Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing

Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify (1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, (2) activities aimed at replacing, reducing, or refining the use of animals, and (3) recommendations for future work in this area

Regionally aggregated, stitched and de‐drifted CMIP‐climate data, processed with netCDF‐SCM v2.0.0

The world's most complex climate models are currently running a range of experiments as part of the Sixth Coupled Model Intercomparison Project (CMIP6). Added to the output from the Fifth Coupled Model Intercomparison Project (CMIP5), the total data volume will be in the order of 20PB. Here, we present a dataset of annual, monthly, global, hemispheric and land/ocean means derived from a selection of experiments of key interest to climate data analysts and reduced complexity climate modellers. The derived dataset is a key part of validating, calibrating and developing reduced complexity climate models against the behaviour of more physically complete models. In addition to its use for reduced complexity climate modellers, we aim to make our data accessible to other research communities. We facilitate this in a number of ways. Firstly, given the focus on annual, monthly, global, hemispheric and land/ocean mean quantities, our dataset is orders of magnitude smaller than the source data and hence does not require specialized ‘big data’ expertise. Secondly, again because of its smaller size, we are able to offer our dataset in a text-based format, greatly reducing the computational expertise required to work with CMIP output. Thirdly, we enable data provenance and integrity control by tracking all source metadata and providing tools which check whether a dataset has been retracted, that is identified as erroneous. The resulting dataset is updated as new CMIP6 results become available and we provide a stable access point to allow automated downloads. Along with our accompanying website (cmip6.science.unimelb.edu.au), we believe this dataset provides a unique community resource, as well as allowing non-specialists to access CMIP data in a new, user-friendly way

Municipal health expectancy in Japan: decreased healthy longevity of older people in socioeconomically disadvantaged areas

BACKGROUND: Little is known about small-area variation in healthy longevity of older people and its socioeconomic correlates. This study aimed to estimate health expectancy at 65 years (HE65) at the municipal level in Japan, and to examine its relation to area socio-demographic conditions. METHODS: HE65 of municipalities (N = 3361) across Japan was estimated by a linear regression formula with life expectancy at 65 years and the prevalence of those certificated as needing nursing care. The relation between HE65 and area socio-demographic indicators was examined using correlation coefficients. RESULTS: The estimated HE65 (years) ranged from 13.13 to 17.39 for men and from 14.84 to 20.53 for women. HE65 was significantly positively correlated with the proportion of elderly and per capita income, and negatively correlated with the percentage of households of a single elderly person, divorce rate, and unemployment rate. These relations were stronger in large municipalities (with a population of more than 100,000) than in small and medium-size municipalities. CONCLUSION: A decrease in healthy longevity of older people was associated with a higher percentage of households of a single elderly person and divorce rate, and lower socioeconomic conditions. This study suggests that older people in urban areas are susceptible to socio-demographic factors, and a social support network for older people living in socioeconomically disadvantaged conditions should be encouraged

Global commitment towards sustainable energy

Energy is crucial to economic and social development and improves quality of life. However, fossil fuel energy produces greenhouse gases (GHGs) and cannot be sustained for a long time. It is essential to tackle these problems by moving towards renewable and sustainable energy. Some countries, including those in the Arabian Gulf region, are still in the appraisal stage of adopting different forms of renewable energy. This paper reviews the business potential and likely GHG reductions associated with adopting renewable energy in Oman. It is revealed that 1·9 Mt of annual carbon dioxide emissions could be cut by producing 10% of the country’s electricity from renewables. The paper further discusses the global sustainable energy commitment under the UN Framework Convention on Climate Change and reviews the 2030 targets of some countries that are high producers of GHGs. It is anticipated that if all these planned targets are achieved, the total sustainable energy contribution could grow by nearly 11 000 TWh by 2030. These plans provide guidance for those countries still preparing to submit their plans to the UN

On future efforts to cope with global environmental problems

Meeting: World Commission on Environment and Development, Public Hearing, 27 Feb. 1987, Tokyo, JPRelated to DAP 87-4249 under which IDRC supported the WCED to acquire and duplicate original papers, submissions, tapes and transcripts, became the depository of all original archival materials and received the right to microfiche the collection for broader disseminatio

cmip5 output1 MIROC MIROC-ESM rcp60

'rcp60' is an experiment of the CMIP5 - Coupled Model Intercomparison Project Phase 5 (https://pcmdi.llnl.gov/mips/cmip5). CMIP5 is meant to provide a framework for coordinated climate change experiments for the next five years and thus includes simulations for assessment in the AR5 as well as others that extend beyond the AR5. 4.4 rcp60 (4.4 RCP6) - Version 1: Future projection (2006-2100) forced by RCP6. RCP6 is a representative concentration pathway which approximately results in a radiative forcing of 6 W m-2 at year 2100, relative to pre-industrial conditions. Experiment design: https://pcmdi.llnl.gov/mips/cmip5/experiment_design.html List of output variables: https://pcmdi.llnl.gov/mips/cmip5/datadescription.html Output: time series per variable in model grid spatial resolution in netCDF format Earth System model and the simulation information: CIM repository Entry name/title of data are specified according to the Data Reference Syntax (https://pcmdi.llnl.gov/mips/cmip5/docs/cmip5_data_reference_syntax.pdf) as activity/product/institute/model/experiment/frequency/modeling realm/MIP table/ensemble member/version number/variable name/CMOR filename.nc

cmip5 output1 MIROC MIROC-ESM-CHEM piControl

piControl is an experiment of the CMIP5 - Coupled Model Intercomparison Project Phase 5 ( https://pcmdi.llnl.gov/mips/cmip5 ). CMIP5 is meant to provide a framework for coordinated climate change experiments for the next five years and thus includes simulations for assessment in the AR5 as well as others that extend beyond the AR5. 3.1 piControl (3.1 Pre-Industrial Control) - Version 1: Pre-Industrial coupled atmosphere/ocean control run. Imposes non-evolving pre-industrial conditions. Experiment design: https://pcmdi.llnl.gov/mips/cmip5/experiment_design.html List of output variables: https://pcmdi.llnl.gov/mips/cmip5/datadescription.html Output: time series per variable in model grid spatial resolution in netCDF format Earth System model and the simulation information: CIM repository Entry name/title of data are specified according to the Data Reference Syntax ( https://pcmdi.llnl.gov/mips/cmip5/docs/cmip5_data_reference_syntax.pdf ) as activity/product/institute/model/experiment/frequency/modeling realm/MIP table/ensemble member/version number/variable name/CMOR filename.nc

cmip5 output1 MIROC MIROC-ESM past1000

past1000 is an experiment of the CMIP5 - Coupled Model Intercomparison Project Phase 5 ( https://pcmdi.llnl.gov/mips/cmip5 ). CMIP5 is meant to provide a framework for coordinated climate change experiments for the next five years and thus includes simulations for assessment in the AR5 as well as others that extend beyond the AR5. past1000 (3.6 Last millennium) - Version 2: Consistent with PMIP (Paleo Model Intercomparison Project) requirements, Impose evolving conditions including: Solar Variations and Volcanic Aerosols. Experiment design: https://pcmdi.llnl.gov/mips/cmip5/experiment_design.html List of output variables: https://pcmdi.llnl.gov/mips/cmip5/datadescription.html Output: time series per variable in model grid spatial resolution in netCDF format Earth System model and the simulation information: CIM repository Entry name/title of data are specified according to the Data Reference Syntax ( https://pcmdi.llnl.gov/mips/cmip5/docs/cmip5_data_reference_syntax.pdf ) as activity/product/institute/model/experiment/frequency/modeling realm/MIP table/ensemble member/version number/variable name/CMOR filename.nc