1,298 research outputs found
Rapid purification of quantum systems by measuring in a feedback-controlled unbiased basis
Rapid-purification by feedback --- specifically, reducing the mean impurity
faster than by measurement alone --- can be achieved by making the eigenbasis
of the density matrix to be unbiased relative to the measurement basis. Here we
further examine the protocol introduced by Combes and Jacobs [Phys.Rev.Lett.
{\bf 96}, 010504 (2006)] involving continuous measurement of the observable
for a -dimensional system. We rigorously re-derive the lower bound
on the achievable speed-up factor, and also an upper bound, namely
, for all feedback protocols that use measurements in unbiased bases.
Finally we extend our results to independent measurements on a register of
qubits, and derive an upper bound on the achievable speed-up factor that
scales linearly with .Comment: v2: published versio
Optimal Weighting of Preclinical Alzheimer’s Cognitive Composite (PACC) Scales to Improve their Performance as Outcome Measures for Alzheimer’s Disease Clinical Trials
Introduction: Cognitive composite scales constructed by combining existing neuropsychometric tests are seeing wide application as endpoints for clinical trials and cohort studies of Alzheimer’s disease (AD) predementia conditions. Preclinical Alzheimer’s Cognitive Composite (PACC) scales are composite scores calculated as the sum of the component test scores weighted by the reciprocal of their standard deviations at the baseline visit. Reciprocal standard deviation is an arbitrary weighting in this context, and may be an inefficient utilization of the data contained in the component measures. Mathematically derived optimal composite weighting is a promising alternative.
Methods: Sample size projections using standard power calculation formulas were used to describe the relative performance of component measures and their composites when used as endpoints for clinical trials. Power calculations were informed by (n=1,333) amnestic mild cognitive impaired participants in the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set.
Results: A composite constructed using PACC reciprocal standard deviation weighting was both less sensitive to change than one of its component measures and less sensitive to change than its optimally weighted counterpart. In standard sample size calculations informed by NACC data, a clinical trial using the PACC weighting would require 38% more subjects than a composite calculated using optimal weighting.
Discussion: These findings illustrate how reciprocal standard deviation weighting can result in inefficient cognitive composites, and underscore the importance of component weights to the performance of composite scales. In the future, optimal weighting parameters informed by accumulating clinical trial data may improve the efficiency of clinical trials in AD
Optimal control of entanglement via quantum feedback
It has recently been shown that finding the optimal measurement on the
environment for stationary Linear Quadratic Gaussian control problems is a
semi-definite program. We apply this technique to the control of the
EPR-correlations between two bosonic modes interacting via a parametric
Hamiltonian at steady state. The optimal measurement turns out to be nonlocal
homodyne measurement -- the outputs of the two modes must be combined before
measurement. We also find the optimal local measurement and control technique.
This gives the same degree of entanglement but a higher degree of purity than
the local technique previously considered [S. Mancini, Phys. Rev. A {\bf 73},
010304(R) (2006)].Comment: 10 pages, 5 figure
EPIC 220204960: A Quadruple Star System Containing Two Strongly Interacting Eclipsing Binaries
We present a strongly interacting quadruple system associated with the K2
target EPIC 220204960. The K2 target itself is a Kp = 12.7 magnitude star at
Teff ~ 6100 K which we designate as "B-N" (blue northerly image). The host of
the quadruple system, however, is a Kp = 17 magnitude star with a composite
M-star spectrum, which we designate as "R-S" (red southerly image). With a 3.2"
separation and similar radial velocities and photometric distances, 'B-N' is
likely physically associated with 'R-S', making this a quintuple system, but
that is incidental to our main claim of a strongly interacting quadruple system
in 'R-S'. The two binaries in 'R-S' have orbital periods of 13.27 d and 14.41
d, respectively, and each has an inclination angle of >89 degrees. From our
analysis of radial velocity measurements, and of the photometric lightcurve, we
conclude that all four stars are very similar with masses close to 0.4 Msun.
Both of the binaries exhibit significant ETVs where those of the primary and
secondary eclipses 'diverge' by 0.05 days over the course of the 80-day
observations. Via a systematic set of numerical simulations of quadruple
systems consisting of two interacting binaries, we conclude that the outer
orbital period is very likely to be between 300 and 500 days. If sufficient
time is devoted to RV studies of this faint target, the outer orbit should be
measurable within a year.Comment: 20 pages, 18 figures, 7 tables; accepted for publication in MNRA
Regulating the automobile
Division of Policy Research and Analysis.
National Science Foundatio
The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant
AbstractIn yeast, three AAA superfamily metalloproteases (Yme1p, Afg3p and Rca1p) are localized to the mitochondrial inner membrane where they perform roles in the assembly and turnover of the respiratory chain complexes. We have investigated the function of the proposed human orthologue of yeast Yme1p, encoded by the YME1L gene on chromosome 10p. Transfection of both HEK-293EBNA and yeast cells with a green fluorescent protein-tagged YME1L cDNA confirmed mitochondrial targeting. When expressed in a yme1 disruptant yeast strain, YME1L restored growth on glycerol at 37°C. We propose that YME1L plays a phylogenetically conserved role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies
Single-dose pharmacokinetics and pharmacodynamics of recombinant human follicle-stimulating hormone (org 32489) in gonadotropin-deficient volunteers
The Perceived Size and Shape of Objects in Peripheral Vision
Little is known about how we perceive the size and shape of objects in far peripheral vision. Observations made during an artistic study of visual space suggest that objects appear smaller and compressed in the periphery compared with central vision. To test this, we conducted three experiments. In Experiment 1, we asked participants to draw how a set of peripheral discs appeared when viewed peripherally without time or eye movement constraints. In Experiment 2, we used the method of constant stimuli to measure when a briefly presented peripheral stimulus appeared bigger or smaller compared with a central fixated one. In Experiment 3, we measured how accurate participants were in discriminating shapes presented briefly in the periphery. In Experiment 1, the peripheral discs were reported as appearing significantly smaller than the central disc, and as having an elliptical or polygonal contour. In Experiment 2, participants judged the size of peripheral discs as being significantly smaller when compared with the central disc across most of the peripheral field, and in Experiment 3, participants were quite accurate in reporting the shape of the peripheral object, except in the far periphery. Our results show that objects in the visual periphery are perceived as diminished in size when presented for long and brief exposures, suggesting diminution is an intrinsic feature of the structure of the visual space. Shape distortions, however, are reported only with longer exposures
4pi Models of CMEs and ICMEs
Coronal mass ejections (CMEs), which dynamically connect the solar surface to
the far reaches of interplanetary space, represent a major anifestation of
solar activity. They are not only of principal interest but also play a pivotal
role in the context of space weather predictions. The steady improvement of
both numerical methods and computational resources during recent years has
allowed for the creation of increasingly realistic models of interplanetary
CMEs (ICMEs), which can now be compared to high-quality observational data from
various space-bound missions. This review discusses existing models of CMEs,
characterizing them by scientific aim and scope, CME initiation method, and
physical effects included, thereby stressing the importance of fully 3-D
('4pi') spatial coverage.Comment: 14 pages plus references. Comments welcome. Accepted for publication
in Solar Physics (SUN-360 topical issue
Analytical and computational study of magnetization switching in kinetic Ising systems with demagnetizing fields
An important aspect of real ferromagnetic particles is the demagnetizing
field resulting from magnetostatic dipole-dipole interaction, which causes
large particles to break up into domains. Sufficiently small particles,
however, remain single-domain in equilibrium. This makes such small particles
of particular interest as materials for high-density magnetic recording media.
In this paper we use analytic arguments and Monte Carlo simulations to study
the effect of the demagnetizing field on the dynamics of magnetization
switching in two-dimensional, single-domain, kinetic Ising systems. For systems
in the ``Stochastic Region,'' where magnetization switching is on average
effected by the nucleation and growth of fewer than two well-defined critical
droplets, the simulation results can be explained by the dynamics of a simple
model in which the free energy is a function only of magnetization. In the
``Multi-Droplet Region,'' a generalization of Avrami's Law involving a
magnetization-dependent effective magnetic field gives good agreement with our
simulations.Comment: 29 pages, REVTeX 3.0, 10 figures, 2 more figures by request.
Submitted Phys. Rev.
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