Architecture as Public Policy. The Role and Effectiveness of National Architectural Policies in the European Union: the cases of Ireland, Scotland and The Netherlands.

Since the beginning of the 1990s, a growing number of European countries have been developing national policies on Architecture. Reflecting the wide diversity of cultures across the EU, some member states have adopted comprehensive policies setting up a wide range of initiatives while others have approved national legislation addressed to clients and stakeholders or created cultural institutions. Despite their differences, all the approaches share the will to promote well-designed living environments. Hosting these concerns, the EU Council adopted a Resolution on Architectural Quality in 2001, encouraging the member states to promote architecture and urban design as a way to achieve high-quality environments. However, some member states remain sceptical and even suspicious about the effectiveness of a formal policy on Architecture and prefer not to follow this trend without further evidence. In the face of this phenomenon, it is relevant to clarify the role of a national Architectural policy and if it really enhances the role of the state in promoting better places. Following an inductive research strategy, the main objective of this research is to improve the understanding of the role and effectiveness of national Architecture policies in processes of design governance. The research will start by examining to what extent the adoption of formal Architecture policies by the member states has been influenced by an Europeanization process. Then it will explore the comprehensive Architecture policies discourse to uncover the main values and ideas that underlie a formal policy in this domain. Finally, this research will seek to evaluate the effectiveness of a formal Architecture policy through a comparative analysis of current practices among three EU member states: Ireland, Scotland and the Netherlands. In sum, this research is a theorization of Architecture as public policy, a methodology for the study of this phenomenon and a comparative study of national Architecture policies

Plasma Calcium, Inorganic Phosphate and Magnesium During Hypocalcaemia Induced by a Standardized EDTA Infusion in Cows

The intravenous Na2EDTA infusion technique allows effective specific chelation of circulating Ca2+ leading to a progressive hypocalcaemia. Methods previously used were not described in detail and results obtained by monitoring total and free ionic calcium were not comparable due to differences in sampling and analysis. This paper describes a standardized EDTA infusion technique that allowed comparison of the response of calcium, phosphorus and magnesium between 2 groups of experimental cows. The concentration of the Na2EDTA solution was 0.134 mol/l and the flow rate was standardized at 1.2 ml/kg per hour. Involuntary recumbency occurred when ionised calcium dropped to 0.39 – 0.52 mmol/l due to chelation. An initial fast drop of ionized calcium was observed during the first 20 min of infusion followed by a fluctuation leading to a further drop until recumbency. Pre-infusion [Ca2+] between tests does not correlate with the amount of EDTA required to induce involuntary recumbence. Total calcium concentration measured by atomic absorption remained almost constant during the first 100 min of infusion but declined gradually when the infusion was prolonged. The concentration of inorganic phosphate declined gradually in a fluctuating manner until recumbency. Magnesium concentration remained constant during infusion. Such electrolyte responses during infusion were comparable to those in spontaneous milk fever. The standardized infusion technique might be useful in future experimental studies

Digital dual-rate burst-mode receiver for 10G and 1G coexistence in optical access networks

A digital dual-rate burst-mode receiver, intended to support 10 and 1 Gb/s coexistence in optical access networks, is proposed and experimentally characterized. The receiver employs a standard DC-coupled photoreceiver followed by a 20 GS/s digitizer and the detection of the packet presence and line-rate is implemented in the digital domain. A polyphase, 2 samples-per-bit digital signal processing algorithm is then used for efficient clock and data recovery of the 10/1.25 Gb/s packets. The receiver performance is characterized in terms of sensitivity and dynamic range under burst-mode operation for 10/1.25 Gb/s intensity modulated data in terms of both the packet error rate (PER) and the payload bit error rate (pBER). The impact of packet preamble lengths of 16, 32, 48, and 64 bits, at 10 Gb/s, on the receiver performance is investigated. We show that there is a trade-off between pBER and PER that is limited by electrical noise and digitizer clipping at low and high received powers, respectively, and that a 16/2-bit preamble at 10/1.25 Gb/s is sufficient to reliably detect packets at both line-rates over a burst-to-burst dynamic range of 14,5dB with a sensitivity of -18.5dBm at 10 Gb/s. (C)2011 Optical Society of Americ

Kidney transplants in mice. An analysis of the immune status of mice bearing long-term, H-2 incompatible transplants

Kidney transplants between strains of mice which are incompatible at either the K or the D end of the H-2 complex usually function for prolonged periods supporting the lives of nephrectomized recipients. This occurs with no recipient treatment. With multiple H-2 and non-H-2 determined incompatibilities, transplants may be rejected but more slowly than skin grafts. In the strain combination studied most extensively in these experiments (B10.D2 to B6AF(1)) in which the incompatibility was confined to the K end of the H-2 region, about 70 percent of recipients survived for many weeks with normal blood urea nitrogen levels. Skin grafts between untreated members of these strains were rejected promptly (mean survival time of 13.5 +/- 1.1 days) as were kidney transplants to recipients of prior skin grafts. Donor strain skin grafts to recipients of kidney transplants after kidney transplantation enjoyed greatly prolonged survival whereas skin grafts from a third party (A.SW) were rejected normally. If kidney tissue was transferred in the form of free grafts without primary vascular union, it was rejected promptly leaving its recipient highly immunized. Cellular and humoral immunity to donor antigens declined over the first few weeks after transplantation, and the spleens of long-term recipients contained no “killer cells.” Recipient lymphoid cells could mount active graft versus host reactions to donor strain antigens on transfer to neonatal mice. Nevertheless, they were distinctly less able to respond specifically by the production of killer cells to donor strain antigens after sensitization in vitro. No evidence that this defect was associated with the presence of suppressor cells was forthcoming from several types of in vivo and in vitro tests

When Kinks Come to Life: An Exploration of Paraphilic Concordance and Underlying Mediators

Paraphilia is defined as a condition in which sexual excitement relies on fantasizing about and / or participating in unusual sexual behavior. Although recent studies have assessed the concordance between paraphilic interests and paraphilic behaviors, few studies have studied which individual traits and demographics predict engaging in paraphilic behaviors, or indeed, the level of concordance between arousal and behavior. The current study replicated and expanded Joyal and Carpentier (2022). We assessed concordance between paraphilic arousal and behavior. Further, we assessed the impact of Dark Tetrad traits, impulsivity, social desirability and demographic variables on engaging in paraphilic behaviors using self-report questionnaires in a sample from the general population and FetLife. Finally, we were interested in whether these individual differences moderated the concordance between arousal and behavior. Results indicated high concordance between paraphilic arousal and behavior for all paraphilias except pedophilia and hebephilia. Younger, male participants showed higher were more likely to engage in various paraphilias than women and older participants. Machiavellianism was linked with lower paraphilic behavior, particularly impulsive or risky ones. Psychopathy predicted engaging in more deviant or illegal paraphilias, whereas sadism only showed an association for engaging in frotteurism and narcissism was not a predictor for engaging in any paraphilia. For several paraphilias, individual traits moderated the effect of arousal on behavior. Implications of these findings and future directions are discussed

Effect of Anionic Salt and Highly Fermentable Carbohydrate Supplementations on Urine pH and on Experimentally Induced Hypocalcaemia in Cows

The objective of this experiment was to determine the effect of dietary grain on calcium homeostasis. Six rumen-fistulated dairy cows with 3 or more previous lactations and no history of parturient paresis were randomly assigned to a sequence of diets in a crossover study with 4 periods of 10 days each. Dietary treatments were: A control ration consisting of wrap grass silage alone (1), the control ration supplemented with ammonium chloride and ammonium sulphate salt solution (2), control ration following a period with supplementation (3) and control ration supplemented with increasing amounts of barley from 4 to 10 kg/cow per day, expected to produce subclinical rumen acidosis (4). Daily intake of the diets was adjusted to 14 kg DM/cow per day. On day 11, the calcium-regulating mechanisms in cows were challenged until recumbency by a standardized intravenous EDTA infusion and cows were left to recover spontaneously. Anion supplementation and the feeding of highly fermentable carbohydrate lowered urine pH below 7.0 due to subclinical acidosis. During spontaneous recovery from EDTA induced hypocalcaemia, the cows more quickly regained a whole blood free calcium concentration of 1.00 mmol/L if they had most recently been supplemented with either anionic salts or with increasing amounts of barley, as compared to the basic ration. It is concluded that so-called slug-feeding or 'steaming up' with highly fermentable carbohydrates before parturition in milk fever susceptible cows enhanced calcium homeostasis similar to the effect seen in cows on anionic diets

Dynamical cluster disruption and its implications for multiple population models in the E-MOSAICS simulations

© 2018 The Author(s). Published by Oxford University Press on behalf of the Royal Astronomical Society. Several models have been advanced to explain the multiple stellar populations observed in globular clusters (GCs). Most models necessitate a large initial population of unenriched stars that provide the pollution for an enriched population, and which are subsequently lost from the cluster. This scenario generally requires clusters to lose > 90 per cent of their birth mass. We use a suite of 25 cosmological zoom-in simulations of present-day Milky Way mass galaxies from the E-MOSAICS project to study whether dynamical disruption by evaporation and tidal shocking provides the necessary mass-loss. We find that GCs with present-day masses M > 105M⊙were only 2-4 times more massive at birth, in conflict with the requirements of the proposed models. This factor correlates weakly with metallicity, gas pressure at birth, or galactocentric radius, but increases towards lower GC masses. To reconcile our results with observational data, either an unphysically steep cluster mass-size relation must be assumed, or the initial enriched fractions must be similar to their present values. We provide the required relation between the initial enriched fraction and cluster mass. Dynamical cluster mass-loss cannot reproduce the high observed enriched fractions nor their trend with cluster mass