Individualization and Equality:Women’s careers and organizational form

Some feminist writings have claimed that ‘bureaucracy’ is inherently ‘patriarchal’. This paper challenges this argument by comparing the experience of women in Ireland in a state sector organization and in a cluster of software firms. While the bureaucratic state company has been reformed to incorporate equal opportunities, in the individualised or ‘marketized’ software companies women’s progress is at the whim of individual managers and motherhood and a career are largely incompatible. If bureaucratic organizations can be reformed in this way, it cannot be claimed that there is any inherent link between bureaucracy and patriarchy. Instead organizations can be either bureaucratic or marketized, and either patriarchal or woman-friendly. These are two separate dimensions which change independently of each other. On this basis the paper suggests that the contemporary ‘remasculinization’ of management occurs because earlier reforms in bureaucratic organizations are now being eroded.

Brain organization and retinal pathways in the sleepy lizard, Tiliqua rugosa

Brain structure and retinal pathways to the brain of the sleepy lizard Tiliqua rugosa were described, with this species identifiable as a type II lizard according to brain organisation. The retinal pathway appeared entirely crossed to the opposite side of the brain with termination of retinal fibres observed in the optic thalamus, pretectum, tectum and brainstem tegmentum

A Multi-Faceted Study of Nematic Order Reconstruction in Microfluidic Channels

We study order reconstruction (OR) solutions in the Beris-Edwards framework for nematodynamics, for both passive and active nematic flows in a microfluidic channel. OR solutions exhibit polydomains and domain walls, and as such, are of physical interest. We show that OR solutions exist for passive flows with constant velocity and pressure, but only for specific boundary conditions. We prove the existence of unique, symmetric and non-singular nematic profiles, for boundary conditions that do not allow for OR solutions. We compute asymptotic expansions for OR-type solutions for passive flows with non-constant velocity and pressure, and active flows, which shed light into the internal structure of domain walls. The asymptotics are complemented by extensive numerical studies that demonstrate the universality of OR-type structures in static and dynamic scenarios

Obesity surgery and cancer. What are the unanswered questions?

Obesity has become a global epidemic with a soaring economic encumbrance due to its related morbidity and mortality. Amongst obesity-related conditions, cancer is indeed the most redoubtable. Bariatric surgery has been proven to be the most effective treatment for obesity and its associatedmetabolic and cardiovascular disorders. However, the understanding of whether and how bariatric surgery determines a reduction in cancer risk is limited. Obesity-related malignancies primarily include colorectal and hormone-sensitive (endometrium, breast, prostate) cancers. Additionally, esophago-gastric tumors are growing to be recognized as a new category mainly associated with post-bariatric surgery outcomes. In fact, certain types of surgical procedures have been described to induce the development and subsequent progression of pre-cancerous esophageal and gastric lesions. This emerging category is of great concern and further research is required to possibly prevent such risks. Published data has generated conflicting results. In fact, while overall cancer risk reduction was reported particularly in women, some authors showed no improvement or even increased cancer incidence. Although various studies have reported beneficial effects of surgery on risk of specific cancer development, fundamental insights into the pathogenesis of obesity-related cancer are indispensable to fully elucidate its mechanisms

Socioemotional wellbeing of mixed race/ethnic children in the UK and US: patterns and mechanisms

Existing literature suggests that mixed race/ethnicity children are more likely to experience poor socioemotional wellbeing in both the US and the UK, although the evidence is stronger in the US. It is suggested that this inequality may be a consequence of struggles with identity formation, more limited connections with racial/ethnic/cultural heritage, and increased risk of exposure to racism. Using data from the UK Millennium Cohort Study (n = 13,734) and the US Early Childhood Longitudinal Study-Birth Cohort (n ~ 6250), we examine differences in the socioemotional wellbeing of mixed and non-mixed 5/6 year old children in the UK and US and explore heterogeneity in outcomes across different mixed groups in both locations. We estimate a series of linear regressions to examine the contribution of factors that may explain any observed differences, including socio-economic and cultural factors, and examine the extent to which these processes vary across the two nations. We find no evidence of greater risk for poor socioemotional wellbeing for mixed race/ethnicity children in both national contexts. We find that mixed race/ethnicity children experience socio-economic advantage compared to their non-mixed minority counterparts and that socio-economic advantage is protective for socioemotional wellbeing. Cultural factors do not contribute to differences in socioemotional wellbeing across mixed and non-mixed groups. Our evidence suggests then that at age 5/6 there is no evidence of poorer socioemotional wellbeing for mixed race/ethnicity children in either the UK or the US. The contrast between our findings and some previous literature, which reports that mixed race/ethnicity children have poorer socioemotional wellbeing, may reflect changes in the meaning of mixed identities across periods and/or the developmental stage of the children we studied

Dissection of a functional interaction between the DNA translocase, FtsK, and the XerD recombinase

Successful bacterial circular chromosome segregation requires that any dimeric chromosomes, which arise by crossing over during homologous recombination, are converted to monomers. Resolution of dimers to monomers requires the action of the XerCD site-specific recombinase at dif in the chromosome replication terminus region. This reaction requires the DNA translocase, FtsK(C), which activates dimer resolution by catalysing an ATP hydrolysis-dependent switch in the catalytic state of the nucleoprotein recombination complex. We show that a 62-amino-acid fragment of FtsK(C) interacts directly with the XerD C-terminus in order to stimulate the cleavage by XerD of BSN, a dif-DNA suicide substrate containing a nick in the ‘bottom’ strand. The resulting recombinase–DNA covalent complex can undergo strand exchange with intact duplex dif in the absence of ATP. FtsK(C)-mediated stimulation of BSN cleavage by XerD requires synaptic complex formation. Mutational impairment of the XerD–FtsK(C) interaction leads to reduction in the in vitro stimulation of BSN cleavage by XerD and a concomitant deficiency in the resolution of chromosomal dimers at dif in vivo, although other XerD functions are not affected

Potential remediation of 137Cs and 90Sr contaminated soil by accumulation in Alamo switchgrass

Cesium-137 ( 137Cs) and Strontium-90 ( 90Sr) are radionuclides characteristic of nuclear fallout from nuclear weapons testing and nuclear reactor accidents. Alamo switchgrass (Panicum virginatum L.) is a perennial C4 species native to central North America that produces exceptionally high biomass yields in short periods of time. In three separate experiments, Alamo switchgrass plants were tested for their ability to accumulate 137 Cs and 90 Sr from a contaminated growth medium. Plants in experiment I were grown in 33 x 20 x 7 cm plastic pans containing 2.5 kg sand. Plants in experiments 2 and 3 were grown in 30 x 3 cm diameter test tubes containing 0.3 kg growth medium. After 3 months of plant growth, either 102 Bq 137 Cs or 73 Bq 90Sr g-1 soil were added to the growth medium. Plants in all three experiments were grown within a greenhouse that was maintained at 22 ± 2 °C with a photosynthetic active radiation of 400-700 umol m-2 s-1 and a 14-16 h photoperiod. Above-ground plant biomass did not differ between plants that were not exposed to these radionuclides (controls) and those that were exposed to growth medium containing 137Cs or 90Sr over the course of the experiment. Plants accumulated 44 and 36% of the total amount of 90Sr and 137CS added to growth medium after the first 5 harvests. After the first two harvests, the concentration of 137CS and 90Sr in plant tissue and the amount of 137Cs or 90Sr removed from growth medium declined with each successive harvest. Duration of exposure correlated curvilinearly with accumulation of both 90Sr and 137CS by plants (r2 = 0.95 and 0.78, respectively). As concentration of both 137Cs and 90Sr in growth medium increased, plant accumulation of both radionuclides increased and correlated curvilinearly in seedlings (r2 = 0.83 and 0.89 respectively)

pH dependence of cyanide and imidazole binding to the heme domains of \u3cem\u3eSinorhizobium meliloti\u3c/em\u3e and \u3cem\u3eBradyrhizobium japonicum\u3c/em\u3e FixL

Equilibrium and kinetic properties of cyanide and imidazole binding to the heme domains of Sinorhizobium meliloti and Bradyrhizobium japonicum FixL (SmFixLH and BjFixLH) have been investigated between pH 5 and 11. KD determinations were made at integral pH values, with the strongest binding at pH 9 for both ligands. KD for the cyanide complexes of BjFixLH and SmFixLH is 0.15 ± 0.09 and 0.50 ± 0.20 μM, respectively, and 0.70 ± 0.01 mM for imido-BjFixLH. The association rate constants are pH dependent with maximum values of 443 ± 8 and 252 ± 61 M−1 s−1 for cyano complexes of BjFixLH and SmFixLH and (5.0 ± 0.3) × 104 and (7.0±1.4) × 104M−1 s−1 for the imidazole complexes. The dissociation rate constants are essentially independent of pH above pH 5; (1.2 ± 0.3) × 10−4 and (1.7 ± 0.3) × 10−4 s−1 for the cyano complexes of BjFixLH and SmFixLH, and (73±19) and (77±14) s−1 for the imidazole complexes. Two ionizable groups in FixLH affect the rate of ligand binding. The more acidic group, identified as the heme 6 propionic acid, has a pKa of 7.6 ± 0.2 in BjFixLH and 6.8 ± 0.2 in SmFixLH. The second ionization is due to formation of hydroxy-FixLH with pKa values of 9.64± 0.05 for BjFixLH and 9.61 ± 0.05 for SmFixLH. Imidazole binding is limited by the rate of heme pocket opening with maximum observed values of 680 and 1270 s−1 for BjFixLH and SmFixLH, respectively

A multi-faceted study of nematic order reconstruction in microfluidic channels

We study order reconstruction (OR) solutions in the Beris-Edwards framework for nematodynamics, for both passive and active nematic flows in a microfluidic channel. OR solutions exhibit polydomains and domain walls, and as such, are of physical interest. We show that OR solutions exist for passive flows with constant velocity and pressure, but only for specific boundary conditions. We prove the existence of unique, symmetric and non-singular nematic profiles, for boundary conditions that do not allow for OR solutions. We compute asymptotic expansions for OR-type solutions for passive flows with non-constant velocity and pressure, and active flows, which shed light into the internal structure of domain walls. The asymptotics are complemented by extensive numerical studies that demonstrate the universality of OR-type structures in static and dynamic scenarios

Bull Riding Injuries In Central Queensland

Background Bull riding is an increasingly popular and growing professional sport in Australia. This is the first national study that investigates bull riding-related injuries. Method A six-year retrospective study of patients admitted to Rockhampton Base Hospital with acute injuries sustained whilst bull riding. Patients were identified from the Rockhampton Hospital international coding system and surgical audit excel databases. Supporting information was found from patient chart review. Results Thirty-eight patients were admitted during the study. Injuries increased from 2008. The most common injuries were to limbs (52%), chest (15%) and brain (10%). Life-threatening injuries were all caused by a direct kick or trampling by the bull; 5% of patients needed air transfer to Brisbane, and 10% to Rockhampton for their acute care. The only complication was infection of open wounds. The average hospital stay was 2.2 (range= 1-5, SD= 1.1) days and 64% of patients required operative intervention. Conclusion Patients that had been kicked or trampled should be identified as having potentially life-threatening injuries, and transferred for review at an appropriate facility. Due to the high risk of infection all contaminated wounds should be washed out formally and receive antibiotics. Protective equipment should be encouraged among riders