Remotely forced nearshore upwelling in southern California

[1] Alongshore winds in Baja California strongly influence nearshore temperatures hundreds of kilometers to the north at Point Loma, San Diego, California, on timescales of a week to a year. The time lag between wind and temperature is consistent with first mode coastal trapped wave phase speed. The nearshore cross-shelf circulation forced by the coastal trapped waves is, at least much of the year, oppositely directed at the surface and bottom. No relation is found between the winds and temperature for periods greater than a year. It is argued that similar results may be found elsewhere in the Southern California Bight. The relationship between stratification and bottom temperature varies over the 1.3 years of data, but for much of the time, warmer bottom waters are associated with even warmer surface waters and thus stronger stratification. The effects of the remotely forced cross-shelf exchange on coastal pollution, nutrient dynamics, and larval transport are briefly discussed

The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer.

Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress. Recent studies have characterized the oncogenic role of ATF5 in the development of several different types of cancer, notably glioblastoma. Preclinical assessment of a systemically deliverable dominant-negative ATF5 (dnATF5) biologic has found that targeting ATF5 results in tumor regression and tumor growth inhibition of glioblastoma xenografts in mouse models. In this review, we comprehensively and critically detail the current scientific literature on ATF5 in the context of cellular differentiation, survival, and response to stressors in normal tissues. Furthermore, we will discuss how the prosurvival role of ATF5 aides in cancer development, followed by current advances in targeting ATF5 using dominant-negative biologics, and perspectives on future research

Masers and the Massive Star Formation Process: New Insights Through Infrared Observations

Our mid-infrared and near-infrared surveys over the last five years have helped to strengthen and clarify the relationships between water, methanol, and OH masers and the star formation process. Our surveys show that maser emission seems to be more closely associated with mid-infrared emission than cm radio continuum emission from UC HII regions. We find that masers of all molecular species surveyed trace a wide variety of phenomena and show a proclivity for linear distributions. The vast majority of these linear distributions can be explained by outflows or shocks, and in general do not appear to trace circumstellar disks as was previously thought. Some water and methanol masers that are not associated with radio continuum emission appear to trace infrared-bright hot cores, the earliest observable stage of massive stellar life before the onset of a UC HII region.Comment: 6 pages, 3 figures, to appear in the proceedings of IAU Symposium 227: "Massive Star Birth: A Crossroads of Astrophysics", version with full-resolution images available at http://www.ctio.noao.edu/~debuize

The dynamics and optimal control of spinning spacecraft with movable telescoping appendages. Part C: Effect of flexibility during boom deployment

The dynamics of a spinning symmetrical spacecraft system during the deployment (or retraction) of flexible boom-type appendages were investigated. The effect of flexibility during boom deployment is treated by modelling the deployable members as compound spherical pendula of varying length (according to a control law). The orientation of the flexible booms with respect to the hub, is described by a sequence of two Euler angles. The boom members contain a flexural stiffness which can be related to an assumed effective restoring linear spring constant, and structural damping which effects the entire system. Linearized equations of motion for this system, when the boom length is constant, involve periodic coefficients with the frequency of the hub spin. A bounded transformation is found which converts this system into a kinematically equivalent one involving only constant coefficients

MARKET COMPETITION AND METROPOLITAN-AREA GROCERY PRICES

This paper examines the relationship of 1987 retail grocery prices to supermarket sales concentration across 95 U.S. metropolitan areas. The regression model incorporates a large number of population, retail-cost, and retail competition factors and separate prices by type of grocery item. We find that the concentration-price relationship is sensitive to item type: positive for packaged, branded, dry groceries and unrelated for produce, meat, and dairy product prices. As for market rivalry, we find that small grocery stores provide no grocery price competition for supermarkets. However, branded grocery prices are driven down by fast-food places and by rapid price churning, whereas for unbranded foods the presence of warehouse stores places downward pressure on supermarket prices while fast-food presence does not. For the branded-groceries component, we also find prices higher in large, fast-growing, low- income, Eastern cities. We also find that cities where rents, wages, and electricity costs are high tend to have high dry grocery prices. However, for the unbranded-products component retail costs are unrelated to prices, and cities in the South have the highest prices.retail grocery trade, pricing policy, variable price merchandising, market competition, category management, market structure, sales concentration, price discrimination, price rivalry, oligopoly, food demand, food prices, Consumer/Household Economics,

The effects of different rates of ascent on the incidence of altitude decompression sickness

The effect of different rates of ascent on the incidence of altitude decompression sickness (DCS) was analyzed by a retrospective study on 14,123 man-flights involving direct ascent up to 38,000 ft altitude. The data were classified on the basis of altitude attained, denitrogenation at ground level, duration of stay at altitude, rest or exercise while at altitude, frequency of exercise at altitude, and ascent rates. This database was further divided on the basis of ascent rates into different groups from 1000 ft/min up to 53,000 ft/min. The database was analyzed using multiple correlation and regression methods, and the results of the analysis reveal that ascent rates influence the incidence of DCS in combination with the various factors mentioned above. Rate of ascent was not a significant predictor of DCS and showed a low, but significant multiple correlation (R=0.31) with the above factors. Further, the effects of rates below 2500 ft/min are significantly different from that of rates above 2500 ft/min on the incidence of symptoms (P=0.03) and forced descent (P=0.01). At rates above 2500 ft/min and up to 53,000 ft/min, the effects of ascent rates are not significantly different (P greater than 0.05) in the population examined while the effects of rates below 2500 ft/min are not clear

The dynamics and control of large flexible space structures. Part B: Development of continuum model and computer simulation

The equations of motion of an arbitrary flexible body in orbit were derived. The model includes the effects of gravity with all its higher harmonics. As a specific example, the motion of a long, slender, uniform beam in circular orbit was modelled. The example considers both the inplane and three dimensional motion of the beam in orbit. In the case of planar motion with only flexible vibrations, the pitch motion is not influenced by the elastic motion of the beam. For large values of the square of the ratio of the structural modal frequency to the orbital angular rate the elastic motion was decoupled from the pitch motion. However, for small values of the ratio and small amplitude pitch motion, the elastic motion was governed by a Hill's 3 term equation. Numerical simulation of the equation indicates the possibilities of instability for very low values of the square of the ratio of the modal frequency to the orbit angular rate. Also numerical simulations of the first order nonlinear equations of motion for a long flexible beam in orbit were performed. The effect of varying the initial conditions and the number of modes was demonstrated

Peeling Back the Onion Competitive Advantage Through People: Test of a Causal Model

Proponents of the resource-based view (RBV) of the firm have identified human resource management (HRM) and human capital as organizational resources that can contribute to sustainable competitive success. A number of empirical studies have documented the relationship between systems of human resource policies and practices and firm performance. The mechanisms by which HRM leads to firm performance, however, remain largely unexplored. In this study, we explore the pathways leading from HRM to firm performance. Specifically, we use structural equation modeling to test a model positing a set of causal relationships between high performance work systems (HPWS), employee retention, workforce productivity and firm market value. Within a set of manufacturing firms, results indicate the primary impact of HPWS on productivity and market value is through its influence on employee retention