Association between maternal depression symptoms across the first eleven years of their child’s life and subsequent offspring suicidal ideation

Depression is common, especially in women of child-bearing age; prevalence estimates for this group range from 8% to 12%, and there is robust evidence that maternal depression is associated with mental health problems in offspring. Suicidal behaviour is a growing concern amongst young people and those exposed to maternal depression are likely to be especially at high risk. The aim of this study was to utilise a large, prospective population cohort to examine the relationship between depression symptom trajectories in mothers over the first eleven years of their child’s life and subsequent adolescent suicidal ideation. An additional aim was to test if associations were explained by maternal suicide attempt and offspring depressive disorder. Data were utilised from a population-based birth cohort: the Avon Longitudinal Study of Parents and Children. Maternal depression symptoms were assessed repeatedly from pregnancy to child age 11 years. Offspring suicidal ideation was assessed at age 16 years. Using multiple imputation, data for 10,559 families were analysed. Using latent class growth analysis, five distinct classes of maternal depression symptoms were identified (minimal, mild, increasing, sub-threshold, chronic-severe). The prevalence of past-year suicidal ideation at age 16 years was 15% (95% CI: 14-17%). Compared to offspring of mothers with minimal symptoms, the greatest risk of suicidal ideation was found for offspring of mothers with chronic-severe symptoms [OR 3.04 (95% CI 2.19,4.21)], with evidence for smaller increases in risk of suicidal ideation in offspring of mothers with sub-threshold, increasing and mild symptoms. These associations were not fully accounted for by maternal suicide attempt or offspring depression diagnosis. Twenty-six percent of non-depressed offspring of mothers with chronic-severe depression symptoms reported suicidal ideation. Risk for suicidal ideation should be considered in young people whose mothers have a history of sustained high levels of depression symptoms, even when the offspring themselves do not have a depression diagnosis

Avaliação da eficiência da mistura pronta de glyphosate + 2,4-D no controle da Commelina virginica L. em citros Efficacy evaluation of ready mixture of glyphosate + 2,4-D in Commelina virginica L. control in citrus

Um dos herbicidas mais utilizados para o controle de plantas daninhas em pós-emergência nos pomares cítricos paulistas é o glyphosate. No entanto, este herbicida aplicado isoladamente e nas doses recomendadas, tem proporcionado seleção da planta daninha trapoeraba (Commelina virginica L.), devido à grande tolerância da mesma, somada à eficiente eliminação das demais espécies da comunidade infestante. Em vista disso, e pela falta de opções , faz-se necessária a pesquisa de outros herbicidas ou misturas de herbicidas que sejam eficientes no controle da trapoeraba, de baixa toxicidade para os aplicadores, sistêmicos, e que sejam seletivos às plantas cítricas. O presente trabalho foi desenvolvido com o objetivo de estudar a eficiência da mistura pronta dos herbicidas glyphosate + 2,4-D amina no controle da trapoeraba em citros [Citrus sinensis (L.) Osbeck], em comparação com estes mesmos herbicidas aplicados isoladamente, bem como os possíveis efeitos fitotóxicos da mesma à cultura. O experimento foi instalado na região de Catanduva-SP, em um pomar de laranja Pera clone Rio, enxertada sobre limão Cravo, com dez anos de idade, plantado em um espaçamento de 8,0 x 6,5 m. A aplicação dos herbicidas foi realizada em 20 de fevereiro de 1991, de forma dirigida, em pós-emergência tardia da trapoeraba, quando a mesma já florescia e tinha altura variável entre 15 e 60 cm. A análise e interpretação dos resultados obtidos mostraram que a mistura pronta de glyphosate + 2,4-D apresenta um controle superior da trapoeraba em relação aos produtos aplicados isoladamente, não havendo diferenças significativas no controle para doses superiores a 0,60 + 0,80 kg i.a./ha. Os dados obtidos reforçam a teoria de sinergismo entre os dois produtos. Em nenhum dos tratamentos foi verificado sintomas visuais de intoxicação nas laranjeiras.<br>In citrus orchard of São Paulo state, Brazil, one of the most employed post-emergency herbicide for weed control is glyphosate. However, when this herbicide is applied alone and at the recommended rates, it has been observed a selection of the weed Commelina virginica L. due to its great tolerance and the elimination of other weeds. Because of that, other chemicals must be studied to solve the problem. In this particular case, the herbicide should be sistemic and have a low toxicity to the operator and to the citrus trees. This work was conducted to study the efficacy of a ready mixture of glyphosate + 2,4-D compared to the products sprayed alone in orange orchards [Citrus sinensis (L.) Osbeck]. The phytotoxicity effects were studied too. The experiment was carried out in Catanduva, São Paulo, Brazil, in a ten years old orange orchard, with 8,0 x 6,0m spacing. On february, 20 th, 1991, the herbicides were sprayed directly on 15-60cm height Commelina during its flowering. The results showed that the ready mixture was better in Commelina control than other treatments. No significant differences were observed for the rates greater than 0,60 + 0,80 kg a.i./ha. The results reinforced the sinergism theory within both products. None of the treatments caused visual phytotoxicity to orange trees

Eficácia do halosulfuron no controle de tiririca (Cyperus rotundus) na cultura da cana-de-açúcar Efficacy of halosulphuron for the control of purple nutsedge in the sugar cane

A flora daninha infestante de um canavial é bastante específica e bem característica. O uso contínuo do mesmo herbicida é um dos fatores relacionados ao manejo, que mais tem contribuído para essa seleção. A tiririca (Cyperus rotundus) aparece como uma das principais espécies daninhas infestantes dos canaviais. O objetivo do presente trabalho foi avaliar a eficiência do controle químico da tiririca, através da utilização do herbicida halosulfuron, pertencente ao grupo químico das sulfoniluréias, na cultura da cana-de-açúcar. O experimento foi instalado na EPAMIG, em Prudente de Morais - MG, em 24 de março de 1994, com a variedade RB-72454, em solo de várzea Glei Pouco Úmido, textura argilo-siltosa com pH 5,8 e 2,9% de matéria orgânica. O delineamento experimental adotado foi o de blocos ao acaso com seis tratamentos e quatro repetições. Os herbicidas halosulfuron e 2,4-D (produto utilizado para comparação) foram aplicados em pós-emergência, em área total (cana-planta com altura média de 65cm), com pulverizador costal à pressão constante de 2,4kgf/cm2 ; munido de barra com dois bicos de jato plano (tipo "leque") 110.03, e vazão de 260 l/ha. No momento da aplicação a tiririca encontrava se no final da fase vegetativa e início do florescimento, com altura variando entre 15 e 30cm. O herbicida halosulfuron foi aplicado em mistura com o surfactante do grupo Tallow Amina, a 0,5% v/v. Foram realizadas avaliações de controle de plantas daninhas aos 15, 30, 60 e 90 dias após a aplicação dos herbicidas, baseando-se na contagem do número de manifestações epígeas vivas em 0,2m2 por parcela. Pelos resultados obtidos o halosulfuron, na dosagem de 131,25 g i.a./ha, mostrou-se altamente eficiente no controle pós-emergente da tiririca na cultura da cana-de-açúcar, proporcionando, aos 60 dias após a aplicação, um controle superior a 90%. Testes de viabilidade de tubérculos coletados 90 dias após a aplicação dos herbicidas, até a profundidade de 0,20m, mostraram que doses de 93,75; 112,5 e 131,25 g i.a./ha de halosulfuron chegaram a reduzir em respectivamente 47,7%, 52,7% e 60,7% o número de tubérculos viáveis. Esse resultado foi muito superior ao obtido com a aplicação do 2,4-D, que apresentou redução de apenas 23% no número de tubérculos viáveis. O produto mostrou-se totalmente seletivo à cultura, tendo sido aplicado em pós-emergência, na área total, não tendo sido observado qualquer sintoma de injúria caracterizado por necrose ou redução do crescimento das plantas.<br>The weed flora infesting sugar cane fields is specific and well characterized. The continuous use of the same hebicide is one of the crop managing factors which has mostly contributed to this weed selection. The purple nutsedge (Cyperus rotundus) is one of most important weed species infesting sugar cane fields. The objective of this studv was to evaluate the efficiency of the chemical control of purple nutsedge bv the herbicide halosulphuron, a sulphonylurea, ln the sugar cane crop. The experiment was set up at the EPAMIG Experimental Station, Prudente de Morais - MG, March 24, 1994, with the variety RB-72454, in a humic-glev silt-clay lowland soil, pH 5.8 and 2.9 organic matter. The experimental lavout was a randomized block design, with six tratments and five replications. The herbicides halosulphuron and 2,4-D (control) were applied as post-emergence, covering the whole area (sugar cane plants were 65cm tall), with a hand-held, 2,4kgf/cm2 constant pressure spraver, with two 110.03 flat spray tips, at the rate of 260 l/ha. During herbicide application, 15-30cm high purple nutsedges were terminating their vegetative growth and begining to flower. Halosulphuron was applied in a mixture wlth a Tallow Amine surfactant, 0.5% v/v. Weed control evaluation were done at 15, 30, 60 and 90 days after herbicide application, couting the number of live sproutings ln 0.2m2/plot . Results showed that halosulphuron, at the rate of 131,25 g i.a./ha gave better than 90% weed control 90 days after application. Viability tests performed in tubers collected 20cm deep, 90 days after herbicide application, showed that halosulphuron rates of 93,75; 112,5 and 131,25 g i.a./ha reduced viable tubers by 47,7%, 52,7% and 60,7% respectively. These results are significantlv better than those obtained with 2,4-D, which reduced viable tubers by only 23%. Halosulphuron appeared to be selective to sugar cane when applied in post-emergence covering the hole area, showing no injury svmptoms such as necrosis or stunted growth

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control

Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial resistance (AMR) countermeasures. We undertook a detailed, interdisciplinary, longitudinal analysis of dairy slurry waste. The slurry contained a population of ARB and ARGs, with resistances to current, historical and never-used on-farm antibiotics; resistances were associated with Gram-negative and Gram-positive bacteria and mobile elements (ISEcp1, Tn916, Tn21-family transposons). Modelling and experimental work suggested that these populations are in dynamic equilibrium, with microbial death balanced by fresh input. Consequently, storing slurry without further waste input for at least 60 days was predicted to reduce ARB spread onto land, with > 99 % reduction in cephalosporin resistant Escherichia coli. The model also indicated that for farms with low antibiotic use, further reductions are unlikely to reduce AMR further. We conclude that the slurry tank is a critical point for measurement and control of AMR, and that actions to limit the spread of AMR from dairy waste should combine responsible antibiotic use, including low total quantity, avoidance of human critical antibiotics, and choosing antibiotics with shorter half-lives, coupled with appropriate slurry storage