The intersection between toxicology and aging research: A toxic aging coin perspective.

We are imminently faced with the challenges of an increasingly aging population and longer lifespans due to improved health care. Concomitantly, we are faced with ubiquitous environmental pollution linked with various health effects and age-related diseases which contribute to increased morbidity with age. Geriatric populations are rarely considered in the development of environmental regulations or in toxicology research. Today, life expectancy is often into one’s 80s or beyond, which means multiple decades living as a geriatric individual. Hence, adverse health effects and late-onset diseases might be due to environmental exposures as a geriatric, and we currently have no way of knowing. Considering aging from a different perspective, the term “gerontogen” was coined in 1987 to describe chemicals that accelerate biological aging but has largely been left out of toxicology research. Thus, we are challenged with a two-faced problem that we can describe as a “toxic aging coin”; on one side we consider how age affects the toxic outcome of chemicals, whereas on the other side we consider how chemicals accelerate aging (i.e. how chemicals act as gerontogens). Conveniently, both sides of this coin can be tackled with a single animal study that considers multiple age groups and assesses basic toxicology of the chemical(s) tested and aging-focused endpoints. Here, I introduce the concept of this toxic aging coin and some key considerations for how it applies to toxicology research. My discussion of this concept will focus on the brain, my area of expertise, but could be translated to any organ system

The Organization of Technology in the Pine Hills of Mississippi

This thesis details the use of experimental flintknapping to better understand stone tool production and the organization of technology among Woodland period hunter-gatherers within the Pine Hills region of Mississippi. The Pine Hills region is characterized archaeologically by the presence of numerous sites consisting of flake scatters and little other material remains. Local tool stone resources consist of high grade chert in the form of small river cobbles, which restricts potential tool forms available to users. Research for this project focused on the statistical analysis of debitage created during the experimental replication of stone tools using local chert cobbles. Special attention was given to attributes of flake debris in relation to the tool production continuum. The results of this analysis indicate that a suite of attributes exists which accurately predict the position of a flake along the production continuum. Additionally, the results show that these attributes differ from those identified by previous studies. These attributes were used to reexamine three archaeological sites within the project area (22FO1515, 22FO1545, and 22FO1546). The reanalysis of two of these sites indicates that they served as residential locations within a mobile hunter-gatherer foraging system. Reanalysis of the third site was unable to determine site function due to site disturbance and the recovery procedure employed. Consequently, the use of 3.2mm screens is suggested as standard recovery procedure within the Pine Hills

THE BEEF COW-CALF ENTERPRISE IN THE GEORGIA PIEDMONT: A CASE STUDY IN CONSPICUOUS PRODUCTION

Livestock Production/Industries,

Development of a simulator for studying simplified lunar escape systems

Design and development of lunar escape system simulator for investigation of lunar escape problems and simplified manual guidance and control for lunar escape vehicle

Saturated hydrocarbon polymeric binder for advanced solid propellant and hybrid solid grains Quarterly report no. 3, 1 May - 31 Jul. 1966

Saturated hydrocarbon polymeric binder for advanced solid propellant and hybrid solid grain

Saturated hydrocarbon polymeric binder for advanced solid propellant and hybrid solid grains Quarterly report no. 2, 1 Feb. - 30 Apr. 1966

Synthesis and analysis of ethylene-neohexene copolymers with other non ketene-imine group free radicals for solid and hybrid grain propellant saturated hydrocarbon binder progra

Description and flight tests of an oculometer

A remote sensing oculometer was successfully operated during flight tests with a NASA experimental Twin Otter aircraft at the Langley Research Center. Although the oculometer was designed primarily for the laboratory, it was able to track the pilot's eye-point-of-regard (lookpoint) consistently and unobtrusively in the flight environment. The instantaneous position of the lookpoint was determined to within approximately 1 deg. Data were recorded on both analog and video tape. The video data consisted of continuous scenes of the aircraft's instrument display and a superimposed white dot (simulating the lookpoint) dwelling on an instrument or moving from instrument to instrument as the pilot monitored the display information during landing approaches