Phenological characteristics of global coccolithophore blooms

Coccolithophores are recognized as having a significant influence on the global carbon cycle through the production and export of calcium carbonate (often referred to as particulate inorganic carbon or PIC). Using remotely sensed PIC and chlorophyll data, we investigate the seasonal dynamics of coccolithophores relative to a mixed phytoplankton community. Seasonal variability in PIC, here considered to indicate changes in coccolithophore biomass, is identified across much of the global ocean. Blooms, which typically start in February–March in the low-latitude (~30°) Northern Hemisphere and last for ~6–7 months, get progressively later (April–May) and shorter (3–4 months) moving poleward. A similar pattern is observed in the Southern Hemisphere, where blooms that generally begin around August–September in the lower latitudes and which last for ~8 months get later and shorter with increasing latitude. It has previously been considered that phytoplankton blooms consist of a sequential succession of blooms of individual phytoplankton types. Comparison of PIC and chlorophyll peak dates suggests instead that in many open ocean regions, blooms of coccolithophores and other phytoplankton can co-occur, conflicting with the traditional view of species succession that is thought to take place in temperate regions such as the North Atlantic

Same-Sex Couples, Families, and Marriage: Embracing and Resisting Heteronormativity

Abstract This article focuses on lesbian and gay couples and families and the politics of same-sex marriage. Drawing from the literature on same-sex couples, same-sex marriage, and queer theory's concept of heteronormativity, we argue that gay and lesbian couples and families both affirm and challenge heterosexual and gendered family forms. First, we review literature that discusses how same-sex relationships and families are similar to and different from conventional heterosexual relationships and families. Second, we discuss the socio-legal and cultural inequalities faced by LGBT families. Third, we discuss the politics of same-sex marriage, examining the debate among social conservatives, pro-marriage activists, and queer critics over the desirability of same-sex marriage. We conclude that the growing visibility of LGBT couples and families has made their exclusion from the institution of marriage more conspicuous and that recognition of LGBT relationships and families seems likely to increase

The Origin of the 24-micron Excess in Red Galaxies

Observations with the Spitzer Space Telescope have revealed a population of red-sequence galaxies with a significant excess in their 24-micron emission compared to what is expected from an old stellar population. We identify 900 red galaxies with 0.15<z<0.3 from the AGN and Galaxy Evolution Survey (AGES) selected from the NOAO Deep Wide-Field Survey Bootes field. Using Spitzer/MIPS, we classify 89 (~10%) with 24-micron infrared excess (f24>0.3 mJy). We determine the prevalence of AGN and star-formation activity in all the AGES galaxies using optical line diagnostics and mid-IR color-color criteria. Using the IRAC color-color diagram from the IRAC Shallow Survey, we find that 64% of the 24-micron excess red galaxies are likely to have strong PAH emission features in the 8-micron IRAC band. This fraction is significantly larger than the 5% of red galaxies with f24<0.3 mJy that are estimated to have strong PAH emission, suggesting that the infrared emission is largely due to star-formation processes. Only 15% of the 24-micron excess red galaxies have optical line diagnostics characteristic of star-formation (64% are classified as AGN and 21% are unclassifiable). The difference between the optical and infrared results suggest that both AGN and star-formation activity is occurring simultaneously in many of the 24-micron excess red galaxies. These results should serve as a warning to studies that exclusively use optical line diagnostics to determine the dominant emission mechanism in the infrared and other bands. We find that ~40% of the 24-micron excess red galaxies are edge-on spiral galaxies with high optical extinctions. The remaining sources are likely to be red galaxies whose 24-micron emission comes from a combination of obscured AGN and star-formation activity.Comment: ApJ, accepted; 11 pages, 7 figures; corrected reference to IRAC Shallow Survey in abstrac

Shining Light on Merging Galaxies I: The Ongoing Merger of a Quasar with a `Green Valley' Galaxy

Serendipitous observations of a pair z = 0.37 interacting galaxies (one hosting a quasar) show a massive gaseous bridge of material connecting the two objects. This bridge is photoionized by the quasar (QSO) revealing gas along the entire projected 38 kpc sightline connecting the two galaxies. The emission lines that result give an unprecedented opportunity to study the merger process at this redshift. We determine the kinematics, ionization parameter (log U ~ -2.5 +- 0.03), column density (N_H ~ 10^{21} cm^{-2}), metallicity ([M/H] ~ -0.20 +- 0.15), and mass (~ 10^8 Msun) of the gaseous bridge. We simultaneously constrain properties of the QSO-host (M_DM>8.8x 10^{11} Msun) and its companion galaxy (M_DM>2.1 x 10^{11} Msun; M_star ~ 2 x 10^{10} Msun; stellar burst age=300-800 Myr; SFR~6 Msun/yr; and metallicity 12+log (O/H)= 8.64 +- 0.2). The general properties of this system match the standard paradigm of a galaxy-galaxy merger caught between first and second passage while one of the galaxies hosts an active quasar. The companion galaxy lies in the so-called `green valley', with a stellar population consistent with a recent starburst triggered during the first passage of the merger and has no detectable AGN activity. In addition to providing case-studies of quasars associated with galaxy mergers, quasar/galaxy pairs with QSO-photoionized tidal bridges such as this one offer unique insights into the galaxy properties while also distinguishing an important and inadequately understood phase of galaxy evolution.Comment: 23 pages, 12 figures, 5 tables, Submitted to ApJ, revised to address referee's comment

Tempo and mode of gene expression evolution in the brain across primates

Primate evolution has led to a remarkable diversity of behavioral specializations and pronounced brain size variation among species (Barton, 2012; DeCasien and Higham, 2019; Powell et al., 2017). Gene expression provides a promising opportunity for studying the molecular basis of brain evolution, but it has been explored in very few primate species to date (e.g. Khaitovich et al., 2005; Khrameeva et al., 2020; Ma et al., 2022; Somel et al., 2009). To understand the landscape of gene expression evolution across the primate lineage, we generated and analyzed RNA-seq data from four brain regions in an unprecedented eighteen species. Here, we show a remarkable level of variation in gene expression among hominid species, including humans and chimpanzees, despite their relatively recent divergence time from other primates. We found that individual genes display a wide range of expression dynamics across evolutionary time reflective of the diverse selection pressures acting on genes within primate brain tissue. Using our samples that represent a 190-fold difference in primate brain size, we identified genes with variation in expression most correlated with brain size. Our study extensively broadens the phylogenetic context of what is known about the molecular evolution of the brain across primates and identifies novel candidate genes for the study of genetic regulation of brain evolution

Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE.

PURPOSE: To report 36-month outcomes of RIDE (NCT00473382) and RISE (NCT00473330), trials of ranibizumab in diabetic macular edema (DME). DESIGN: Phase III, randomized, multicenter, double-masked, 3-year trials, sham injection-controlled for 2 years. PARTICIPANTS: Adults with DME (n=759), baseline best-corrected visual acuity (BCVA) 20/40 to 20/320 Snellen equivalent, and central foveal thickness (CFT) ≥ 275 μm on optical coherence tomography. METHODS: Patients were randomized equally (1 eye per patient) to monthly 0.5 mg or 0.3 mg ranibizumab or sham injection. In the third year, sham patients, while still masked, were eligible to cross over to monthly 0.5 mg ranibizumab. Macular laser was available to all patients starting at month 3; panretinal laser was available as necessary. MAIN OUTCOME MEASURES: The proportion of patients gaining ≥15 Early Treatment Diabetic Retinopathy Study letters in BCVA from baseline at month 24. RESULTS: Visual acuity (VA) outcomes seen at month 24 in ranibizumab groups were consistent through month 36; the proportions of patients who gained ≥15 letters from baseline at month 36 in the sham/0.5 mg, 0.3 mg, and 0.5 mg ranibizumab groups were 19.2%, 36.8%, and 40.2%, respectively, in RIDE and 22.0%, 51.2%, and 41.6%, respectively, in RISE. In the ranibizumab arms, reductions in CFT seen at 24 months were, on average, sustained through month 36. After crossover to 1 year of treatment with ranibizumab, average VA gains in the sham/0.5 mg group were lower compared with gains seen in the ranibizumab patients after 1 year of treatment (2.8 vs. 10.6 and 11.1 letters). Per-injection rates of endophthalmitis remained low over time (∼0.06% per injection). The incidence of serious adverse events potentially related to systemic vascular endothelial growth factor inhibition was 19.7% in patients who received 0.5 mg ranibizumab compared with 16.8% in the 0.3 mg group. CONCLUSIONS: The strong VA gains and improvement in retinal anatomy achieved with ranibizumab at month 24 were sustained through month 36. Delayed treatment in patients receiving sham treatment did not seem to result in the same extent of VA improvement observed in patients originally randomized to ranibizumab. Ocular and systemic safety was generally consistent with the results seen at month 24. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references

Regional characteristics of the temporal variability in the global particulate inorganic carbon inventory

Coccolithophores are a biogeochemically important calcifying group of phytoplankton that exert significant influence on the global carbon cycle. They can modulate the air‐sea flux of CO2 through the processes of photosynthesis and calcification and, as one of the primary contributors to the oceanic particulate inorganic carbon (PIC) pool, promote the export of organic carbon to depth. Here we present the first interannually resolved, global analysis of PIC standing stock. Average, global PIC standing stock in the top 100 m is estimated to be 27.04 ± 4.33 Tg PIC, with turnover times of ~7 days, which suggests PIC is likely removed by active processes such as grazing or rapid sinking, mediated through biogenic packaging (i.e., fecal pellets). We find that the Southern Hemisphere plays a significant role in the variability in PIC inventories and that interannual variability in PIC standing stock is driven primarily by variability in the midlatitude oceanic gyres and regions within the Great Calcite Belt of the Southern Ocean. Our results provide a framework against which future changes in global PIC standing stocks may be assessed

Ubiquitous outflows in DEEP2 spectra of star-forming galaxies at z=1.4

Galactic winds are a prime suspect for the metal enrichment of the intergalactic medium and may have a strong influence on the chemical evolution of galaxies and the nature of QSO absorption line systems. We use a sample of 1406 galaxy spectra at z~1.4 from the DEEP2 redshift survey to show that blueshifted Mg II 2796, 2803 A absorption is ubiquitous in starforming galaxies at this epoch. This is the first detection of frequent outflowing galactic winds at z~1. The presence and depth of absorption are independent of AGN spectral signatures or galaxy morphology; major mergers are not a prerequisite for driving a galactic wind from massive galaxies. Outflows are found in coadded spectra of galaxies spanning a range of 30x in stellar mass and 10x in star formation rate (SFR), calibrated from K-band and from MIPS IR fluxes. The outflows have column densities of order N_H ~ 10^20 cm^-2 and characteristic velocities of ~ 300-500 km/sec, with absorption seen out to 1000 km/sec in the most massive, highest SFR galaxies. The velocities suggest that the outflowing gas can escape into the IGM and that massive galaxies can produce cosmologically and chemically significant outflows. Both the Mg II equivalent width and the outflow velocity are larger for galaxies of higher stellar mass and SFR, with V_wind ~ SFR^0.3, similar to the scaling in low redshift IR-luminous galaxies. The high frequency of outflows in the star-forming galaxy population at z~1 indicates that galactic winds occur in the progenitors of massive spirals as well as those of ellipticals. The increase of outflow velocity with mass and SFR constrains theoretical models of galaxy evolution that include feedback from galactic winds, and may favor momentum-driven models for the wind physics.Comment: Accepted by ApJ. 25 pages, 17 figures. Revised to add discussions of intervening absorbers and AGN-driven outflows; conclusions unchange

Neoadjuvant Talazoparib in Patients With Germline BRCA1/2 Mutation-Positive, Early-Stage Triple-Negative Breast Cancer: Exploration of Tumor BRCA Mutational Status

BACKGROUND: Talazoparib monotherapy in patients with germline BRCA-mutated, early-stage triple-negative breast cancer (TNBC) showed activity in the neoadjuvant setting in the phase II NEOTALA study (NCT03499353). These biomarker analyses further assessed the mutational landscape of the patients enrolled in the NEOTALA study. METHODS: Baseline tumor tissue from the NEOTALA study was tested retrospectively using FoundationOne RESULTS: All patients enrolled (N = 61) had TNBC. In the biomarker analysis population, 75.0% (39/52) and 25.0% (13/52) of patients exhibited BRCA1 and BRCA2 mutations, respectively. Strong concordance (97.8%) was observed between tumor BRCA and germline BRCA mutations, and 90.5% (38/42) of patients with tumor BRCA mutations evaluable for somatic-germline-zygosity were predicted to exhibit BRCA loss of heterozygosity (LOH). No patients had non-BRCA germline DNA damage response (DDR) gene variants with known/likely pathogenicity, based on a panel of 14 non-BRCA DDR genes. Ninety-eight percent of patients had TP53 mutations. Genomic LOH, assessed continuously or categorically, was not associated with response. CONCLUSION: The results from this exploratory biomarker analysis support the central role of BRCA and TP53 mutations in tumor pathobiology. Furthermore, these data support assessing germline BRCA mutational status for molecular eligibility for talazoparib in patients with TNBC

Seeking order amidst chaos: a systematic review of classification systems for causes of stillbirth and neonatal death, 2009-2014.

BACKGROUND: Each year, about 5.3 million babies die in the perinatal period. Understanding of causes of death is critical for prevention, yet there is no globally acceptable classification system. Instead, many disparate systems have been developed and used. We aimed to identify all systems used or created between 2009 and 2014, with their key features, including extent of alignment with the International Classification of Diseases (ICD) and variation in features by region, to inform the World Health Organization's development of a new global approach to classifying perinatal deaths. METHODS: A systematic literature review (CINAHL, EMBASE, Medline, Global Health, and PubMed) identified published and unpublished studies and national reports describing new classification systems or modifications of existing systems for causes of perinatal death, or that used or tested such systems, between 2009 and 2014. Studies reporting ICD use only were excluded. Data were independently double-extracted (except from non-English publications). Subgroup analyses explored variation by extent and region. RESULTS: Eighty-one systems were identified as new, modifications of existing systems, or having been used between 2009 and 2014, with an average of ten systems created/modified each year. Systems had widely varying characteristics: (i) comprehensiveness (40 systems classified both stillbirths and neonatal deaths); (ii) extent of use (systems were created in 28 countries and used in 40; 17 were created for national use; 27 were widely used); (iii) accessibility (three systems available in e-format); (iv) underlying cause of death (64 systems required a single cause of death); (v) reliability (10 systems tested for reliability, with overall Kappa scores ranging from .35-.93); and (vi) ICD alignment (17 systems used ICD codes). Regional databases were not searched, so system numbers may be underestimated. Some non-differential misclassification of systems was possible. CONCLUSIONS: The plethora of systems in use, and continuing system development, hamper international efforts to improve understanding of causes of death. Recognition of the features of currently used systems, combined with a better understanding of the drivers of continued system creation, may help the development of a truly effective global system.The Mater Research Institute, University of Queensland, AustraliaThis is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s12884-016-1071-