Substantial contribution of iodine to Arctic ozone destruction

Unlike bromine, the effect of iodine chemistry on the Arctic surface ozone budget is poorly constrained. We present ship-based measurements of halogen oxides in the high Arctic boundary layer from the sunlit period of March to October 2020 and show that iodine enhances springtime tropospheric ozone depletion. We find that chemical reactions between iodine and ozone are the second highest contributor to ozone loss over the study period, after ozone photolysis-initiated loss and ahead of bromine.Iodine chemistry plays a more important role than bromine chemistry in tropospheric ozone losses in the Arctic, according to ship-based observations of halogen oxides from March to October 2020.Peer reviewe

Co-Design Futures for AI and Space: A Workbook Sprint

Artificial Intelligence (AI) is continuously moving into our surroundings. In its various forms, it has the potential to disrupt most aspects of human life. Yet, the discourse around AI has long been by experts and for experts. In this paper, we argue for a participatory approach towards designing human-AI interactions. We outline how we used design methodology to organise an interdisciplinary workshop with a diverse group of students – a workbook sprint with 45 participants from four different programs and 13 countries – to develop speculative design futures in five focus areas. We then provide insights into our findings and share our lessons learned regarding our workshop topic – AI and Space – our process, and our research. We learned that involving non-experts in complex technical discourses – such as AI – through the structural rigour of design methodology is a viable approach. We then conclude by laying out how others might use our findings and initiate their own workbook sprint to explore complex technologies in a human-centred way

Co-Design Futures for AI and Space: A Workbook Sprint

Artificial Intelligence (AI) is continuously moving into our surroundings. In its various forms, it has the potential to disrupt most aspects of human life. Yet, the discourse around AI has long been by experts and for experts. In this paper, we argue for a participatory approach towards designing human-AI interactions. We outline how we used design methodology to organise an interdisciplinary workshop with a diverse group of students – a workbook sprint with 45 participants from four different programs and 13 countries – to develop speculative design futures in five focus areas. We then provide insights into our findings and share our lessons learned regarding our workshop topic – AI and Space – our process, and our research. We learned that involving non-experts in complex technical discourses – such as AI – through the structural rigour of design methodology is a viable approach. We then conclude by laying out how others might use our findings and initiate their own workbook sprint to explore complex technologies in a human-centred way

SFTA3 – a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension

The study aimed to characterize the expression and function of SFTA3 at the ocular surface and in tears. Ocular tissues, conjunctival (HCjE) and human corneal (HCE) epithelial cell lines as well as tearfilm of patients suffering from different forms of dry eye disease (DED) were analyzed by means of RT-PCR, western blot, immunohistochemistry, and ELISA. A possible role of recombinant SFTA3 in corneal wound healing was investigated performing in vitro scratch assays. Tear film regulatory properties were analyzed with the spinning drop method and the regulation of SFTA3 transcripts was studied in HCE and HCjE after incubation with proinflammatory cytokines as well as typical ocular pathogens by real-time RT-PCR and ELISA. The results reveal that human ocular tissue as well as tears of healthy volunteers express SFTA3 whereas tears from patients with DED showed significantly increased SFTA3 levels. In vitro wounding of HCE cell cultures that had been treated with recombinant SFTA3 demonstrated a significantly increased wound closure rate and rSFTA3 reduced the surface tension of tear fluid. The results indicate that SFTA3 at the ocular surface seemed to be involved in wound healing and the reduction of surface tension