An Application To Astronomy

From time immemorial mankind has gazed out into the universe wondering about many things. One of them being whether a day night come when men could travel from earth to one or all of the distant planets. With the advent of modern technology, this dream is not entirely out of reach, particularly because of the invention of rockets. However, it is not the purpose of this paper to discuss whether man will reach another planet, though it does seem very likely be will, but to discuss the relation between two bodies separated by a distance

Reclaiming a Sense of Place: Geospatial Technologies and the Flat Rock Cemetery Project

The Flat Rock community in southern DeKalb County, Georgia (just outside Atlanta) is one of the oldest continually-occupied African-American communities in Georgia. Although history shows that many African-American communities in the South were broken apart as former slaves migrated north in search of jobs and a more equitable life, Flat Rock remained an intact community. This was largely due to the efforts of individuals who were able to purchase land and later sell it in small parcels to fellow community members. Proximity—both to ancestors and significant places—is a cross-culturally important component to the creation of a sense of community. Placed on a high peak in DeKalb County, the Flat Rock Cemetery became such a place for the Flat Rock community. It contains burials dating from 1834 (three years prior to the official establishment of the community) through 1959. In the spring of 2008, Johnny Waits, president of the Flat Rock Archive, proposed a project to the members of the Greater Atlanta Archaeological Society (GAAS) involving the clearing and mapping of this historic cemetery. These initial meetings eventually led to the involvement of Georgia State University (GSU). Through the use of a total station, Jeffrey Glover of GSU and his students have been mapping the cemetery and conducting research into its material culture. The objectives of this project, due to be completed in 2009, include completion of the cemetery map and the subsequent connection of identified graves to the archival data collected by Mr. Waits. These data will be integrated with photographic images of tombstones and material offerings, and will be established on GSU’s geospatial server using ESRI’s ArcServer. These interactive maps will be made accessible to visitors to the Flat Rock archive web site

Did the call for boycott by the Catholic bishops affect the polio vaccination coverage in Kenya in 2015? A cross-sectional study

Introduction: Polio eradication is now feasible after removal of Nigeria from the list of endemic countries and global reduction of cases of wild polio virus in 2015 by more than 80%. However, all countries must remain focused to achieve eradication. In August 2015, the Catholic bishops in Kenya called for boycott of a polio vaccination campaign citing safety concerns with the polio vaccine. We conducted a survey to establish if the coverage was affected by the boycott. Methods: A cross sectional survey was conducted in all the 32 counties that participated in the campaign. A total of 90,157 children and 37,732 parents/guardians were sampled to determine the vaccination coverage and reasons for missed vaccination. Results: The national vaccination coverage was 93% compared to 94% in the November 2014 campaign. The proportion of parents/guardians that belonged to Catholic Church was 31% compared to 7% of the children who were missed. Reasons for missed vaccination included house not being visited (44%), children not being at home at time of visit (38%), refusal by parents (12%), children being asleep (1%), and various other reasons (5%). Compared to the November 2014 campaign, the proportion of children who were not vaccinated due to parent’s refusal significantly increased from 6% to 12% in August 2015. Conclusion: The call for boycott did not affect the campaign significantly. However, if the call for boycott is repeated in future it could have some significant negative implication to polio eradication. It is therefore important to ensure that any vaccine safety issues are addressed accordingly.Pan African Medical Journal 2016; 2

1973: Abilene Christian College Bible Lectures - Full Text

JESUS Being the Abilene Christian College Annual Bible Lectures 1973 Published by ABILENE CHRISTIAN COLLEGE BOOK STORE ACC Station Abilene, Texas 7960

Up-Regulation of Hepatitis C Virus Replication and Production by Inhibition of MEK/ERK Signaling

BACKGROUND: Viruses interact with and exploit the host cellular machinery for their multiplication and propagation. The MEK/ERK signaling pathway positively regulates replication of many RNA viruses. However, whether and how this signaling pathway affects hepatitis C virus (HCV) replication and production is not well understood. METHODS AND RESULTS: In this study, we took advantage of two well-characterized MEK/ERK inhibitors and MEK/ERK dominant negative mutants and investigated the roles of the MEK/ERK signaling pathway in HCV gene expression and replication. We showed that inhibition of MEK/ERK signaling enhanced HCV gene expression, plus- and minus-strand RNA synthesis, and virus production. In addition, we showed that this enhancement was independent of interferon-alpha (IFN-alpha) antiviral activity and did not require prior activation of the MEK/ERK signaling pathway. Furthermore, we showed that only MEK and ERK-2 but not ERK-1 was involved in HCV replication, likely through regulation of HCV RNA translation. CONCLUSIONS: Taken together, these results demonstrate a negative regulatory role of the MEK/ERK signaling pathway in HCV replication and suggest a potential risk in targeting this signaling pathway to treat and prevent neoplastic transformation of HCV-infected liver cells

Mathematical Modelling as a Proof of Concept for MPNs as a Human Inflammation Model for Cancer Development

<p><b>Left:</b> Typical development in stem cells (top panel A) and mature cells (bottom panel B). Healthy hematopoietic cells (full blue curves) dominate in the early phase where the number of malignant cells (stipulated red curves) are few. The total number of cells is also shown (dotted green curves). When a stem cell mutates without repairing mechanisms, a slowly increasing exponential growth starts. At a certain stage, the malignant cells become dominant, and the healthy hematopoietic cells begin to show a visible decline. Finally, the composition between the cell types results in a takeover by the malignant cells, leading to an exponential decline in hematopoietic cells and ultimately their extinction. The development is driven by an approximately exponential increase in the MPN stem cells, and the development is closely followed by the mature MPN cells. <b>Right:</b> B)The corresponding allele burden (7%, 33% and 67% corresponding to ET, PV, and PMF, respectively) defined as the ratio of MPN mature cells to the total number of mature cells.</p