Hepatocellular Carcinoma Arising in Non-Cirrhotic Haemochromatosis

Hepatocellular carcinoma arising in a patient with genetic haemachromatosis, without cirrhosis, has only been described once previously. We present a patient with a 15 year history of genetic haemachromatosis who underwent resection of a hepatocellular carcinoma in a liver with normal architecture

Ares I-X First Stage Separation Loads and Dynamics Reconstruction

The Ares I-X flight test provided NASA with the opportunity to test hardware and gather critical data to ensure the success of future Ares I flights. One of the primary test flight objectives was to evaluate the environment during First Stage separation to better understand the conditions that the J-2X second stage engine will experience at ignition [1]. A secondary objective was to evaluate the effectiveness of the stage separation motors. The Ares I-X flight test vehicle was successfully launched on October 29, 2009, achieving most of its primary and secondary test objectives. Ground based video camera recordings of the separation event appeared to show recontact of the First Stage and the Upper Stage Simulator followed by an unconventional tumbling of the Upper Stage Simulator. Closer inspection of the videos and flight test data showed that recontact did not occur. Also, the motion during staging was as predicted through CFD analysis performed during the Ares I-X development. This paper describes the efforts to reconstruct the vehicle dynamics and loads through the staging event by means of a time integrated simulation developed in TREETOPS, a multi-body dynamics software tool developed at NASA [2]. The simulation was built around vehicle mass and geometry properties at the time of staging and thrust profiles for the first stage solid rocket motor as well as for the booster deceleration motors and booster tumble motors. Aerodynamic forces were determined by models created from a combination of wind tunnel testing and CFD. The initial conditions such as position, velocity, and attitude were obtained from the Best Estimated Trajectory (BET), which is compiled from multiple ground based and vehicle mounted instruments. Dynamic loads were calculated by subtracting the inertial forces from the applied forces. The simulation results were compared to the Best Estimated Trajectory, accelerometer flight data, and to ground based video

Masswe Colonic Haemorrhage from a Solitary Caecal Varix

A 51 year old lady with chronic active hepatitis presented with massive lower gastrointestinal tract bleeding. Angiography demonstrated a solitary varix in the caecum which was found at laparotomy to be entering the bowel wall at the site ofadhesions from a previous appendicectomy. The portal pressure was found to be raised. Aright hemicolectomy stopped the blood loss, but she subsequently died ofliver failure. Solitary colonic varices associated with adhesions are extremely rare and their optimal management has not been established

Written language skills in children with specific language impairment

Background. Young children are often required to carry out writing tasks in an educational context. However, little is known about the patterns of writing skills that children with Specific Language Impairment (CwSLI) have relative to their typically developing peers

Evaluation of a cervical cancer screening program based on HPV testing and LLETZ excision in a low resource setting

We conducted studies in Vanuatu to evaluate potential screening and treatment strategies to assist with control of cervical cancer. In a pilot study of 496 women, visual inspection and cytology were evaluated as screening tests for detection of CIN 2 or worse (CIN2+), observed in 21 of 206 subjects biopsied on the basis of abnormal visual inspection or cytology. Sensitivity of visual inspection with Lugol's Iodine for detection of CIN2+ on biopsy was 0.63, specificity was 0.32, and the positive predictive value was 0.09. For HSIL cytology, sensitivity was 0.99, specificity was 0.77, and the positive predictive value was 0.88. HSIL cytology was significantly more sensitive and had a significantly higher PPV for CIN 2+ than visual inspection (

English derivational suffix frequency and children\u27s stress judgments

Considering the importance of word and stem frequency in the adult lexical processing literature, and the effect of input frequency on children\u27s acquisition of words (Tardif, Shatz, & Naigles, 1997), it was hypothesized that children\u27s acquisition of English morphologically conditioned stress alternations would be affected by the frequency with which children were exposed to different stress-changing suffixes (e.g., -tion, -ity, and -ic). Study 1 determined the proportional representation of suffixes in a children\u27s literature corpus, thereby allowing the suffix variable to be established. Study 2 empirically examined the effect of suffix frequency on school-aged children\u27s judgments of primary stress placement. Findings suggest that age and suffix frequency both play a role in children\u27s awareness of stress placement. © 2001 Elsevier Science (USA)