185 research outputs found
Esophageal granular cell tumor colliding with intramucosal adenocarcinoma: a case report
We report a case of a granular cell tumor colliding with intramucosal adenocarcinoma of the esophagus. A 58-year-old white was found to have a 5 mm nodule in the distal esophagus detected by upper gastrointestinal endoscopy performed as part of the workup of long standing reflux. Endoscopic biopsies revealed intramucosal adenocarcinoma arising in the setting of Barrett’s esophagus. The adenocarcinoma infiltrated a granular cell tumor also present at the nodular site. Endoscopic mucosal resection using Duette band ligation and hot snare electrocautery was performed. Margins were negative for both tumors, and endoscopic surveillance for recurrence is planned
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Observations of Reactive Gaseous Mercury in the Free Troposphere at the Mount Bachelor Observatory
We measured gaseous elemental mercury (GEM), particulate mercury (PHg), and reactive gaseous mercury (RGM), along with CO, ozone, and aerosol scatter at the Mount Bachelor Observatory (2.7 km above sea level), Oregon, from May to August 2005. The mean mercury concentrations (at standard conditions) were 1.54 ng/m3 (GEM), 5.2 pg/m3 (PHg), and 43 pg/m3 (RGM). RGM enhancements, up to 600 pg/m3, occurred at night and were linked to a diurnal pattern of upslope and downslope flows that mixed in boundary layer air during the day and free tropospheric air at night. During the night, RGM was inversely correlated (P < 0.0001) with CO (r = −0.36), GEM (r = −0.73), and H2O (r = −0.44), was positively correlated with ozone (r = 0.38), and could not be linked to recent anthropogenic emissions from local sources or long-range transport. Principal component analysis and a composite of change in RGM versus change in GEM during RGM enhancements indicate that a nearly quantitative shift in speciation is associated with increases in ozone and decreases in water vapor and CO. This argues that high concentrations of RGM are present in the free troposphere because of in situ oxidation of GEM to RGM. A global chemical transport model reproduces the RGM mean and diurnal pattern but underestimates the magnitude of the largest observed enhancements. Since the only modeled, in situ RGM production mechanisms are oxidation of GEM by ozone and OH, this implies that there are faster reaction rates or additional RGM production mechanisms in the free troposphere.Earth and Planetary SciencesEngineering and Applied Science
The initial mass function of early-type galaxies
We determine an absolute calibration of the initial mass function (IMF) of
early-type galaxies, by studying a sample of 56 gravitational lenses identified
by the SLACS Survey. Under the assumption of standard Navarro, Frenk & White
dark matter halos, a combination of lensing, dynamical, and stellar population
synthesis models is used to disentangle the stellar and dark matter
contribution for each lens. We define an "IMF mismatch" parameter
\alpha=M*(L+D)/M*(SPS) as the ratio of stellar mass inferred by a joint lensing
and dynamical models (M*(L+D)) to the current stellar mass inferred from
stellar populations synthesis models (M*(SPS)). We find that a Salpeter IMF
provides stellar masses in agreement with those inferred by lensing and
dynamical models (=0.00+-0.03+-0.02), while a Chabrier IMF
underestimates them (=0.25+-0.03+-0.02). A tentative trend is
found, in the sense that \alpha appears to increase with galaxy velocity
dispersion. Taken at face value, this result would imply a non universal IMF,
perhaps dependent on metallicity, age, or abundance ratios of the stellar
populations. Alternatively, the observed trend may imply non-universal dark
matter halos with inner density slope increasing with velocity dispersion.
While the degeneracy between the two interpretations cannot be broken without
additional information, the data imply that massive early-type galaxies cannot
have both a universal IMF and universal dark matter halos.Comment: 10 pages 4 figures. Resubmitted to ApJ taking into account referee's
comment
Noise Properties of the BOOMERANG Instrument
In this paper we report a short description of the BOOMERANG experiment explaining his scientific goal and the technologies implied. We concentrate then on the analysis of the noise properties discussing in particular the scan synchronous noise. Finally we present the calibration technique and the sensitivity of all the channels
Summary: Combating Climate Change with Section 115 of the Clean Air Act
The scale and scope of the climate crisis calls for comprehensive nationwide efforts to reduce greenhouse gas emissions. New legislation, passed by Congress and signed by the President, is the first and best option for climate action at the federal level. This could be a version of the Green New Deal, a carbon tax, sectoral limits, an emissions cap with compliance trading, or another approach. What matters most is that the legislation effectively cut the greenhouse gas emissions driving the world’s temperatures ever higher. Unfortunately, the prospect for federal legislation is uncertain, while strong and decisive action is needed now. A president committed to tackling climate change will need a backup plan in case Congress remains gridlocked, one that relies on existing statutes to achieve the deep emission reductions the science says we need
Safety and Short-Term Toxicity of a Novel Cationic Lipid Formulation for Human Gene Therapy
Overview summary Although several viral vectors have been widely applied to the treatment of human disease, the development of nonviral vectors is still in their infancy. In this report, a novel cationic lipid, DMRIE/DOPE, has been incorporated into the DNA–liposome formulation that improves transfection efficiencies and allows up to 1,000-fold higher concentrations of DNA to be administered in vivo. In this paper, the safety and toxicity of this formulation is described in two species, mice and pigs, suggesting that it may prove useful for human gene therapy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63224/1/hum.1993.4.6-781.pd
The Cosmology of Composite Inelastic Dark Matter
Composite dark matter is a natural setting for implementing inelastic dark
matter - the O(100 keV) mass splitting arises from spin-spin interactions of
constituent fermions. In models where the constituents are charged under an
axial U(1) gauge symmetry that also couples to the Standard Model quarks, dark
matter scatters inelastically off Standard Model nuclei and can explain the
DAMA/LIBRA annual modulation signal. This article describes the early Universe
cosmology of a minimal implementation of a composite inelastic dark matter
model where the dark matter is a meson composed of a light and a heavy quark.
The synthesis of the constituent quarks into dark mesons and baryons results in
several qualitatively different configurations of the resulting dark matter
hadrons depending on the relative mass scales in the system.Comment: 31 pages, 4 figures; references added, typos correcte
The Australia Telescope 20 GHz (AT20G) Survey: The Bright Source Sample
The Australia Telescope 20 GHz (AT20G) Survey is a blind survey of the whole
Southern sky at 20 GHz (with follow-up observations at 4.8 and 8.6 GHz) carried
out with the Australia Telescope Compact Array (ATCA) from 2004 to 2007. The
Bright Source Sample (BSS) is a complete flux-limited subsample of the AT20G
Survey catalogue comprising 320 extragalactic (|b|>1.5 deg) radio sources south
of dec = -15 deg with S(20 GHz) > 0.50 Jy. Of these, 218 have near simultaneous
observations at 8 and 5 GHz. In this paper we present an analysis of radio
spectral properties in total intensity and polarisation, size, optical
identifications and redshift distribution of the BSS sources. The analysis of
the spectral behaviour shows spectral curvature in most sources with spectral
steepening that increases at higher frequencies (the median spectral index
\alpha, assuming S\propto \nu^\alpha, decreases from \alpha_{4.8}^{8.6}=0.11
between 4.8 and 8.6 GHz to \alpha_{8.6}^{20}=-0.16 between 8.6 and 20 GHz),
even if the sample is dominated by flat spectra sources (85 per cent of the
sample has \alpha_{8.6}^{20}>-0.5). The almost simultaneous spectra in total
intensity and polarisation allowed us a comparison of the polarised and total
intensity spectra: polarised fraction slightly increases with frequency, but
the shapes of the spectra have little correlation. Optical identifications
provided an estimation of redshift for 186 sources with a median value of 1.20
and 0.13 respectively for QSO and galaxies.Comment: 34 pages, 19 figures, tables of data included, replaced with version
published in MNRA
An Acidic Motif Retains Vesicular Monoamine Transporter 2 on Large Dense Core Vesicles
The release of biogenic amines from large dense core vesicles (LDCVs) depends on localization of the vesicular monoamine transporter VMAT2 to LDCVs. We now find that a cluster of acidic residues including two serines phosphorylated by casein kinase 2 is required for the localization of VMAT2 to LDCVs. Deletion of the acidic cluster promotes the removal of VMAT2 from LDCVs during their maturation. The motif thus acts as a signal for retention on LDCVs. In addition, replacement of the serines by glutamate to mimic phosphorylation promotes the removal of VMAT2 from LDCVs, whereas replacement by alanine to prevent phosphorylation decreases removal. Phosphorylation of the acidic cluster thus appears to reduce the localization of VMAT2 to LDCVs by inactivating a retention mechanism
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Subsurface Biogeochemical Heterogeneity (Field-scale removal of U(VI) from groundwater in an alluvial aquifer by electron donor amendment)
Determine if biostimulation of alluvial aquifers by electron donor amendment can effectively remove U(VI) from groundwater at the field scale. Uranium contamination in groundwater is a significant problem at several DOE sites. In this project, the possibility of accelerating bioreduction of U(VI) to U(IV) as a means of decreasing U(VI) concentrations in groundwater is directly addressed by conducting a series of field-scale experiments. Scientific goals include demonstrating the quantitative linkage between microbial activity and U loss from groundwater and relating the dominant terminal electron accepting processes to the rate of U loss. The project is currently focused on understanding the mechanisms for unexpected long-term ({approx}2 years) removal of U after stopping electron donor amendment. Results obtained in the project successfully position DOE and others to apply biostimulation broadly to U contamination in alluvial aquifers
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