these agents throughout the spectrum of industries. Two population-based case-control studies were conducted in Montreal. Study I (1979-1986) included 857 cases and 1066 controls, and Study II (1996-2001) comprised 736 cases and 894 controls. Detailed job histories were obtained by interview and evaluated by an expert team of chemist-hygienists to estimate degree of exposure to approximately 300 substances for each job. Gas and arc welding fumes were among the agents evaluated. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) of lung cancer using logistic regression, adjusting for smoking history and other covariates. The two studies provided similar results, so a pooled analysis was conducted. Among all subjects, no significant association was found between lung cancer and gas welding fumes (OR = 1.1; 95% CI = 0.9-1.4) or arc welding fumes (OR = 1.0; 95% CI = 0.8-1.2). However, when restricting attention to light smokers, there was an increased risk of lung cancer in relation to gas welding fumes (OR = 2.9; 95% CI = 1.7-4.8) and arc welding fumes (OR = 2.3; 95% CI = 1.3-3.8), with even higher OR estimates among workers with the highest cumulative exposures. In conclusion, there was no detectable excess risk of lung cancer due to welding fumes among moderate to heavy smokers; but among light smokers we found an excess risk related to both types of welding fumes

Eventos de supercontagio.

Los eventos de supercontagio, aquellos donde se produce una transmisión de la enfermedad a un número de personas mucho mayor al promedio para esa misma enfermedad, presentan un riesgo importante para el manejo de la pandemia de COVID-19 en los próximos meses. En esta nota intentamos avanzar en la caracterización, a partir de un repaso de la literatura existente, de los eventos de supercontagio, entender su relevancia en el marco de la COVID-19, y presentar algunas posibles acciones que, a través del control de este tipo de eventos, podrían ser útiles para el manejo general de la pandemia, en especial en el caso de Uruguay