Dust-Bounded ULIRGs? Model Predictions for Infrared Spectroscopic Surveys

The observed faintness of infrared fine-structure line emission along with the warm far-infrared (FIR) colors of ultraluminous infrared galaxies (ULIRGs) is a long-standing problem. In this work, we calculate the line and continuum properties of a cloud exposed to an Active Galactic Nucleus (AGN) and starburst spectral energy distribution (SED). We use an integrated modeling approach, predicting the spectrum of ionized, atomic, and molecular environments in pressure equilibrium. We find that the effects of high ratios of impinging ionizing radiation density to particle density (i.e. high ionization parameters, or U) can reproduce many ULIRG observational characteristics. Physically, as U increases, the fraction of UV photons absorbed by dust increases, corresponding to fewer photons available to photoionize and heat the gas, producing what is known as a "dust-bounded" nebula. We show that high U effects can explain the "[C II] deficit", the ~1 dex drop in the [C II] 158 micron /FIR ratio seen in ULIRGs when compared to starburst or normal galaxies. Additionally, by increasing U through increasing the ionizing photon flux, warmer dust and thus higher IRAS F(60)/F(100) ratios result. High U effects also predict an increase in [O I]63 micron /[C II] 158 micron and a gradual decline in [O III] 88 micron /FIR, similar to the magnitude of the trends observed, and yield a reasonable fit to [Ne V]14 micron /FIR ratio AGN observations.Comment: 34 pages, 13 figures, accepted for publication in the Astrophysical Journa

Multi-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis

The combined application of next-generation sequencing platforms has provided an economical approach to unlocking the potential of the turkey genome

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Erratum: Corrigendum: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

International Chicken Genome Sequencing Consortium. The Original Article was published on 09 December 2004. Nature432, 695–716 (2004). In Table 5 of this Article, the last four values listed in the ‘Copy number’ column were incorrect. These should be: LTR elements, 30,000; DNA transposons, 20,000; simple repeats, 140,000; and satellites, 4,000. These errors do not affect any of the conclusions in our paper. Additional information. The online version of the original article can be found at 10.1038/nature0315

Acute effects of cocaine on the neurobiology of cognitive control

Compromised ability to exert control over drug urges and drug-seeking behaviour is a characteristic of addiction. One specific cognitive control function, impulse control, has been shown to be a risk factor for the development of substance problems and has been linked in animal models to increased drug administration and relapse. We present evidence of a direct effect of cocaine on the neurobiology underlying impulse control. In a laboratory test of motor response inhibition, an intravenous cocaine administration improved task performance in 13 cocaine users. This improvement was accompanied by increased activation in right dorsolateral and inferior frontal cortex, regions considered critical for this cognitive function. Similarly, for both inhibitory control and action monitoring processes, cocaine normalized activation levels in lateral and medial prefrontal regions previously reported to be hypoactive in users relative to drug-naive controls. The acute amelioration of neurocognitive dysfunction may reflect a chronic dysregulation of those brain regions and the cognitive processes they subserve. Furthermore, the effects of cocaine on midline function suggest a dopaminergically mediated intersection between cocaine's acute reinforcing effects and its effects on cognitive control

Interrupting the “stream of consciousness”: an fMRI investigation. [Research Support,

In functional neuroimaging, a local decrease in blood flow during an active task, relative to a ''resting'' baseline, is referred to as taskinduced deactivation (TID). TID may occur when resources shift from ongoing, internally generated processing typical of ''resting'' states to processing required by an exogenous task. We previously found specific brain regions in which TID increased as task processing demands increased. When engaged in an exogenous cognitive task, reallocation of resources from areas involved in internal processing should result in suspension of that processing. Self-reported thought content has been used as an indicator of the extent of internal processing activity. We investigated the relationship between TID and task-unrelated thought (TUT) frequency using an auditory target detection task with seven levels of task difficulty. At varied intervals during task performance, subjects indicated whether they were experiencing a TUT. We expected TUT frequency to decrease as task demands increased and for this pattern to correlate with TID magnitude across conditions. Generally, fewer TUTs were reported during difficult task conditions than during easier conditions. As TID magnitude increased across task conditions, the frequency of TUTs declined (r = 0.90, P = 0.005). Four left hemisphere regions (posterior parieto-occipital cortex, anterior cingulate gyrus, fusiform gyrus, and middle frontal gyrus) showed strong relationships between TUTs and TID (r > 0.79, P < 0.05 corrected). As these regions have been implicated in semantic processing and selfreferential thought, the findings support the suspension of internal cognitive processing as one mechanism for TID.