10 research outputs found
Kea cooperate better with sharing affiliates
- Author
- A Braun
- AJ King
- AL Vail
- AM Seed
- Amelia Wein
- AP Melis
- AP Melis
- B Chapais
- B Hare
- BF McMahon
- C Boesch
- C Scheid
- CM Drea
- D Werdenich
- E Visalberghi
- ED Jarvis
- Elodie Jocteur
- F Aureli
- F Péron
- FBM Waal De
- G Schino
- GK Gajdon
- I Bailey
- J Altmann
- J Diamond
- J Diamond
- JJM Massen
- JM Engelmann
- JM Plotnik
- Jorg J. M. Massen
- JR Jackson
- JS Gilchrist
- JW Jolles
- K Asakawa-Haas
- K Mendres
- KA Cronin
- KA Cronin
- KA Cronin
- L Huber
- L McNally
- L Ostojić
- M O’Hara
- M Suchak
- MM Symington
- MP Crawford
- N Solomon
- NJ Emery
- O Petit
- OAE Rasa
- R Bshary
- R Bshary
- R Chalmeau
- R Chalmeau
- R Noë
- R Noë
- R Schwing
- Raoul Schwing
- RM Seyfarth
- Ronald Noë
- S Hirata
- S Molesti
- S Molesti
- S Olkowicz
- S Tebbich
- SA Kuczaj II
- SF Brosnan
- TF Wright
- TM Eppley
- WD Koenig
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Controlled studies that focus on intraspecific cooperation tasks have revealed striking similarities, but also differences, in abilities across taxa as diverse as primates, fish, and birds. Such comparisons may provide insight into the specific socio-ecological selection pressures that led to the evolution of cooperation. Unfortunately, however, compared to primates data on birds remain relatively scarce. We tested a New Zealand psittaciform, the kea, in a dyadic cooperation task using the loose-string design. During trials our subjects were in separate compartments, but obtained a common reward that could be divided multiple ways, allowing the examination of reward division effects. Ten individuals were tested twice in 44 combinations of partners. Dyads with a high affiliation score attempted to cooperate more often and were also more often successful in doing so. Furthermore, dyads that shared rewards more equally seemed to be more likely to attempt cooperation in the next trial. Like other bird and some monkey species, but unlike, for example, chimpanzees, kea did not spontaneously show understanding of either the role of the partner or the mechanism behind the cooperation task. This may point to true disparities between species, but may also be due to differences in task design and/or the amount of exposure to similar tasks and individual skills of the subjects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10071-016-1017-y) contains supplementary material, which is available to authorized users
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
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- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
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- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
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- Amundson A
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- Andreo J
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- Andresen D
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- Antonishen D
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- Anuschek V
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- Zhao L
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- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Scripting and consuming black bodies in hip hop music and pimp movies
- Publication venue
- Association for the Study of African American Life and History
- Publication date
- Field of study
Feminist film critics maintain that the dominant look in cinema is, historically, a\ud
gendered gaze. More precisely, this viewpoint argues that the dominant visual and\ud
narrative conventions of filmmaking generally fix "women as image" and "men as\ud
bearer of the image." I would like to suggest that Hollywood cinema also frames\ud
a highly particularized racial gaze-that is, a representational system that positions\ud
Blacks as image and Whites as bearer of the image
The changing discourse of intercultural ethics: a diachronic meta-analysis
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Du Bois and the Sociology of Religion: Rediscovering a Founding Figure*
- Author
- Anderson Elijah
- Bainbridge William Sims
- Berger Peter
- Berger Peter
- Carroll Jackson W.
- Christiano Kevin J.
- Du Bois William Edward Burghardt
- Du Bois William Edward Burghardt
- Du Bois William Edward Burghardt
- Du Bois William Edward Burghardt
- Durkheim Emile.
- Durkheim Emile.
- Ellison Christopher E.
- Finke Roger
- Frazier E. Franklin
- Geertz Clifford
- Greeley Andrew M
- Greeley Andrew M
- Greeley Andrew M
- Greeley Andrew M
- Greeley Andrew M
- Hadaway C. Kirk
- Henslin James M
- Johnstone Ronald L
- Kornblum William
- Lewis David L
- Lincoln C. Eric
- Mayo-Smith Richmond
- Mays Benjamin E.
- Nelsen Hart M.
- Niebuhr H. Richard
- Roberts Keith. A
- Roof Wade C
- Roof Wade C.
- Simmel Georg.
- Stark Rodney
- Stark Rodney
- Washington Booker T.
- Weber Max.
- Weber Max.
- Woolever Cynthia
- Wright II Earl
- Wright II Earl
- Zuckerman Phil
- Zuckerman Phil
- Zuckerman Phil
- Zuckerman Phil
- Zuckerman Phil
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Set Trippin’: An Intersectional Examination of Gang Members
- Author
- Alexander Michelle
- Anderson Elijah
- Archer L.
- Batchelor S.
- Becker Howard
- Bell Derrick
- Bonilla-Silva Eduardo
- Burks Megan
- Camangian Patrick
- Campbell A.
- Charmaz Kathy
- Chesney-Lind Meda
- Collins Patricia Hill
- Crenshaw Kimberle
- Crenshaw Kimberle
- Del Carmen Alejandro
- DuBois W. E. B.
- Durán Robert
- Erlanger Howard
- Esbensen Finn-Aage
- Foucault Michel
- Hagedorn John. M
- hooks bell.
- Jackson II Ronald L.
- Jones Nikki
- Ladson-Billings Gloria
- Leviss Perri
- Massey Douglas S.
- Mehan Hugh
- Miller J.
- Moore Joan
- Moore Joan
- Rios Victor
- Sanders William B.
- Solórzano Daniel
- Towns Armond R.
- U.S. Census Bureau
- Venkatesh Sudhir
- Vigil James Diego
- Vigil James Diego
- Whyte William Foote
- Wing Adrein K.
- Winton Richard
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy.
- Author
- A Gherman
- A Rakkolainen
- AA Kenedy
- Alejandro Estrada-Cuzcano
- Amiya K Ghosh
- B Budny
- C Thauvin-Robinet
- Carlos A Murga-Zamalloa
- Carsten Bergmann
- Chi V Dang
- Corinne Antignac
- Corinne Stoetzel
- Daniela A Brito
- David S Williams
- DF Gudbjartsson
- E Kim
- E Otto
- E Otto
- EA Otto
- EA Otto
- Eamonn R Maher
- Edgar A Otto
- EM Valente
- Eric A Pierce
- F Hildebrandt
- F Hildebrandt
- F Hildebrandt
- Friedhelm Hildebrandt
- G Mollet
- Gokul Ramaswami
- Gudrun Nürnberg
- H Khanna
- H Olbrich
- Hartmut P H Neumann
- Heather M McLaughlin
- Helene Dollfus
- Hemant Khanna
- Irma Lopez
- JA Sayer
- James D Cavalcoli
- James MacDonald
- Jennifer M Kasanuki
- Jeroen van Reeuwijk
- JH Moyer
- Jinghua Hu
- Jinny Conte
- Joseph Washburn
- JS Andersen
- K Baker
- K Strauch
- Karlien L M Coene
- KL Coene
- L Kruglyak
- Lisa M Guay-Woodford
- Liyun Sang
- M Attanasio
- M Delous
- M Delous
- M Matsuda
- MA Schluter
- MI Ferrante
- Moumita Chaki
- Mónica Bettencourt Dias
- Nicholas Katsanis
- Nicholas Obermüller
- Peter K Jackson
- Peter Nürnberg
- PL Beales
- Q Liu
- Qin Liu
- Rachel H Giles
- Rannar Airik
- Richard A Lewis
- RJ Simms
- Rob W J Collin
- Robert H Lyons
- Robert K Koenekoop
- Ronald Roepman
- S Graser
- SB Ng
- Shawn Levy
- Sophie Saunier
- Stef J F Letteboer
- Suresh B Patil
- Susanne Held
- T Watnick
- Toby W Hurd
- V Patel
- Vanda Lopes
- VE Torres
- VH Gattone II
- Weibin Zhou
- XH Zhang
- Xiaoshu Bei
- Xinmin Zhang
- Yukiko Yamashita
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2010
- Field of study
Contains fulltext :
88200.pdf (publisher's version ) (Closed access)Nephronophthisis-related ciliopathies (NPHP-RC) are recessive disorders that feature dysplasia or degeneration occurring preferentially in the kidney, retina and cerebellum. Here we combined homozygosity mapping with candidate gene analysis by performing 'ciliopathy candidate exome capture' followed by massively parallel sequencing. We identified 12 different truncating mutations of SDCCAG8 (serologically defined colon cancer antigen 8, also known as CCCAP) in 10 families affected by NPHP-RC. We show that SDCCAG8 is localized at both centrioles and interacts directly with OFD1 (oral-facial-digital syndrome 1), which is associated with NPHP-RC. Depletion of sdccag8 causes kidney cysts and a body axis defect in zebrafish and induces cell polarity defects in three-dimensional renal cell cultures. This work identifies loss of SDCCAG8 function as a cause of a retinal-renal ciliopathy and validates exome capture analysis for broadly heterogeneous single-gene disorders.1 oktober 201
The Soviet critique of new left legal theory: A descriptive bibliography
- Author
- A. B. Veber
- A. Merrit
- Alan Hunt
- Aleksandr F. Shishkin
- Aleksandr G. Goikhbarg
- Aleksandr G. Goikhbarg
- Aleksei S. Bogomolov
- Anatolii P. Butenko
- Anatolii V. Lunacharskii
- Andrei Y. Vyshinsky
- Andrew Fraser
- Ann F. Ginger
- Ann F. Ginger
- Antonio Gramsci
- Antonio Gramsci
- Antonio Gramsci
- Arnold Petersen
- Arnold Petersen
- Arnold Petersen
- B. R. Lopukhov
- Barry Hindess
- Bernard E. Bykhovskii
- Bernard E. Galitz
- Bernard Edelman
- Blanke
- Boris M. Leibzon
- Cheng P'u
- Christopher J. Arthur
- Colin Sumner
- Corliss Lamont
- Dale Riepe
- David A. Gold
- David Grood De
- David Grood De
- David Laibman
- David Laibman
- David Trierman
- Earl Klee
- Eduard I. Batalov
- Eduard I. Batalov
- Edward D'Angelo
- Edward P. Thompson
- Edward P. Thompson
- Ernest Mandel
- Ernest Mandel
- Ernesto Che Guevara
- Ernesto Che Guevara
- Eugene D. Genovese
- Evgenii A. Korovin
- Fedor V. Konstantinov
- Florynce Kennedy
- G. S. Ostroumov
- Galina L. Belkina
- Gene Ann Condon
- Georg Lukács
- George E. Novack
- George E. Novack
- George E. Novack
- Georgi Dimitrov
- Gilbert Green
- Harold J. Berman
- Harry K. Wells
- Herbert Aptheker
- Herbert Aptheker
- Herbert Marcuse
- Herbert Marcuse
- Hiroshi Oda
- Ho Ming
- Ileana Rodriquez
- Ilia D. Perlov
- Isaac D. Balbus
- Isaac D. Balbus
- Iurii A. Zamoshkin
- Iurii A. Zamoshkin
- Jack Levine
- Jack Woddis
- James E. Jackson
- James Weinstein
- Jerry Tung
- John Hoffman
- John Lewis
- John Lewis
- John Oakley
- John Somerville
- Joseph Reynolds
- Jürgen Habermas
- Kenneth Cloke
- Khachik N. Momjan
- Kim II Sung
- Klaus Mehnert
- Leon Trotsky
- Leonid S. Mamut
- Louis Althusser
- Louis Althusser
- Louis B. Boudin
- M. K. Mamardashvili
- Maiia I. Novinskaia
- Mao Tse-Tung
- Mark Tushnut
- Mark Tushnut
- Mary Alice Waters
- Maureen E. Cain
- Maureen E. Cain
- Maurice Cornforth
- Max Azicri
- Max Horkheimer
- Michael Jaworskyj
- Michael Tigar
- Mikhail L. Altaiskii
- Mitchell Franklin
- Mitchell Franklin
- Monty Johnson
- Nathan Hakman
- Neil Mullin
- Nicos A. Poulantzas
- Nikolai I. Bukharin
- Norman Freed
- Paul K. Crosser
- Paul Q. Hirst
- Paul Q. Hirst
- Pavel F. Yudin
- Peter Gabel
- Peter N. Fedoseev
- Peter N. Fedoseev
- Piers Beirne
- Piers Beirne
- R. Warrington
- Ralph M. Faris
- Ralph Miliband
- Ralph Miliband
- Richard Johnson
- Richard Kinsey
- Robbie Gray
- Robert Heisler
- Robert Lefcourt
- Robert P. Wolff
- Robert Sharlet
- Robert Sharlet
- Robert Steigerwald
- Robert Steigerwald
- Robert Steigerwald
- Ronald Dworkin
- Ronald Weitzer
- Rudolf Schlesinger
- Sergei N. Bratus
- Sergey A. Golunskiy
- Sergey A. Golunskiy
- Stanley Diamond
- Stephen Sedley
- Theodore W. Adorno
- Toby Terrar
- V. Y. Zhukov
- Viktor S. Shevtsov
- Vladimir A. Tumanov
- Vladimir I. Lenin
- Walter Schneir
- Warren S. Gramm
- Y. Olesevich
- Zenon Bankowski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
- Beth Safirstein
- Bethanie Wilkinson
- Beverly E. Sha
- Beverly Ewing
- Bindu Balani
- Blanca Gomez
- Bo Shopsin
- Boerries Brandenburg
- Brandie Taylor
- Brandon J. Essink
- Brandy Ball
- Breanz Watkins
- Brenda Dorcely
- Brendan Levy
- Brett Gray
- Brett Leav
- Brian D.W. Chow
- Brit Sovic
- Brittany Feijoo
- Brittany Stewart
- Bruce C. Gebhardt
- Bruce G. Rankin
- Bruce McClenathan
- Bruno Valenti
- Bryan Gordon
- C. Mary Healy
- Caitlin J. Guiney
- Caitlin Moran
- Candace Smith
- Candice Montros
- Carina A. Rodriguez
- Carl Fichtenbaum
- Carl P. Griffin
- Carlos A. Fierro
- Carlos del Rio
- Carlos Lopez
- Carlos Malvestutto
- Carmel B. Dyer
- Carmen A. Paez
- Carmen Amador
- Carmen D. Zorrilla
- Carmen Medina
- Carol Ann Linebarger
- Carol Kauffman
- Carol L. Mitchell
- Carolene Stephenson
- Caroline Greene
- Carolyn Scatamacchia
- Carolyn Tran
- Carrie Johnston
- Carrie Sopher
- Catherine A. Bunce
- Catherine Mary Healy
- Catherine Q. Gular
- Cathy Laflan
- Cecilia McKeown-Bragas
- Celia Gonzalez
- Celia Maxwell
- Charles Harper
- Charles M. Fogarty
- Charlotte-Paige Rolle
- Charnell Cromer
- Chelsea Miles
- Chelsie Nutsch
- Chelsie Nutsch
- Chen S. Tan
- Chenchen Yu
- Cheryl Nuss
- Cheryl Young
- Chimeremma Nnadi
- Chinar Desai
- Christian Tomaszewski
- Christina A. Rostad
- Christina Bacher
- Christina Kennelly
- Christine Akamine
- Christine B. Turley
- Christine Hull
- Christine Wilson
- Christopher Carpenter
- Christopher Dedon
- Christopher Galloway
- Christopher Matich
- Christy Schmeck
- Christy Sweet
- Clarence B. Creech II
- Clarisse Baudelaire
- Claudia De La Matta Rodriguez
- Claudia Espinosa
- Claudio Nuñez Lagos
- Clint C. Guillory
- Clint Wilson
- Codi M. Anthony
- Colleen F. Kelley
- Colleen Jacobsen
- Connie Moya
- Cora Sonnier
- Corey G. Anderson
- Corey M. Chen
- Cornell Calinescu
- Corrina Pavetto
- Cortney Burch
- Cory J. Huffine
- Craig Dietz
- Cristina Cicogna
- Crystal Rowell
- Cynthia Becher Strout
- Cynthia Brown
- Cynthia Bueno
- Cynthia L. Gay
- Cynthia L. Monaco
- Cynthia Montano-Pereira
- Cyrus Hoseyni
- Dakotah C. Lane
- Dalia Tovar
- Daniel Duncanson
- Daniel Hoft
- Daniel Kaul
- Daniel S. Graciaa
- Daniel T. Lawler
- Daniela Pineda Méndez
- Danielle Raley
- Danny Sugimoto
- Danyel Johnson
- Darlene Bartilucci
- David B. Musante
- David Beckmann
- David Browder
- David Dellaero
- David Fitz-Patrick
- David Halpert
- David I. Bernstein
- David J. Diemert
- David J. Ensz
- David Kline
- David L. Fried
- David Metzger
- David Pampe
- David Pitrak
- David R. Andes
- David Rosenberg
- David Tatelbaum
- David Wohl
- Dawn Furey
- Dawn Robison
- Dean Follmann
- Dean M. Boswell
- Deanna Cooper
- Debora Dunbar
- Deborah A. Theodore
- Deborah Murray
- Debra B. Schroeck
- Delia Bullock
- Denis Tarakjian
- Denise Casey
- Denise Roadman
- Denise Sample
- Denisse Alejandra González Estrada
- Derek Lewis
- Derek M. Smith
- Destiny S. Heinzig-Cartwright
- Diana Badillo
- Diana F. Florescu
- Diana Vegas
- Dianca Sierra
- Diane H. Johnson
- Dilek Ince
- Dima Dandachi
- Dirk Heerwegh
- Dolores Rijos
- Donald M. Brandon
- Donald Quinn
- Donna Percy
- Doris Franco-Vitteri
- Douglas S. Denham
- E. Javier Pretell Alva
- Edgar Garcia
- Edith Swann
- Eduardo Gabriel Vázquez Saldaña
- Edward C. Jones-López
- Edward E. Walsh
- Edward Ellerbeck
- Edward M. Tavel Jr.
- Elham Ghadishah
- Elie Gharib
- Elisa Swieboda
- Elissa Malkin
- Elizabeth Barranco-Santana
- Elizabeth Bennett
- Elizabeth Bruce
- Elizabeth Danford
- Elizabeth Duke
- Elizabeth E. Robison
- Elizabeth Everette
- Elizabeth Formentini
- Elizabeth Hammershaimb
- Elizabeth Parker
- Elizabeth Secord
- Ellie Carmody
- Elliot DeHaan
- Elwaleed Elnagar
- Emily Degan
- Emily Oppenheim
- Emma Bainbridge
- Emmanuel B. Walter
- Eneyda Giuvanela Llerena Zegarra
- Enrique Ocaña
- Eric A. Meyerowitz
- Eric Bravo
- Eric McGrath
- Eric Miller
- Erica Herc
- Erica Johnson
- Erica Osmundsen
- Erica Sanchez
- Erika A. Cutz
- Erika Mendoza
- Erin A. Goecker
- Erin Cooksey
- Erin Coston
- Ernesto Delgado
- Esther L. Harmon
- Esther S. Huffine
- Evan C. Ewers
- Evan J. Anderson
- Evelyn Hall
- Evelyn Lomasney
- Evelyn Quevedo
- Fan Yang
- Farah Irani
- Farhan Siddiqui
- Fernanda Morales
- Fernando L. Merino
- Filip Dubovsky
- Flora Castellino
- Florence Momplaisir
- Florida Aristy
- Frances Downing
- Frank James
- Frank S. Eder
- Frank Struyf
- Fred E. Newton
- Frederick Raiser III
- Fredric Santiago
- Gail Broder
- Gary Albert
- Gary Headden
- Gary Horwith
- Gary Luckasen
- Gary Simon
- Gayle D. Hennekes
- Genevieve Beninati
- Genevieve Iwuala
- George H. Bauer Jr.
- George H. Freeman
- Georgette Ebuh
- Georgettea Geuss
- Gerald Kelty
- Germán Áñez
- Getahun Abate
- Gina Rivero
- Glenda E. Gray
- Glenn Wortman
- Gowdhami Mohan
- Grant Ellsworth
- Grant Geiger
- Greg Hachigian
- Greg Wilson
- Gregg H. Lucksinger
- Gregory C. Utz
- Gregory Holt
- Gregory J. Feldman
- Gregory M. Glenn
- Gregory M. Gottschlich
- Griet Van Roey
- Guillermo Miguel Ruiz-Palacios
- Gysella Muniz
- Hala Webster
- Hana M. El Sahly
- Hanh Chu
- Hanh Chu
- Hannah Catan
- Hannah Harrington
- Hannah Nevarez
- Haoua Dunbar
- Hayes Williams
- Heather Rattenbury-Shaw
- Henry Peralta
- Hilario Alvarado
- Hillary Dunlevy
- Holli Hamilton
- Holly E. Janes
- Hong V. Tieu
- Horacio Marafioti
- Howard I. Schwartz
- Howard Schwartz
- Hussain Malbari
- Huub G. Gelderblom
- Hyman Scott
- Ian De Proost
- Ian Frank
- Ian Hirsch
- Iksung Cho
- Ilse Van Dromme
- Insiya Valika
- Irene Graham
- Irene McKnight
- Iris García
- Isaac Thomsen
- Isabel Pereira
- Issac Pena-Renteria
- Jack Stapleton
- Jacob Coleman
- Jacqueline Miller
- Jacqueline Muenzner
- Jaleh Ostovar
- Jaleh Ostovar
- Jalima Quintero
- James Andersen
- James Fry
- James G. Kublin
- James H. Conway
- James Longe
- James Lovell
- James N. Goldenberg
- James Peacock
- James Ramsey
- James T. Peterson
- James W. Hurst
- James Walker
- James Zhou
- Jamie Ackerman
- Jamshid Saleh
- Jan Patterson
- Janet Garvey
- Janet Hill
- Janet Mendez
- Janet Otto
- Janeth Pacheco-Flores
- Janice Suyehira
- Janine Maenza
- Jarek Juraszek
- Jason F. Okulicz
- Jason Milligan
- Jay Meyer
- Jayasree Krishnankutty
- Jeanne Blevins
- Jeb Andrews
- Jeff Kingsley
- Jeffrey A. Henderson
- Jeffrey Adelglass
- Jeffrey Dugas Sr.
- Jeffrey Klein
- Jeffrey M. Jacobson
- Jeffrey Meier
- Jeffrey Rosen
- Jeffrey S. Overcash
- Jeffrey Thessing
- Jeffry Jacqmein
- Jenina Garcia
- Jennie Johnson
- Jennifer A. Johnson
- Jennifer A. Whitaker
- Jennifer Bashour
- Jennifer Berry
- Jennifer Chang
- Jennifer Foley
- Jennifer Knishinsky
- Jennifer Knowles
- Jennifer L. Dong
- Jennifer McCarter
- Jennifer Petts
- Jennifer Schwartz
- Jennifer Winbigler
- Jenny Hendriks
- Jerald Sadoff
- Jeremy Ackermann
- Jeremy Brown
- Jerome Custers
- Jerome G. Naifeh
- Jesse L. Clark
- Jessica E. Justman
- Jessica G. Andriesen
- Jessica Heimonen
- Jessica Ibarra
- Jessica L. Ansel
- Jessica L. Lee
- Jessica L. Weidler
- Jessica M. Mena
- Jessica Ortega
- Jessica Rodriguez
- Jessica Stahl
- Jewel J. White
- Jill Blumenthal
- Jill Kessler
- Jill York
- Jim Callis
- Joan Rothenberg
- Joanne L. Billings
- Jocelyn Zuleica Olmos Vega
- Jodi Meck
- Joel Solis
- Johan Vingerhoets
- John A. Kirby
- John J. Treanor
- John Johnson
- John Lucaj
- John M. Hill
- John Mascola
- John S. Kizer
- John Sanders
- John W. McGettigan Jr.
- John Witbeck
- Jon F. Dedon
- Jon Finley
- Jonathan Staben
- Jonlyn McGettigan
- Jordan Coslet
- Jordan L. Whatley
- Jorge A. Benitez
- Jorge A. Chacón
- Jorge Caso
- Jorge F. Méndez Galván
- Jose A. Bazan
- Jose C. Mancilla
- Jose Castillo Mancilla
- Jose Gonzales-Zamora
- Joseph Bocchini
- Joseph Boscia
- Joseph D. Davis
- Joseph Eron Jr.
- Joseph Grillo
- Joseph J. Eron
- Joseph L. Newberg
- Joseph P. Connor
- Joseph Yusin
- Joshua Rindt
- José O. Alemán
- Joy Nelson
- Juan J. Rivera
- Juan Luis Yrivarren Giorza
- Juan P. Torres
- Juan V. Guanira-Carranza
- Juana R. Pavie
- Juana Rivera
- Judith Borger
- Judith Brady
- Judith L. Kirstein
- Judith Martin
- Judy Pi
- Julia Hutter
- Julia Lord
- Julian A. Torres
- Julie A. Ake
- Julie Hussey
- Julie Ledgerwood
- Julie White
- Julio Nasim
- Justin Singletary
- Kacie Sales
- Kami Kim
- Karen Deutsch
- Karen Freudemann
- Karen L. Kotloff
- Karen Ruperto
- Karen Sofia Vega Orozco
- Karen Tashima
- Karin Choquette
- Karina Cano Martínez
- Karl M. Thompson
- Karla Beatriz Tafur Bances
- Karla Zepeda
- Kary Kelly
- Kate Harden
- Kate Jaegle
- Kate Zenlea
- Katherine Smith
- Katherine Stapleton
- Kathleen Linder
- Kathleen M. Mullane
- Kathleen M. Neuzil
- Kathleen Menasche
- Kathleen S. Jones
- Kathryn E. Stephenson
- Kawsar R. Talaat
- Keith R. Jerome
- Keith W. Vrbicky
- Kelly Kush
- Kelly McQuarrie
- Ken Ho
- Kendra Enright
- Kendra Lisec
- Kenneth Finkelstein
- Kenneth H. Mayer
- Kenneth Steil
- Kevin D. Cannon
- Kevin Parks
- Kevin Zhang
- Kia Lee
- Kia Lee
- Kim Quillin
- Kimberly Mueller
- Kimberly Nieves
- Kimberly Nofz
- Kimberly Snell
- Kinara S. Yang
- Kirsten Hauge
- Kristen Johnson
- Kristen K. Pierce
- Kristen Kiersey
- Kristin Bialobok
- Kristin Marks
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- Vladimir Berthaud
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- Westly Keating
- Whitney West
- Will Hernandez
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- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
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- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
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