Wetlands Classification: A Tool for Protection or Abandonment?

The notion of the networked society is more than ever true nowadays. The Internet has a big impact on our daily lives. Network operators provide the underlying infrastructure and continuously deploy services in order to meet customer demands. The amount of data transported through operator networks is also increasing with the introduction of new high band width services and over the network content. That being said, operators, most often deploy or operate networks to meet these demands without any regard to energy-efficiency. As the price of electricity continues to grow,  tends to become a problem with serious implications. To solve this problem a trend towards more energy efficient networks has emerged. In this thesis, we investigate a way to facilitate the introduction of new energy efficiency paradigms for fixed networks. Towards this end, we investigate the energy efficiency schemes proposed up to now and select one that we believe is more realistic to deploy. Furthermore, we specify the inputs required for the selected “green” routing approach. Moreover, we study existing and new protocols that can provide basic network monitoring functionality that enables the acquirement of these inputs. In the end, a Software Defined Networking (SDN) approach is proposed to facilitate the development of energy-efficient aware networks. The details of a basic SDN monitoring application are presented from an abstract architectural point of view and three designs stemming from this basic architecture are discussed. The three designs are namely All_Flow, First_Switch and Port_FlowRemoved. The first two were implemented as steps towards understanding the full capabilities of performing monitoring in SDN enabled networks and provided useful input towards realizing the third one as a proof of concept. Their usage and faults are discussed as they can provide useful insight for possible future implementations. The Port_FlowRemoved is the design and implementation that is suggested as providing the most fitting results for the monitoring purpose at hand. This purpose is to retrieve the identified inputs for the selected “green” networking approach. The differentiation factor among the three designs is how they collect the required inputs from the network. A fast-prototype is created as a proof of concept in order to validate the proposed architecture and thus empower the validity of the idea.

FUN3D and USM3D Analysis of the Propulsion Aerodynamic Workshop 2018 S-Duct Test Case

This work presents the results of Fun3D and USM3D analyses that were performed for the 4th AIAA Propulsion Aerodynamics Workshop (PAW). The PAW workshop is separated into three sections that focus on internal duct flows, nozzle flows and a special topic. This paper focuses on the internal duct flow section of PAW04 while an accompanying paper discusses the analyses performed for the nozzle portion. For the internal duct flow section, the PAW04 participants were provided with the two configurations consisting of an S-duct with and without aerodynamic interface plane (AIP) rake legs modeled. The participants were asked to perform a grid refinement study as well as a turbulence model study for the configuration with the rake legs. The analyses discussed here were performed on custom grids developed under the guidelines of the workshop. Additionally, the paper discusses the development and use of flow controllers for matching the desired flow characteristics. The results show that both solvers do well for predicting internal flow characteristics of the S-duct based on direct comparison with the experimental data. However, the CFD-to-CFD comparison proved to be more challenging due to the localized occurrence of supersonic flow near the rake legs when using the mass flow controller. A turbulence model study was performed to compare the two-equation SST model to the SA-QCR model. The results show that although the turbulence model does affect the solution, it makes a minimal impact on pressure recovery and inlet distortion intensity for this case. Suggestions for future workshops include gridding guidelines similar to those employed for the Drag Prediction Workshop series for the grid refinement study and a time accuracy study

Are we Bridging the Divide in IWO Psychology?

This paper examines the knowledge transfer process within the profession of work and organisational psychology. In consonance with the theme of the 2011 congress, it considers the extent to which proposed ‘bridging mechanisms’ can provide useful vehicles for operationalising the pursuit of the dual goal of improving both the well-being of individuals and the effectiveness of work organizations. It considers the way in which the profession attempts to ground its concepts in a sound evidence base and then successfully mobilise this knowledge at the interface of research and practice. It does so by critically examining the scientist-practitioner model and the ways in which this model can be operationalised by practitioners and researchers. The criticism which is aimed at academics is that their research is irrelevant; it explores narrow concepts too often with student samples. Practitioners, on the other hand, are accused of too infrequently bringing scientific findings from the research literature to their practice. The problem has been cast in terms of both one of knowledge production and also knowledge transfer and is typified, at least in one direction – the impact of research upon practice, by what has in other professions, most notably medicine and more recently management, been called evidence-based practice. Denise Rousseau, in her 2005 presidential address to the American Academy of Management defined evidence-based management (EBM) as “translating principles based on best evidence into organizational practices” and there have been a number of attempts to invoke a similar model of evidence-based practice in the field of work and organisational psychology. In 2007 Anderson described the academic-practitioner divide as ‘natural’, suggesting the way forward was to focus on ‘bridging mechanisms’ describing six which had been proposed at the 1995 SIOP conference. What is the situation over decade later? To what extent have these bridges been built? This paper explores the nature and extent of these bridges by presenting case studies and findings from a UK survey of IWO psychologists

Partial response to carboplatin in an RRx-001 pretreated patient with EGFR-inhibitor-resistance and T790M-negative NSCLC.

Few therapeutic options are available for T790M-negative non-small cell lung cancer (NSCLC) after failure of primary epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and chemotherapy. This report presents the case of a 71-year-old Asian female never smoker with EGFR mutated T790M negative non squamous cell lung cancer (NSCLC) pre-treated with the experimental epi-immunotherapeutic agent, RRx-001, that re-responded to single agent carboplatin after failure of platinum doublets, TKIs, pemetrexed and nivolumab. The management of advanced EGFR mutation-positive NSCLC is briefly reviewed herein and the emerging paradigm of episensitization, which contradicts the long-standing and widely accepted tenet about the immutability of resistance and the futility of therapeutic rechallenge, is introduced as a strategy to avert treatment failure and thereby stave off deterioration and death

Evidence synthesis on the occurrence, causes, consequences, prevention and management of bullying and harassment behaviours to inform decision making in the NHS

Background Workplace bullying is a persistent problem in the NHS with negative implications for individuals, teams, and organisations. Bullying is a complex phenomenon and there is a lack of evidence on the best approaches to manage the problem. Aims Research questions What is known about the occurrence, causes, consequences and management of bullying and inappropriate behaviour in the workplace? Objectives Summarise the reported prevalence of workplace bullying and inappropriate behaviour. Summarise the empirical evidence on the causes and consequences of workplace bullying and inappropriate behaviour. Describe any theoretical explanations of the causes and consequences of workplace bullying and inappropriate behaviour. Synthesise evidence on the preventative and management interventions that address workplace bullying interventions and inappropriate behaviour. Methods To fulfil a realist synthesis approach the study was designed across four interrelated component parts: Part 1: A narrative review of the prevalence, causes and consequences of workplace bullying Part 2: A systematic literature search and realist review of workplace bullying interventions Part 3: Consultation with international bullying experts and practitioners Part 4: Identification of case studies and examples of good practic

Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets.

Small-cell lung cancer (SCLC), initially exquisitely sensitive to first-line cisplatin/etoposide, invariably relapses and acquires a multidrug chemoresistant phenotype that generally renders retreatment with first-line therapy both futile and counterproductive. This report presents the case of a 77-year-old Caucasian male with extensive-stage refractory SCLC who was restarted on platinum doublets as part of a clinical trial called TRIPLE THREAT (NCT02489903) involving pretreatment with the epi-immunotherapeutic agent RRx-001, and who achieved a partial response after only 4 cycles. The patient had received a platinum drug twice before, in 2009 for a diagnosis of non-small-cell lung cancer (squamous cell carcinoma) and in 2015 for SCLC, suggesting that RRx-001 pretreatment may sensitize or resensitize refractory SCLC patients to first-line chemotherapy

Simulation of underground gravity gradients from stochastic seismic fields

We present results obtained from a finite-element simulation of seismic displacement fields and of gravity gradients generated by those fields. The displacement field is constructed by a plane wave model with a 3D isotropic stochastic field and a 2D fundamental Rayleigh field. The plane wave model provides an accurate representation of stationary fields from distant sources. Underground gravity gradients are calculated as acceleration of a free test mass inside a cavity. The results are discussed in the context of gravity-gradient noise subtraction in third generation gravitational-wave detectors. Error analysis with respect to the density of the simulated grid leads to a derivation of an improved seismometer placement inside a 3D array which would be used in practice to monitor the seismic field.Comment: 24 pages, 12 figure

Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization.

RRx-001, an experimental systemically non-toxic epi-immunotherapeutic agent, which potentiates the resensitization of resistant cancer cells to formerly effective therapies, is under active investigation in several clinical trials that are based on sequential or concomitant rechallenge to resistant first- or second-line regimens. One of these trials is designated TRIPLE THREAT (NCT02489903), because it explores the conditioning or priming effect of RRx-001 on three tumor types - non-small cell lung cancer (NSCLC), small cell lung cancer and high-grade neuroendocrine tumors - prior to re-administration of platinum doublets. In follow-up to a recent case study, which describes early monotherapeutic benefit with RRx-001 in a refractory EGFR-mutated NSCLC tumor, we present subsequent evidence of a radiological partial response to reintroduced platinum doublets after RRx-001. For the 50% of patients with EGFR-mutated NSCLC who progress on EGFR-tyrosine kinase inhibitors (without evidence of a T790M mutations) as well as platinum doublets and pemetrexed/taxane, no other clinically established treatment options exist. A retrial of these therapies in EGFR-positive NSCLC patients via priming with epigenetic agents such as RRx-001 constitutes a strategy to 'episensitize' tumors (i.e. reverse resistance by epigenetic means) and to extend overall survival