3,589 research outputs found

    The GlueX DIRC Project

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    The GlueX experiment was designed to search for and study the pattern of gluonic excitations in the meson spectrum produced through photoproduction reactions at a new tagged photon beam facility in Hall D at Jefferson Laboratory. The particle identification capabilities of the GlueX experiment will be enhanced by constructing a DIRC (Detection of Internally Reflected Cherenkov light) detector, utilizing components of the decommissioned BaBar DIRC. The DIRC will allow systematic studies of kaon final states that are essential for inferring the quark flavor content of both hybrid and conventional mesons. The design for the GlueX DIRC is presented, including the new expansion volumes that are currently under development.Comment: 8 pages, 6 figure

    Removing Barriers That Prevent Parents From Low Socioeconomic Backgrounds From Being Involved in Their Children’s High School Education

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    Abstract The purpose of this qualitative case study was to describe the barriers that prevent parents from low socioeconomic backgrounds from being involved in their children’s high school education at District X in rural East Texas. Fifteen high school teacher participants were interviewed and provided their experiences and perceptions to support the interviews and focus groups. The primary findings identified teachers’ perceptions of the barriers that prevent parental involvement, parents’ commitment to their children’s high school education, and the teacher’s role in removing barriers that prevent parents from low socioeconomic backgrounds from being involved in their children’s high school education. Building solid partnerships, attending cultural and parental involvement training, creating shared commitments with parents, and developing positive perceptions of parents were strategies teachers used to help remove barriers that prevented parents from low socioeconomic backgrounds from being involved in their children’s high school education. Increasing two-way communication with parents, being culturally sensitive, and improving COVID-19 safety measures created a welcoming environment for parents. School districts must improve professional development practices throughout the school year to increase parental involvement through creative strategies and programs. This study is important because of the decrease in parental involvement for parents from low socioeconomic backgrounds, and it provides pertinent information for parents and teachers to create a sustainable partnership

    An Infrared through Radio Study of the Properties and Evolution of IRDC Clumps

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    We examine the physical properties and evolutionary stages of a sample of 17 clumps within 8 Infrared Dark Clouds (IRDCs) by combining existing infrared, millimeter, and radio data with new Bolocam Galactic Plane Survey (BGPS) 1.1 mm data, VLA radio continuum data, and HHT dense gas (HCO+ and N2H+) spectroscopic data. We combine literature studies of star formation tracers and dust temperatures within IRDCs with our search for ultra-compact (UC) HII regions to discuss a possible evolutionary sequence for IRDC clumps. In addition, we perform an analysis of mass tracers in IRDCs and find that 8 micron extinction masses and 1.1 mm Bolocam Galactic Plane Survey (BGPS) masses are complementary mass tracers in IRDCs except for the most active clumps (notably those containing UCHII regions), for which both mass tracers suffer biases. We find that the measured virial masses in IRDC clumps are uniformly higher than the measured dust continuum masses on the scale of ~1 pc. We use 13CO, HCO+, and N2H+ to study the molecular gas properties of IRDCs and do not see any evidence of chemical differentiation between hot and cold clumps on the scale of ~1 pc. However, both HCO+ and N2H+ are brighter in active clumps, due to an increase in temperature and/or density. We report the identification of four UCHII regions embedded within IRDC clumps and find that UCHII regions are associated with bright (>1 Jy) 24 micron point sources, and that the brightest UCHII regions are associated with "diffuse red clumps" (an extended enhancement at 8 micron). The broad stages of the discussed evolutionary sequence (from a quiescent clump to an embedded HII region) are supported by literature dust temperature estimates; however, no sequential nature can be inferred between the individual star formation tracers.Comment: 33 pages, 26 figures, 6 tables, accepted for publication in ApJ. Full resolution version available here: http://casa.colorado.edu/~battersb/Publications.htm

    Identification of plant calmodulin binding protein genes

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    Cell-specific activity-dependent fractionation of layer 2/3→5B excitatory signaling in mouse auditory cortex

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    © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Journal of Neuroscience 35 (2015): 3112-3123, doi:10.1523/JNEUROSCI.0836-14.2015.Auditory cortex (AC) layer 5B (L5B) contains both corticocollicular neurons, a type of pyramidal-tract neuron projecting to the inferior colliculus, and corticocallosal neurons, a type of intratelencephalic neuron projecting to contralateral AC. Although it is known that these neuronal types have distinct roles in auditory processing and different response properties to sound, the synaptic and intrinsic mechanisms shaping their input–output functions remain less understood. Here, we recorded in brain slices of mouse AC from retrogradely labeled corticocollicular and neighboring corticocallosal neurons in L5B. Corticocollicular neurons had, on average, lower input resistance, greater hyperpolarization-activated current (Ih), depolarized resting membrane potential, faster action potentials, initial spike doublets, and less spike-frequency adaptation. In paired recordings between single L2/3 and labeled L5B neurons, the probabilities of connection, amplitude, latency, rise time, and decay time constant of the unitary EPSC were not different for L2/3→corticocollicular and L2/3→corticocallosal connections. However, short trains of unitary EPSCs showed no synaptic depression in L2/3→corticocollicular connections, but substantial depression in L2/3→corticocallosal connections. Synaptic potentials in L2/3→corticocollicular connections decayed faster and showed less temporal summation, consistent with increased Ih in corticocollicular neurons, whereas synaptic potentials in L2/3→corticocallosal connections showed more temporal summation. Extracellular L2/3 stimulation at two different rates resulted in spiking in L5B neurons; for corticocallosal neurons the spike rate was frequency dependent, but for corticocollicular neurons it was not. Together, these findings identify cell-specific intrinsic and synaptic mechanisms that divide intracortical synaptic excitation from L2/3 to L5B into two functionally distinct pathways with different input–output functions.This work was supported by National Institutes of Health grants DC013272 (T.T. and G.M.G.S.), DC007905 (T.T.), NS061963 (G.M.G.S), R03DC012585 (J.W.M.), T32DC011499 (C.T.A.), and F32DC013734 (C.T.A), and by the Albert and Ellen Grass Faculty Award (T.T. and G.M.G.S.) and Charles Evans Foundation Award (T.T. and G.M.G.S.).2015-08-1

    Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?

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    Experience shapes and molds the brain throughout life.These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor (AMPAR), is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity.These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target
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