Duality Violation and the K --> pi pi Electroweak Penguin Operator Matrix Elements from Hadronic Tau Decays

We discuss a preliminary study of the impact of duality violations on extractions from tau decay data of the D=6 VEVs which determine chiral limit Standard Model K-->pi pi matrix elements of the electroweak penguin operators.Comment: 4 pages, 5 figures, prepared for the Proceedings of the 11th Particle and Nuclear Intersections Conference (PANIC 2011), Boston, USA, July 24-29, 201

alpha_s from tau decays revisited

Being a determination at low energies, the analysis of hadronic tau decay data provides a rather precise determination of the strong coupling alpha_s after evolving the result to M_Z. At such a level of precision, even small non-perturbative effects become relevant for the central value and error. While those effects had been taken into account in the framework of the operator product expansion, contributions going beyond it, so-called duality violations, have previously been neglected. The following investigation fills this gap through a finite-energy sum rule analysis of tau decay spectra from the OPAL experiment, including duality violations and performing a consistent fit of all appearing QCD parameters. The resulting values for alpha_s(M_tau) are 0.307(19) in fixed-order perturbation theory and 0.322(26) in contour-improved perturbation theory, which translates to the n_f=5 values 0.1169(25) and 0.1187(32) at M_Z, respectively.Comment: 4 pages, 3 figures. Prepared for the Proceedings of the International Workshop on e+e- collisions from Phi to Psi (PHIPSI11), Sep. 19-22, 2011, BINP, Novosibirsk, Russi

Importance Of Toll-Like Receptors For B Lymphocyte Survival In Primary Sjögren’s Syndrome

The Sjögren's syndrome is a systemic autoimmune disease characterized by lymphocytic infiltration of the glands responsible for mouth and eyes dryness. A minority of infiltrating B cells is organized as germinal centers while the majority is aggregated into clusters of transitional and marginal zone B cells. The Toll-like receptor 9 (TLR9) recognizes microbial DNA but also, sometimes, the self DNA. It appears to be a key determinant of the survival and differentiation of B lymphocytes. After laser micro-dissection of B cells from salivary glands, analyses by quantitative RT-PCR showed that transitional B cells express high level of TLR9 mRNA unlike B cells from germinal centers. B lymphocytes from healthy donors were sorted by flow cytometry and stimulated in vitro with their TLR9. It induces survival, activation and proliferation associated with phenotypic changes. Transitional B cells exhibited characteristics of the marginal zone, whereas mature B cells expressed follicular germinal center specificities. Finally, IgM and IgG were secreted by both population, but with elevated production of autoantibodies by the transitional B cells. Increased expression of TLR9 by transitional B cells suggests that they may be highly sensitive to differentiate into autoantibody secreting cells through maturation into the marginal zone into the salivary glands. TLR9 might be a target for forthcoming biotherapies. Le syndrome de Gougerot-Sjögren est une maladie autoimmune systémique caractérisée par une infiltration lymphocytaire des glandes responsable d'une sécheresse buccale et oculaire. Une minorité des lymphocytes B infiltrants est organisée en centres germinatifs tandis que la majorité est regroupée en agrégats de lymphocytes B transitionnels et de la zone marginale. Le Toll-like receptor 9 (TLR9) reconnaît l'ADN microbien mais aussi, parfois, l'ADN du soi. Il apparaît donc comme un élément déterminant de la survie et la différenciation des lymphocytes B. Après micro-dissection laser des lymphocytes B des glandes salivaires, une analyse par RT-PCR quantitative a montré que les lymphocytes B transitionnels expriment fortement l'ARNm de TLR9 contrairement à ceux des centres germinatifs. Des lymphocytes B de donneurs sains ont été triés par cytométrie en flux puis stimulés in vitro par leur TLR9. Il s’ensuit une survie, une activation et une prolifération associées à des modifications phénotypiques. Les lymphocytes B transitionnels présentent des caractéristiques de la zone marginale, tandis que les lymphocytes B matures expriment des spécificités folliculaires des centres germinatifs. Enfin, des IgM et des IgG sont sécrétées par les deux types de population, mais avec une production d'auto-anticorps plus élevée issue de la différenciation des lymphocytes B transitionnels. L’expression accrue de TLR9 par les lymphocytes B transitionnels suggère qu'ils pourraient être particulièrement sensibles à une différenciation en cellules sécrétrices d'auto-anticorps par une maturation vers la zone marginale au sein des glandes salivaires. Le TLR9 pourrait bien devenir la cible des futures biothérapies.The Sjögren's syndrome is a systemic autoimmune disease characterized by lymphocytic infiltration of the glands responsible for mouth and eyes dryness. A minority of infiltrating B cells is organized as germinal centers while the majority is aggregated into clusters of transitional and marginal zone B cells. The Toll-like receptor 9 (TLR9) recognizes microbial DNA but also, sometimes, the self DNA. It appears to be a key determinant of the survival and differentiation of B lymphocytes. After laser micro-dissection of B cells from salivary glands, analyses by quantitative RT-PCR showed that transitional B cells express high level of TLR9 mRNA unlike B cells from germinal centers. B lymphocytes from healthy donors were sorted by flow cytometry and stimulated in vitro with their TLR9. It induces survival, activation and proliferation associated with phenotypic changes. Transitional B cells exhibited characteristics of the marginal zone, whereas mature B cells expressed follicular germinal center specificities. Finally, IgM and IgG were secreted by both population, but with elevated production of autoantibodies by the transitional B cells. Increased expression of TLR9 by transitional B cells suggests that they may be highly sensitive to differentiate into autoantibody secreting cells through maturation into the marginal zone into the salivary glands. TLR9 might be a target for forthcoming biotherapies. Le syndrome de Gougerot-Sjögren est une maladie autoimmune systémique caractérisée par une infiltration lymphocytaire des glandes responsable d'une sécheresse buccale et oculaire. Une minorité des lymphocytes B infiltrants est organisée en centres germinatifs tandis que la majorité est regroupée en agrégats de lymphocytes B transitionnels et de la zone marginale. Le Toll-like receptor 9 (TLR9) reconnaît l'ADN microbien mais aussi, parfois, l'ADN du soi. Il apparaît donc comme un élément déterminant de la survie et la différenciation des lymphocytes B. Après micro-dissection laser des lymphocytes B des glandes salivaires, une analyse par RT-PCR quantitative a montré que les lymphocytes B transitionnels expriment fortement l'ARNm de TLR9 contrairement à ceux des centres germinatifs. Des lymphocytes B de donneurs sains ont été triés par cytométrie en flux puis stimulés in vitro par leur TLR9. Il s’ensuit une survie, une activation et une prolifération associées à des modifications phénotypiques. Les lymphocytes B transitionnels présentent des caractéristiques de la zone marginale, tandis que les lymphocytes B matures expriment des spécificités folliculaires des centres germinatifs. Enfin, des IgM et des IgG sont sécrétées par les deux types de population, mais avec une production d'auto-anticorps plus élevée issue de la différenciation des lymphocytes B transitionnels. L’expression accrue de TLR9 par les lymphocytes B transitionnels suggère qu'ils pourraient être particulièrement sensibles à une différenciation en cellules sécrétrices d'auto-anticorps par une maturation vers la zone marginale au sein des glandes salivaires. Le TLR9 pourrait bien devenir la cible des futures biothérapies

A new type of CP symmetry, family replication and fermion mass hierarchies

We study a two-Higgs-doublet model with four generalised CP symmetries in the scalar sector. Electroweak symmetry breaking leads automatically to spontaneous breaking of two of them. We require that these four CP symmetries can be extended from the scalar sector to the full Lagrangian and call this requirement the principle of maximal CP invariance. The Yukawa interactions of the fermions are severely restricted by this requirement. In particular, a single fermion family cannot be coupled to the Higgs fields. For two fermion families, however, this is possible. Enforcing the absence of flavour-changing neutral currents, we find degenerate masses in both families or one family massless and one massive. In the latter case the Lagrangian is highly symmetric, with the mass hierarchy being generated by electroweak symmetry breaking. Adding a third family uncoupled to the Higgs fields and thus keeping it massless we get a model which gives a rough approximation of some features of the fermions observed in Nature. We discuss a number of predictions of the model which may be checked in future experiments at the LHC.Comment: 24 pages. Version published in EPJC. Minor changes as suggested by the refere

Duality violations in tau hadronic spectral moments

Evidence is presented for the necessity of including duality violations in a consistent description of spectral function moments employed in the precision determination of $\alpha_s$ from $\tau$ decay. A physically motivated ansatz for duality violations in the spectral functions enables us to perform fits to spectral moments employing both pinched and unpinched weights. We describe our analysis strategy and provide some preliminary findings. Final numerical results await completion of an ongoing re-determination of the ALEPH covariance matrices incorporating correlations due to the unfolding procedure which are absent from the currently posted versions. To what extent this issue affects existing analyses and our own work will require further study.Comment: 6 pages, 3 figures. Talk given at 11th International Workshop on Tau Lepton Physics, Manchester, UK, 13-17 September 201

Instability of the origami of a ferrofluid drop in a magnetic field

Capillary origami is the wrapping of an usual fluid drop by a planar elastic membrane due to the interplay between capillary and elastic forces. Here, we use a drop of magnetic fluid whose shape is known to strongly depend on an applied magnetic field. We study the quasi-static and dynamical behaviors of such a magnetic capillary origami. We report the observation of an overturning instability that the origami undergoes at a critical magnetic field. This instability is triggered by an interplay between magnetic and gravitational energies in agreement with the theory presented here. Additional effects of elasticity and capillarity on this instability are also discussed.Comment: in press in PRL (2011

TOLL-LIKE RECEPTOR 9 DRIVES THE MATURATION OF B LYMPHOCYTES IN THE SALIVARY GLANDS OF PATIENTS WITH SJÖGREN’S SYNDROME

Oral Communication presented at the ";Forum des Jeunes Chercheurs";, Brest (France) 2011