Corrective factors for adjusting weaning weights of beef calves to a standard age

The purpose of this work is to develop correction factors for adjusting weaning weights of calves to a constant age and sex basis. Development of a method of adjusting weaning weights to a standard age should greatly enhance the value of calf weights in experimental work

An examination of the relationship between cool season tornadoes and cloud-to-ground lightning flashes

The southeast United States is prone to severe weather throughout the year. Despite technological advances, some severe weather events occasionally remain unwarned in this part of the country. Past studies examined the relationship between cloud-to-ground (CG) lightning and warm season severe weather episodes. The present study examined the relationship between cool season tornadoes and CG lightning, with a focus over the southeastern United States, where most cool season tornadoes occur. Data from the Storm Prediction Center and National Lightning Detection Network (NLDN) were used to investigate CG lightning properties within 50 km and one hour before tornado touchdown. This was completed over a period of 13 cool seasons from October 1989 through March 2002. Of 3325 tornado events, 2358 contained at least one NLDN-detectable flash. CG lightning attributes of peak current, multiplicity, and flash density compared well with those of prior warm season lightning research. Overall event frequency appeared to be lower than in the warm season. Almost all Central Plains events were accompanied by at least one NLDN-detectable flash. Up to 70% of tornado events near the Gulf of Mexico and Atlantic coasts contained no NLDN-detectable lightning. Although it is not known why this trend was observed, it is speculated that NLDN detection efficiency and/or storm structure differences may play a role in these observations. Warm season studies have correlated tornadoes with predominantly positive (>50% positive CG lightning), or PPCG storms. Gridded maps showed the greatest percentage and highest frequency of cool season PPCG storms across Kansas and Nebraska, with up to 70% of events associated with PPCG lightning. A secondary, albeit lower, frequency maximum extended 1ð to 2ð inland across Louisiana into North Carolina. This study also subjectively defined a storm with âÂÂenhancedâ positive cloud-to-ground (EPCG) lightning as one containing >25% positive cloud-to-ground lightning, which corresponds to approximately the 75th percentile of all cool season tornadoes. This has lead to speculation that EPCG criterion may be a better indicator of the possibility of severe weather than the traditional PPCG criterion

INSPIRE: A phase III study of the BLP25 liposome vaccine (L-BLP25) in Asian patients with unresectable stage III non-small cell lung cancer

<p>Abstract</p> <p>Background</p> <p>Previous research suggests the therapeutic cancer vaccine L-BLP25 potentially provides a survival benefit in patients with locally advanced unresectable stage III non-small cell lung carcinoma (NSCLC). These promising findings prompted the phase III study, INSPIRE, in patients of East-Asian ethnicity. East-Asian ethnicity is an independent favourable prognostic factor for survival in NSCLC. The favourable prognosis is most likely due to a higher incidence of EGFR mutations among this patient population.</p> <p>Methods/design</p> <p>The primary objective of the INSPIRE study is to assess the treatment effect of L-BLP25 plus best supportive care (BSC), as compared to placebo plus BSC, on overall survival time in East-Asian patients with unresectable stage III NSCLC and either documented stable disease or an objective response according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria following primary chemoradiotherapy. Those in the L-BLP25 arm will receive a single intravenous infusion of cyclophosphamide (300 mg/m²) 3 days before the first L-BLP25 vaccination, with a corresponding intravenous infusion of saline to be given in the control arm. A primary treatment phase of 8 subcutaneous vaccinations of L-BLP25 930 μg or placebo at weekly intervals will be followed by a maintenance treatment phase of 6-weekly vaccinations continued until disease progression or discontinuation from the study.</p> <p>Discussion</p> <p>The ongoing INSPIRE study is the first large study of a therapeutic cancer vaccine specifically in an East-Asian population. It evaluates the potential of maintenance therapy with L-BLP25 to prolong survival in East-Asian patients with stage III NSCLC where there are limited treatment options currently available.</p> <p>Study number</p> <p>EMR 63325-012</p> <p>Trial Registration</p> <p>Clinicaltrials.gov reference: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01015443">NCT01015443</a></p

Vortex precession in Bose-Einstein condensates: observations with filled and empty cores

We have observed and characterized the dynamics of singly quantized vortices in dilute-gas Bose-Einstein condensates. Our condensates are produced in a superposition of two internal states of 87Rb, with one state supporting a vortex and the other filling the vortex core. Subsequently, the state filling the core can be partially or completely removed, reducing the radius of the core by as much as a factor of 13, all the way down to its bare value. The corresponding superfluid rotation rates, evaluated at the core radius, vary by a factor of 150, but the precession frequency of the vortex core about the condensate axis changes by only a factor of two.Comment: 4 pages, 3 figure

The amphioxus genome and the evolution of the chordate karyotype

Lancelets ('amphioxus') are the modern survivors of an ancient chordate lineage, with a fossil record dating back to the Cambrian period. Here we describe the structure and gene content of the highly polymorphic approx520-megabase genome of the Florida lancelet Branchiostoma floridae, and analyse it in the context of chordate evolution. Whole-genome comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also partial reconstruction of its genomic organization, as well as a description of two genome-wide duplications and subsequent reorganizations in the vertebrate lineage. These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution

Seasonal changes in patterns of gene expression in avian song control brain regions.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Photoperiod and hormonal cues drive dramatic seasonal changes in structure and function of the avian song control system. Little is known, however, about the patterns of gene expression associated with seasonal changes. Here we address this issue by altering the hormonal and photoperiodic conditions in seasonally-breeding Gambel's white-crowned sparrows and extracting RNA from the telencephalic song control nuclei HVC and RA across multiple time points that capture different stages of growth and regression. We chose HVC and RA because while both nuclei change in volume across seasons, the cellular mechanisms underlying these changes differ. We thus hypothesized that different genes would be expressed between HVC and RA. We tested this by using the extracted RNA to perform a cDNA microarray hybridization developed by the SoNG initiative. We then validated these results using qRT-PCR. We found that 363 genes varied by more than 1.5 fold (>log(2) 0.585) in expression in HVC and/or RA. Supporting our hypothesis, only 59 of these 363 genes were found to vary in both nuclei, while 132 gene expression changes were HVC specific and 172 were RA specific. We then assigned many of these genes to functional categories relevant to the different mechanisms underlying seasonal change in HVC and RA, including neurogenesis, apoptosis, cell growth, dendrite arborization and axonal growth, angiogenesis, endocrinology, growth factors, and electrophysiology. This revealed categorical differences in the kinds of genes regulated in HVC and RA. These results show that different molecular programs underlie seasonal changes in HVC and RA, and that gene expression is time specific across different reproductive conditions. Our results provide insights into the complex molecular pathways that underlie adult neural plasticity

Reducing Violence Without Police: A Review of Research Evidence

Arnold Ventures sought to review the research evidence for violence reduction strategies that do not rely on law enforcement. The John Jay College Research and Evaluation Center (JohnJayREC) and an expert group of researchers from public policy, criminology, law, public health, and social science fields conducted the scan. The research group members worked collaboratively to identify, translate, and summarize the most critical and actionable studies

Strengths and Weaknesses of Immunotherapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis of 12 Randomized Controlled Trials

Background: Lung cancer is one of the leading causes of cancer death worldwide. Non-small-cell lung cancer (NSCLC) accounts for approximately 85 % of all lung cancers. Immunotherapy has yielded no consistent benefit to date for those patients. Assessing the objective efficacy and safety of immunotherapy for advanced NSCLC patients will help to instruct the future development of immunotherapeutic drugs. Methodology and Principal Findings: We performed a meta-analysis of 12 randomized controlled trials including 3134 patients (1570 patients in the immunotherapy group and 1564 patients in the control group) with histologically confirmed stage IIIA, IIIB, or IV NSCLC. The analysis was executed with efficacy end points regarding overall survival (OS), progressionfre