52 research outputs found
Optimised and Rapid Pre-clinical Screening in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
- Author
- AC Ludolph
- AC Ludolph
- Andrew Grierson
- Aneurin J. Kennerley
- B van Zundert
- B Zhang
- BM Morrison
- Brigitte Pettmann
- C Bendotti
- C Bendotti
- C Bories
- C Kilkenny
- CJ Alves
- CL Goodrick
- Claire Sunyach
- CM Wooley
- CR Hayworth
- D Frey
- DH Vrinten
- DJ Graber
- DS Howland
- Ellen J. Bennett
- F Faul
- FJ Miana-Mena
- GM Alexander
- Guiseppe Battaglia
- J Amendola
- J Kong
- J Schnabel
- Jason Berwick
- JP De Bono
- JS Henkel
- K Kim
- KJ Brooks
- KJ De Vos
- L Dupuis
- LR Fischer
- M Benatar
- Maria A. Deli
- ME Gurney
- MF Festing
- MFW Festing
- Mimoun Azzouz
- MM Reinholz
- P Barneoud
- Pamela J. Shaw
- Paul Kasher
- Paul Sharp
- PC Wong
- PF Kennel
- PH Tu
- PK Andrus
- R Chia
- RA Taft
- RE Bittner
- Richard J. Mead
- RJ Ferrante
- S Boillee
- S Garbuzova-Davis
- S Knippenberg
- S Pun
- S Scott
- TD Heiman-Patterson
- TL Williamson
- W Russell
- Z Mourelatos
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The human SOD1G93A transgenic mouse has been used extensively since its development in 1994 as a model for amyotrophic lateral sclerosis (ALS). In that time, a great many insights into the toxicity of mutant SOD1 have been gained using this and other mutant SOD transgenic mouse models. They all demonstrate a selective toxicity towards motor neurons and in some cases features of the pathology seen in the human disease. These models have two major drawbacks. Firstly the generation of robust preclinical data in these models has been highlighted as an area for concern. Secondly, the amount of time required for a single preclinical experiment in these models (3–4 months) is a hurdle to the development of new therapies. We have developed an inbred C57BL/6 mouse line from the original mixed background (SJLxC57BL/6) SOD1G93A transgenic line and show here that the disease course is remarkably consistent and much less prone to background noise, enabling reduced numbers of mice for testing of therapeutics. Secondly we have identified very early readouts showing a large decline in motor function compared to normal mice. This loss of motor function has allowed us to develop an early, sensitive and rapid screening protocol for the initial phases of denervation of muscle fibers, observed in this model. We describe multiple, quantitative readouts of motor function that can be used to interrogate this early mechanism. Such an approach will increase throughput for reduced costs, whilst reducing the severity of the experimental procedures involved
Erratum to: Methods for evaluating medical tests and biomarkers
- Author
- Gowri Gopalakrishna
- null null
- Miranda Langendam
- Rob Scholten
- Patrick Bossuyt
- Mariska Leeflang
- Anna Noel-Storr
- James Thomas
- Iain Marshall
- Byron Wallace
- Penny Whiting
- Clare Davenport
- Mariska Leeflang
- Gowri GopalaKrishna
- Isabel de Salis
- Sue Mallett
- Robert Wolff
- Penny Whiting
- Richard Riley
- Marie Westwood
- Jos Kleinen
- Gary Collins
- Hans Reitsma
- Karel Moons
- Antonia Zapf
- Annika Hoyer
- Katharina Kramer
- Oliver Kuss
- J. Ensor
- J. J. Deeks
- E. C. Martin
- R. D. Riley
- Gerta Rücker
- Susanne Steinhauser
- Martin Schumacher
- Richard Riley
- Joie Ensor
- Kym Snell
- Brian Willis
- Thomas Debray
- Karel Moons
- Jon Deeks
- Gary Collins
- Lavinia Ferrante di Ruffano
- Brian Willis
- Clare Davenport
- Sue Mallett
- Sian Taylor-Phillips
- Chris Hyde
- Jon Deeks
- Sue Mallett
- Stuart A. Taylor
- Gauraang Batnagar
- Sian Taylor-Phillips
- Lavinia Ferrante Di Ruffano
- Farah Seedat
- Aileen Clarke
- Jon Deeks
- Sarah Byron
- Frances Nixon
- Rebecca Albrow
- Thomas Walker
- Carla Deakin
- Chris Hyde
- Zhivko Zhelev
- Harriet Hunt
- Lavinia Ferrante di Ruffano
- Yaling Yang
- Lucy Abel
- James Buchanan
- Thomas Fanshawe
- Bethany Shinkins
- Laure Wynants
- Jan Verbakel
- Sabine Van Huffel
- Dirk Timmerman
- Ben Van Calster
- Mariska Leeflang
- Aeliko Zwinderman
- Patrick Bossuyt
- Jason Oke
- Jack O’Sullivan
- Rafael Perera
- Brian Nicholson
- Hannah L. Bromley
- Tracy E. Roberts
- Adele Francis
- Denniis Petrie
- G. Bruce Mann
- Kinga Malottki
- Holly Smith
- Jon Deeks
- Lucinda Billingham
- Alice Sitch
- Sue Mallett
- Jon Deeks
- Oke Gerke
- Mie Holm-Vilstrup
- Eivind Antonsen Segtnan
- Ulrich Halekoh
- Poul Flemming Høilund-Carlsen
- Bernard G. Francq
- Jon Deeks
- Alice Sitch
- Jac Dinnes
- Julie Parkes
- Walter Gregory
- Jenny Hewison
- Doug Altman
- William Rosenberg
- Peter Selby
- Julien Asselineau
- Paul Perez
- Aïssatou Paye
- Emilie Bessede
- Cécile Proust-Lima
- Christiana Naaktgeboren
- Joris de Groot
- Anne Rutjes
- Patrick Bossuyt
- Johannes Reitsma
- Karel Moons
- Gary Collins
- Emmanuel Ogundimu
- Jonathan Cook
- Yannick Le Manach
- Doug Altman
- Laure Wynants
- Yvonne Vergouwe
- Sabine Van Huffel
- Dirk Timmerman
- Ben Van Calster
- Romin Pajouheshnia
- Rolf Groenwold
- Karen Moons
- Johannes Reitsma
- Linda Peelen
- Ben Van Calster
- Daan Nieboer
- Yvonne Vergouwe
- Bavo De Cock
- Micael J. Pencina
- Ewout W. Steyerberg
- Jennifer Cooper
- Sian Taylor-Phillips
- Nick Parsons
- Chris Stinton
- Steve Smith
- Andy Dickens
- Rachel Jordan
- Alexandra Enocson
- David Fitzmaurice
- Alice Sitch
- Peymane Adab
- Bernard G. Francq
- Charles Boachie
- Gaj Vidmar
- Karoline Freeman
- Martin Connock
- Sian Taylor-Phillips
- Rachel Court
- Aileen Clarke
- Joris de Groot
- Christiana Naaktgeboren
- Hans Reitsma
- Carl Moons
- Jessica Harris
- Andrew Mumford
- Zoe Plummer
- Kurtis Lee
- Barnaby Reeves
- Chris Rogers
- Veerle Verheyden
- Gianni D. Angelini
- Gavin J. Murphy
- Jeremy Huddy
- Melody Ni
- Katherine Good
- Graham Cooke
- Patrick Bossuyt
- George Hanna
- Jie Ma
- Doug Altman
- Gary Collins
- K. G. M. Moons
- Joris A. H. de Groot
- Sue Mallett
- Doug G. Altman
- Johannes B. Reitsma
- Gary S. Collins
- Karel G. M. Moons
- Douglas G. Altman
- Johannes B. Reitsma
- Gary S. Collins
- Adina Najwa Kamarudin
- Ruwanthi Kolamunnage-Dona
- Trevor Cox
- Melody Ni
- Jeremy Huddy
- Simone Borsci
- George Hanna
- Teresa Pérez
- M.Carmen Pardo
- Angel Candela-Toha
- Alfonso Muriel
- Javier Zamora
- Sabina Sanghera
- Syed Mohiuddin
- Richard Martin
- Jenny Donovan
- Joanna Coast
- Mikyung Kelly Seo
- John Cairns
- Elizabeth Mitchell
- Alison Smith
- Judy Wright
- Peter Hall
- Michael Messenger
- Nicola Calder
- Nyantara Wickramasekera
- Karen Vinall-Collier
- Andrew Lewington
- Romin Pajouheshnia
- Johanna Damen
- Rolf Groenwold
- Karel Moons
- Linda Peelen
- Michael Messenger
- David Cairns
- Alison Smith
- Michelle Hutchinson
- Judy Wright
- Peter Hall
- Nicola Calder
- Cathie Sturgeon
- Liz Mitchel
- Rebecca Kift
- Sofia Christakoudi
- Manohursingh Rungall
- Paula Mobillo
- Rosa Montero
- Tjir-Li Tsui
- Sui Phin Kon
- Beatriz Tucker
- Steven Sacks
- Chris Farmer
- Terry Strom
- Paramit Chowdhury
- Irene Rebollo-Mesa
- Maria Hernandez-Fuentes
- Johanna A. A. G. Damen
- Thomas P. A. Debray
- Pauline Heus
- Lotty Hooft
- Karel G. M. Moons
- Romin Pajouheshnia
- Johannes B. Reitsma
- Rob J. P. M. Scholten
- Johanna A. A. G. Damen
- Lotty Hooft
- Ewoud Schuit
- Thomas P. A. Debray
- Gary S. Collins
- Ioanna Tzoulaki
- Camille M. Lassale
- George C. M. Siontis
- Virginia Chiocchia
- Corran Roberts
- Michael Maia Schlüssel
- Stephen Gerry
- James A. Black
- Pauline Heus
- Yvonne T. van der Schouw
- Linda M. Peelen
- Karel G. M. Moons
- Johanna A. A. G. Damen
- Thomas P. A. Debray
- Pauline Heus
- Lotty Hooft
- Karel G. M. Moons
- Romin Pajouheshnia
- Johannes B. Reitsma
- Rob J. P. M. Scholten
- Jie Ma
- Doug Altman
- Gary Collins
- Graeme Spence
- David McCartney
- Ann van den Bruel
- Daniel Lasserson
- Gail Hayward
- Werner Vach
- Antoinette de Jong
- Coreline Burggraaff
- Otto Hoekstra
- Josée Zijlstra
- Henrica de Vet
- Harriet Hunt
- Chris Hyde
- Sara Graziadio
- Joy Allen
- Louise Johnston
- Rachel O’Leary
- Michael Power
- Joy Allen
- Sara Graziadio
- Louise Johnson
- Rachel O’Leary
- Michael Power
- Ray Waters
- John Simpson
- Louise Johnston
- Joy Allen
- Sara Graziadio
- Rachel O’Leary
- Ray Waters
- Michael Power
- Sue Mallett
- Thomas R. Fanshawe
- Peter Phillips
- Andrew Plumb
- Emma Helbren
- Steve Halligan
- Stuart A. Taylor
- Alastair Gale
- Sue Mallett
- Peggy Sekula
- Douglas G. Altman
- Willi Sauerbrei
- Sue Mallett
- Thomas R. Fanshawe
- Julia R. Forman
- Susan J. Dutton
- Yemisi Takwoingi
- Elizabeth M. Hensor
- Thomas E. Nichols
- Bethany Shinkins
- Yaling Yang
- Lucy Abel
- Lavinia Ferrante Di Ruffano
- Thomas Fanshawe
- Emmanuelle Kempf
- Raphael Porcher
- Jennifer de Beyer
- Karel Moons
- Douglas Altman
- Hans Reitsma
- Sally Hopewell
- Willi Sauerbrei
- Gary Collins
- John Dennis
- Beverley Shields
- Angus Jones
- William Henley
- Ewan Pearson
- Andrew Hattersley
- Pauline Heus
- Johanna A. A. G. Damen
- Romin Pajouheshnia
- Rob J. P. M. Scholten
- Johannes B. Reitsma
- Gary S. Collins
- Douglas G. Altman
- Karel G. M. Moons
- Lotty Hooft
- Beverley Shields
- John Dennis
- Angus Jones
- William Henley
- Ewan Pearson
- Andrew Hattersley
- Fueloep Scheibler
- Anne Rummer
- Sibylle Sturtz
- Robert Großelfinger
- Katie Banister
- Craig Ramsay
- Augusto Azuara-Blanco
- Jonathan Cook
- Charles Boachie
- Jennifer Burr
- Manjula Kumarasamy
- Rupert Bourne
- Ijeoma Uchegbu
- Simone Borsci
- Jennifer Murphy
- George Hanna
- Ijeoma Uchegbu
- Alex Carter
- Jen Murphy
- Melody Ni
- Joachim Marti
- Julie Eatock
- Ijeoma Uchegbu
- Julie Robotham
- Maria Dudareva
- Mark Gilchrist
- Alison Holmes
- Ijeoma Uchegbu
- Simone Borsci
- Phillip Monaghan
- Sarah Lord
- Andrew StJohn
- Sverre Sandberg
- Christa Cobbaert
- Lieselotte Lennartz
- Wilma Verhagen-Kamerbeek
- Christoph Ebert
- Patrick Bossuyt
- Andrea Horvath
- Kevin Jenniskens
- Christiana Naaktgeboren
- Johannes Reitsma
- Karel Moons
- Joris de Groot
- Chris Hyde
- Jaime Peters
- Bogdan Grigore
- Jaime Peters
- Chris Hyde
- Chris Hyde
- Obi Ukoumunne
- Jaime Peters
- Zhivko Zhelev
- Brooke Levis
- Andrea Benedetti
- Alexander W. Levis
- John P. A. Ioannidis
- Ian Shrier
- Pim Cuijpers
- Simon Gilbody
- Lorie A. Kloda
- Dean McMillan
- Scott B Patten
- Russell J. Steele
- Roy C Ziegelstein
- Charles H. Bombardier
- Flavia de Lima Osório
- Jesse R. Fann
- Dwenda Gjerdingen
- Femke Lamers
- Manote Lotrakul
- Sonia R Loureiro
- Bernd Löwe
- Juwita Shaaban
- Lesley Stafford
- Henk C. P. M. van Weert
- Mary A. Whooley
- Linda S. Williams
- Karin A. Wittkampf
- Albert S. Yeung
- Brett D. Thombs
- Jaime Peters
- Chris Cooper
- James Buchanan
- Tom Nieto
- Claire Smith
- Olga Tucker
- Janine Dretzke
- Andrew Beggs
- Nirmala Rai
- Clare Davenport
- Sue Bayliss
- Simon Stevens
- Kym Snell
- Sue Mallet
- Jon Deeks
- Sudha Sundar
- Emma Hall
- Nuria Porta
- David Lorente Estelles
- Johann de Bono
- null null
- null null
- null null
- null null
- null null
- null null
- Publication venue
- Springer Nature
- Publication date
- 01/01/2003
- Field of study
[This corrects the article DOI: 10.1186/s41512-016-0001-y.]
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo Musicò
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- Annaïg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila Oláh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- Aurélie Ledreux
- Avital A Rodal
- Ayesha Saleem
- Ákos M Lőrincz
- Áurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E Benediktsdóttir
- Bernadett R Bodnár
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
- Beth Holder
- Bianca C Pachane
- Biao Lu
- Bingdong Sui
- Birke J Benedikter
- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
- Bong Hwan Sung
- Bonita H Powell
- Brachyahu M Kestecher
- Bradley Whitehead
- Brian Dobosh
- Bridges Esther M.
- Brucale Marco
- Bruce A Stanton
- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
- Camille V Trinidad
- Cansu Gorgun
- Carla Mazzeo
- Carlos Salomon
- Carmen Campos-Silva
- Carmen Carceller
- Carmen Fernandez-Becerra
- Carmen Jerónimo
- Carney Randy P.
- Carolina Balbi
- Carolina Soekmadji
- Caroline Gilbert
- Caroline J Reddel
- Catherine A Sánchez
- Catherine Martel
- Cecilia Bucci
- Cecilia Lässer
- Celine Elie-Caille
- Cécile E Malnou
- Changhai Tian
- Changjin Lee
- Chantal M Boulanger
- Charisse N Winston
- Charles J Blijdorp
- Charles P Lai
- Charlotte Lawson
- Chaya Brodie
- Chelsea N Davis
- Cherie Blenkiron
- Chiew Yong Ng
- Chihchen Chen
- Chitranshi Nitin
- Christian Neri
- Christian P Pallasch
- Christian Preußer
- Christina Nedeva
- Christopher Fernandez-Prada
- Chungmin Han
- Claudia M Radu
- Cláudio Pinheiro
- Clémence Belleannée
- Clotilde Billottet
- Clotilde Théry
- Cocucci Emanuele
- Colin L Hisey
- Cora L Alvarez
- Coralie L Guerin
- Crescitelli Rossella
- Crislyn D'Souza-Schorey
- Cristina Fornaguera
- Cristina Pr Xavier
- Cristóbal Cerda-Troncoso
- D Craig Hooper
- D Michiel Pegtel
- Daan Paget
- Dakota Gustafson
- Dalila Iannotta
- Daniel Bachurski
- Daniel H Kim
- Daniel J MacPhee
- Daniel S Lark
- Daniel W Hagey
- Daniela Boselli
- Daniela Freitas
- Daniela L Papademetrio
- Daniele D'Arrigo
- Daniele Noël
- Danielle J Beetler
- Danilo Mladenović
- David A Armstrong
- David A Routenberg
- David C Lyden
- David D Roberts
- David J Lundy
- David Juncker
- David Laurin
- David Otaegui
- David P Al-Adra
- David R Brigstock
- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
- Delaram Khamari
- Denis Corbeil
- Dennis K Jeppesen
- Di Vizio Dolores
- Diego Kyburz
- Dilara C Ozkocak
- Dimitri Aubert
- Dina Ak Ahmed
- Dinesh Upadhya
- Dionysios C Watson
- Dirk P Dittmer
- Dirk Strunk
- Dmitry Ter-Ovanesyan
- Dolores Di Vizio
- Dominic Guanzon
- Donald G Phinney
- Dong Jun Park
- Dong-Gyu Jo
- Dong-Sup Lee
- Dongin Kim
- Dorian Forte
- Dorival M Rodrigues-Junior
- Doste R Mamand
- Driedonks Tom A. P.
- Dylan Burger
- Edina Gyukity-Sebestyén
- Edison Salas-Huenuleo
- Edit I Buzas
- Eduardo Marbán
- Eduardo Martínez-Martínez
- Eduardo Reategui
- Edveena Hanser
- Edwin van der Pol
- Efrat Levy
- Eisuke Dohi
- Elena Aikawa
- Elena Izquierdo
- Elena Khomyakova
- Elena S Martens-Uzunova
- Elena Vacchi
- Elham Hosseini-Beheshti
- Elias Sulaiman
- Elisa Lázaro-Ibáñez
- Elisa Tonoli
- Elise Madec
- Elizabeth R Dellar
- Elke Pogge von Strandmann
- Ellis K Fok
- Elżbieta Karnas
- Emanuele Cocucci
- Emilia Scharrig
- Emilio Di Ianni
- Emma Kc Symonds
- Enis Kostallari
- Eqbal Mohamadi
- Erdbrügger Uta
- Erez Eitan
- Eric Boilard
- Erica Bazzan
- Ernesto Gargiulo
- Esmahan Durmaz
- Estefanía Lozano-Andrés
- Esther M Bridges
- Esther Nm Nolte-'t Hoen
- Eszter Á Tóth
- Etienne Doré
- Etienne Moussay
- Eva Rohde
- Eva-Maria Krämer-Albers
- Evan A Gizzie
- Ewa K Zuba-Surma
- Ewa Ł Stępień
- Émilie Velot
- Fabian Braun
- Fabiana Geraci
- Fabienne Archer
- Fabrice Lucien
- Faezeh Shekari
- Faisal J Alibhai
- Falcon‐Perez Juan M.
- Farah Fatima
- Farrukh Aqil
- Fatah Kashanchi
- Fatemeh Momen-Heravi
- Fausto Almeida
- Federica Collino
- Federico Cocozza
- Federico Colombo
- Ferdinando Pucci
- Fernanda Jadue
- Fernando Souza-Fonseca-Guimaraes
- Flora Guerra
- Florian Puhm
- Fons Aj van de Loo
- Francesc E Borràs
- Francesca Perut
- Francesco Valle
- Francois Mullier
- Frank Rm Stassen
- Franz L Ricklefs
- Fred H Hochberg
- Frederic St-Denis-Bissonnette
- Frederik J Verweij
- Fu Qing‐Ling
- Fumihiko Urabe
- Gabrielis Kundrotas
- Gabriella Dobra
- Gabriella Pocsfalvi
- Gagan Deep
- Ganesh V Shelke
- Ganesha Poojary
- Ganna Stepanova
- Geneviève Bart
- Georges E Grau
- Georgia K Atkin-Smith
- Georgios Giamas
- Géraldine C Genard
- Ghasem Hosseini Salekdeh
- Gi-Hoon Nam
- Giorgia Melli
- Giovanni Camussi
- Giuseppina Poppa
- Gloria Alvarez-Llamas
- Goberdhan Deborah C. I.
- Gorjana Rackov
- Graca Raposo
- Gregory E Rice
- Gregory Lavieu
- Guanshu Liu
- Guido Jenster
- Guillaume van Niel
- Guoku Hu
- Guoping Li
- Hadi Valadi
- Hafiza Padinharayil
- Hakho Lee
- Han Sang Kim
- Hang Yin
- Hannah K Jackson
- Hanser Edveena
- Hao Chen
- Hao Zhang
- Hargita Hegyesi
- Harmeet Malhi
- Harris Adrian L.
- Harry Holthofer
- Harry Vm Spiers
- Haseeb Zubair
- Haughey Norman J.
- Heather H Pua
- Hendrix An
- Henrique Girão
- Heon-Jin Lee
- Hernando A Del Portillo
- Hernán González-King Garibotti
- Héctor Peinado
- Hidetoshi Tahara
- Hilal A Rather
- Hill Andrew F.
- Hiroaki Komuro
- Honami Naora
- Hongkuan Fan
- Houjian Cai
- Huaqi Su
- Hugo R Caires
- Hyo Jung An
- Hyungsoon Im
- Igea D'Agnano
- Igor V Kurochkin
- Ilaria Giusti
- Ilaria Prada
- Iliya Lefterov
- Imola Cs Szigyártó
- In-San Kim
- Indira Prasadam
- Inge Nelissen
- Ioannis Azoidis
- Irene Bertolini
- Irina Nazarenko
- Irma Schabussova
- Isabel Barranco
- Ivan J Vechetti
- Ivan Kh Poon
- Ivanov Alexander R.
- Ivica Marić
- J Brian Byrd
- Jacky G Goetz
- Jacob A Cleary
- Jamal Ghanam
- Jameel M Inal
- James G Patton
- Jan Lötvall
- Jan Van Deun
- Jana Zarubova
- Jane Howard
- Janine Stam
- Janis A Müller
- Janne Leivo
- Janos Zempleni
- Janusz Rak
- Jascinta P Santavanond
- Jason P Webber
- Javier Ramirez-Ricardo
- Javier Sotillo
- Jean-Marie Bach
- Jeff Bouffard
- Jeff Wm Bulte
- Jeffrey L Franklin
- Jeffrey S Schorey
- Jen Alexander-Brett
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- van Herwijnen Martijn J. C.
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- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments
- Author
- Adele Francis
- Adina Najwa Kamarudin
- Aeliko Zwinderman
- Aileen Clarke
- Aileen Clarke
- Alastair Gale
- Albert S. Yeung
- Alex Carter
- Alexander W. Levis
- Alexandra Enocson
- Alfonso Muriel
- Alice Sitch
- Alice Sitch
- Alice Sitch
- Alison Holmes
- Alison Smith
- Alison Smith
- Andrea Benedetti
- Andrea Horvath
- Andrew Beggs
- Andrew Hattersley
- Andrew Hattersley
- Andrew Lewington
- Andrew Mumford
- Andrew Plumb
- Andrew StJohn
- Andy Dickens
- Angel Candela-Toha
- Angus Jones
- Angus Jones
- Ann van den Bruel
- Anna Noel-Storr
- Anne Rummer
- Anne Rutjes
- Annika Hoyer
- Antoinette de Jong
- Antonia Zapf
- Augusto Azuara-Blanco
- Aïssatou Paye
- Barnaby Reeves
- Bavo De Cock
- Beatriz Tucker
- Ben Van Calster
- Ben Van Calster
- Ben Van Calster
- Bernard G. Francq
- Bernard G. Francq
- Bernd Löwe
- Bethany Shinkins
- Bethany Shinkins
- Beverley Shields
- Beverley Shields
- Bogdan Grigore
- Brett D. Thombs
- Brian Nicholson
- Brian Willis
- Brian Willis
- Brooke Levis
- Byron Wallace
- Camille M. Lassale
- Carl Moons
- Carla Deakin
- Cathie Sturgeon
- Charles Boachie
- Charles Boachie
- Charles H. Bombardier
- Chris Cooper
- Chris Farmer
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Rogers
- Chris Stinton
- Christa Cobbaert
- Christiana Naaktgeboren
- Christiana Naaktgeboren
- Christiana Naaktgeboren
- Christoph Ebert
- Claire Smith
- Clare Davenport
- Clare Davenport
- Clare Davenport
- Coreline Burggraaff
- Corran Roberts
- Craig Ramsay
- Cécile Proust-Lima
- Daan Nieboer
- Daniel Lasserson
- David Cairns
- David Fitzmaurice
- David Lorente Estelles
- David McCartney
- Dean McMillan
- Denniis Petrie
- Dirk Timmerman
- Dirk Timmerman
- Doug Altman
- Doug Altman
- Doug Altman
- Doug Altman
- Doug G. Altman
- Douglas Altman
- Douglas G. Altman
- Douglas G. Altman
- Douglas G. Altman
- Dwenda Gjerdingen
- E. C. Martin
- Eivind Antonsen Segtnan
- Elizabeth M. Hensor
- Elizabeth Mitchell
- Emilie Bessede
- Emma Hall
- Emma Helbren
- Emmanuel Ogundimu
- Emmanuelle Kempf
- Ewan Pearson
- Ewan Pearson
- Ewoud Schuit
- Ewout W. Steyerberg
- Farah Seedat
- Femke Lamers
- Flavia de Lima Osório
- Frances Nixon
- Fueloep Scheibler
- G. Bruce Mann
- Gail Hayward
- Gaj Vidmar
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary S. Collins
- Gary S. Collins
- Gary S. Collins
- Gary S. Collins
- Gauraang Batnagar
- Gavin J. Murphy
- George C. M. Siontis
- George Hanna
- George Hanna
- George Hanna
- Gerta Rücker
- Gianni D. Angelini
- Gowri Gopalakrishna
- Gowri GopalaKrishna
- Graeme Spence
- Graham Cooke
- Hannah L. Bromley
- Hans Reitsma
- Hans Reitsma
- Hans Reitsma
- Harriet Hunt
- Harriet Hunt
- Henk C. P. M. van Weert
- Henrica de Vet
- Holly Smith
- Iain Marshall
- Ian Shrier
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ioanna Tzoulaki
- Irene Rebollo-Mesa
- Isabel de Salis
- J. Ensor
- J. J. Deeks
- Jac Dinnes
- Jack O’Sullivan
- Jaime Peters
- Jaime Peters
- Jaime Peters
- Jaime Peters
- James A. Black
- James Buchanan
- James Buchanan
- James Thomas
- Jan Verbakel
- Janine Dretzke
- Jason Oke
- Javier Zamora
- Jen Murphy
- Jennifer Burr
- Jennifer Cooper
- Jennifer de Beyer
- Jennifer Murphy
- Jenny Donovan
- Jenny Hewison
- Jeremy Huddy
- Jeremy Huddy
- Jesse R. Fann
- Jessica Harris
- Jie Ma
- Jie Ma
- Joachim Marti
- Joanna Coast
- Johann de Bono
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna Damen
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes Reitsma
- Johannes Reitsma
- Johannes Reitsma
- John Cairns
- John Dennis
- John Dennis
- John P. A. Ioannidis
- John Simpson
- Joie Ensor
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jonathan Cook
- Jonathan Cook
- Joris A. H. de Groot
- Joris de Groot
- Joris de Groot
- Joris de Groot
- Jos Kleinen
- Josée Zijlstra
- Joy Allen
- Joy Allen
- Joy Allen
- Judy Wright
- Judy Wright
- Julia R. Forman
- Julie Eatock
- Julie Parkes
- Julie Robotham
- Julien Asselineau
- Juwita Shaaban
- K. G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karen Moons
- Karen Vinall-Collier
- Karin A. Wittkampf
- Karoline Freeman
- Katharina Kramer
- Katherine Good
- Katie Banister
- Kevin Jenniskens
- Kinga Malottki
- Kurtis Lee
- Kym Snell
- Kym Snell
- Laure Wynants
- Laure Wynants
- Lavinia Ferrante di Ruffano
- Lavinia Ferrante Di Ruffano
- Lavinia Ferrante di Ruffano
- Lavinia Ferrante Di Ruffano
- Lesley Stafford
- Lieselotte Lennartz
- Linda M. Peelen
- Linda Peelen
- Linda Peelen
- Linda S. Williams
- Liz Mitchel
- Lorie A. Kloda
- Lotty Hooft
- Lotty Hooft
- Lotty Hooft
- Lotty Hooft
- Louise Johnson
- Louise Johnston
- Louise Johnston
- Lucinda Billingham
- Lucy Abel
- Lucy Abel
- M.Carmen Pardo
- Manjula Kumarasamy
- Manohursingh Rungall
- Manote Lotrakul
- Maria Dudareva
- Maria Hernandez-Fuentes
- Marie Westwood
- Mariska Leeflang
- Mariska Leeflang
- Mariska Leeflang
- Mark Gilchrist
- Martin Connock
- Martin Schumacher
- Mary A. Whooley
- Melody Ni
- Melody Ni
- Melody Ni
- Micael J. Pencina
- Michael Maia Schlüssel
- Michael Messenger
- Michael Messenger
- Michael Power
- Michael Power
- Michael Power
- Michelle Hutchinson
- Mie Holm-Vilstrup
- Mikyung Kelly Seo
- Miranda Langendam
- Nick Parsons
- Nicola Calder
- Nicola Calder
- Nirmala Rai
- null null
- null null
- null null
- null null
- null null
- null null
- null null
- Nuria Porta
- Nyantara Wickramasekera
- Obi Ukoumunne
- Oke Gerke
- Olga Tucker
- Oliver Kuss
- Otto Hoekstra
- Paramit Chowdhury
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Paul Perez
- Paula Mobillo
- Pauline Heus
- Pauline Heus
- Pauline Heus
- Pauline Heus
- Peggy Sekula
- Penny Whiting
- Penny Whiting
- Peter Hall
- Peter Hall
- Peter Phillips
- Peter Selby
- Peymane Adab
- Phillip Monaghan
- Pim Cuijpers
- Poul Flemming Høilund-Carlsen
- R. D. Riley
- Rachel Court
- Rachel Jordan
- Rachel O’Leary
- Rachel O’Leary
- Rachel O’Leary
- Rafael Perera
- Raphael Porcher
- Ray Waters
- Ray Waters
- Rebecca Albrow
- Rebecca Kift
- Richard Martin
- Richard Riley
- Richard Riley
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob Scholten
- Robert Großelfinger
- Robert Wolff
- Rolf Groenwold
- Rolf Groenwold
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Rosa Montero
- Roy C Ziegelstein
- Rupert Bourne
- Russell J. Steele
- Ruwanthi Kolamunnage-Dona
- Sabina Sanghera
- Sabine Van Huffel
- Sabine Van Huffel
- Sally Hopewell
- Sara Graziadio
- Sara Graziadio
- Sara Graziadio
- Sarah Byron
- Sarah Lord
- Scott B Patten
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sibylle Sturtz
- Simon Gilbody
- Simon Stevens
- Simone Borsci
- Simone Borsci
- Simone Borsci
- Sofia Christakoudi
- Sonia R Loureiro
- Stephen Gerry
- Steve Halligan
- Steve Smith
- Steven Sacks
- Stuart A. Taylor
- Stuart A. Taylor
- Sudha Sundar
- Sue Bayliss
- Sue Mallet
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sui Phin Kon
- Susan J. Dutton
- Susanne Steinhauser
- Sverre Sandberg
- Syed Mohiuddin
- Teresa Pérez
- Terry Strom
- Thomas Debray
- Thomas E. Nichols
- Thomas Fanshawe
- Thomas Fanshawe
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas R. Fanshawe
- Thomas R. Fanshawe
- Thomas Walker
- Tjir-Li Tsui
- Tom Nieto
- Tracy E. Roberts
- Trevor Cox
- Ulrich Halekoh
- Veerle Verheyden
- Virginia Chiocchia
- Walter Gregory
- Werner Vach
- Willi Sauerbrei
- Willi Sauerbrei
- William Henley
- William Henley
- William Rosenberg
- Wilma Verhagen-Kamerbeek
- Yaling Yang
- Yaling Yang
- Yannick Le Manach
- Yemisi Takwoingi
- Yvonne T. van der Schouw
- Yvonne Vergouwe
- Yvonne Vergouwe
- Zhivko Zhelev
- Zhivko Zhelev
- Zoe Plummer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests
Erratum to: Methods for evaluating medical tests and biomarkers
- Author
- Adele Francis
- Adina Najwa Kamarudin
- Aeliko Zwinderman
- Aileen Clarke
- Aileen Clarke
- Alastair Gale
- Albert S. Yeung
- Alex Carter
- Alexander W. Levis
- Alexandra Enocson
- Alfonso Muriel
- Alice Sitch
- Alice Sitch
- Alice Sitch
- Alison Holmes
- Alison Smith
- Alison Smith
- Andrea Benedetti
- Andrea Horvath
- Andrew Beggs
- Andrew Hattersley
- Andrew Hattersley
- Andrew Lewington
- Andrew Mumford
- Andrew Plumb
- Andrew StJohn
- Andy Dickens
- Angel Candela-Toha
- Angus Jones
- Angus Jones
- Ann van den Bruel
- Anna Noel-Storr
- Anne Rummer
- Anne Rutjes
- Annika Hoyer
- Antoinette de Jong
- Antonia Zapf
- Augusto Azuara-Blanco
- Aïssatou Paye
- Barnaby Reeves
- Bavo De Cock
- Beatriz Tucker
- Ben Van Calster
- Ben Van Calster
- Ben Van Calster
- Bernard G. Francq
- Bernard G. Francq
- Bernd Löwe
- Bethany Shinkins
- Bethany Shinkins
- Beverley Shields
- Beverley Shields
- Bogdan Grigore
- Brett D. Thombs
- Brian Nicholson
- Brian Willis
- Brian Willis
- Brooke Levis
- Byron Wallace
- Camille M. Lassale
- Carl Moons
- Carla Deakin
- Cathie Sturgeon
- Charles Boachie
- Charles Boachie
- Charles H. Bombardier
- Chris Cooper
- Chris Farmer
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Rogers
- Chris Stinton
- Christa Cobbaert
- Christiana Naaktgeboren
- Christiana Naaktgeboren
- Christiana Naaktgeboren
- Christoph Ebert
- Claire Smith
- Clare Davenport
- Clare Davenport
- Clare Davenport
- Coreline Burggraaff
- Corran Roberts
- Craig Ramsay
- Cécile Proust-Lima
- Daan Nieboer
- Daniel Lasserson
- David Cairns
- David Fitzmaurice
- David Lorente Estelles
- David McCartney
- Dean McMillan
- Denniis Petrie
- Dirk Timmerman
- Dirk Timmerman
- Doug Altman
- Doug Altman
- Doug Altman
- Doug Altman
- Doug G. Altman
- Douglas Altman
- Douglas G. Altman
- Douglas G. Altman
- Douglas G. Altman
- Dwenda Gjerdingen
- E. C. Martin
- Eivind Antonsen Segtnan
- Elizabeth M. Hensor
- Elizabeth Mitchell
- Emilie Bessede
- Emma Hall
- Emma Helbren
- Emmanuel Ogundimu
- Emmanuelle Kempf
- Ewan Pearson
- Ewan Pearson
- Ewoud Schuit
- Ewout W. Steyerberg
- Farah Seedat
- Femke Lamers
- Flavia de Lima Osório
- Frances Nixon
- Fueloep Scheibler
- G. Bruce Mann
- Gail Hayward
- Gaj Vidmar
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary S. Collins
- Gary S. Collins
- Gary S. Collins
- Gary S. Collins
- Gauraang Batnagar
- Gavin J. Murphy
- George C. M. Siontis
- George Hanna
- George Hanna
- George Hanna
- Gerta Rücker
- Gianni D. Angelini
- Gowri Gopalakrishna
- Gowri GopalaKrishna
- Graeme Spence
- Graham Cooke
- Hannah L. Bromley
- Hans Reitsma
- Hans Reitsma
- Hans Reitsma
- Harriet Hunt
- Harriet Hunt
- Henk C. P. M. van Weert
- Henrica de Vet
- Holly Smith
- Iain Marshall
- Ian Shrier
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ioanna Tzoulaki
- Irene Rebollo-Mesa
- Isabel de Salis
- J. Ensor
- J. J. Deeks
- Jac Dinnes
- Jack O’Sullivan
- Jaime Peters
- Jaime Peters
- Jaime Peters
- Jaime Peters
- James A. Black
- James Buchanan
- James Buchanan
- James Thomas
- Jan Verbakel
- Janine Dretzke
- Jason Oke
- Javier Zamora
- Jen Murphy
- Jennifer Burr
- Jennifer Cooper
- Jennifer de Beyer
- Jennifer Murphy
- Jenny Donovan
- Jenny Hewison
- Jeremy Huddy
- Jeremy Huddy
- Jesse R. Fann
- Jessica Harris
- Jie Ma
- Jie Ma
- Joachim Marti
- Joanna Coast
- Johann de Bono
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna Damen
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes Reitsma
- Johannes Reitsma
- Johannes Reitsma
- John Cairns
- John Dennis
- John Dennis
- John P. A. Ioannidis
- John Simpson
- Joie Ensor
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jonathan Cook
- Jonathan Cook
- Joris A. H. de Groot
- Joris de Groot
- Joris de Groot
- Joris de Groot
- Jos Kleinen
- Josée Zijlstra
- Joy Allen
- Joy Allen
- Joy Allen
- Judy Wright
- Judy Wright
- Julia R. Forman
- Julie Eatock
- Julie Parkes
- Julie Robotham
- Julien Asselineau
- Juwita Shaaban
- K. G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karen Moons
- Karen Vinall-Collier
- Karin A. Wittkampf
- Karoline Freeman
- Katharina Kramer
- Katherine Good
- Katie Banister
- Kevin Jenniskens
- Kinga Malottki
- Kurtis Lee
- Kym Snell
- Kym Snell
- Laure Wynants
- Laure Wynants
- Lavinia Ferrante di Ruffano
- Lavinia Ferrante Di Ruffano
- Lavinia Ferrante di Ruffano
- Lavinia Ferrante Di Ruffano
- Lesley Stafford
- Lieselotte Lennartz
- Linda M. Peelen
- Linda Peelen
- Linda Peelen
- Linda S. Williams
- Liz Mitchel
- Lorie A. Kloda
- Lotty Hooft
- Lotty Hooft
- Lotty Hooft
- Lotty Hooft
- Louise Johnson
- Louise Johnston
- Louise Johnston
- Lucinda Billingham
- Lucy Abel
- Lucy Abel
- M.Carmen Pardo
- Manjula Kumarasamy
- Manohursingh Rungall
- Manote Lotrakul
- Maria Dudareva
- Maria Hernandez-Fuentes
- Marie Westwood
- Mariska Leeflang
- Mariska Leeflang
- Mariska Leeflang
- Mark Gilchrist
- Martin Connock
- Martin Schumacher
- Mary A. Whooley
- Melody Ni
- Melody Ni
- Melody Ni
- Micael J. Pencina
- Michael Maia Schlüssel
- Michael Messenger
- Michael Messenger
- Michael Power
- Michael Power
- Michael Power
- Michelle Hutchinson
- Mie Holm-Vilstrup
- Mikyung Kelly Seo
- Miranda Langendam
- Nick Parsons
- Nicola Calder
- Nicola Calder
- Nirmala Rai
- null null
- null null
- null null
- null null
- null null
- null null
- null null
- Nuria Porta
- Nyantara Wickramasekera
- Obi Ukoumunne
- Oke Gerke
- Olga Tucker
- Oliver Kuss
- Otto Hoekstra
- Paramit Chowdhury
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Paul Perez
- Paula Mobillo
- Pauline Heus
- Pauline Heus
- Pauline Heus
- Pauline Heus
- Peggy Sekula
- Penny Whiting
- Penny Whiting
- Peter Hall
- Peter Hall
- Peter Phillips
- Peter Selby
- Peymane Adab
- Phillip Monaghan
- Pim Cuijpers
- Poul Flemming Høilund-Carlsen
- R. D. Riley
- Rachel Court
- Rachel Jordan
- Rachel O’Leary
- Rachel O’Leary
- Rachel O’Leary
- Rafael Perera
- Raphael Porcher
- Ray Waters
- Ray Waters
- Rebecca Albrow
- Rebecca Kift
- Richard Martin
- Richard Riley
- Richard Riley
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob Scholten
- Robert Großelfinger
- Robert Wolff
- Rolf Groenwold
- Rolf Groenwold
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Rosa Montero
- Roy C Ziegelstein
- Rupert Bourne
- Russell J. Steele
- Ruwanthi Kolamunnage-Dona
- Sabina Sanghera
- Sabine Van Huffel
- Sabine Van Huffel
- Sally Hopewell
- Sara Graziadio
- Sara Graziadio
- Sara Graziadio
- Sarah Byron
- Sarah Lord
- Scott B Patten
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sibylle Sturtz
- Simon Gilbody
- Simon Stevens
- Simone Borsci
- Simone Borsci
- Simone Borsci
- Sofia Christakoudi
- Sonia R Loureiro
- Stephen Gerry
- Steve Halligan
- Steve Smith
- Steven Sacks
- Stuart A. Taylor
- Stuart A. Taylor
- Sudha Sundar
- Sue Bayliss
- Sue Mallet
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sui Phin Kon
- Susan J. Dutton
- Susanne Steinhauser
- Sverre Sandberg
- Syed Mohiuddin
- Teresa Pérez
- Terry Strom
- Thomas Debray
- Thomas E. Nichols
- Thomas Fanshawe
- Thomas Fanshawe
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas R. Fanshawe
- Thomas R. Fanshawe
- Thomas Walker
- Tjir-Li Tsui
- Tom Nieto
- Tracy E. Roberts
- Trevor Cox
- Ulrich Halekoh
- Veerle Verheyden
- Virginia Chiocchia
- Walter Gregory
- Werner Vach
- Willi Sauerbrei
- Willi Sauerbrei
- William Henley
- William Henley
- William Rosenberg
- Wilma Verhagen-Kamerbeek
- Yaling Yang
- Yaling Yang
- Yannick Le Manach
- Yemisi Takwoingi
- Yvonne T. van der Schouw
- Yvonne Vergouwe
- Yvonne Vergouwe
- Zhivko Zhelev
- Zhivko Zhelev
- Zoe Plummer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
[This corrects the article DOI: 10.1186/s41512-016-0001-y.]
Cancer data quality and harmonization in Europe: the experience of the BENCHISTA Project – international benchmarking of childhood cancer survival by stage
- Author
- Adela Canete Nieto
- Adela Canete Nieto
- Adela Cañete Nieto
- Adele Caldarella
- Aina H Dahlen
- Andrea Di Cataldo
- Angela Lopez-Cortes
- Angela Polanco
- Anna Gavin
- Antonio G Russo
- Arantza Lopez de Munain
- Beatriz De Camargo
- Bernward Zeller
- Bernward Zeller
- Brigitte Lacour
- Carlotta Sacerdote
- Charles Stiller
- Charles Stiller
- Claire Poulalhon
- Claudia E Kuehni
- Dana Coza
- Danila Bruno
- David S Morrison
- Deirdre Fitzpatrick
- Deirdre Murray
- Dobrin Konstantinov
- Dyfed Wyn Huws
- Elena Pardo
- Eleni T Petridou
- Elisabetta Borciani
- Elizabeth Van Eycken
- Emilia De Santis
- Emmanuel Desandes
- Eugenia Spata
- Evdoxia Bouka
- Fabio Didonè
- Fabio Falcini
- Federico Gervasi
- Fernando Almela-Vich
- Filippo Spreafico
- Francesca Bella
- Francesco Cuccaro
- Francesco Vetrano
- Friederike Erdmann
- Gabriela Caldas
- Gemma Gatta
- Gianbattista Spagnoli
- Giuseppe Sampietro
- Henrike Karim-Kos
- Jacqueline Clavel
- Jan Stary
- Janet Warlow
- Jaroslav Sterba
- Jason D Pole
- Jeanette F Winther
- Jerzy Kowalczyk
- Joanne Aitken
- Johannesen Tom Børge
- Karen Smith
- Kathy Pritchard-Jones
- Kayo Nakata
- Keiu Paapsi
- Laura Botta
- Leisa O’Neil
- Lindsay Frazier
- Lisa L. Hjalgrim
- Lisa L. Hjalgrim
- Lisa L. Hjalgrim
- Lorenza Boschetti
- Luca Boni
- Lucia Mangone
- Lucy Irvine
- Magda Rognoni
- Marcela Guevara
- Marceli de Oliveira Santos
- Margherita Ferrante
- Maria Dolores Chirlaque
- Maria José Sanchez
- Maria L Gambino
- Maria Michiara
- Mario Sekerija
- Marià Carulla
- Massimo Rugge
- Meric Klein
- Michael Mian
- Mihaela Bucurenci
- Milena M Maule
- Miriam J Azzopardi
- Monika Hack
- Monika Jedrzejczyk
- Nancy Van Damme
- Nathalie Gaspar
- Nieves Fuster-Camarena
- Nuria Aragones
- Paola Ballotari
- Paola Coccia
- Paul Stacey
- Päivi Lähteenmäki
- Ra f a e l Marcos-Gragera
- Rafael Peris-Bonet
- Raquel Lopez
- Riccardo Capocaccia
- Roberto V Rizzello
- Rocco Galasso
- Rosalba Amodio
- Rosalia Ragusa
- Ruth Ladenstein
- Sandra Strauss
- Shelagh M Redmond
- Simon Bailey
- Sonia Manasse
- Stefano Ferretti
- Stefano Guzzinati
- Sumit Gupta
- Teresa Intrieri
- The BENCHISTA Project Working Group
- Tiziana Scuderi
- Tomohiro Matsuda
- Vesna Zadnik
- Zdravka Valerianova
- Zsuzsanna Jakab
- Zsuzsanna Jakab
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/08/2023
- Field of study
IntroductionVariation in stage at diagnosis of childhood cancers (CC) may explain differences in survival rates observed across geographical regions. The BENCHISTA project aims to understand these differences and to encourage the application of the Toronto Staging Guidelines (TG) by Population-Based Cancer Registries (PBCRs) to the most common solid paediatric cancers.MethodsPBCRs within and outside Europe were invited to participate and identify all cases of Neuroblastoma, Wilms Tumour, Medulloblastoma, Ewing Sarcoma, Rhabdomyosarcoma and Osteosarcoma diagnosed in a consecutive three-year period (2014-2017) and apply TG at diagnosis. Other non-stage prognostic factors, treatment, progression/recurrence, and cause of death information were collected as optional variables. A minimum of three-year follow-up was required. To standardise TG application by PBCRs, on-line workshops led by six tumour-specific clinical experts were held. To understand the role of data availability and quality, a survey focused on data collection/sharing processes and a quality assurance exercise were generated. To support data harmonization and query resolution a dedicated email and a question-and-answers bank were created.Results67 PBCRs from 28 countries participated and provided a maximally de-personalized, patient-level dataset. For 26 PBCRs, data format and ethical approval obtained by the two sponsoring institutions (UCL and INT) was sufficient for data sharing. 41 participating PBCRs required a Data Transfer Agreement (DTA) to comply with data protection regulations. Due to heterogeneity found in legal aspects, 18 months were spent on finalizing the DTA. The data collection survey was answered by 68 respondents from 63 PBCRs; 44% of them confirmed the ability to re-consult a clinician in cases where stage ascertainment was difficult/uncertain. Of the total participating PBCRs, 75% completed the staging quality assurance exercise, with a median correct answer proportion of 92% [range: 70% (rhabdomyosarcoma) to 100% (Wilms tumour)].ConclusionDifferences in interpretation and processes required to harmonize general data protection regulations across countries were encountered causing delays in data transfer. Despite challenges, the BENCHISTA Project has established a large collaboration between PBCRs and clinicians to collect detailed and standardised TG at a population-level enhancing the understanding of the reasons for variation in overall survival rates for CC, stimulate research and improve national/regional child health plans
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
- Bianchi A.
- Bilenko I. A.
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
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- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
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- Bayley Joseph
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- Bedakihale V. M.
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- Benedetto V.
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- Bera Sayantani
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- Bergamin Fabio
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- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
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- Bhaumik Shubhagata
- Bhowmick S.
- Bianchi A.
- Bilenko I. A.
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
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- Boldrini Mattia
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- C. Utina Andrei
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- Cabras Giuseppe
- Cabrita Ricardo
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- Cagnoli Gianpietro
- Cahillane Craig
- Callaghan J. D.
- Callister T. A.
- Calloni E.
- Camp J. B.
- Caneva Santoro Giada
- CANNAVACCIUOLO Marco
- Cannon Kipp C.
- Cao H.
- Capistran L. A.
- Capocasa Eleonora
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- Carapella G.
- Carbognani F.
- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini C.
- Castaldi G.
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- CHAKRABORTY PRATIK.
- Chalathadka Subrahmanya Shreevathsa
- Chan C.
- Chan M.
- Chan W. L.
- Chandra K.
- Chang R. -J.
- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen K. H.
- Chen X.
- Chen Yanbei
- Chen Yi-Ru
- Chen Yitian
- Cheng H. P.
- Chessa Piero
- Cheung H. T.
- Chia H. Y.
- Chiadini Francesco
- Chiang C.
- Chiarini G.
- Chiba A.
- Chiba R.
- Chierici R.
- Chincarini Andrea
- CHIOFALO MARIA. LUISA.
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chun Lung Chan Juno
- Chung K. W.
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi M.
- Ciobanu A. A.
- Ciolfi Riccardo
- Clara F.
- Clark James
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Cleva F.
- Coccia E.
- Codazzo Elena
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- Colleoni Marta
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- Colombo Alberto
- Colpi Monica
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- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
- Countryman Stefan
- Coupechoux J. -F.
- Cousins Bryce
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creed R.
- Creighton Jolien
- Creighton T. D.
- Cremonese Paolo
- Criswell Alexander
- Crockett-Gray J. C. G.
- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
- Cuoco E.
- Cusinato Marco
- César Martins Julio
- D'Angelo Beatrice
- D'Antonio S.
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
- Daumas A.
- Davari N.
- Dave I.
- Davenport A.
- Davier M.
- Davies T. F.
- Davis Derek
- Davis L.
- Davis Michael C.
- Daw Edward
- Dax Maximilian
- De Bolle Jorden
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis Fabio
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo Walter
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
- Dent Thomas
- Depasse Antoine
- DePergola N.
- Dhani A.
- Dhurandhar S.
- Di Cesare Martina
- Di Fiore L.
- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
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- Sergeev A.
- SERRA Marco
- Servignat Gaël
- Shaffer T.
- Shah Urja
- Shahriar Selim
- Shams B.
- Shao Lijing
- Shapiro Key Joey
- Sharan Salafia Om
- Sharma A. K.
- Sharma P.
- Sharma-Chaudhary S.
- Shawhan Peter
- SHCHEBLANOV Nikita
- Shen B.
- Shikano Yutaka
- Shikauchi M.
- shimode katsuhiko
- Shinkai Hisa-aki
- Shiota J.
- Shoemaker D. H.
- Shoemaker Deirdre
- Short R. W.
- ShyamSundar S.
- Sider A.
- Siegel Harrison
- Sieniawska M.
- Sigg Daniel
- Silenzi Laura
- Simmonds M.
- Singer Leo
- Singh A.
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- SINGH MUKESH. KUMAR.
- Singha Ayatri
- Sintes Alicia M.
- Sipala V.
- Skliris Vasileios
- Slagmolen Bram J. J.
- Slaven-Blair T. J.
- Smetana J.
- Smith Joshua
- Smith Leigh
- Smith Rory
- Smith W. J.
- Soldateschi Jacopo
- Somiya Kentaro
- Soni K.
- soni siddharth
- Sordini V.
- Sorrentino F.
- Sorrentino Nunziato
- Soulard R.
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- Southgate A.
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- Spagnuolo V.
- Spencer Andrew
- Spera Mario
- Spinicelli P.
- Srivastava A. K.
- Stachurski Federico
- STEER Danièle
- Steffano Bonilla Marceline
- Steinlechner J.
- Steinlechner Sebastian
- Stergioulas Nikolaos
- Stevens P.
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- Stratta Giulia
- Strong M. D.
- Strunk A.
- Sturani R.
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- Suchenek M.
- Sueltmann N.
- Sullivan Andrew G.
- Sullivan K. D.
- Sun Ling
- Sunil S.
- Sur Ankan
- Suresh Jishnu
- Sutton Patrick
- Suzuki Takamasa
- Suzuki Takanori
- Swinkels Bas L.
- Sylvia Biscoveanu Andrea
- Syx A.
- Szczepańczyk Marek
- Szewczyk Paweł
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- Sébastien Göttel Alexandre
- Tacca Matteo
- Tagoshi Hideyuki
- Tait Simon
- Tak Lun Tsang Terrence
- Takahashi Hirotaka
- Takahashi Ryutaro
- Takamori Akiteru
- Takatani K.
- Takeda Hiroki
- Takeda M.
- Takidera H.
- Talbot C.
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- Tamaki M.
- Tamanini Nicola
- Tanabe D.
- Tanaka K.
- Tanaka Shuta
- Tanaka Takahiro
- Tanasijczuk A. J.
- Tang D.
- Tanioka Satoshi
- Tanner D. B.
- Tao Liu
- Tapia San Martín E. N.
- Tapia R. D.
- Tarafder R.
- Taranto C.
- Taruya Atsushi
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- Tenorio Rodrigo
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- Theodoropoulos A.
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- Tiwari A.
- tiwari shubhanshu
- Tiwari Srishti
- tiwari vaibhav
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- Tomita K.
- Tomura Tomonobu
- Tong-Yu C.
- Toriyama A.
- Toropov Nikita
- Torres Forne Alejandro
- Torrie C. I.
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- Tosta e Melo Iara
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- TRAPANANTI Angela
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- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
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- Yu Hang
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- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
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- Zeeshan M.
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- Zeoli M.
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- Zevin Michael
- Zhang A. C.
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- Zhang Rui
- Zhang T.
- Zhang Ya
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Late maturation of adult-born neurons in the temporal dentate gyrus.
- Publication venue
- Public Library of Science (PLoS)
- Publication date
- 07/11/2012
- Field of study
Hippocampal function varies along its septotemporal axis, with the septal (dorsal) pole more frequently involved in spatial learning and memory and the temporal (ventral) pole playing a greater role in emotional behaviors. One feature that varies across these subregions is adult neurogenesis. New neurons are more numerous in the septal hippocampus but are more active in the temporal hippocampus during water maze training. However, many other aspects of adult neurogenesis remain unexplored in the context of septal versus temporal subregions. In addition, the dentate gyrus contains another functionally important anatomical division along the transverse axis, with the suprapyramidal blade showing greater experience-related activity than the infrapyramidal blade. Here we ask whether new neurons differ in their rates of survival and maturation along the septotemporal and transverse axes. We found that neurogenesis is initially higher in the infrapyramidal than suprapyramidal blade, but these cells are less likely to survive, resulting in similar densities of neurons in the two blades by four weeks. Across the septotemporal axis, neurogenesis was higher in septal than temporal pole, while the survival rate of new neurons did not differ. Maturation was assessed by immunostaining for the neuronal marker, NeuN, which increases in expression level with maturation, and for the immediate-early gene, Arc, which suggests a neuron is capable of undergoing activity-dependent synaptic plasticity. Maturation occurred approximately 1-2 weeks earlier in the septal pole than in the temporal pole. This suggests that septal neurons may contribute to function sooner; however, the prolonged maturation of new temporal neurons may endow them with a longer window of plasticity during which their functions could be distinct from those of the mature granule cell population. These data point to subregional differences in new neuron maturation and suggest that changes in neurogenesis could alter different hippocampus-dependent behaviors with different time courses
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