11 research outputs found
Multi-Timescale Perceptual History Resolves Visual Ambiguity
- Author
- A Kristjansson
- A Maier
- A Pastukhov
- AB Bonds
- AJ Noest
- Albert V. van den Berg
- André J. Noest
- D Rose
- DA Leopold
- DA Leopold
- DG Albrecht
- G Gilboa
- HR Wilson
- I Ohzawa
- J Orbach
- J Pearson
- Jan W. Brascamp
- JF Mitchell
- JM Wolfe
- JR Muller
- JW Brascamp
- LT Maloney
- MC Dorris
- MO Ernst
- MO Ernst
- N Ulanovsky
- O Carter
- PJ Drew
- R Kanai
- Raymond van Ee
- RM McPeek
- Ryota Kanai
- Sheng He
- Tomas H. J. Knapen
- V Maljkovic
- X Chen
- Y Jiang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2008
- Field of study
When visual input is inconclusive, does previous experience aid the visual system in attaining an accurate perceptual interpretation? Prolonged viewing of a visually ambiguous stimulus causes perception to alternate between conflicting interpretations. When viewed intermittently, however, ambiguous stimuli tend to evoke the same percept on many consecutive presentations. This perceptual stabilization has been suggested to reflect persistence of the most recent percept throughout the blank that separates two presentations. Here we show that the memory trace that causes stabilization reflects not just the latest percept, but perception during a much longer period. That is, the choice between competing percepts at stimulus reappearance is determined by an elaborate history of prior perception. Specifically, we demonstrate a seconds-long influence of the latest percept, as well as a more persistent influence based on the relative proportion of dominance during a preceding period of at least one minute. In case short-term perceptual history and long-term perceptual history are opposed (because perception has recently switched after prolonged stabilization), the long-term influence recovers after the effect of the latest percept has worn off, indicating independence between time scales. We accommodate these results by adding two positive adaptation terms, one with a short time constant and one with a long time constant, to a standard model of perceptual switching
Mycotic aneurysm of the popliteal artery secondary to Streptococus pneumoniae: a case report and review of the literature
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases
- Author
- A Pandey
- A Rassi Jr
- A Stauch
- Abhishek Pandey
- Alexandra Zoueva
- Alison P. Galvani
- Amy Pinsent
- Andy Dobson
- BK Singh
- Brajendra K. Singh
- Bruce Y. Lee
- BY Lee
- BY Lee
- BY Lee
- C Bern
- CE Brook
- Charles King
- D Gurarie
- D Gurarie
- David Gurarie
- David J. Blok
- DJ Blok
- E Dumonteil
- Edwin Michael
- Emily R. Adams
- Epke A. Le Rutte
- F Courtin
- F Liu
- G Gunawardena
- Graham F. Medley
- H Taylor
- H Turner
- H Turner
- H Turner
- Hajnal Farkas
- J Alvar
- J Convit
- J Lessler
- J Truscott
- James Truscott
- Jan Hendrik Richardus
- Jeffrey Townsend
- Jennifer K. Peterson
- JK Peterson
- JW Eaton
- K Ichimori
- K Ramaiah
- Kat S. Rock
- Katherine Atkins
- KM Mitchell
- KM Mitchell
- KS Rock
- KS Warren
- L Coffeng
- L Diawara
- LA Chapman
- LE Coffeng
- Lisa Reimer
- Lloyd A. C. Chapman
- Louise Dyson
- Louise Kelly-Hope
- Luc Coffeng
- M Bonds
- M Chan
- M Gambhir
- M Katabarwa
- M Rodriguez-Perez
- M Rodriguez-Perez
- M Traore
- M Winnen
- MA Irvine
- Manoj Gambhir
- Martial Ndeffo-Mbah
- Martin Walker
- MarĂa-Gloria Basáñez
- Matt J. Keeling
- Matthew Behrend
- Michael A. Irvine
- MN Katabarwa
- O Restif
- Orin Courtenay
- PE Fine
- PH Lamberton
- R Anderson
- R Anderson
- R Lovato
- R May
- RE Crump
- Ron E. Crump
- Roy M. Anderson
- S Njenga
- S Subramanian
- S Swaminathan
- S West
- Sake J. de Vlas
- Sarah Bartsch
- Sarah Jervis
- SJ Brooker
- Steve J. Torr
- Subramanian Swaminathan
- T. DĂ©irdre Hollingsworth
- Thomas M. Lietman
- Travis C. Porco
- WA Stolk
- WC Smith
- WHO
- WHO
- WHO
- WHO
- WHO
- WHO
- WHO
- Wilma Stolk
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination
- Author
- A Aguilera
- A Coquelle
- A Dershowitz
- A Hellman
- AD Simmons
- AM Carr
- AM Deshpande
- AM Lyndaker
- AP Davis
- AW Murray
- B McClintock
- B Ren
- BM Green
- BM Green
- BM Green
- C Payen
- C Vaziri
- CA Lovejoy
- CS Hoffman
- D Dominguez-Sola
- D Koshland
- D Romero
- DE Libuda
- DJ McBride
- E Arentson
- EE Arias
- EJ Louis
- EL Ivanov
- ES Lander
- EV Mirkin
- F Pâques
- G Ira
- G-F Richard
- GM Wilmes
- HJ McCune
- I Voineagu
- IF Davidson
- J Bartkova
- J Fishman-Lobell
- J Herrick
- J Jin
- J O'Neil
- J Seo
- J-M Chen
- JC Venter
- JFX Diffley
- JJ Blow
- JL Argueso
- Joachim J. Li
- JR Lydeard
- JW Szostak
- JW Welch
- K Labib
- K VanHulle
- Kenneth J. Finn
- L Bonds
- LR Borlado
- LS Symington
- M Ciullo
- M Debatisse
- M Debatisse
- M Liontos
- M Melixetian
- MJ McEachern
- ML Hoang
- MP Strout
- N Murphy
- N Sugawara
- N Sugawara
- P Karakaidos
- P Liu
- PA Mieczkowski
- PJ Hahn
- PJ Hastings
- R Beroukhim
- R Di Micco
- RD Kolodner
- RE Mills
- S Girirajan
- S Le
- S Levy
- SG Durkin
- Sue Jinks-Robertson
- T Santarius
- T Weinert
- TD Halazonetis
- TD Petes
- V Archambault
- V Narayanan
- VQ Nguyen
- W Zhu
- W Zhu
- Y Kuwahara
- Z Zhu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Cognitive load effects on early visual perceptual processing
- Author
- A Angelucci
- A Angelucci
- A Angelucci
- A Dorais
- A Mack
- A Moscatelli
- A Seitz
- AB Bonds
- AM Mood
- AT Smith
- BA Dosher
- BA Dosher
- BC Motter
- BC Skottun
- BG Breitmeyer
- C Casco
- C Kaernbach
- C Sestieri
- C Wang
- CC Pack
- CD Gilbert
- CD Gilbert
- CM Sylvester
- CM Sylvester
- D Baldauf
- D Marr
- D Marr
- D Tadin
- D Tadin
- D Tadin
- David Sewell
- DC Somers
- DG Pelli
- DG Pelli
- DH Brainard
- DH Hubel
- DH Hubel
- DH Hubel
- DH O’connor
- DJ Heeger
- DM Levi
- DM Levi
- E Freeman
- E Freeman
- E Mach
- EH Adelson
- EL Cameron
- F Cutzu
- F Fang
- F Pestilli
- F Pestilli
- GC DeAngelis
- GT Buracas
- H Pashler
- H Piéron
- H Strasburger
- HE Jones
- HJ MĂĽller
- I Fujita
- J Chen
- J Churan
- J Churan
- Jason Forte
- JH Reynolds
- JH Reynolds
- JH Reynolds
- JH Sandell
- JJ Nassi
- JM Hupe
- JM Hupe
- JMG Tsui
- JN Hunter
- JP Thomas
- JR Cavanaugh
- JS Lappin
- JT Enns
- JT Serences
- JW Fockert de
- JW Fockert de
- K Herrmann
- KJ Linnell
- L Cocchi
- L Scocchia
- L Zhaoping
- M Carrasco
- M Carrasco
- M Chen
- M Fahle
- M Ito
- M Roberts
- M Scolari
- MA Silver
- MB Ben-Av
- MD Melnick
- MI Posner
- MP Sceniak
- MW Cannon
- N Konstantinou
- N Lavie
- N Lavie
- Olivia Carter
- P Dayan
- Ping Liu
- PL Smith
- PL Smith
- PL Smith
- PL Smith
- R Desimone
- RBH Tootell
- RE Crist
- RHJ Lubbe Van der
- RL Goldstone
- RT Born
- RT Born
- S Caparos
- S He
- S Ling
- S Yantis
- SA Harrison
- SM Kosslyn
- T Carlson
- T Liu
- W Li
- W Li
- WH Teichner
- WH Teichner
- WJ Harrison
- X Li
- Y Petrov
- Y Petrov
- ZL Lu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A compendium of solid-phase chemistry publications
- Author
- A Ajayaghosh
- A Cheminat
- A De
- A Gopalsamy
- A Hirao
- A Nefzi
- A Nefzi
- A Nefzi
- A Patchomik
- A Patchomik
- A Rockwell
- A Routledge
- A Routledge
- A Routledge
- AA Macdonald
- AA Virgilio
- AA Virgilio
- AD Piscopio
- AJ Bicknell
- AK Saha
- AK Szardenings
- AL Marzinzik
- AL Smith
- AM Bray
- AM Fivush
- AMM Mjalli
- AN Semenov
- AR Katritzky
- AR Katritzky
- AR Mitchell
- AS Hernandez
- AS Kiselyov
- B Altava
- B Drouillat
- B Raju
- B Raju
- B Ruhland
- B Ruhland
- B Yan
- B Yan
- B Yan
- B Yan
- B. Chenera
- BA Bunin
- BA Bunin
- BA Bunin
- BA Bunin
- BA Dressman
- BA Lorsbach
- BB Lohray
- BC Das
- BC Hamper
- BJ Backes
- BJ Backes
- BJ Cohen
- BO Buckman
- BR Stranix
- C Bec
- C Chen
- C Franot
- C Halm
- C Klinguer
- C Mueller
- C Sylvain
- C Zhang
- C Zhang
- CA Willoughby
- CC Leznoff
- CC Leznoff
- CC Leznoff
- CC Leznoff
- CC Leznoff
- CC Leznoff
- CC Leznoff
- CC Leznoff
- CC Leznoff
- CC Zikos
- CD Floyd
- CG Boojamra
- CG Boojamra
- Chan T.-H. and Huang, W.-Q., Polymer-Anchored Organosilyl Protecting Group in Organic Synthesis, J. Chem
- CK Esser
- CP Holmes
- CR Harrison
- CR Harrison
- CR Johnson
- CR Mcarthur
- CU Pittman Jr
- CU Pittman Jr.
- CU Pittman Jr.
- CU Pittman Jr.
- CU Pittman Jr.
- CY Cho
- CY Ho
- D Fancelli
- D Holmes
- D Sarantakis
- D. Vetter
- DA Campbell
- DA Campbell
- DA Goff
- DA Goff
- DA Goff
- DA Nugiel
- DA Nugiel
- DH Coy
- DH Drewry
- DJ Burdick
- DL Marshall
- DL Whitehouse
- DM Dixit
- DP Dygutsch
- DP Rotella
- DP Sutherlin
- DR Barn
- DR Tortolani
- DV Patel
- DW Gordon
- E Giralt
- E Laszlo
- E Nandanan
- EA Boyd
- EC Blossey
- EE Swayze
- EG Brown
- EG Mata
- EJ Kantorowski
- EK Kick
- EM Gordon
- F Bergmann
- F Bergmann
- F Camps
- F Camps
- F Gasparrini
- F Gavifia
- F Gosselin
- F Wang
- F Wang
- F Zaragoza
- F Zaragoza
- FEK Kroll
- Frechet J.M.J. and Haque, K.E., Use of Polymers as Protecting Groups in Organic Synthesis
- Frechet J.M.J. and Pellé, G., Use of Polymers as Protecting Groups in Organic Synthesis. Preparation of Partially Substituted Derivatives of D-Glucose, J. Chem
- Frechet J.M.J. and Seymour, E., Use of Polymers as Protecting Groups in Organic Synthesis VII. Preparation of Monobenzoates of Acyclic Triols, Isr
- FX Woolard
- G Bhalay
- G Byk
- G Dupas
- G Excoffier
- G Liu
- G Shapiro
- G Shapiro
- G Strathdee
- GA Crosby
- GA Crosby
- GB Phillips
- GC Look
- GC Look
- GC Look
- GD Cuny
- GH Veeneman
- GL Bolton
- GO Evans
- GT Wang
- H Deleuze
- H Fretz
- H Ito
- H Shimizu
- H Stephensen
- H-C Zhang
- H-S Moon
- H. Han
- HM Relies
- Hodge
- Hodge P., Khoshdel, E., Waterhouse, J. and Frechet, J.M.J., Michael Additions Catalyzed by Cinchona Alkaloids Bound via Their Vinyl Groups to Preformed Crosslinked Polymers, J. Chem
- HP Nestler
- HS Moon
- HV Meyers
- I Hughes
- I Ojima
- I Sucholeiki
- I Vlattas
- IC Choong
- ID Clarke
- IE Pop
- IE Pop
- J Alsina
- J Chin
- J Green
- J Junggebauer
- J Kowalski
- J Lee
- J Matthews
- J Nielsen
- J Rademann
- J Rebek
- J Rebek Jr.
- J Rebek Jr.
- J Robles
- J Shao
- J Smith
- J-M Kim
- J-P Meyer
- J.M. Burlitch
- J.M. Frechet
- JA Ellman
- JA Girdwood
- JA Hunt
- JA Shin
- JC Nelson
- JCHM Wijkmans
- JI Crowley
- JI Crowley
- JI Crowley
- JJ Baldwin
- JJ Chen
- JJ Parlow
- JJ Rafalko
- JK Judice
- JK Young
- JM Brown
- JM Burlitch
- JM Frechet
- JM Frechet
- JM Goldwasser
- JM Ostresh
- JMJ Frechet
- JMJ Frechet
- JMJ Frechet
- JMJ Frechet
- JMJ Frechet
- JMJ Frechet
- JMJ Frechet
- JP Collman
- JP Collman
- JP Collman
- JP Mayer
- JP Mayer
- JP Mayer
- JP Mayer
- JP Tam
- JR Blanton
- JR Hauske
- JR Morphy
- JS Koh
- JS Panek
- JT Ayers
- JW Apsimon
- JW Guiles
- JY Roberge
- JY Wong
- K Achiwa
- K Akaji
- K Burgess
- K Horiki
- K Kaljuste
- K Kaljuste
- K Kamahori
- K Kamahori
- K Ngu
- K Ngu
- K-L Yu
- K.C. Nicolaou
- KA Beaver
- Kaljuste K. and Undén, A., New Method for the Synthesis of N-Methyl Amino Acids Containing Peptides by Reductive Methylation of Amino Groups on the Solid Phase, Int. J
- KC Nicalaou
- KC Nicolaou
- KF Yip
- KJ Shea
- KM Short
- KS Lam
- L Bemi
- L Yan
- L Yang
- LA Thompson
- LC Dorman
- LD Rottman
- LE Canne
- Leznoff C.C. and Wong, J.Y., Use of Polymer Supports in Organic Synthesis. III. Selective Chemical Reactions on One Aldehyde Group of Symmetrical Dialdehydes, Can
- LF Tietze
- LF Tietze
- LJ Fitzpatrick
- LM Gayo
- LS Richter
- LS Richter
- LS Richter
- LS Richter
- LW James
- M Adinolfi
- M Akiyama
- M Bernard
- M Capka
- M Capka
- M Cemerud
- M Crawshaw
- M Gerlach
- M Gude
- M Hiroshige
- M Kato
- M Kawana
- M Larhed
- M Meldal
- M Meldal
- M Patek
- M Reggelin
- M Schuster
- M Setty-Fichman
- M Zupan
- M. Schuster
- MA Dorman
- MA Findeis
- MA Kraus
- MA Scialdone
- MA Youngman
- Marlowe
- Marx
- MB Shambhu
- MC Desai
- MC Fagnola
- MD Collini
- ME Fraley
- MF Gordeev
- MF Gordeev
- MF Gordeev
- MGL Petrucci
- MH George
- MJ Aurell
- MJ Farrall
- MJ Farrall
- MJ Farrall
- MJ Kurth
- MJ Kurth
- MJ Plunkett
- MJ Plunkett
- MJ Plunkett
- MJ Shapiro
- MJ Sofia
- MM Murphy
- MR Gowravaram
- MS Deshpande
- MV Anuradha
- N Ohtani
- N Thieret
- NE Schore
- NH Vo
- NJ Ede
- NJ Maeji
- NK Terrett
- NL Holy
- NM Khan
- NM Weinshenker
- NM Weinshenker
- NM Weinshenker
- NS Gray
- NW Hird
- O Seitz
- OB Wallace
- O’Donnell M.J., Lugar, C.W., Pottorf, R.S. and Zhou, C.
- O’Donnell M.J., Zhou, C. and Scott, W.L., Solid-Phase Unnatural Peptide Synthesis (UPS), J. Am
- P Heinonen
- P Hodge
- P Jayalekshmy
- P Pietta
- P Roussel
- P Rovero
- P Sieber
- P Tundo
- P Wipf
- P-W Wang
- P. Wipf
- P.A. Tempest
- P.H. Seeberger
- P.I. Svirskaya
- PA Tempest
- Park B.-D., Lee, H.-I., Ryoo, S.-J. and Lee, Y.-S., Convenient Method for Preparing Polystyrene having a Ăź-Hydroxy Group
- PF Alewood
- PG Pietta
- PH Chapman
- PHH Hermkens
- PI Svirskaya
- PI Svirskaya
- PS Furth
- PS Furth
- Q-S Hu
- R Fathi
- R Frenette
- R Grubbs
- R Kalir
- R Mohan
- R Rodebaugh
- R Rodebaugh
- R Seneci
- R Verduyn
- R Williard
- R.H. Grubbs
- RA Zambias
- RB King
- RB Merrifield
- RD Guthrie
- RE Marti
- RH Grubbs
- RJ Card
- RJ Simon
- RJ Simon
- RL Halcomb
- RM Valerio
- RM Valerio
- RN Zuckermann
- RN Zuckermann
- RN Zuckermann
- RP Iyer
- RS Garigipati
- RS Kania
- RT Taylor
- RT Taylor
- RT Taylor
- S Hanessian
- S Hanessian
- S Itsuno
- S Itsuno
- S Kobayashi
- S Kobayashi
- S Kobayashi
- S Marquais
- S Mazur
- S Sarshar
- S Sharma
- S-B Jang
- S-E Yoo
- S-HL Chiu
- SA Kates
- SA Kolodziej
- SC Miller
- SD Brown
- SE Jacobson
- Seymour E. and Frechet, J.M.J., Use of Polymers as Protecting Groups in Organic Synthesis
- SH Dewitt
- SJ Danishefsky
- SJ Danishefsky
- SJ Hocart
- SJ Paikoff
- SK Das
- SK Sharma
- SL Mellor
- SL Mellor
- SL Regen
- SM Allin
- SM Dankwardt
- SM Hutchins
- SM Hutchins
- SM Hutchins
- SM Hutchins
- SP Douglas
- SP Douglas
- SR Gilbertson
- SR Piettre
- SR Pulley
- SS Chu
- SS Isied
- ST Nguyen
- SV Mckinley
- SW Kim
- SY Stevens
- T Masuda
- T Ravindranathan
- T Takagi
- TA Keating
- TA Rano
- TC Norman
- TJ Nieuwstad
- TL Boehm
- TL Deegan
- TM Fyles
- TM Fyles
- TM Fyles
- TR Ancker
- TW Hall
- U Bauer
- U Gerigk
- U Zehavi
- V Arumugam
- V Janout
- V Krchnak
- V Krchnak
- V Yedidia
- W Dumont
- W Li
- W Tan
- WC Chan
- WD Bonds Jr.
- WDF Meutermans
- WF Degrado
- WH Pearson
- WJ Hoekstra
- WL Fitch
- WR Roush
- X Beebe
- X Beebe
- X Cao
- X Du
- X Huang
- X Xiao
- X-Y Xiao
- Y Cheng
- Y Pei
- Y Pei
- Y Sasaki
- Y Uozumi
- YD Ward
- YH Chang
- YM Angell
- YVS Rao
- Z Flegelova
- Z-J Ni
- ZH Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1999
- Field of study
Current views on vision in mammals
- Author
- A Lukáts
- A Shinozaki
- AA Pack
- AB Bonds
- AE Chavez
- AG Palacios
- AM Mass
- AM Mass
- AM Mass
- AY Supin
- B Birgersson
- B Blakeslee
- B Juliusson
- B MĂĽller
- C Arrese
- C Bobu
- C Tailby
- CA Arrese
- CA Arrese
- CA Arrese
- CA Arrese
- CE Schleich
- D Cao
- D Sandmann
- D Wang
- DF Pick
- DH Anderson
- DH Levenson
- DM Hunt
- DM Hunt
- E Soucy
- EB Hanggi
- ER Loew
- F Crescitelli
- F Gaillard
- F Gaillard
- FD Carmona
- FD Hanke
- G Pretterer
- G Yang
- GA Williams
- GA Williams
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GH Jacobs
- GI Rozhkova
- GJ D’Angelo
- GS Souza
- H Hofer
- H Zhao
- HM Petry
- I Kang
- IYa Pavlinov
- J Carroll
- J Eklöf
- J Kremer
- J Nathans
- J Neitz
- J Neitz
- J Neitz
- J Ringo
- JA Cowing
- JA Cowing
- JB Troy
- JD Pettigrew
- JD Pettigrew
- JM Hemmi
- JR Hetling
- JV Odom
- JW Parry
- K Bumsted
- K Schmid
- KC Catania
- KC Cauteren
- KC Wikler
- KD Feller
- KS Dulai
- L Maffei
- L Peichl
- L Peichl
- L Yin
- LS Carvalho
- M Donaghy
- M Glösmann
- M Ott
- MC Hanna
- MG Talebi
- ML Applebury
- MM Grim
- O Dkhissi-Benuahya
- OYu Orlov
- P Gouras
- P Gouras
- PE MĂĽller
- R Shapley
- RF Foelix
- RL Rockhill
- S Sanyal
- S Yokoyama
- S Yokoyama
- S Yokoyama
- SA Shaaban
- SG Jacobson
- SS Deeb
- T Yamaguchi
- TV Khokhlova
- TV Khokhlova
- TV Khokhlova
- TV Khokhlova
- U Griebel
- U Griebel
- UR Gomes
- VA Casagrande
- VI Govardovskii
- VI Govardovskii
- W Ebeling
- WH Merigan
- WH Merigan
- WL Davies
- Y Shostak
- Y Tan
- Y Umino
- Y Winter
- Z Henderson
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- Field of study
Demystifying the management of hypertriglyceridaemia
- Author
- A Alipour
- A Bartelt
- A Keech
- A Pandor
- A Rossebø
- A Sniderman
- AB Jørgensen
- AC Keech
- AD Sniderman
- AD Sniderman
- AH Kissebah
- AJ Taylor
- AJ Taylor
- AJ Tremblay
- AM Dattilo
- AN Phillips
- AS Wierzbicki
- AS Wierzbicki
- B Cariou
- B Mihaylova
- B Staels
- BG Brown
- BG Nordestgaard
- BG Nordestgaard
- BJ Arsenault
- C Baigent
- C Baigent
- C Dionne
- C Meyers
- C Voors-Pette
- C Xiao
- CM Ballantyne
- CT Johansen
- CT Johansen
- CT Johansen
- CT Johansen
- D Gaudet
- D Gaudet
- DA Leaf
- DB Hunninghake
- DB Zilversmit
- DC Chan
- DC Chan
- DE Bonds
- Dick C. Chan
- DJ Blom
- DJ Rader
- E Di Angelantonio
- E Matteucci
- EA Stein
- EC Lee
- EJ Schaefe
- EM Ooi
- Esther M. M. Ooi
- EY Chew
- FJ Raal
- FM Sacks
- FM Sacks
- G Lambert
- G Livesey
- G Walldius
- GD Kolovou
- Gerald F. Watts
- GF Watts
- GF Watts
- GF Watts
- GG Schwartz
- H Denison
- H Ginsberg
- H Shimano
- HB Rubin
- HB Rubins
- HE Bays
- HE Bays
- HN Ginsberg
- HP Kohler
- I Shai
- I Tabas
- IJ Goldberg
- J Borén
- J Bosch
- J Fleg
- J Rubiés-Prat
- JD Brunzell
- JD Brunzell
- JG Robinson
- JJ Kastelein
- JL Goldstein
- JR Guyton
- JW Anderson
- K Kikuchi
- KA Britton
- L Berglund
- L Wang
- LA Carlson
- LA Leiter
- LF van Gaal
- LJ Appel
- M Adiels
- M Cuchel
- M Granér
- M Jun
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- M Miller
- M Miller
- M Rubenfire
- M Yokoyama
- MC Brouwers
- MC Roncaglioni
- ME Cobble
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- MH Davidson
- MH Davidson
- MH Davidson
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- MJ Chapman
- MJ Chapman
- MJ Graham
- MJ Veerkamp
- ML Hannuksela
- MP Moyer
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- O Faergeman
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- TG Cole
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- V Fonseca
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- VG Athyros
- W Kim
- W Lu
- WC Knowler
- WE Boden
- WT Friedewald
- XY Zheng
- Y Cui
- Z Reiner
- ZA Fayad
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD
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- A Bartelt
- A Hiuge
- A Loft
- A Montagner
- A Montagner
- A RodrĂguez-Vilarrupla
- A Toubal
- A Tsuchida
- AB Jørgensen
- AJ Sanyal
- AM Lincoff
- AR Majithia
- AS Banks
- AS Divakaruni
- AV Khera
- B Cannon
- B Cariou
- B Cariou
- B Cariou
- B Lefebvre
- B Staels
- B Staels
- Barbara Gross
- Bart Staels
- BF Voight
- BH-J Chang
- BK He
- C Bastie
- C Bastie
- C Bruedigam
- C Christodoulides
- C Fernández-Miranda
- C Giaginis
- C Glineur
- C Koliaki
- C Vernochet
- C-H Lee
- CJ Chou
- CJ Villanueva
- CLJ Vrins
- CM Kusminski
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- CZ Larter
- D Altshuler
- D Auboeuf
- D Kramer
- D Levin
- D Pan
- DE Bonds
- DL Sprecher
- E Barroso
- E Barroso
- E Benetti
- E Bruckert
- E Dalmas
- E Hondares
- E Ip
- E Ip
- E Morán-Salvador
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- E Pino
- EJ Olson
- F Lalloyer
- F Oger
- F Wang
- FW Quelle
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- G Medina-Gomez
- H Kim
- H Zhang
- H Zhou
- H-J Jun
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- HE Bays
- I Escalona-Nandez
- IK Vila
- J Dubois-Chevalier
- J Laurin
- J Tee
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- JB Hansen
- JD Lewis
- JFP Berbée
- JG Neels
- JH Choi
- JI Odegaard
- JM Lehmann
- JM Peters
- JM Peters
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- JT Haas
- JW Jonker
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- K Hellemans
- K Iwaisako
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- K Ravnskjaer
- K Schoonjans
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- L Jiang
- L Nagy
- L Qiang
- L SalvadĂł
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- L Serrano-Marco
- L Wang
- L Zheng
- L-H Zhang
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- LD Roberts
- LF Van Gaal
- LM Sanderson
- M Ahmadian
- M Basaranoglu
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- M Lee
- M Lemoine
- M Loviscach
- M Pawlak
- M Pawlak
- M Pawlak
- M Schuler
- M Tuccori
- MA Abdelmegeed
- MD Leibowitz
- MI Lefterova
- Michal Pawlak
- MJ Barbera
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- P Trayhurn
- PA Dutchak
- Philippe Lefebvre
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- S Jeong
- S Jeong
- S Liu
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- SE Kahn
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- SE Wiley
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- T Coll
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
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- Zamlynskyy M
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- Zateyshchikova A
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- Zyatenkova E
- Ă…kerberg A
- Ă–stberg S
- Ĺśpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)