A technical framework to describe occupant behavior for building energy simulations

ABSTRACT Green buildings that fail to meet expected design performance criteria indicate that technology alone does not guarantee high performance. Human influences are quite often simplified and ignored in the design, construction, and operation of buildings. Energy-conscious human behavior has been demonstrated to be a significant positive factor for improving the indoor environment while reducing the energy use of buildings. In our study we developed a new technical framework to describe energyrelated human behavior in buildings. The energy-related behavior includes accounting for individuals and groups of occupants and their interactions with building energy services systems, appliances and facilities. The technical framework consists of four key components: i. the drivers behind energy-related occupant behavior, which are biological, societal, environmental, physical, and economical in nature ii. the needs of the occupants are based on satisfying criteria that are either physical (e.g. thermal, visual and acoustic comfort) or non-physical (e.g. entertainment, privacy, and social reward) iii. the actions that building occupants perform when their needs are not fulfilled iv. the systems with which an occupant can interact to satisfy their needs The technical framework aims to provide a standardized description of a complete set of human energyrelated behaviors in the form of an XML schema. For each type of behavior (e.g., occupants opening/closing windows, switching on/off lights etc.) we identify a set of common behaviors based on a literature review, survey data, and our own field study and analysis. Stochastic models are adopted or developed for each type of behavior to enable the evaluation of the impact of human behavior on energy use in buildings, during either the design or operation phase. We will also demonstrate the use of the technical framework in assessing the impact of occupancy behavior on energy saving technologies. The technical framework presented is part of our human behavior research, a 5-year program under the

On the nature of the high-energy rollover in 1H 0419-577

A NuSTAR/Swift observation of the luminous Seyfert 1 galaxy 1H 0419-577 taken during 2015 reveals one of the most extreme high-energy cut-offs observed to date from an AGN – an origin due to thermal Comptonization would imply a remarkably low coronal temperature kT ∼ 15 keV. The low-energy peak of the spectrum in the hard X-ray NuSTAR band, which peaks before the expected onset of a Compton hump, rules out strong reflection as the origin of the hard excess in this AGN. We show the origin of the high-energy rollover is likely due to a combination of both thermal Comptonization and an intrinsically steeper continuum, which is modified by absorption at lower energies. Furthermore, modelling the broad-band XUV continuum shape as a colour-corrected accretion disc, requires the presence of a variable warm absorber to explain all flux and spectral states of the source, consistent with the previous work on this AGN. While absorber variations produce marked spectral variability in this AGN, consideration of all flux states allows us to isolate a colourless component of variability that may arise from changes in the inner accretion flow, typically at around 10 rg

Time evolution of methotrexate-induced kidney injury: A comparative study between different biomarkers of renal damage in rats

Methotrexate (MTX) is commonly used in the treatment of malignant diseases and autoimmune and chronic inflammatory disorders. Along with its effective therapeutic power, MTX has adverse effects on the kidneys. Discovery of new biomarkers is required to improve the early detection of renal damage and optimize the effectiveness of treatments. The aim of this study was to evaluate the time course of MTX-induced nephrotoxicity and to compare the urinary excretion of the organic anion transporter 5 (uOat5) with alterations in other markers of renal function, and to elucidate the possible molecular mechanisms involved in uOat5. Animals were exposed to a unique dose of MTX (80 mg/kg body weight, intraperitoneal). Experiments were carried out at days 2, 4, 8 or 14 after MTX administration. Markers of renal damage, such as creatinine and urea plasma levels, urinary activity of alkaline phosphatase, microalbuminuria, urinary excretion of neutrophil gelatinase-associated lipocalin (uNGAL) and histopathology, were evaluated. Renal organic anion transporter 5 (Oat5) expression and its presence in different urine fraction were assessed by western blotting. uOat5 was significantly increased 2 days after MTX treatment, before than any alteration in other parameters of kidney injury or renal morphology occurred. uNGAL showed an inverted pattern of urinary excretion compared to uOat5. Exosomal pathway is involved in the urinary excretion of Oat5 and depends on the degree of damage induced by MTX. These experimental data allow proposing uOat5 as a potential non-invasive biomarker for early detection of MTX-induced nephrotoxicity.Fil: Severin, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmaceuticas. Departamento de Ciencias Fisiológicas. Area Farmacología; ArgentinaFil: Campagno, Romina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmaceuticas. Departamento de Ciencias Fisiológicas. Area Farmacología; ArgentinaFil: Brandoni, Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmaceuticas. Departamento de Ciencias Fisiológicas. Area Farmacología; ArgentinaFil: Torres, Adriana Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmaceuticas. Departamento de Ciencias Fisiológicas. Area Farmacología; Argentin

A deep X-ray view of the bare AGN Ark 120. I. Revealing the Soft X-ray Line Emission

The Seyfert 1 galaxy, Ark 120, is a prototype example of the so-called class of bare nucleus AGN, whereby there is no known evidence for the presence of ionized gas along the direct line of sight. Here deep ($>400$ ks exposure), high resolution X-ray spectroscopy of Ark 120 is presented, from XMM-Newton observations which were carried out in March 2014, together with simultaneous Chandra/HETG exposures. The high resolution spectra confirmed the lack of intrinsic absorbing gas associated with Ark 120, with the only X-ray absorption present originating from the ISM of our own Galaxy, with a possible slight enhancement of the Oxygen abundance required with respect to the expected ISM values in the Solar neighbourhood. However, the presence of several soft X-ray emission lines are revealed for the first time in the XMM-Newton RGS spectrum, associated to the AGN and arising from the He and H-like ions of N, O, Ne and Mg. The He-like line profiles of N, O and Ne appear velocity broadened, with typical FWHM widths of $\sim5000$ km s$^{-1}$, whereas the H-like profiles are unresolved. From the clean measurement of the He-like triplets, we deduce that the broad lines arise from gas of density $n_{\rm e}\sim10^{11}$ cm$^{-3}$, while the photoionization calculations infer that the emitting gas covers at least 10 percent of $4\pi$ steradian. Thus the broad soft X-ray profiles appear coincident with an X-ray component of the optical-UV Broad Line Region on sub-pc scales, whereas the narrow profiles originate on larger pc scales, perhaps coincident with the AGN Narrow Line Region. The observations show that Ark 120 is not intrinsically bare and substantial X-ray emitting gas exists out of our direct line of sight towards this AGN

The Suzaku view of highly-ionised outflows in AGN: II -- Location, energetics and scalings with Bolometric Luminosity

Ongoing studies with XMM-Newton have shown that powerful accretion disc winds, as revealed through highly-ionised Fe\,K-shell absorption at E>=6.7 keV, are present in a significant fraction of Active Galactic Nuclei (AGN) in the local Universe (Tombesi et al. 2010). In Gofford et al. (2013) we analysed a sample of 51 Suzaku-observed AGN and independently detected Fe K absorption in ~40% of the sample, and we measured the properties of the absorbing gas. In this work we build upon these results to consider the properties of the associated wind. On average, the fast winds (v_out>0.01c) are located ~10^{15-18} cm (typically ~10^{2-4} r_s) from their black hole, their mass outflow rates are of the order ~0.01-1 Msun/yr or ~(0.01-1) M_edd and kinetic power is constrained to ~10^{43-45} erg/s, equivalent to ~(0.1-10%) L_edd. We find a fundamental correlation between the source bolometric luminosity and the wind velocity, with v_out \propto L_bol^{\alpha} and \alpha=0.4^{+0.3}_{-0.2}$ (90% confidence), which indicates that more luminous AGN tend to harbour faster Fe K winds. The mass outflow rate M_out, kinetic power L_k and momentum flux P_out of the winds are also consequently correlated with L_bol, such that more massive and more energetic winds are present in more luminous AGN. We investigate these properties in the framework of a continuum-driven wind, showing that the observed relationships are broadly consistent with a wind being accelerated by continuum-scattering. We find that, globally, a significant fraction (~85%) of the sample can plausibly exceed the L_k/L_bol~0.5% threshold thought necessary for feedback, while 45% may also exceed the less conservative ~5% of L_bol threshold as well. This suggests that the winds may be energetically significant for AGN--host-galaxy feedback processes

An XMM-Newton observation of the extreme Narrow Line Seyfert 1 Galaxy, Mrk 359

We present XMM-Newton observations of Mrk 359, the first Narrow Line Seyfert 1 galaxy discovered. Even among NLS1s, Mrk 359 is an extreme case with extraordinarily narrow optical emission lines. The XMM-Newton data show that Mrk 359 has a significant soft X-ray excess which displays only weak absorption and emission features. The (2-10) keV continuum, including reflection, is flatter than the typical NLS1, with Gamma approximately 1.84. A strong emission line of equivalent width approximately 200 eV is also observed, centred near 6.4 keV. We fit this emission with two line components of approximately equal strength: a broad iron-line from an accretion disc and a narrow, unresolved core. The unresolved line core has an equivalent width of approximately 120 eV and is consistent with fluorescence from neutral iron in distant reprocessing gas, possibly in the form of a `molecular torus'. Comparison of the narrow-line strengths in Mrk 359 and other low-moderate luminosity Seyfert 1 galaxies with those in QSOs suggests that the solid angle subtended by the distant reprocessing gas decreases with increasing AGN luminosity.Comment: Accepted for publication in MNRA

High Resolution X-ray Spectroscopy of the Seyfert 1, Mrk 1040. Revealing the Failed Nuclear Wind with Chandra

High resolution X-ray spectroscopy of the warm absorber in the nearby X-ray bright Seyfert 1 galaxy, Mrk 1040 is presented. The observations were carried out in the 2013-2014 timeframe using the Chandra High Energy Transmission Grating with a total exposure of 200 ks. A multitude of absorption lines from Ne, Mg and Si are detected from a wide variety of ionization states. In particular, the detection of inner K-shell absorption lines from Ne, Mg and Si, from charge states ranging from F-like to Li-like ions, suggests the presence of a substantial amount of low ionization absorbing gas, illuminated by a steep soft X-ray continuum. The observations reveal at least 3 warm absorbing components ranging in ionization parameter from $\log\xi = 0-2$ and with column densities of $N_{\rm H} =1.5-4.0 \times 10^{21}$cm$^{-2}$. The velocity profiles imply that the outflow velocities of the absorbing gas are low and within $\pm100$ km s$^{-1}$ of the systemic velocity of Mrk 1040, which suggests any outflowing gas may have stalled in this AGN on large enough scales. The warm absorber is likely located far from the black hole, within 300 pc of the nucleus and is spatially coincident with emission from an extended Narrow Line Region as seen in the HST images. The iron K band spectrum reveals only narrow emission lines, with Fe K$\alpha$ at 6.4 keV consistent with originating from reflection off Compton thick pc-scale reprocessing gas

Evidence-informed health policy: are we beginning to get there at last

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Combinatorial RNA Design: Designability and Structure-Approximating Algorithm

In this work, we consider the Combinatorial RNA Design problem, a minimal instance of the RNA design problem which aims at finding a sequence that admits a given target as its unique base pair maximizing structure. We provide complete characterizations for the structures that can be designed using restricted alphabets. Under a classic four-letter alphabet, we provide a complete characterization of designable structures without unpaired bases. When unpaired bases are allowed, we provide partial characterizations for classes of designable/undesignable structures, and show that the class of designable structures is closed under the stutter operation. Membership of a given structure to any of the classes can be tested in linear time and, for positive instances, a solution can be found in linear time. Finally, we consider a structure-approximating version of the problem that allows to extend bands (helices) and, assuming that the input structure avoids two motifs, we provide a linear-time algorithm that produces a designable structure with at most twice more base pairs than the input structure.Comment: CPM - 26th Annual Symposium on Combinatorial Pattern Matching, Jun 2015, Ischia Island, Italy. LNCS, 201