Internacionalização Acelerada de Empresas de Base Tecnológica: o Caso das Born Globals Brasileiras

The born global phenomenon has been made apparent, mainly in high technology sectors, which requires new theoretical understandings about the role of nascent and small international companies. This article analyzes the relationship between a company’s external environment in its country of origin, internal organizational factors and the factors relating to how some technology-based firms (TBFs) internationalize. A survey was applied to Brazilian TBFs. At the end of the data collection period, the first database generated 214 responses. Out of these, 85 (39.7%) were obtained from companies involved in some kind of business abroad. However, only 54 questionnaires were considered valid for this research. The data were analyzed using logistic regression statistical techniques. The results show that external factors influence the internationalization of TBFs more as compared to internal factors. Integration in the value chain and an entrepreneur’s ability to manage internationally are the factors that best distinguish the internationalization of born-global TBFs. Thus, this paper contributes to the discussion of the internationalization process of born-globals and TBFs, filling the gap regarding the importance of external, internal and entrepreneurial factors in these companies’ internationalization processes

Effect of raw sugar cane bagasse on performance and ingestive behavior of beef cattle

Avaliou-se o efeito da utilização do bagaço de cana-de-açúcar in natura (BIN), obtido por dois métodos de extração do açúcar, moagem convencional ou difusão, como fonte de fibra em dietas que continham bagaço tratado sob pressão e vapor (BTPV), como principal fonte de volumoso sobre o desempenho e o comportamento ingestivo de bovinos confinados. Para avaliação do desempenho, foram utilizados 84 machos não castrados das raças Nelore, Canchim e Holandesa, com média de peso inicial de 270kg, distribuídos em delineamento de blocos ao acaso. Para a avaliação do comportamento ingestivo, foram utilizados quatro garrotes da raça Nelore, em delineamento de quadrado latino 4 x 4. Os tratamentos consistiram na substituição do BTPV pelo BIN na matéria seca, constituindo as dietas experimentais: 5% BIN moagem convencional; 5% BIN difusão, 10% BIN difusão e 15% BIN difusão. O consumo de MS foi menor no tratamento com 15% de BIN obtido por difusão (BINdif), em relação ao teor de inclusão de 10%. Não houve diferença (P>0,05) entre os tratamentos para ganho diário de peso, conversão alimentar e peso vivo final entre os tratamentos. Os tempos despendidos com as atividades de ruminação (minutos/kg de MS) e mastigação (minutos/kg de MS ou de FDN) foram maiores (P<0,05) no tratamento com 15% de BINdif na dieta. O BINdif pode ser utilizado como fonte de fibra íntegra em até 15% da MS da dieta sem prejudicar o desempenho dos animais.This study was conducted to evaluate effects of replacing steam pressure treated sugar cane bagasse by two types of raw sugar cane bagasse extracted through grinding or diffusion, on performance and ingestive behavior of beef cattle. Eighty four young bulls (Nelore, Canchim and Holstein) with 270kg of body weight at the beginning of the experiment were used in a randomized block design. Ingestive behavior was evaluated using four Nelore young bulls in a 4 x 4 Latin square design. Treatments were the direct substitution of steam pressure treated sugarcane bagasse by raw bagasse (RB), corresponding to the experimental treatments: 5% RB from grinding; 5% RB from diffusion; 10% RB from diffusion and 15% RB from diffusion. Dry matter intake was lower in treatment with 15% of bagasse obtained by diffusion (BINdif) in comparison to 10% BINdif. There were no differences (P>0.05) among treatments for average daily gain, feed conversion and final live weight. Ruminating time (minutes/kg of DM) and chewing time (minutes/kg of DM or NDF) was greater (P>0.05) when BINdif was added at 15% level to diets. BINdif can be added up to 15% of the dietary DM with no detrimental effect on beef cattle performance

Five-Year Outcome in Stroke Patients Submitted to Thrombolysis

BACKGROUND AND PURPOSE: Little is known on long-term follow-up after thrombolysis in ischemic stroke patients because the majority of studies evaluated outcome at 3 to 12 months. We aimed to assess 5-year outcome after intravenous thrombolysis (IVT). METHODS: Cohort study based on the prospective registry of all consecutive ischemic stroke patients submitted to IVT in our Stroke Unit. Five-year outcome, including living settings, functional outcome, stroke recurrence, and mortality, was ascertained by telephonic interviews and additional review of clinical records. Multivariate analyses were performed to identify predictors of outcome and mortality. Excellent outcome was defined as modified Rankin scale 0 to 1. RESULTS: Five-year outcome was available for 155/164 patients submitted to IVT. At 5 years, 32.9% of patients had an excellent outcome (95% confidence interval (CI) =25.5-43.3) and mortality was 43.9% (95%CI=36.1-51.7). Increasing age (odds ratio =0.93, 95% CI =0.90-0.97) and increasing National Institute of Health Stroke Scale (NIHSS) 24 h after thrombolysis (odds ratio =0.81, 95% CI =0.74-0.90) were independently associated with a lower likelihood of an excellent 5-year outcome. Age (hazards ratio =1.07, 95% CI =1.03-1.11) and excellent functional outcome 3 months after thrombolysis (hazards ratio =0.28, 95%CI=0.12-0.66) were independently associated with mortality during follow-up. CONCLUSIONS: One third of ischemic stroke patients have excellent 5-year outcome after IVT. Younger age, lower NIHSS 24 h after IVT, and excellent 3-month functional outcome are independent predictors of excellent 5-year outcome

Influence of delivery method on neuroprotection by bone marrow mononuclear cell therapy following ventral root reimplantation with fibrin sealant

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOThe present work compared the local injection of mononuclear cells to the spinal cord lateral funiculus with the alternative approach of local delivery with fibrin sealant after ventral root avulsion (VRA) and reimplantation. For that, female adult Lewis rats were divided into the following groups: avulsion only, reimplantation with fibrin sealant; root repair with fibrin sealant associated with mononuclear cells; and repair with fibrin sealant and injected mononuclear cells. Cell therapy resulted in greater survival of spinal motoneurons up to four weeks post-surgery, especially when mononuclear cells were added to the fibrin glue. Injection of mononuclear cells to the lateral funiculus yield similar results to the reimplantation alone. Additionally, mononuclear cells added to the fibrin glue increased neurotrophic factor gene transcript levels in the spinal cord ventral horn. Regarding the motor recovery, evaluated by the functional peroneal index, as well as the paw print pressure, cell treated rats performed equally well as compared to reimplanted only animals, and significantly better than the avulsion only subjects. The results herein demonstrate that mononuclear cells therapy is neuroprotective by increasing levels of brain derived neurotrophic factor (BDNF) and glial derived neurotrophic factor (GDNF). Moreover, the use of fibrin sealant mononuclear cells delivery approach gave the best and more long lasting results.The present work compared the local injection of mononuclear cells to the spinal cord lateral funiculus with the alternative approach of local delivery with fibrin sealant after ventral root avulsion (VRA) and reimplantation. For that, female adult Lewis98113FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO2010/0986-5; 2010/00729-2sem informaçãosem informaçã

Direct spinal ventral root repair following avulsion: effectiveness of a new heterologous fibrin sealant on motoneuron survival and regeneration

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORAxonal injuries at the interface between central and peripheral nervous system, such as ventral root avulsion (VRA), induce important degenerative processes, mostly resulting in neuronal and motor function loss. In the present work, we have compared two different fibrin sealants, one derived from human blood and another derived from animal blood and Crotalus durissus terrificus venom, as a promising treatment for this type of injury. Lewis rats were submitted to VRA (L4-L6) and had the avulsed roots reimplanted to the surface of the spinal cord, with the aid of fibrin sealant. The spinal cords were processed to evaluate neuronal survival, synaptic stability, and glial reactivity, 4 and 12 weeks after lesion. Sciatic nerves were processed to investigate Schwann cell activity by p75(NTR) expression (4 weeks after surgery) and to count myelinated axons and morphometric evaluation (12 weeks after surgery). Walking track test was used to evaluate gait recovery, up to 12 weeks. The results indicate that both fibrin sealants are similarly efficient. However, the snake-derived fibrin glue is a potentially safer alternative for being a biological and biodegradable product which does not contain human blood derivatives. Therefore, the venom glue can be a useful tool for the scientific community due to its advantages and variety of applications.Axonal injuries at the interface between central and peripheral nervous system, such as ventral root avulsion (VRA), induce important degenerative processes, mostly resulting in neuronal and motor function loss. In the present work, we have compared two d2016116FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR2013/04409-02014/06892-3; 300552/2013-9; 310207/2011-8563582/2010-323038.000823/2011-21; 23038.005536/2012-3

The role of potassium channels in the endothelial dysfunction induced by periodontitis

Objective: Periodontitis is associated with endothelial dysfunction, which is clinically characterized by a reduction in endothelium-dependent relaxation. However, we have previously shown that impairment in endothelium-dependent relaxation is transient. Therefore, we evaluated which mediators are involved in endothelium-dependent relaxation recovery. Material and methods: Rats were subjected to ligature-induced experimental periodontitis. Twenty-one days after the procedure, the animals were prepared for blood pressure recording, and the responses to acetylcholine or sodium nitroprusside were obtained before and 30 minutes after injection of a nitric oxide synthase inhibitor (L-NAME), cyclooxygenase inhibitor (Indomethacin, SC-550 and NS- 398), or calcium-dependent potassium channel blockers (apamin plus TRAM- 34). The maxilla and mandible were removed for bone loss analysis. Blood and gingivae were obtained for C-reactive protein (CRP) and myeloperoxidase (MPO) measurement, respectively. Results: Experimental periodontitis induces bone loss and an increase in the gingival MPO and plasmatic CRP. Periodontitis also reduced endothelium-dependent vasodilation, a hallmark of endothelial dysfunction, 14 days after the procedure. However, the response was restored at day 21. We found that endothelium-dependent vasodilation at day 21 in ligature animals was mediated, at least in part, by the activation of endothelial calcium-activated potassium channels. Conclusions: Periodontitis induces impairment in endothelial-dependent relaxation; this impairment recovers, even in the presence of periodontitis. The recovery is mediated by the activation of endothelial calcium-activated potassium channels in ligature animals. Although important for maintenance of vascular homeostasis, this effect could mask the lack of NO, which has other beneficial properties

Selectivity of pre-and post-emergence herbicides to very-early maturing soybean cultivars

The combination of pre- and post-emergence herbicides may affect their selectivity to soybean plants, especially to short-cycle cultivars. The objective of this work was to evaluate the selectivity of pre- and post-emergence herbicides to very-early maturing soybean cultivars. Two field experiments were conducted, one in Mandaguaçu, Paraná (E1) and other in Rio Verde, Goiás (E2), Brazil, using a 4×7 factorial arrangement. The treatments consisted of four pre-emergence herbicide managements (S-metolachlor at 1440 g ha-1, diclosulam at 25.2 g ha-1, sulfentrazone at 300 g ha-1, and no herbicide application); and seven post-emergence herbicide managements (lactofen at 120 g ha-1, chlorimuron-ethyl at 12.5 g ha-1, bentazon at 720 g ha-1, lactofen at 120 g ha-1 + chlorimuron-ethyl at 12.5 g ha-1, glyphosate at 900 g a. e. ha-1, two sequential glyphosate applications at 720 g a. e. ha-1 each, and no herbicide application). The early-maturing soybean cultivars evaluated showed sensitivity to the herbicides used. The combined use of pre- and post-emergence herbicides increased the occurrence of injuries in the plants. Diclosulam and sulfentrazone were the least selective pre-emergence herbicides. All herbicide combinations used affected soybean grain yield in E1; lactofen, chlorimuron, and bentazon presented the least selectivity in E2.The combination of pre- and post-emergence herbicides may affect their selectivity to soybean plants, especially to short-cycle cultivars. The objective of this work was to evaluate the selectivity of pre- and post-emergence herbicides to very-early maturing soybean cultivars. Two field experiments were conducted, one in Mandaguaçu, Paraná (E1) and other in Rio Verde, Goiás (E2), Brazil, using a 4×7 factorial arrangement. The treatments consisted of four pre-emergence herbicide managements (S-metolachlor at 1440 g ha-1, diclosulam at 25.2 g ha-1, sulfentrazone at 300 g ha-1, and no herbicide application); and seven post-emergence herbicide managements (lactofen at 120 g ha-1, chlorimuron-ethyl at 12.5 g ha-1, bentazon at 720 g ha-1, lactofen at 120 g ha-1 + chlorimuron-ethyl at 12.5 g ha-1, glyphosate at 900 g a. e. ha-1, two sequential glyphosate applications at 720 g a. e. ha-1 each, and no herbicide application). The early-maturing soybean cultivars evaluated showed sensitivity to the herbicides used. The combined use of pre- and post-emergence herbicides increased the occurrence of injuries in the plants. Diclosulam and sulfentrazone were the least selective pre-emergence herbicides. All herbicide combinations used affected soybean grain yield in E1; lactofen, chlorimuron, and bentazon presented the least selectivity in E2

Avaliação do desempenho físico entre blocos de adobe com adição de pó de pedra comparados com adições de esterco e serragem

As construções em adobe são realizadas em várias partes do mundo. No entanto, essa tradição construtiva, originada das tradições portuguesas, caiu em desuso no Brasil. Dessa forma, o conhecimento e aprimoramento de técnicas para a confecção e uso do adobe se torna uma solução para alguns dos problemas atuais da construção civil, principalmente por ser um material de baixo impacto ambiental. O objetivo do trabalho foi avaliar as propriedades físico-mecânicas de adobes produzidos com solo do Pantanal Mato-Grossense, com incorporação de outros materiais, sendo uma mistura de solo: esterco: serragem: água (traço em volume de 6: 1: 1: 0,9) e outra de solo: pó de brita: água (traço em volume de 6 :1: 0,9), identificando as influências causadas pelas incorporações. O estudo sobre técnicas de construção vernaculares começou como exercício pedagógico da disciplina de Construções Rurais, no IFMT. A forma de produção e preparação da massa do adobe teve como referência trabalhos de Ferreira et al. (2012), Amaral (2017), Vendramini et al. (2018), entre outros. Os ensaios foram balizados pelas NBR 10836 (ABNT, 2013), NBR 16814 (ABNT, 2020) e NBR 9779 (ABNT, 2012). Concluímos que os tijolos de adobe fabricados e testados com incorporação de pó de brita atenderam às especificações normativas de resistência à compressão, enquanto os tijolos produzidos com esterco e serragem não atingiram o valor de referência. Quanto aos resultados da absorção de água por capilaridade, os valores dos testes demostraram que o material é vulnerável à água e não resiste à saturação por 48 horas consecutivas