Boron enrichment in Martian clay

We have detected a concentration of boron in martian clay far in excess of that in any previously reported extra-terrestrial object. This enrichment indicates that the chemistry necessary for the formation of ribose, a key component of RNA, could have existed on Mars since the formation of early clay deposits, contemporary to the emergence of life on Earth. Given the greater similarity of Earth and Mars early in their geological history, and the extensive disruption of Earth's earliest mineralogy by plate tectonics, we suggest that the conditions for prebiotic ribose synthesis may be better understood by further Mars exploration

Damage-induced phosphorylation of Sld3 is important to block late origin firing.

Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion. However, in response to DNA damage or replication fork stalling, eukaryotic cells block activation of unfired origins. Human cells derived from patients with ataxia telangiectasia are deficient in this process due to the lack of a functional ataxia telangiectasia mutated (ATM) kinase and elicit radioresistant DNA synthesis after γ-irradiation(2). This effect is conserved in budding yeast, as yeast cells lacking the related kinase Mec1 (ATM and Rad3-related (ATR in humans)) also fail to inhibit DNA synthesis in the presence of DNA damage. This intra-S-phase checkpoint actively regulates DNA synthesis by inhibiting the firing of late replicating origins, and this inhibition requires both Mec1 and the downstream checkpoint kinase Rad53 (Chk2 in humans). However, the Rad53 substrate(s) whose phosphorylation is required to mediate this function has remained unknown. Here we show that the replication initiation protein Sld3 is phosphorylated by Rad53, and that this phosphorylation, along with phosphorylation of the Cdc7 kinase regulatory subunit Dbf4, blocks late origin firing in Saccharomyces cerevisiae. Upon exposure to DNA-damaging agents, cells expressing non-phosphorylatable alleles of SLD3 and DBF4 (SLD3-m25 and dbf4-m25, respectively) proceed through the S phase faster than wild-type cells by inappropriately firing late origins of replication. SLD3-m25 dbf4-m25 cells grow poorly in the presence of the replication inhibitor hydroxyurea and accumulate multiple Rad52 foci. Moreover, SLD3-m25 dbf4-m25 cells are delayed in recovering from transient blocks to replication and subsequently arrest at the DNA damage checkpoint. These data indicate that the intra-S-phase checkpoint functions to block late origin firing in adverse conditions to prevent genomic instability and maximize cell survival

Advancing airborne Doppler lidar wind profiling in turbulent boundary layer flow – an LES-based optimization of traditional scanning-beam versus novel fixed-beam measurement systems

There is a need for improved wind measurements inside the planetary boundary layer (PBL), including the capability to sample turbulent flow. Airborne Doppler lidar (ADL) provides unique capabilities for spatially resolved and targeted wind measurements in the PBL. However, ADL wind profiling in the PBL is challenging, as turbulence violates the flow homogeneity assumption used in wind profile retrieval and thereby introduces error in the retrieved wind profiles. As turbulence is a dominant source of error it is necessary to investigate and optimize ADL wind profiling capabilities in turbulent PBL flow. This study investigates the potential of a novel multiple-fixed-beam ADL system design to provide improved wind information in turbulent PBL flow compared to traditional single-scanning-beam ADL systems. To achieve this, an LES-based (LES: large eddy simulation) airborne Doppler lidar simulator presented in Gasch et al. (2020) is employed and extended in this study. Results show that a multiple-fixed-beam system with settings comparable to those of commonly used single-scanning-beam systems offers distinct advantages. Advantages include overall reduced wind profile retrieval error due to turbulence and improved spatial representation alongside higher wind profile availability. The study also offers insight into the dependence of the retrieval error on system setup parameters and retrieval parameters for both fixed-beam and scanning-beam systems. When using a fixed-beam system, an order of magnitude higher wind profile resolution appears possible compared to traditional scanning systems at comparable retrieval accuracy. Thus, using multiple-fixed-beam systems opens the door to better sampling of turbulent PBL flow. Overall, the simulator provides a cost-effective tool to investigate and optimize wind profile error characteristics due to turbulence and to optimize system setup and retrieval strategies for ADL wind profiling in turbulent flow

Advancing airborne Doppler lidar wind profiling in turbulent boundary layer flow – an LES-based optimization of traditional scanning-beam versus novel fixed-beam measurement systems

There is a need for improved wind measurements inside the planetary boundary layer (PBL), including the capability to sample turbulent flow. Airborne Doppler lidar (ADL) provides unique capabilities for spatially resolved and targeted wind measurements in the PBL. However, ADL wind profiling in the PBL is challenging, as turbulence violates the flow homogeneity assumption used in wind profile retrieval and thereby introduces error in the retrieved wind profiles. As turbulence is a dominant source of error it is necessary to investigate and optimize ADL wind profiling capabilities in turbulent PBL flow. This study investigates the potential of a novel multiple-fixed-beam ADL system design to provide improved wind information in turbulent PBL flow compared to traditional single-scanning-beam ADL systems. To achieve this, an LES-based (LES: large eddy simulation) airborne Doppler lidar simulator presented in Gasch et al. (2020) is employed and extended in this study. Results show that a multiple-fixed-beam system with settings comparable to those of commonly used single-scanning-beam systems offers distinct advantages. Advantages include overall reduced wind profile retrieval error due to turbulence and improved spatial representation alongside higher wind profile availability. The study also offers insight into the dependence of the retrieval error on system setup parameters and retrieval parameters for both fixed-beam and scanning-beam systems. When using a fixed-beam system, an order of magnitude higher wind profile resolution appears possible compared to traditional scanning systems at comparable retrieval accuracy. Thus, using multiple-fixed-beam systems opens the door to better sampling of turbulent PBL flow. Overall, the simulator provides a cost-effective tool to investigate and optimize wind profile error characteristics due to turbulence and to optimize system setup and retrieval strategies for ADL wind profiling in turbulent flow.</p

Occupational Therapists’ Perspectives During the COVID-19 Pandemic

On March 11, 2020, the World Health Organization declared the outbreak of the coronavirus disease 2019 (COVID-19) as a global pandemic. Hospitals, nursing homes, and communities worldwide were flooded with patients diagnosed with COVID-19, resulting in the increased need for medical care and treatment by health care professionals, such as occupational therapists. This study analyzes output from a quantitative online survey design, which was created on SurveyMonkey and included 43 questions. Data from the survey were collected, categorized, and measured through the SurveyMonkey computer system and included information gathered from 204 occupational therapists from October 2020 to February 2020. Based on the survey results, occupational therapists believe that their profession has an ethical duty to provide skilled interventions to patients diagnosed with COVID-19. The majority of the occupational therapists were worried about their health and their family’s health as a result of COVID-19. In addition, many of the. therapists reported a close contact and subsequent positive test for COVID-19. Health care administrators and leaders should use the common perspectives among health care workers to guide them as they provide additional support and implement changes during the COVID-19 pandemic. Interventions that could be implemented by health care administrators include self-care training, psychological support, and safe opportunities to engage in meaningful activities

Locking Solar Tracking Bushing

The contents of this final design review (FDR) outline the progress made by a team of four mechanical engineering students at California Polytechnic State University, San Luis Obispo to solve the problem of torsional galloping in solar tracker panels since the preliminary design review. The project proposed by the sponsor, Christian Friedrich, on behalf of ARaymond is a design for a friction based braking system integrated into a redesigned bushing. The CDR contains details about the system design, the design justification, the manufacturing plan, and design verification plan. In the system design section, the four manufacturing subsystems (bushing mount, actuation, power screw, and braking system) will be analyzed. This analysis will be expanded upon in the manufacturing plan where the current manufacturing plan for the project deliverable will be explained. The CDR will also detail any changes that have been made since the preliminary design review (PDR). Since the PDR, the frictional force that is needed to dampen the system has been adjusted to emulate the system more accurately. The project objectives are to dampen oscillation through frictional means, withstand gravitational and wind static loads of 7.5 metric tons, and endure wearing for 30 years. The overall structure of the bushing has been altered in a variety of different ways. First, the outer journal has been completely separated into two parts to increase the available contact area for the band brake which permits multiple different band orientations to test. As a result, the inner journal has increased in axial length in accordance with the outer journal separation. The lever arm system has also been altered to allow the power screw to interface with the lever arm system. The lever arm system also straddles the I-beam support for ease of rotation and proper power screw engagement. In order to accommodate the separation between the outer journals, an additional mounting plate has been incorporated to mount both halves of the outer journal. Finally, the power screw has been re-oriented to be perpendicular with the I-beam to increase support and adjustability

Pointcatcher software:analysis of glacial time-lapse photography and integration with multi-temporal digital elevation models

Terrestrial time-lapse photography offers insight into glacial processes through high spatial and temporal resolution imagery. However, oblique camera views complicate measurement in geographic coordinates, and lead to reliance on specific imaging geometries or simplifying assumptions for calculating parameters such as ice velocity. We develop a novel approach that integrates time-lapse imagery with multi-temporal digital elevation models to derive full 3D coordinates for natural features tracked throughout a monoscopic image sequence. This enables daily independent measurement of horizontal (ice flow) and vertical (ice melt) velocities. By combining two terrestrial laser scanner surveys with a 73-day sequence from Sólheimajökull, Iceland, variations in horizontal ice velocity of ~10% were identified over timescales of ~25 days. An overall surface elevation decrease of ~3.0 m showed rate changes asynchronous with the horizontal velocity variations, demonstrating a temporal disconnect between the processes of ice surface lowering and mechanisms of glacier movement. Our software, ‘Pointcatcher’, is freely available for user-friendly interactive processing of general time-lapse sequences and includes Monte Carlo error analysis and uncertainty projection onto DEM surfaces. It is particularly suited for analysis of challenging oblique glacial imagery, and we discuss good features to track, both for correction of camera motion and for deriving ice velocities