The Optical Rotation of Camphor and Some Derivatives

The formidable mass of accumulated data relating to the optical rotation of camphor and its derivatives suggests at first sight that this field of research has already been exhausted. Closer examination, however, shows that this is far from being the case; on every side supplementary work is necessary, whilst the field itself is so extensive that a vast expanse of fresh ground remains to be broken. The application of the Drude equation by Lowry and his co-workers has resulted in valuable additions to our knowledge of the dispersion measurements of these compounds, but temperature-rotation data and the effects of solvent action are lacking and, with camphor derivatives in general, even if we except the case of camphor itself, these two highly important factors in rotation have either been neglected altogether or accorded no more than a passing consideration. It was in part, therefore, at once the justification and aim in commencing the present work, to repair in some measure this omission and to place on record measurements of these influences which, apart from any resulting theory or generalisation, would have, ipso facto, a real value. In addition, and in this lay the chief incentive to the work, it was believed that investigation of the rotatory power of camphor compounds could scarcely fail to be of interest when referred to characteristic diagrams of the type already studied by Professor Patterson and his colleagues for compounds of a less complex character. Accordingly, in addition to camphor itself, certain of its sulphonic and halogen derivatives have been selected, and examined in such detail as the merits of each case seemed to require

Sub-Shot-Noise Quantum Optical Interferometry: A Comparison of Entangled State Performance within a Unified Measurement Scheme

Phase measurement using a lossless Mach-Zehnder interferometer with certain entangled $N$-photon states can lead to a phase sensitivity of the order of 1/N, the Heisenberg limit. However, previously considered output measurement schemes are different for different input states to achieve this limit. We show that it is possible to achieve this limit just by the parity measurement for all the commonly proposed entangled states. Based on the parity measurement scheme, the reductions of the phase sensitivity in the presence of photon loss are examined for the various input states.Comment: 5 pages, 2 figure

Redescription of Lemuricola (Madoxyuris) bauchoti (Nematoda, Oxyuridae) from Lemur catta in Madagascar

Lemuricola (Madoxyuris) bauchoti Chabaud, Brygoo et Petter, 1965 is redescribed from material collected from the ring-tailed lemur, Lemur catta, from the Beza Mahafaly Special Reserve in Madagascar using the scanning electron microscope. This is a new host record and the first oxyurid reported from the ring-tailed lemur. Previously, records of each species of the subgenus Madoxyuris have been restricted to a single host species, but the close relationship between these nematodes and their Strepsirrhini hosts will only be proven when additional records fill in the gaps in their distribution.Centro de Estudios Parasitológicos y de Vectore

Confinement of Skyrmions in Nanoscale FeGe Device-like Structures

Skyrmion-based devices have been proposed as a promising solution for low-energy data storage. These devices include racetrack or logic structures and require skyrmions to be confined in regions with dimensions comparable to the size of a single skyrmion. Here we examine skyrmions in FeGe device shapes using Lorentz transmission electron microscopy to reveal the consequences of skyrmion confinement in a device-like structure. Dumbbell-shaped elements were created by focused ion beam milling to provide regions where single skyrmions are confined adjacent to areas containing a skyrmion lattice. Simple block shapes of equivalent dimensions were also prepared to allow a direct comparison with skyrmion formation in a less complex, yet still confined, device geometry. The impact of applying a magnetic field and varying the temperature on the formation of skyrmions within the shapes was examined. This revealed that it is not just confinement within a small device structure that controls the position and number of skyrmions but that a complex device geometry changes the skyrmion behavior, including allowing skyrmions to form at lower applied magnetic fields than in simple shapes. The impact of edges in complex shapes is observed to be significant in changing the behavior of the magnetic textures formed. This could allow methods to be developed to control both the position and number of skyrmions within device structures

Magnetic Vortex States in Toroidal Iron Oxide Nanoparticles: Combining Micromagnetics with Tomography

Iron oxide nanorings have great promise for biomedical applications because of their magnetic vortex state, which endows them with a low remanent magnetization while retaining a large saturation magnetization. Here we use micromagnetic simulations to predict the exact shapes that can sustain magnetic vortices, using a toroidal model geometry with variable diameter, ring thickness, and ring eccentricity. Our model phase diagram is then compared with simulations of experimental geometries obtained by electron tomography. High axial eccentricity and low ring thickness are found to be key factors for forming vortex states and avoiding net-magnetized metastable states. We also find that while defects from a perfect toroidal geometry increase the stray field associated with the vortex state, they can also make the vortex state more energetically accessible. These results constitute an important step toward optimizing the magnetic behavior of toroidal iron oxide nanoparticles

Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons.

The ∼20,000 cells of the suprachiasmatic nucleus (SCN), the master circadian clock of the mammalian brain, coordinate subordinate cellular clocks across the organism, driving adaptive daily rhythms of physiology and behavior. The canonical model for SCN timekeeping pivots around transcriptional/translational feedback loops (TTFL) whereby PERIOD (PER) and CRYPTOCHROME (CRY) clock proteins associate and translocate to the nucleus to inhibit their own expression. The fundamental individual and interactive behaviors of PER and CRY in the SCN cellular environment and the mechanisms that regulate them are poorly understood. We therefore used confocal imaging to explore the behavior of endogenous PER2 in the SCN of PER2::Venus reporter mice, transduced with viral vectors expressing various forms of CRY1 and CRY2. In contrast to nuclear localization in wild-type SCN, in the absence of CRY proteins, PER2 was predominantly cytoplasmic and more mobile, as measured by fluorescence recovery after photobleaching. Virally expressed CRY1 or CRY2 relocalized PER2 to the nucleus, initiated SCN circadian rhythms, and determined their period. We used translational switching to control CRY1 cellular abundance and found that low levels of CRY1 resulted in minimal relocalization of PER2, but yet, remarkably, were sufficient to initiate and maintain circadian rhythmicity. Importantly, the C-terminal tail was necessary for CRY1 to localize PER2 to the nucleus and to initiate SCN rhythms. In CRY1-null SCN, CRY1Δtail opposed PER2 nuclear localization and correspondingly shortened SCN period. Through manipulation of CRY proteins, we have obtained insights into the spatiotemporal behaviors of PER and CRY sitting at the heart of the TTFL molecular mechanism

Redescription of Lemuricola (Madoxyuris) bauchoti (Nematoda, Oxyuridae) from Lemur catta in Madagascar

Lemuricola (Madoxyuris) bauchoti Chabaud, Brygoo et Petter, 1965 is redescribed from material collected from the ring-tailed lemur, Lemur catta, from the Beza Mahafaly Special Reserve in Madagascar using the scanning electron microscope. This is a new host record and the first oxyurid reported from the ring-tailed lemur. Previously, records of each species of the subgenus Madoxyuris have been restricted to a single host species, but the close relationship between these nematodes and their Strepsirrhini hosts will only be proven when additional records fill in the gaps in their distribution.Fil: Robles, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; ArgentinaFil: Loudon, James E.. State University of Colorado at Boulder; Estados UnidosFil: Kinsella, John M.. Helm West Laboratory; Estados UnidosFil: Hunter Ishikawa, Mandala. State University of Colorado - Fort Collins; Estados UnidosFil: Miller, David S.. State University of Colorado - Fort Collins; Estados UnidosFil: Sauther, Michelle L.. State University of Colorado at Boulder; Estados UnidosFil: Cuozzo, Frank P.. University of North Dakota; Estados Unido