Návrh aplikační architektury pro publikaci fotografických dat z mobilního mapovacího systému

Cílem této práce je návrh architektury řešení aplikace, která bude umožňovat publikaci pořízených fotografických dat z mobilního mapovacího systému pro potřeby společnosti GEOREAL, spol. s r.o. Analytická část se věnuje popisu mobilního mapovacího systému včetně jeho použití v praxi. Dále se tato část věnuje technologiím pro publikaci prostorových dat a trendům ve vývoji webových aplikací, na které navazuje výběr vhodných technologií pro implementaci prototypu aplikace. Realizační část popisuje návrh struktury aplikace, softwarové řešení a následné testování webové aplikace pro publikaci prostorových dat a vyhodnocení dosažených výsledků.ObhájenoThe aim of this work is to design the architecture of the application, which will allow the publication of photographic data from a mobile mapping system for the needs of GEOREAL, spol. s r.o. The analytical part deals with the description of the mobile mapping system, including its use in practice. Furthermore, this part deals with technologies for the publication of spatial data and trends in the development of web applications, which is followed by a selection of suitable technologies for the implementation of a prototype application. The implementation part describes the design of the application structure, software solution and subsequent testing of the web application for the publication of spatial data and evaluation of the achieved results

Automated Man-in-the-Middle Attack Against Wi‑Fi Networks

Currently used wireless communication technologies suffer security weaknesses that can be exploited allowing to eavesdrop or to spoof network communication. In this paper, we present a practical tool that can automate the attack on wireless security. The developed package called wifimitm provides functionality for the automation of MitM attacks in the wireless environment. The package combines several existing tools and attack strategies to bypass the wireless security mechanisms, such as WEP, WPA, and WPS. The presented tool can be integrated into a solution for automated penetration testing. Also, a popularization of the fact that such attacks can be easily automated should raise public awareness about the state of wireless security

A highly durable graphene monolayer electrode under long-term hydrogen evolution cycling

Achieving long term stability of single graphene sheets towards repeated electrochemical hydrogen evolution reaction (HER) cycling has been challenging. Here, we show through appropriate electrode preparation that it is possible to obtain highly durable isolated graphene electrodes, which can survive several hundreds of HER cycles with virtually no damage to the sp2-carbon framework and persistently good electron transfer characteristics.Peer Reviewe

Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism

The impressive impact of cisplatin on cancer on one side and severe side effects, as well as the development of drug resistance during treatment on the other side, were the factors motivating scientists to design and synthesize new more potent analogues lacking disadvantages of cisplatin. Platinum(IV) complexes represent one of the perspective groups of platinum-based drugs. In this review, we summarize recent findings on both in vitro and in vivo effects of platinum(IV) complexes with adamantylamine. Based on a literary overview of the mechanisms of activity of platinum-based cytostatics, we discuss opportunities for modulating the effects of novel platinum complexes through interactions with apoptotic signaling pathways and with cellular lipids, including modulations of the mitochondrial cell death pathway, oxidative stress, signaling of death ligands, lipid metabolism/signaling, or intercellular communication. These approaches might significantly enhance the efficacy of both novel and established platinum-based cytostatics

Impact of Polychlorinated Biphenyls Contamination on Estrogenic Activity in Human Male Serum

Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lower-chlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as anti-estrogens. Coplanar PCBs had no direct effect on estrogen receptor (ER) activation in this in vitro model. In human male serum samples, high levels of PCBs were associated with a decreased ER-mediated activity and an increased dioxin-like activity, as determined by the DR-CALUX assay. 17β-Estradiol (E(2)) was responsible for a major part of estrogenic activity identified in total serum extracts. Significant negative correlations were found between dioxin-like activity, as well as mRNA levels of cytochromes P450 1A1 and 1B1 in lymphocytes, and total estrogenic activity. For sample fractions containing only persistent organic pollutants (POPs), the increased frequency of anti-estrogenic samples was associated with a higher sum of PCBs. This suggests that the prevalent non-dioxin-like PCBs were responsible for the weak antiestrogenic activity of some POPs fractions. Our data also suggest that it might be important to pay attention to direct effects of PCBs on steroid hormone levels in heavily exposed subjects

Применение технологии набрызгбетонирования в Новоавстрийском Методе Туннелирования (NATM)

У статті проаналізовані суть і основні принципи Новоавстрійського Методу Тунелювання (NATM), що широко застосовується в зарубіжній практиці будівництва транспортних тунелів. Також розглянуто застосування технології торкретування, яка лежить в основі методу.Essence and basic principles of New Austrian Tunnelling Method (NATM), which widely used in foreign practice building of transport tunnels, is analysed in the article. Application of gunite technology, being the basis of method, is also considered