Energy-Dependent Timing of Thermal Emission in Solar Flares

We report solar flare plasma to be multi-thermal in nature based on the theoretical model and study of the energy-dependent timing of thermal emission in ten M-class flares. We employ high-resolution X-ray spectra observed by the Si detector of the "Solar X-ray Spectrometer" (SOXS). The SOXS onboard the Indian GSAT-2 spacecraft was launched by the GSLV-D2 rocket on 8 May 2003. Firstly we model the spectral evolution of the X-ray line and continuum emission flux F(\epsilon) from the flare by integrating a series of isothermal plasma flux. We find that multi-temperature integrated flux F(\epsilon) is a power-law function of \epsilon with a spectral index (\gamma) \approx -4.65. Next, based on spectral-temporal evolution of the flares we find that the emission in the energy range E= 4 - 15 keV is dominated by temperatures of T= 12 - 50 MK, while the multi-thermal power-law DEM index (\gamma) varies in the range of -4.4 and -5.7. The temporal evolution of the X-ray flux F(\epsilon,t) assuming a multi-temperature plasma governed by thermal conduction cooling reveals that the temperature-dependent cooling time varies between 296 and 4640 s and the electron density (n_e) varies in the range of n_e= (1.77-29.3)*10^10 cm-3. Employing temporal evolution technique in the current study as an alternative method for separating thermal from non-thermal components in the energy spectra, we measure the break-energy point ranging between 14 and 21\pm1.0 keV.Comment: Solar Physics, in pres

Colorectal Foreign Body: A Case Report

Background:Emergency surgeons seldom encounter cases of foreign body ingestion/insertion. Both children and adults may present with ingestion or insertion of foreign body inside body cavitiesCase presentation: Two foreign nationals were brought by customs officer to emergency department with alleged history of insertion of cocaine packets through anus.Any subjects that caused omission from patients were admitted and rectal examinations were carried out. Rectum was filled with cocaine capsules which were retrieved manually as far as we could reach.Conclusion: It is likely that the use of various objects for anal eroticism is increasing, resulting in an increased incidence of retained rectal foreign bodies.Copyright©2012 Department of Forensic Medicine and Toxicology. Allrights reserved.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage; Plasmodium falciparum; and; Cryptosporidium parvum; in cell-culture studies. Target deconvolution in; P. falciparum; has shown that cladosporin inhibits lysyl-tRNA synthetase (; Pf; KRS1). Here, we report the identification of a series of selective inhibitors of apicomplexan KRSs. Following a biochemical screen, a small-molecule hit was identified and then optimized by using a structure-based approach, supported by structures of both; Pf; KRS1 and; C. parvum; KRS (; Cp; KRS). In vivo proof of concept was established in an SCID mouse model of malaria, after oral administration (ED; 90; = 1.5 mg/kg, once a day for 4 d). Furthermore, we successfully identified an opportunity for pathogen hopping based on the structural homology between; Pf; KRS1 and; Cp; KRS. This series of compounds inhibit; Cp; KRS and; C. parvum; and; Cryptosporidium hominis; in culture, and our lead compound shows oral efficacy in two cryptosporidiosis mouse models. X-ray crystallography and molecular dynamics simulations have provided a model to rationalize the selectivity of our compounds for; Pf; KRS1 and; Cp; KRS vs. (human); Hs; KRS. Our work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis

Fractures of metacarpal bone: evaluation of functional outcome of open reduction and internal fixation with mini locking plate: a hospital based study

Background: Metacarpal bones fracture is very common. Management of metacarpal fractures varies from conservative to percutaneous pinning to various surgical methods. We endeavour to evaluate the functional outcome of metacarpal fractures in patients managed with open reduction and internal fixation with mini locking plate.Methods: A total of 32 patients with extra-articular metacarpal bones fracture were recruited for the study. After open reduction the fractures were fixed with the mini locking plate, postoperative day 3, plaster removed and active and passive exercises started. The Michigan hand score was used for functional evaluation, grip strength, visual analogue scale score, range of motion evaluated at follow up till six months.Results: All the 32 patients achieved union, 31 had full union at 6 weeks whereas 1 patient has delayed union. The Michigan hand outcome questionnaire score of 97.5 % at 6 months in all 32 patients. A total of 5 out of 32 patients had complications, the most common being finger stiffness followed by superficial infection and delayed union.Conclusions: We concluded that metacarpal plating with mini locking plate is a good option to achieve and maintain a rigid fixation and this method produces a better outcome in unstable fractures of metacarpal bones

Emergency Department Chief Complaint and Diagnosis Data to Detect Influenza-Like Illness with an Electronic Medical Record

Background: The purpose of syndromic surveillance is early detection of a disease outbreak. Such systems rely on the earliest data, usually chief complaint. The growing use of electronic medical records (EMR) raises the possibility that other data, such as emergency department (ED) diagnosis, may provide more specific information without significant delay, and might be more effective in detecting outbreaks if mechanisms are in place to monitor and report these data.Objective: The purpose of this study is to characterize the added value of the primary ICD-9 diagnosis assigned at the time of ED disposition compared to the chief complaint for patients with influenza-like illness (ILI).Methods: The study was a retrospective analysis of the EMR of a single urban, academic ED with an annual census of over 60, 000 patients per year from June 2005 through May 2006. We evaluate the objective in two ways. First, we characterize the proportion of patients whose ED diagnosis is inconsistent with their chief complaint and the variation by complaint. Second, by comparing time series and applying syndromic detection algorithms, we determine which complaints and diagnoses are the best indicators for the start of the influenza season when compared to the Centers for Disease Control regional data for Influenza-Like Illness for the 2005 to 2006 influenza season using three syndromic surveillance algorithms: univariate cumulative sum (CUSUM), exponentially weighted CUSUM, and multivariate CUSUM.Results: In the first analysis, 29% of patients had a different diagnosis at the time of disposition than suggested by their chief complaint. In the second analysis, complaints and diagnoses consistent with pneumonia, viral illness and upper respiratory infection were together found to be good indicators of the start of the influenza season based on temporal comparison with regional data. In all examples, the diagnosis data outperformed the chief-complaint data.Conclusion: Both analyses suggest the ED diagnosis contains useful information for detection of ILI. Where an EMR is available, the short time lag between complaint and diagnosis may be a price worth paying for additional information despite the brief potential delay in detection, especially considering that detection usually occurs over days rather than hours. [West J Emerg Med. 2010; 11(1):1-9]

Confirming the Warm and Dense Sub-Saturn TIC 139270665 b with the Automated Planet Finder and Unistellar Citizen Science Network

We report the discovery and confirmation of the Transiting Exoplanet Survey Satellite (TESS) single-transit, warm and dense sub-Saturn, TIC 139270665 b. This planet is unusually dense for its size: with a bulk density of 2.13 g cm−3 (0.645RJ, 0.463MJ), it is the densest warm sub-Saturn of the TESS family. It orbits a metal-rich G2 star. We also found evidence of a second planet, TIC 139270665 c, with a longer period of 1010 220 780 - + days and minimum mass M i P sin of 4.89 0.37 0.66 - + MJ. First clues of TIC 139270665 b’s existence were found by citizen scientists inspecting TESS photometric data from sector 47 in 2022 January. Radial velocity measurements from the Automated Planet Finder combined with TESS photometry and spectral energy distributions via EXOFASTv2 system modeling suggested a 23.624 0.031 0.030 - + day orbital period for TIC 139270665 b and also showed evidence for the second planet. Based on this estimated period, we mobilized the Unistellar citizen science network for photometric follow-up, capitalizing on their global distribution to capture a second transit of TIC 139270665 b. This citizen science effort also served as a test bed for an education initiative that integrates young students into modern astrophysics data collection. The Unistellar photometry did not definitively detect a second transit, but did enable us to further constrain the planet’s period. As a transiting, warm, and dense sub-Saturn, TIC 139270665 b represents an interesting laboratory for further study to enhance our models of planetary formation and evolution