Monte Carlo study of tunable negative-zero-positive index of refraction in nanosphere dispersed liquid crystals

Khoo et al.1, 2 have shown that nanosphere dispersed nematic liquid crystal (NDLC) constitutes a new type of metamaterial with index of refraction tunable from negative to positive values. Recently3 we have combined this approach with Monte Carlo simulations of inhomogeneous molecular order in planar NLC cells. Lebwohl - Lasher effective hamiltonian with Rapini - Papoular term for anchoring forces was used. Electric field and amplitude of anchoring forces are control parameters which determine the profiles of order parameter. In this paper we study, using the same approach, local spatial distribution of refractive index in NDLC planar cell. We show that NDLC material consists of layers with negative-zero-positive index of refraction. The spatial organization of those layers strongly depends on incident light wavelength. The role of spatially modulated external electric field for tuning of refractive index of NDLC is briefly discussed

Modelling semantic transparency

We present models of semantic transparency in which the perceived trans- parency of English noun–noun compounds, and of their constituent words, is pre- dicted on the basis of the expectedness of their semantic structure. We show that such compounds are perceived as more transparent when the first noun is more frequent, hence more expected, in the language generally; when the compound semantic rela- tion is more frequent, hence more expected, in association with the first noun; and when the second noun is more productive, hence more expected, as the second ele- ment of a noun–noun compound. Taken together, our models of compound and con- stituent transparency lead us to two conclusions. Firstly, although compound trans- parency is a function of the transparencies of the constituents, the two constituents differ in the nature of their contribution. Secondly, since all the significant predictors in our models of compound transparency are also known predictors of processing speed, perceived transparency may itself be a reflex of ease of processing

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood. Here we report that prostaglandin signalling affects ciliogenesis by regulating anterograde intraflagellar transport (IFT). Zebrafish leakytail (lkt) mutants show ciliogenesis defects, and the lkt locus encodes an ATP-binding cassette transporter (ABCC4). We show that Lkt/ABCC4 localizes to the cell membrane and exports prostaglandin E2 (PGE2), a function that is abrogated by the Lkt/ABCC4T804M mutant. PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation. Importantly, PGE2 signalling increases anterograde but not retrograde velocity of IFT and promotes ciliogenesis in mammalian cells. These findings lead us to propose that Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde IFT, thereby promoting ciliogenesis

The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling

Proper assignment of cellular fates relies on correct interpretation of Wnt and Hedgehog (Hh) signals. Members of the Wnt Inhibitory Factor-1 (WIF1) family are secreted modulators of these extracellular signaling pathways. Vertebrate WIF1 binds Wnts and inhibits their signaling, but its Drosophila melanogaster ortholog Shifted (Shf) binds Hh and extends the range of Hh activity in the developing D. melanogaster wing. Shf activity is thought to depend on reinforcing interactions between Hh and glypican HSPGs. Using zebrafish embryos and the heterologous system provided by D. melanogaster wing, we report on the contribution of glypican HSPGs to the Wnt-inhibiting activity of zebrafish Wif1 and on the protein domains responsible for the differences in Wif1 and Shf specificity. We show that Wif1 strengthens interactions between Wnt and glypicans, modulating the biphasic action of glypicans towards Wnt inhibition; conversely, glypicans and the glypican-binding “EGF-like” domains of Wif1 are required for Wif1's full Wnt-inhibiting activity. Chimeric constructs between Wif1 and Shf were used to investigate their specificities for Wnt and Hh signaling. Full Wnt inhibition required the “WIF” domain of Wif1, and the HSPG-binding EGF-like domains of either Wif1 or Shf. Full promotion of Hh signaling requires both the EGF-like domains of Shf and the WIF domains of either Wif1 or Shf. That the Wif1 WIF domain can increase the Hh promoting activity of Shf's EGF domains suggests it is capable of interacting with Hh. In fact, full-length Wif1 affected distribution and signaling of Hh in D. melanogaster, albeit weakly, suggesting a possible role for Wif1 as a modulator of vertebrate Hh signaling

The processing of compounds in bilingual aphasia: a multiple-case study.

Background: While converging evidence has led to the view that people with aphasia exploit compositional procedures when producing compound words, the issue of what compoundinternal characteristics are at play during these procedures is still under debate. It has been argued that constituent position and/or morphosyntactic prominence, i.e., being the head constituent of a compound, may influence the manner in which compounds are accessed. However, findings obtained from patient performances are thus far inconclusive, because positional and headedness effects are frequently confounded in a language. Aims: In order to disentangle position-in-the-string and headedness effects in compound production in aphasia, the main objective of this study is to investigate the performance of bilingual patients speaking languages in which these effects can be teased apart. Our secondary goal is to probe the roles of grammatical category (adjectives vs. nouns) and of between-language phonological similarity, as both these factors have been demonstrated to influence compound processing. Method & Procedure: Three English-French bilingual persons with aphasia participated in the study. Three experimental tasks, reading, repetition and translation of isolated compound words, were administrated in each language. We contrasted French and English compounds that differ in the position of the head constituent, left for French and right for English. Outcomes & Results: Two participants showed a similar pattern, a significantly reduced number of errors for the head (or first) constituent as compared to the non-head (or second) constituent in French and an equivalent number of errors for both constituents in English, pointing to the cumulative effects of headedness and first-position-in-the-string in French, and to the mutual cancelling out of these effects in English. The third participant exhibited a non-head constituent advantage in both languages, indicating that semantic modification of the head constituent by the non-head constituent plays a prominent role in her accessing procedures. For all three participants, phonological similarity influenced production, while grammatical category did not. Conclusions: Our results reveal that headedness and position interact in the processing of compounds. They also demonstrate that compound constituents are processed asymmetrically across and within languages, thus confirming that people with aphasia are sensitive to compound-internal structure. Moreover, they show that patients rely on varying structural information when accessing compounds