Towards mechanomagnetics in elastic crystals: insights from [Cu(acac)2_2]

We predict that the magnetic properties of \cuacac, an elastically flexible crystal, change dramatically when the crystal is bent. We find that unbent \cuacac\ is an almost perfect Tomonaga-Luttinger liquid. Broken-symmetry density functional calculations reveal that the magnetic exchange interactions along the chains is an order of magnitude larger than the interchain exchange. The geometrically frustrated interchain interactions cannot magnetically order the material at any experimentally accessible temperature. The ordering temperature ($T_N$), calculated from the chain random phase approximation, increases by approximately 24 orders of magnitude when the material is bent. We demonstrate that geometric frustration both suppresses $T_N$ and enhances the sensitivity of $T_N$ to bending. In \cuacac, $T_N$ is extremely sensitive to bending, but remains too low for practical applications, even when bent. Partially frustrated materials could achieve the balance of high $T_N$ and good sensitivity to bending required for practical applications of mechanomagnetic elastic crystals

Scheduling of users with Markovian time-varying transmission rates

We address the problem of developing a well-performing and implementable scheduler of users with wireless connection to the base station. The main feature of such real-life systems is that the quality conditions of the user channels are time-varying, which turn into the time-varying transmission rate due to different modulation and coding schemes. We assume that this phenomenon follows a Markovian law and most of the discussion is dedicated to the case of three quality conditions of each user, for which we characterize an optimal index policy and show that threshold policies (of giving higher priority to users with higher transmission rate) are not necessarily optimal. For the general case of arbitrary number of quality conditions we design a scheduler and propose its two practical approximations, and illustrate the performance of the proposed index-based schedulers and existing alternatives in a variety of simulation scenarios

Opportunistic scheduling of flows with general size distribution in wireless time-varying channels

In this paper we study how to design an opportunistic scheduler when flow sizes have a general service time distribution with the objective of minimizing the expected holding cost. We allow the channel condition to have two states which in particular covers the important special case of ON/OFF channels. We formulate the problem as a multi-armed restless bandit problem, a particular class of Markov decision processes. Since an exact solution is out of reach, we characterize in closed-form the Whittle index, which allows us to define a heuristic scheduling rule for the problem. We then particularize the index to the important subclass of distributions with a decreasing hazard rate. We finally evaluate the performance of the proposed Whittle-index based scheduler by simulation of a wireless network. The numerical results show that the performance of the proposed scheduler is very satisfactory

Searching for unity: Real-world versus item-based visual search in age-related eye disease

When studying visual search, item-based approaches using synthetic targets and distractors limit the real-world applicability of results. Everyday visual search can be impaired in patients with common eye diseases like glaucoma and age-related macular degeneration. We highlight some results in the literature that suggest assessment of real-word search tasks in these patients could be clinically useful

The Effect of Haptic Cues on Working Memory in 3D Menu Selection

We investigated the effect of haptic cues on working memory in 3D menu selection. We conducted a 3D menu selection task in two different conditions: visual only and visual with haptic. For the visual condition, participants were instructed to select 3D menu items and memorize the order of selection. For the visual with haptic condition, we used magnetic haptic effect on each 3D menu item. Results showed that participants needed less number of trials for memorizing the selection sequence in visual with haptic condition than in visual only condition. Subjective data, collected from a questionnaire, indicated that visual with haptic condition was more suitable for selection and memorization

The design-by-adaptation approach to universal access: learning from videogame technology

This paper proposes an alternative approach to the design of universally accessible interfaces to that provided by formal design frameworks applied ab initio to the development of new software. This approach, design-byadaptation, involves the transfer of interface technology and/or design principles from one application domain to another, in situations where the recipient domain is similar to the host domain in terms of modelled systems, tasks and users. Using the example of interaction in 3D virtual environments, the paper explores how principles underlying the design of videogame interfaces may be applied to a broad family of visualization and analysis software which handles geographical data (virtual geographic environments, or VGEs). One of the motivations behind the current study is that VGE technology lags some way behind videogame technology in the modelling of 3D environments, and has a less-developed track record in providing the variety of interaction methods needed to undertake varied tasks in 3D virtual worlds by users with varied levels of experience. The current analysis extracted a set of interaction principles from videogames which were used to devise a set of 3D task interfaces that have been implemented in a prototype VGE for formal evaluation

In-plane superfluid density and microwave conductivity of the organic superconductor kappa-(BEDT-TTF)(2)Cu[N(CN)(2)]Br: evidence for d-wave pairing and resilient quasiparticles

We report the in-plane microwave surface impedance of a high-quality single crystal of kappa-(BEDT-TTF)(2)Cu[N(CN)(2)]Br. In the superconducting state, we find three independent signatures of d-wave pairing: (i) a strong, linear temperature dependence of superfluid density; (ii) deep in the superconducting state the quasiparticle scattering rate Gamma similar to T-3; and (iii) no BCS coherence peak is observed in the quasiparticle conductivity. Above T-c, the Kadowaki-Woods ratio and the temperature dependence of the in-plane conductivity show that the normal state is a Fermi liquid below similar or equal to 23 K, yet resilient quasiparticles dominate the transport up to similar or equal to 50 K

Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing

AbstractIn the UK, the Medicines and Healthcare products Regulatory Agency consulted on proposals “to improve and strengthen the UK clinical trials legislation to help us make the UK the best place to research and develop safe and innovative medicines”. The purpose of the consultation was to help finalise the proposals and contribute to the drafting of secondary legislation. We discussed these proposals as members of the Trials Methodology Research Partnership Adaptive Designs Working Group, which is jointly funded by the Medical Research Council and the National Institute for Health and Care Research. Two topics arose frequently in the discussion: the emphasis on legislation, and the absence of questions on data sharing. It is our opinion that the proposals rely heavily on legislation to change practice. However, clinical trials are heterogeneous, and as a result some trials will struggle to comply with all of the proposed legislation. Furthermore, adaptive design clinical trials are even more heterogeneous than their non-adaptive counterparts, and face more challenges. Consequently, it is possible that increased legislation could have a greater negative impact on adaptive designs than non-adaptive designs. Overall, we are sceptical that the introduction of legislation will achieve the desired outcomes, with some exceptions. Meanwhile the topic of data sharing — making anonymised individual-level clinical trial data available to other investigators for further use — is entirely absent from the proposals and the consultation in general. However, as an aspect of the wider concept of open science and reproducible research, data sharing is an increasingly important aspect of clinical trials. The benefits of data sharing include faster innovation, improved surveillance of drug safety and effectiveness and decreasing participant exposure to unnecessary risk. There are already a number of UK-focused documents that discuss and encourage data sharing, for example, the Concordat on Open Research Data and the Medical Research Council’s Data Sharing Policy. We strongly suggest that data sharing should be the norm rather than the exception, and hope that the forthcoming proposals on clinical trials invite discussion on this important topic.</jats:p

Gapless spinons and a field-induced soliton gap in the hyper-honeycomb Cu oxalate framework compound [(C2_{2}H5_{5})3_{3}NH]2_{2}Cu2_{2}(C2_{2}O4_{4})3_{3}

We report a detailed study of the specific heat and magnetic susceptibility of single crystals of a spin liquid candidate: the hyper-honeycomb Cu oxalate framework compound [(C$_2$H$_5$)$_3$NH]$_2$Cu$_2$(C$_2$O$_4$)$_3$. The specific heat shows no anomaly associated with a magnetic transition at low temperatures down to $T\sim$ 180 mK in zero magnetic field. We observe a large linear-in-$T$ contribution to the specific heat $\gamma T$, $\gamma = 98(1)$ mK/mol K$^{2}$, at low temperatures, indicative of the presence of fermionic excitations despite the Mott insulating state. The low-$T$ specific heat is strongly suppressed by applied magnetic fields $H$, which induce an energy gap, $\Delta (H)$, in the spin-excitation spectrum. We use the four-component relativistic density-functional theory (DFT) to calculate the magnetic interactions, including the Dzyaloshinskii-Moriya antisymmetric exchange, which causes an effective staggered field acting on one copper sublattice. The magnitude and field dependence of the field-induced gap, $\Delta (H) \propto H^{2/3}$, are accurately predicted by the soliton mass calculated from the sine-Gordon model of weakly coupled antiferromagnetic Heisenberg chains with all parameters determined by our DFT calculations. Thus our experiment and calculations are entirely consistent with a model of [(C$_2$H$_5$)$_3$NH]$_2$Cu$_2$(C$_2$O$_4$)$_3$ in which anisotropic magnetic exchange interactions due to Jahn-Teller distortion cause one copper sublattice to dimerize, leaving a second sublattice of weakly coupled antiferromagnetic chains. We also show that this model quantitatively accounts for the measured temperature-dependent magnetic susceptibility. Thus [(C$_2$H$_5$)$_3$NH]$_2$Cu$_2$(C$_2$O$_4$)$_3$ is a canonical example of a one-dimensional spin-1/2 Heisenberg antiferromagnet and not a resonating-valence-bond quantum spin liquid, as previously proposed.Comment: 8 pages, 6 figure