5,896 research outputs found
Scalar leptoquarks and the rare B meson decays
We study some rare decays of meson involving the quark level transition
in the scalar leptoquark model. We constrain the
leptoquark parameter space using the recently measured branching ratios of
processes. Using such parameters, we obtain the
branching ratios, direct CP violation parameters and isospin asymmetries in and processes. We also obtain the
branching ratios for some lepton flavour violating decays .
We find that the various anomalies associated with the isospin asymmetries of
process can be explained in the scalar leptoquark model.Comment: 28 pages, 7 figures. typos corrected, to appear in Phys. Rev.
The entomopathogenic fungus Beauveria bassiana reduces instantaneous blood feeding in wild multi-insecticide-resistant Culex quinquefasciatus mosquitoes in Benin, West Africa.
BACKGROUND: Mosquito-borne diseases are still a major health risk in many developing countries, and the emergence of multi-insecticide-resistant mosquitoes is threatening the future of vector control. Therefore, new tools that can manage resistant mosquitoes are required. Laboratory studies show that entomopathogenic fungi can kill insecticide-resistant malaria vectors but this needs to be verified in the field. METHODS: The present study investigated whether these fungi will be effective at infecting, killing and/or modifying the behaviour of wild multi-insecticide-resistant West African mosquitoes. The entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana were separately applied to white polyester window netting and used in combination with either a permethrin-treated or untreated bednet in an experimental hut trial. Untreated nets were used because we wanted to test the effect of fungus alone and in combination with an insecticide to examine any potential additive or synergistic effects. RESULTS: In total, 1125 female mosquitoes were collected during the hut trial, mainly Culex quinquefasciatus Say. Unfortunately, not enough wild Anopheles gambiae Giles were collected to allow the effect the fungi may have on this malaria vector to be analysed. None of the treatment combinations caused significantly increased mortality of Cx. quinquefasciatus when compared to the control hut. The only significant behaviour modification found was a reduction in blood feeding by Cx. quinquefasciatus, caused by the permethrin and B. bassiana treatments, although no additive effect was seen in the B. bassiana and permethrin combination treatment. Beauveria bassiana did not repel blood foraging mosquitoes either in the laboratory or field. CONCLUSIONS: This is the first time that an entomopathogenic fungus has been shown to reduce blood feeding of wild mosquitoes. This behaviour modification indicates that B. bassiana could potentially be a new mosquito control tool effective at reducing disease transmission, although further field work in areas with filariasis transmission should be carried out to verify this. In addition, work targeting malaria vector mosquitoes should be carried out to see if these mosquitoes manifest the same behaviour modification after infection with B. bassiana conidia
Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells
Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves. Here we report that loss of NRP1 or NRP2 also impairs sensory neuron positioning in the mouse head, and that this defect is a consequence of inappropriate cranial neural crest cell migration. Specifically, neural crest cells move into the normally crest-free territory between the trigeminal and hyoid neural crest streams and recruit sensory neurons from the otic placode; these ectopic neurons then extend axons between the trigeminal and facioacoustic ganglia. Moreover, we found that NRP1 and NRP2 cooperate to guide cranial neural crest cells and position sensory neurons; thus, in the absence of SEMA3/NRP signalling, the segmentation of the cranial nervous system is lost. We conclude that neuropilins play multiple roles in the sensory nervous system by directing cranial neural crest cells, positioning sensory neurons and organising their axonal projections
Probabilistic Analysis of Optimization Problems on Generalized Random Shortest Path Metrics
Simple heuristics often show a remarkable performance in practice for
optimization problems. Worst-case analysis often falls short of explaining this
performance. Because of this, "beyond worst-case analysis" of algorithms has
recently gained a lot of attention, including probabilistic analysis of
algorithms.
The instances of many optimization problems are essentially a discrete metric
space. Probabilistic analysis for such metric optimization problems has
nevertheless mostly been conducted on instances drawn from Euclidean space,
which provides a structure that is usually heavily exploited in the analysis.
However, most instances from practice are not Euclidean. Little work has been
done on metric instances drawn from other, more realistic, distributions. Some
initial results have been obtained by Bringmann et al. (Algorithmica, 2013),
who have used random shortest path metrics on complete graphs to analyze
heuristics.
The goal of this paper is to generalize these findings to non-complete
graphs, especially Erd\H{o}s-R\'enyi random graphs. A random shortest path
metric is constructed by drawing independent random edge weights for each edge
in the graph and setting the distance between every pair of vertices to the
length of a shortest path between them with respect to the drawn weights. For
such instances, we prove that the greedy heuristic for the minimum distance
maximum matching problem, the nearest neighbor and insertion heuristics for the
traveling salesman problem, and a trivial heuristic for the -median problem
all achieve a constant expected approximation ratio. Additionally, we show a
polynomial upper bound for the expected number of iterations of the 2-opt
heuristic for the traveling salesman problem.Comment: An extended abstract appeared in the proceedings of WALCOM 201
Probabilistic Analysis of Facility Location on Random Shortest Path Metrics
The facility location problem is an NP-hard optimization problem. Therefore,
approximation algorithms are often used to solve large instances. Such
algorithms often perform much better than worst-case analysis suggests.
Therefore, probabilistic analysis is a widely used tool to analyze such
algorithms. Most research on probabilistic analysis of NP-hard optimization
problems involving metric spaces, such as the facility location problem, has
been focused on Euclidean instances, and also instances with independent
(random) edge lengths, which are non-metric, have been researched. We would
like to extend this knowledge to other, more general, metrics.
We investigate the facility location problem using random shortest path
metrics. We analyze some probabilistic properties for a simple greedy heuristic
which gives a solution to the facility location problem: opening the
cheapest facilities (with only depending on the facility opening
costs). If the facility opening costs are such that is not too large,
then we show that this heuristic is asymptotically optimal. On the other hand,
for large values of , the analysis becomes more difficult, and we
provide a closed-form expression as upper bound for the expected approximation
ratio. In the special case where all facility opening costs are equal this
closed-form expression reduces to or or even
if the opening costs are sufficiently small.Comment: A preliminary version accepted to CiE 201
The development of path integration: combining estimations of distance and heading
Efficient daily navigation is underpinned by path integration, the mechanism by which we use self-movement information to update our position in space. This process is well-understood in adulthood, but there has been relatively little study of path integration in childhood, leading to an underrepresentation in accounts of navigational development. Previous research has shown that calculation of distance and heading both tend to be less accurate in children as they are in adults, although there have been no studies of the combined calculation of distance and heading that typifies naturalistic path integration. In the present study 5-year-olds and 7-year-olds took part in a triangle-completion task, where they were required to return to the startpoint of a multi-element path using only idiothetic information. Performance was compared to a sample of adult participants, who were found to be more accurate than children on measures of landing error, heading error, and distance error. 7-year-olds were significantly more accurate than 5-year-olds on measures of landing error and heading error, although the difference between groups was much smaller for distance error. All measures were reliably correlated with age, demonstrating a clear development of path integration abilities within the age range tested. Taken together, these data make a strong case for the inclusion of path integration within developmental models of spatial navigational processing
Effect of formant frequency spacing on perceived gender in pre-pubertal children's voices
<div><p>Background</p><p>It is usually possible to identify the sex of a pre-pubertal child from their voice, despite the absence of sex differences in fundamental frequency at these ages. While it has been suggested that the overall spacing between formants (formant frequency spacing - ΔF) is a key component of the expression and perception of sex in children's voices, the effect of its continuous variation on sex and gender attribution has not yet been investigated.</p><p>Methodology/Principal findings</p><p>In the present study we manipulated voice ΔF of eight year olds (two boys and two girls) along continua covering the observed variation of this parameter in pre-pubertal voices, and assessed the effect of this variation on adult ratings of speakers' sex and gender in two separate experiments. In the first experiment (sex identification) adults were asked to categorise the voice as either male or female. The resulting identification function exhibited a gradual slope from male to female voice categories. In the second experiment (gender rating), adults rated the voices on a continuum from “masculine boy” to “feminine girl”, gradually decreasing their masculinity ratings as ΔF increased.</p><p>Conclusions/Significance</p><p>These results indicate that the role of ΔF in voice gender perception, which has been reported in adult voices, extends to pre-pubertal children's voices: variation in ΔF not only affects the perceived sex, but also the perceived masculinity or femininity of the speaker. We discuss the implications of these observations for the expression and perception of gender in children's voices given the absence of anatomical dimorphism in overall vocal tract length before puberty.</p></div
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