7,794 research outputs found
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs.
We studied the actions of geldanamycin (GA) and herbimycin A (HMA), inhibitors of the chaperone proteins Hsp90 and GRP94, on B chronic lymphocytic leukemia (CLL) cells in vitro. Both drugs induced apoptosis of the majority of CLL isolates studied. Whereas exposure to 4-hour pulses of 30 to 100 nM GA killed normal B lymphocytes and CLL cells with similar dose responses, T lymphocytes from healthy donors as well as those present in the CLL isolates were relatively resistant. GA, but not HMA, showed a modest cytoprotective effect toward CD34+ hematopoietic progenitors from normal bone marrow. The ability of bone marrow progenitors to form hematopoietic colonies was unaffected by pulse exposures to GA. Both GA and HMA synergized with chlorambucil and fludarabine in killing a subset of CLL isolates. GA- and HMA-induced apoptosis was preceded by the up-regulation of the stress-responsive chaperones Hsp70 and BiP. Both ansamycins also resulted in down-regulation of Akt protein kinase, a modulator of cell survival. The relative resistance of T lymphocytes and of CD34+ bone marrow progenitors to GA coupled with its ability to induce apoptosis following brief exposures and to synergize with cytotoxic drugs warrant further investigation of ansamycins as potential therapeutic agents in CLL
A modified ant colony optimization algorithm modeled on tabu-search methods
Author name used in this publication: S. L. Ho2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
A self-learning simulated annealing algorithm for global optimizations of electromagnetic devices
Author name used in this publication: S. L. Ho2000-2001 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
A combined wavelet-element free Galerkin method for numerical calculations of electromagnetic fields
Author name used in this publication: S. L. HoAuthor name used in this publication: J. M. Machado2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
A new implementation of population based incremental learning method for optimizations in electromagnetics
Author name used in this publication: S. L. Ho2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
New differential equations for on-shell loop integrals
We present a novel type of differential equations for on-shell loop
integrals. The equations are second-order and importantly, they reduce the loop
level by one, so that they can be solved iteratively in the loop order. We
present several infinite series of integrals satisfying such iterative
differential equations. The differential operators we use are best written
using momentum twistor space. The use of the latter was advocated in recent
papers discussing loop integrals in N=4 super Yang-Mills. One of our
motivations is to provide a tool for deriving analytical results for scattering
amplitudes in this theory. We show that the integrals needed for planar MHV
amplitudes up to two loops can be thought of as deriving from a single master
topology. The master integral satisfies our differential equations, and so do
most of the reduced integrals. A consequence of the differential equations is
that the integrals we discuss are not arbitrarily complicated transcendental
functions. For two specific two-loop integrals we give the full analytic
solution. The simplicity of the integrals appearing in the scattering
amplitudes in planar N=4 super Yang-Mills is strongly suggestive of a relation
to the conjectured underlying integrability of the theory. We expect these
differential equations to be relevant for all planar MHV and non-MHV
amplitudes. We also discuss possible extensions of our method to more general
classes of integrals.Comment: 39 pages, 8 figures; v2: typos corrected, definition of harmonic
polylogarithms adde
An improved tabu-based vector optimal algorithm for design optimizations of electromagnetic devices
Author name used in this publication: S. Y. YangAuthor name used in this publication: S. L. HoAuthor name used in this publication: J. M. MachadoAuthor name used in this publication: Edward W. C. Lo2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Wavelet-Galerkin method for computations of electromagnetic fields-computation of connection coefficients
Author name used in this publication: S. L. HoAuthor name used in this publication: H. C. Wong2000-2001 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
From Correlators to Wilson Loops in Chern-Simons Matter Theories
We study n-point correlation functions for chiral primary operators in three
dimensional supersymmetric Chern-Simons matter theories. Our analysis is
carried on in N=2 superspace and covers N=2,3 supersymmetric CFT's, the N=6
ABJM and the N=8 BLG models. In the limit where the positions of adjacent
operators become light-like, we find that the one-loop n-point correlator
divided by its tree level expression coincides with a light-like n-polygon
Wilson loop. Remarkably, the result can be simply expressed as a linear
combination of five dimensional two-mass easy boxes. We manage to evaluate the
integrals analytically and find a vanishing result, in agreement with previous
findings for Wilson loops.Comment: 32 pages, 6 figures, JHEP
From correlation functions to Wilson loops
We start with an n-point correlation function in a conformal gauge theory. We
show that a special limit produces a polygonal Wilson loop with sides. The
limit takes the points towards the vertices of a null polygonal Wilson loop
such that successive distances . This produces a fast moving
particle that generates a "frame" for the Wilson loop. We explain in detail how
the limit is approached, including some subtle effects from the propagation of
a fast moving particle in the full interacting theory. We perform perturbative
checks by doing explicit computations in N=4 super-Yang-Mills.Comment: 37 pages, 10 figures; typos corrected, references adde
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