Acousto-ultrasonic input-output characterization of unidirectional fiber composite plate by SH waves

A unidirectional fiberglass epoxy composite plate specimen is modelled as a homogeneous transversely isotropic continuum plate medium. Acousto-ultrasonic non-contact input-output characterization by tracing SH waves in the continuum is studied theoretically with a transmitting and receiving transducer located on the same face of the plate. It is found that the directional dependence of the phase velocity of the SH waves travelling in the transversely isotropic medium has a significant effect on the delay time as opposed to the phase velocity of the SH wave travelling in an isotropic medium

Acousto-ultrasonic input-output characterization of unidirectional fiber composite plate by SV waves

A unidirectional fiberglass epoxy compostie specimen is modelled as a homogeneous transversely isotropic continuum plate medium. Acousto-ultrasonic noncontact input-output characterization is studied theoretically with a transmitting and a receiving transducer located on the same face of the plate. The single reflection problem for an incident SV wave at a plane boundary in transversely isotropic medium is analyzed. An obliquely incident SV wave results in a reflected SV wave and a reflected P wave for an angle of incidence of the incident SV wave less than the critical angle. Otherwise, there exists only an SV wave in the medium as the reflected P wave degenerates into a surface wave travelling parallel to the plane boundary. The amplitude ratio of the reflected SV wave is -1 when the angle of incidence is greater than or = the critical angle. The directional dependence of the phase velocity of the SV wave propagating in the transversely isotropic medium has a significant effect on the delay time, as opposed to the directional independence of the phase velocity of a shear wave propagating in an isotropic medium. The displacements associated with the SV wave in the plate and which may be detected by the noncontact receiving transducer are approximated by an asymptotic solution for an infinite transversely isotropic medium subjected to a harmonic point load

Acousto-ultrasonic input-output characterization of unidirectional fiber composite plate by P waves

The single reflection problem for an incident P wave at a stress free plane boundary in a semi-infinite transversely isotropic medium whose isotropic plane is parallel to the plane boundary is analyzed. It is found that an obliquely incident P wave results in a reflected P wave and a reflected SV wave. The delay time for propagation between the transmitting and the receiving transducers is computed as if the P waves were propagating in an infinite half space. The displacements associated with the P waves in the plate and which may be detected by a noncontact NDE receiving transducer are approximated by an asymptotic solution for an infinite transversely isotropic medium subjected to a harmonic point load

Banking Information Success Acceptance: An Empirical Evaluation

Extending the technology acceptance model, we present a two-level analysis to empirically evaluate the acceptance of business information systems in customer-based retail banking.  Utilizing survey data from a representative banking group in a representative international financial center, regression analysis first indicated that end-user satisfaction, usage and acceptance depend significantly on the system’s perceived usefulness, perceived ease of use and expected ability to meet customer information requirements. In turn, these perceptual-anticipatory considerations were found to be positively and significantly affected by technical-functional factors in the form of user-friendliness and system reliability.  For the corporate strategist, our empirical results suggest enhancing perceived ease of use, perceived usefulness and ability to meet customer information needs in order of importance when introducing or up-grading information systems in retail banking and other service-based business activities

ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3

ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor. Our previous study showed that ARHI can interact with transcription activator Stat3 and inhibit its nuclear translocation in human breast and ovarian cancer cells. To identify proteins that interact with ARHI in nuclear translocation, we have performed proteomic analysis and identified several importins that can associate with ARHI. To further explore this novel finding, we have purified 10 GST-importin fusion proteins (importin 7, 8, 13, b1, a1, a3, a5, a6, a7 as well as mutant a1). Using a GST-pull down assay, we found that ARHI can bind strongly to most importins; however, its binding is significantly reduced with an importin a1 mutant which contains an altered nuclear localization signal (NLS) domain. In addition, an ARHI N-terminal deletion mutant (NTD) exhibits much less binding to all importins than does wild type ARHI ARHI and NTD proteins were purified and tested for their ability to inhibit nuclear importation of proteins in HeLa cells. ARHI protein inhibits interaction of Ran-importin complexes with GFP fusion proteins that contain an NLS domain and a beta-like import receptor binding domain, blocking their nuclear localization. Addition of ARHI also blocked nuclear localization of phosphorylated Stat3β. By GST-pull down assays, we found that ARHI could compete for Ran-importins binding. Thus, ARHI-induced disruption of importin binding to cargo proteins including Stat3 could serve as an important regulatory mechanism that contributes to the tumor suppressor function of ARHI

Evaluation of a multiplexed bead assay for assessment of Epstein-Barr virus immunologic status

Currently, serological assays using either indirect immunofluorescence assay or enzyme-linked immunosorbent assay (ELISA) are performed to evaluate the status of Epstein-Barr virus (EBV) infection in humans. Although these methods are reliable, they are limited to testing an antibody response to a single viral antigen per reaction, thus necessitating a panel of assays to complete the evaluation. In contrast, a new bead-based method (BioPlex 2200; Bio-Rad Laboratories, Hercules, Calif.) can analyze the humoral response to multiple antigens in a single tube. This approach potentially reduces overall cost, turnaround time, and sample volume. The aim of this study was to evaluate the multiplexed EBV serologic assays performed on the BioPlex 2200 platform compared to results of conventional heterophile and ELISA-based assays. A total of 167 nonconsecutive, stored serum samples from adult and pediatric patients submitted for EBV serologic studies were used in the evaluation. Concordance between results generated by the BioPlex 2200 system and conventional assays was calculated. The anti-EA-D assay had the lowest concordance at 91%. The BioPlex 2200 system showed 97% agreement with conventional heterophile and anti-nuclear antigen assays and 92% agreement with the anti-VCA IgG and immunoglobulin M assays. Agreement between the BioPlex 2200 system and conventional testing was 92% with respect to categorization of acute versus nonacute EBV disease. The correlation between these two systems with regard to assignment into one of four categories of EBV status was also good (82%). In summary, there is excellent correlation between contemporary EBV serologic testing and the BioPlex 2200 system

Gestational Weight Gain: How to “Institute” New Guidelines

Presented as part of the Senior Scholars Program at the University of Massachusetts Medical School, May 3, 2010

Thermodynamic Properties of Holographic Multiquark and the Multiquark Star

We study thermodynamic properties of the multiquark nuclear matter. The dependence of the equation of state on the colour charges is explored both analytically and numerically in the limits where the baryon density is small and large at fixed temperature between the gluon deconfinement and chiral symmetry restoration. The gravitational stability of the hypothetical multiquark stars are discussed using the Tolman-Oppenheimer-Volkoff equation. Since the equations of state of the multiquarks can be well approximated by different power laws for small and large density, the content of the multiquark stars has the core and crust structure. We found that most of the mass of the star comes from the crust region where the density is relatively small. The mass limit of the multiquark star is determined as well as its relation to the star radius. For typical energy density scale of $10\text{GeV}/\text{fm}^{3}$, the converging mass and radius of the hypothetical multiquark star in the limit of large central density are approximately $2.6-3.9$ solar mass and 15-27 km. The adiabatic index and sound speed distributions of the multiquark matter in the star are also calculated and discussed. The sound speed never exceeds the speed of light and the multiquark matters are thus compressible even at high density and pressure.Comment: 27 pages, 17 figures, 1 table, JHEP versio