Regulation of the neuronal proteasome by Zif268 (Egr1)

Most forms of neuronal plasticity are associated with induction of the transcription factor Zif268 (Egr1/Krox24/NGF-IA). In a genomewide scan, we obtained evidence for potential modulation of proteasome subunit and regulatory genes by Zif268 in neurons, a finding of significance considering emerging evidence that the proteasome modulates synaptic function. Bioinformatic analysis indicated that the candidate proteasome Zif268 target genes had a rich concentration of putative Zif268 binding sites immediately upstream of the transcriptional start sites. Regulation of the mRNAs encoding the psmb9 (Lmp2) and psme2 (PA28�) proteasome subunits, along with the proteasome-regulatory kinase serum/glucocorticoid-regulated kinase (SGK) and the proteasome-associated antigen peptide transporter subunit 1 (Tap1), was confirmed after transfection of a neuronal cell line with Zif268. Conversely, these mRNAs were upregulated in cerebral cortex tissue from Zif268 knock-out mice relative to controls, confirming that Zif268 suppresses their expression in the CNS. Transfected Zif268 reduced the activity of psmb9, SGK, and Tap1 promoter–reporter constructs. Altered psmb9, SGK, and Tap1 mRNA levels were also observed in an in vivo model of neuronal plasticity involving Zif268 induction: the effect of haloperidol administration on striatal gene expression. Consistent with these effects on proteasome gene expression, increased Zif268 expression suppressed proteasome activity, whereas Zif268 knock-out mice exhibited elevated cortical proteasome activity. Our findings reveal that Zif268 regulates the expression of proteasome and related genes in neuronal cells and provide new evidence that altered expression of proteasome activity after Zif268 induction may be a key component of long-lasting CNS plasticity

S-Duality at the Black Hole Threshold in Gravitational Collapse

We study gravitational collapse of the axion/dilaton field in classical low energy string theory, at the threshold for black hole formation. A new critical solution is derived that is spherically symmetric and continuously self-similar. The universal scaling and echoing behavior discovered by Choptuik in gravitational collapse appear in a somewhat different form. In particular, echoing takes the form of SL(2,R) rotations (cf. S-duality). The collapse leaves behind an outgoing pulse of axion/dilaton radiation, with nearly but not exactly flat spacetime within it.Comment: 8 pages of LaTeX, uses style "revtex"; 1 figure, available in archive, or at ftp://ftp.itp.ucsb.edu/figures/nsf-itp-95-15.ep

Efficient and tunable white‐light emission using a dispersible porous polymer

A dispersible porous polymer (PEG113‐b ‐DVB800‐co ‐AA200) based on the controlled radical polymerization of divinylbenzene and acrylic acid with a poly(ethylene glycol) (PEG) macrochain transfer agent (macro‐CTA) is synthesized and postsynthetically modified with anthracene. This blue‐emitting porous polymer is used to encapsulate the yellow‐emitting fluorophore rhodamine B into its core, resulting in a white‐light emitting dispersion with a quantum yield of 38% and commission internationale de l’éclairage coordinates of (X = 0.33, Y = 0.32)

Probing prospective secondary mathematics teachers’ understanding of visual representations of function transformations: a multiple scripting task approach

In this paper, we use multiple scripting tasks as a research tool to investigate prospective secondary mathematics teachers’ (PSMTs’) mathematical knowledge of function transformations and their inclination to connect multiple representations of functions. Mathematically similar scripting tasks focused on visual representations of function transformations were given at three intervals during a 15-week semester in an undergraduate mathematics course on functions for PSMTs in the United States. Participant responses to these scripting tasks were analysed, and four prevalent themes were identified that reveal initial tendencies to disregard visual observations posed by students in the scripting tasks and limited use of their mathematical knowledge to connect multiple representations of functions.This research is based upon work partially supported by the National Science Foundation (NSF) under grant number DUE-1612380

Social environment shapes the speed of cooperation

Are cooperative decisions typically made more quickly or slowly than non-cooperative decisions? While this question has attracted considerable attention in recent years, most research has focused on one-shot interactions. Yet it is repeated interactions that characterize most important real-world social interactions. In repeated interactions, the cooperativeness of one’s interaction partners (the “social environment”) should affect the speed of cooperation. Specifically, we propose that reciprocal decisions (choices that mirror behavior observed in the social environment), rather than cooperative decisions per se, occur more quickly. We test this hypothesis by examining four independent decision time datasets with a total of 2,088 subjects making 55,968 decisions. We show that reciprocal decisions are consistently faster than non-reciprocal decisions: cooperation is faster than defection in cooperative environments, while defection is faster than cooperation in non-cooperative environments. These differences are further enhanced by subjects’ previous behavior – reciprocal decisions are faster when they are consistent with the subject’s previous choices. Finally, mediation analyses of a fifth dataset suggest that the speed of reciprocal decisions is explained, in part, by feelings of conflict – reciprocal decisions are less conflicted than non-reciprocal decisions, and less decision conflict appears to lead to shorter decision times

The Constitutions of the Free-Masons (1734). An Online Electronic Edition.

This is an online electronic edition of the the first Masonic book printed in America, which was produced in Philadelphia by Benjamin Franklin in 1734, and was a reprint of a work by James Anderson (who is identified as the author in an appendix) printed in London in 1723. This is the seminal work of American Masonry, edited and published by one of the founding fathers, and of great importance to the development of colonial society and the formation of the Republic. The work contains a 40-page history of Masonry: from Adam to the reign of King George I, including, among others, Noah, Abraham, Moses, Solomon, Hiram Abif, Nebuchadnezzar, Augustus Caesar, Vitruvius, King Athelstan the Saxon, Inigo Jones, and James I of England. There are extended descriptions of the Seven Wonders of the World, viz. 1) the Great Pyramid, 2) Solomon’s Temple, 3) the City and Hanging-Gardens of Babylon, 4) the Mausoleum or Tomb of Mausolus, King of Caria, 5) the Lighthouse of Pharos at Alexandria, 6) Phidias’s statue of Jupiter Olympius in Achaia, and 7) the Colossus at Rhodes (although some maintain the 5th is the Obelisk of Semiramis). It is a celebration of the science of Geometry and the Royal Art of Architecture, as practiced from ancient times until the then-current revival of the Roman or Augustan Style. “The Charges of a Free- Mason” and the “General Regulations” concern rules of conduct for individuals and of governance for Lodges and their officers. The work also includes five songs to be sung at meetings, one of which—“A New Song”—appears in print for the first time and may have been composed by Franklin. The document suggests that Masonry, in its modern Anglo-American form, was rooted in Old Testament exegesis (“So that the Israelites, at their leaving Egypt, were a whole Kingdom of Masons, … under the Conduct of their GRAND MASTER MOSES”) and in contemporary Protestant ideals of morality, merit, and political equality