442 research outputs found

    Apes communicate about absent and displaced objects: methodology matters

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    Displaced reference is the ability to refer to an item that has been moved (displaced) in space and/or time, and has been called one of the true hallmarks of referential communication. Several studies suggest that nonhuman primates have this capability, but a recent experiment concluded that in a specific situation (absent entities) human infants display displaced reference but chimpanzees do not. Here we show that chimpanzees and bonobos of diverse rearing histories are capable of displaced reference to absent and displaced objects. It is likely that some of the conflicting findings from animal cognition studies are due to relatively minor methodological differences, but are compounded by interpretation errors. Comparative studies are of great importance in elucidating the evolution of human cognition, however, greater care must be taken with methodology and interpretation for these studies to accurately reflect species differences

    Triggering social interactions:chimpanzees respond to imitation by a humanoid robot and request responses from it

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    Even the most rudimentary social cues may evoke affiliative responses in humans and promote socialcommunication and cohesion. The present work tested whether such cues of an agent may also promotecommunicative interactions in a nonhuman primate species, by examining interaction-promoting behavioursin chimpanzees. Here, chimpanzees were tested during interactions with an interactive humanoid robot, whichshowed simple bodily movements and sent out calls. The results revealed that chimpanzees exhibited twotypes of interaction-promoting behaviours during relaxed or playful contexts. First, the chimpanzees showedprolonged active interest when they were imitated by the robot. Second, the subjects requested ‘social’responses from the robot, i.e. by showing play invitations and offering toys or other objects. This study thusprovides evidence that even rudimentary cues of a robotic agent may promote social interactions inchimpanzees, like in humans. Such simple and frequent social interactions most likely provided a foundationfor sophisticated forms of affiliative communication to emerge

    The crystal structure of Pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex

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    Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes. Cryo-EM has revealed the structures of the membrane-surface bound pre-pore and inserted-pore oligomers, however the molecular contacts that mediate these oligomers are unknown because high-resolution information is not available. Here we have determined the crystal structure of full-length pneumolysin at 1.98 Å resolution. In the structure, crystal contacts demonstrate the likely interactions that enable polymerisation on the cell membrane and the molecular packing of the pre-pore complex. The hemolytic activity is abrogated in mutants that disrupt these intermolecular contacts, highlighting their importance during pore formation. An additional crystal structure of the membrane-binding domain alone suggests that changes in the conformation of a tryptophan rich-loop at the base of the toxin promote monomer-monomer interactions upon membrane binding by creating new contacts. Notably, residues at the interface are conserved in other members of the CDC family, suggesting a common mechanism for pore and pre-pore assembly

    The Experiment Factory: Standardizing Behavioral Experiments

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    The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (de Leeuw (2015); McDonnell et al. (2012); Mason and Suri (2011); Lange et al. (2015)) have provided infrastructure and methods for individual research groups to develop paradigms, missing is a coordinated effort to develop paradigms linked with a system to easily deploy them. This disorganization leads to redundancy in development, divergent implementations of conceptually identical tasks, disorganized and error-prone code lacking documentation, and difficulty in replication. The ongoing reproducibility crisis in psychology and neuroscience research (Baker (2015); Open Science Collaboration (2015)) highlights the urgency of this challenge: reproducible research in behavioral psychology is conditional on deployment of equivalent experiments. A large, accessible repository of experiments for researchers to develop collaboratively is most efficiently accomplished through an open source framework. Here we present the Experiment Factory, an open source framework for the development and deployment of web-based experiments. The modular infrastructure includes experiments, virtual machines for local or cloud deployment, and an application to drive these components and provide developers with functions and tools for further extension. We release this infrastructure with a deployment (http://www.expfactory.org) that researchers are currently using to run a set of over 80 standardized web-based experiments on Amazon Mechanical Turk. By providing open source tools for both deployment and development, this novel infrastructure holds promise to bring reproducibility to the administration of experiments, and accelerate scientific progress by providing a shared community resource of psychological paradigms

    Distal communication by chimpanzees (Pan troglodytes): evidence for common ground?

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    van der Goot et al. (2014) proposed that distal, deictic communication indexed the appreciation of the psychological state of a common ground between a signaler and a receiver. In their study, great apes did not signal distally, which they construed as evidence for the human uniqueness of a sense of common ground. This study exposed 166 chimpanzees to food and an experimenter, at an angular displacement, to ask, “Do chimpanzees display distal communication?” Apes were categorized as (a) proximal or (b) distal signalers on each of four trials. The number of chimpanzees who communicated proximally did not statistically differ from the number who signaled distally. Therefore, contrary to the claim by van der Goot et al., apes do communicate distally

    Migratory Insertion of CO into a Au-C Bond

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    A MeDalPhos-ligated gold(III) metallafluorene complex, generated via C-C oxidative addition of biphenylene, reacts with CO to produce 9-fluorenone. Experimental and computational studies show that this proceeds via a hitherto unknown migratory insertion of CO into a Au(III)-C bond. This process is more energetically challenging compared to other M-C bonds, but once achieved, the product is comparatively stable with respect to retro-carbonylation. Exploiting migratory insertion of CO into Au-C bonds may extend the range of products that are accessible using gold chemistry

    A Comparison of MRI Quantitative Susceptibility Mapping and TRUST-Based Measures of Brain Venous Oxygen Saturation in Sickle Cell Anaemia

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    In recent years, interest has grown in the potential for magnetic resonance imaging (MRI) measures of venous oxygen saturation (Yv) to improve neurological risk prediction. T2-relaxation-under-spin-tagging (TRUST) is an MRI technique which has revealed changes in Yv in patients with sickle cell anemia (SCA). However, prior studies comparing Yv in patients with SCA relative to healthy controls have reported opposing results depending on whether the calibration model, developed to convert blood T2 to Yv, is based on healthy human hemoglobin (HbA), bovine hemoglobin (HbBV) or sickle hemoglobin (HbS). MRI Quantitative Susceptibility Mapping (QSM) is an alternative technique that may hold promise for estimating Yv in SCA as blood magnetic susceptibility is linearly dependent upon Yv, and no significant difference has been found between the magnetic susceptibility of HbA and HbS. Therefore, the aim of this study was to compare estimates of Yv using QSM and TRUST with five published calibration models in healthy controls and patients with SCA. 17 patients with SCA and 13 healthy controls underwent MRI. Susceptibility maps were calculated from a multi-parametric mapping acquisition and Yv was calculated from the mean susceptibility in a region of interest in the superior sagittal sinus. TRUST estimates of T2, within a similar but much smaller region, were converted to Yv using five different calibration models. Correlation and Bland-Altman analyses were performed to compare estimates of Yv between TRUST and QSM methods. For each method, t-tests were also used to explore group-wise differences between patients with SCA and healthy controls. In healthy controls, significant correlations were observed between QSM and TRUST measures of Yv, while in SCA, there were no such correlations. The magnitude and direction of group-wise differences in Yv varied with method. The TRUST-HbBV and QSM methods suggested decreased Yv in SCA relative to healthy controls, while the TRUST-HbS (p < 0.01) and TRUST-HbA models suggested increased Yv in SCA as in previous studies. Further validation of all MRI measures of Yv, relative to ground truth measures such as O15 PET and jugular vein catheterization, is required in SCA before QSM or TRUST methods can be considered for neurological risk prediction

    Age systematics of two young en echelon Samoan volcanic trails

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    Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 12 (2011): Q07025, doi:10.1029/2010GC003438.The volcanic origin of the Samoan archipelago can be explained by one of three models, specifically, by a hot spot forming over a mantle plume, by lithospheric extension resulting from complex subduction tectonics in the region, or by a combination of these two processes, either acting sequentially or synchronously. In this paper, we present results of 36 high-resolution 40Ar/39Ar incremental heating age analyses for the initial (submarine) phase of Samoan volcanoes, ranging from 13.2 Ma for the westernmost Samoan seamounts to 0.27 Ma in the eastern Samoan volcanic province. Taken as a whole, our new age data point to a hot spot origin for the shield-building volcanism in the Samoan lineament, whereby seamounts younger than 5 Ma are consistent with a model of constant 7.1 cm/yr plate motion, analogous to GPS measurements for the Pacific Plate in this region. This makes our new 40Ar/39Ar ages of the submarine basalts all older compared to recent absolute plate motion (APM) models by Wessel et al. (2008), which are based on the inversion of twelve independent seamount trails in the Pacific relative to a fixed reference frame of hot spots and which predict faster plate motions of around 9.3 cm/yr in the vicinity of Samoa. The Samoan ages are also older than APM models by Steinberger et al. (2004) taking into account the motion of hot spots in the Pacific alone or globally. The age systematics become more complicated toward the younger end of the Samoan seamount trail, where its morphology bifurcates into two en echelon subtracks, termed the VAI and MALU trends, as they emanate from two eruptive centers at Vailulu'u and Malumalu seamount, respectively. Spaced ∼50 km apart, the VAI and MALU trends have distinct geochemical characters and independent but overlapping linear 40Ar/39Ar age progressions since 1.5 Ma. These phenomena are not unique to Samoa, as they have been observed at the Hawaiian hot spot, and can be attributed to a geochemical zoning in its underlying mantle source or plume. Moreover, the processes allowing for the emergence of two distinct eruptive centers in the Samoan archipelago, the stepped offset of these subtracks, and their slight obliqueness with respect to the overall seamount trail orientation may very well be controlled by local tectonics, stresses, and extension, also causing the rejuvenated volcanism on the main islands of Savai'i, Upolu, and Tutuila since 0.4 Ma.Financial support is provided by NSF‐OCE 0002875 and NSF‐OCE 0351437
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