175 research outputs found
Approaches in biotechnological applications of natural polymers
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2016
- Field of study
Natural polymers, such as gums and mucilage, are biocompatible, cheap, easily available and non-toxic materials of native origin. These polymers are increasingly preferred over synthetic materials for industrial applications due to their intrinsic properties, as well as they are considered alternative sources of raw materials since they present characteristics of sustainability, biodegradability and biosafety. As definition, gums and mucilages are polysaccharides or complex carbohydrates consisting of one or more monosaccharides or their derivatives linked in bewildering variety of linkages and structures. Natural gums are considered polysaccharides naturally occurring in varieties of plant seeds and exudates, tree or shrub exudates, seaweed extracts, fungi, bacteria, and animal sources. Water-soluble gums, also known as hydrocolloids, are considered exudates and are pathological products; therefore, they do not form a part of cell wall. On the other hand, mucilages are part of cell and physiological products. It is important to highlight that gums represent the largest amounts of polymer materials derived from plants. Gums have enormously large and broad applications in both food and non-food industries, being commonly used as thickening, binding, emulsifying, suspending, stabilizing agents and matrices for drug release in pharmaceutical and cosmetic industries. In the food industry, their gelling properties and the ability to mold edible films and coatings are extensively studied. The use of gums depends on the intrinsic properties that they provide, often at costs below those of synthetic polymers. For upgrading the value of gums, they are being processed into various forms, including the most recent nanomaterials, for various biotechnological applications. Thus, the main natural polymers including galactomannans, cellulose, chitin, agar, carrageenan, alginate, cashew gum, pectin and starch, in addition to the current researches about them are reviewed in this article.. }To the Conselho Nacional de Desenvolvimento Cientfíico e Tecnológico (CNPq) for fellowships (LCBBC and MGCC) and the Coordenação de Aperfeiçoamento de Pessoal de Nvíel Superior (CAPES) (PBSA). This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit, the Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and COMPETE 2020 (POCI-01-0145-FEDER-006684) (JAT)
Lawson criterion for ignition exceeded in an inertial fusion experiment
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of τ Leptons in pp collisions at sqrt[s]=13 TeV
- Author
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- Zorbilmez C
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- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the τ lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two τ leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
Small and inconsistent effects of whole body vibration on athletic performance: a systematic review and meta-analysis
- Author
- A Ekblom
- A Fort
- A Viru
- AM Kinser
- B Friesenbichler
- B Roberts
- BR Ronnestad
- BR Ronnestad
- C Bosco
- C Bosco
- C Bosco
- C Delecluse
- C Lorenzen
- CF Cheng
- CG Maher
- DJ Bunker
- DJ Cochrane
- DJ Cochrane
- DJ Cochrane
- DJ Cochrane
- DJ Cochrane
- E Preatoni
- F Fagnani
- F Naclerio
- F Rauch
- G Annino
- GF Reyes
- GH Taylor
- GJ Marquez
- GM Goodwin
- GM Goodwin
- GM Goodwin
- HH Wang
- IM Wilcock
- J Cohen
- J Fernandez-Rio
- J Fernandez-Rio
- J Mester
- J Mester
- J Padulo
- J Rittweger
- JC Helmkamp
- JD Guggenheimer
- JF Crow
- JL Taylor
- JP Higgins
- L Suarez-Arrones
- LC Marshall
- M Cardinale
- M Cardinale
- M Lesinski
- M Lesinski
- M Wyon
- Melanie Lesinski
- Miguel Fernandez-del-Olmo
- MM Nordlund
- MR Rhea
- MT Jones
- MT Jones
- N Bullock
- N Manimmanakorn
- NA Zagorskaia
- NC Dabbs
- NJ Mansfield
- NN Mahieu
- P Cormie
- R Bertuzzi
- R Fachina
- R Lovell
- S Rogan
- S Turner
- SS Colson
- T Despina
- T Hortobagyi
- T Hortobágyi
- T Lundeberg
- Tibor Hortobágyi
- Urs Granacher
- V Nazarov
- VB Issurin
- VB Issurin
- VB Issurin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at root s=13 TeV
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- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Camen C
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- Campderros JD
- Camporesi T
- Candelise V
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- Canepa A
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- Cardini A
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- Carnevali F
- Cartiglia N
- Carvalho W
- Casarsa M
- Caspart R
- Cassese A
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- Castilla-Valdez H
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- Ceard L
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- Chawla R
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- Chekhovsky V
- Chen C
- Chen G
- Chen H
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- Chen Y
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- Cheng C
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- Cheng Y
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung H
- Chhibra S
- Chiarito B
- Chinellato J
- Chistov R
- Chlebana F
- Cho S
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- Chou J
- Choudhary B
- Choudhury S
- Chowdhury SR
- Christoforou K
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- Ciangottini D
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- Cittolin S
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- Zuolo D
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- Álvarez CR
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for invisible decays of the Higgs boson produced via vector boson fusion in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim A
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Acosta HE
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- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
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- Aimè C
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- Albert A
- Albrecht S
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- Aleksandrov A
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- Alhusseini M
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- Alonso AG
- Alpana A
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- Amaral SSD
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- Anampa KH
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- Tcherniaev E
- Teague D
- Tedeschi T
- Teklishyn M
- Tekten S
- Teles PR
- Templ S
- Tenchini R
- Teodorescu L
- Terkulov A
- Teroerde M
- Terrill W
- Teryaev O
- Tews A
- Teyssier D
- Thayil S
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- Thiel M
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- Tishelman-Charny A
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- Tkaczyk S
- Tobar ÁN
- Tok U
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- Tomalin I
- Tomei TRFP
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- Valencia FV
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- Volobouev I
- Von Cube R
- Vorobyev A
- Vourliotis E
- Voutilainen M
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- Vámi T
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- Warner Z
- Wassmer M
- Watson I
- Wayne M
- Webb S
- Weber H
- Weber M
- Wei K
- Wen Y
- Wertz S
- West C
- Wezenbeek L
- Whitbeck A
- White R
- White S
- Wichmann K
- Wickramage N
- Wickramarathna D
- Wiedenbeck S
- Wieland S
- Wiens L
- Wightman A
- Williams A
- Williams T
- Willmott C
- Wilson G
- Wilson J
- Wimpenny S
- Winer B
- Winterbottom D
- Wisecarver A
- Wissing C
- Wittich P
- Wolf R
- Wong K
- Wong W
- Wood D
- Wozniak K
- Wozniewski S
- Wright D
- Wu Hy
- Wu Z
- Wuchterl S
- Wulz C
- Wunsch S
- Wyslouch B
- Würthwein F
- Xiang Y
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yang H
- Yang S
- Yang U
- Yang Y
- Yao Y
- Yarar H
- Yates B
- Yazgan E
- Ye Z
- Yetkin E
- Yi K
- Yigitbasi E
- Yohay R
- Yoo H
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu G
- Yu I
- Yu Pr
- Yu S
- Yuan L
- Yuan S
- Yuldashev B
- Yumiceva F
- Yzquierdo AP
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli A
- Zeinali M
- Zeuner W
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu R
- Ziemons T
- Zipper N
- Zoi I
- Zolkapli Z
- Zorbakir I
- Zorbilmez C
- Zotto P
- Zotz A
- Zou D
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez CR
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2022
- Field of study
VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage
- Author
- A Castorina
- A Chorny
- A Fernandez-Martin
- A Reboldi
- A Storka
- AJ Harmar
- B Hemmer
- B Kis
- B Kis
- Bhavaani Jayaram
- BT Fife
- C Abad
- C Abad
- C Abad
- C Abad
- C Martinez
- C Martinez
- Catalina Abad
- D Fabricius
- D Fabricius
- D Maimone
- D Pozo
- D Vaudry
- DH Loh
- DR Huang
- DR Staines
- E Cocco
- E Gonzalez-Rey
- E Gonzalez-Rey
- E Gonzalez-Rey
- E Gonzalez-Rey
- E Gonzalez-Rey
- EE Vomhof-DeKrey
- EE Vomhof-DeKrey
- HW Schytz
- J Fahrenkrug
- J Yang
- JA Johnston
- James A. Waschek
- JK Voice
- JL Herrera
- JM Hansen
- KJ Livak
- KM Joo
- L Souza-Moreira
- Laurine Becquet
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Delgado
- M Lara-Marquez
- M Rangachari
- M Sue O’Dorisio
- M Xia
- M Yadav
- N Kawakami
- P Gourlet
- P Kivisakk
- P Rameshwar
- P Schratzberger
- RJ Hermann
- ST Dorsam
- V Sharma
- V Sharma
- Y Arima
- Yossan-Var Tan
- Yuqi Wang
- YV Tan
- YV Tan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre
- Author
- Acharyya A
- Acosta MV
- Adam R
- Adams C
- Agudo I
- Aguirre-Santaella A
- Alfaro J
- Alfaro R
- Alispach C
- Aloisio R
- Amati L
- Ambrosi G
- Anguner EO
- Antonelli LA
- Aramo C
- Araudo A
- Arbeletche LB
- Armstrong T
- Arqueros F
- Asano K
- Ascasibar Y
- Ashley M
- Balazs C
- Ballester O
- Barkov M
- Barrio JA
- Bastieri D
- Batista RA
- Becerra J
- Beck G
- Benbow W
- Benito M
- Berge D
- Bernardini E
- Bernlohr K
- Berti A
- Bertucci B
- Beshley V
- Biasuzzi B
- Biland A
- Bissaldi E
- Biteau J
- Blanch O
- Blazek J
- Bocchino F
- Boisson C
- Bordas P
- Bosnjak Z
- Bottacini E
- Bozhilov V
- Bregeon J
- Brill A
- Bringmann T
- Brown AM
- Brun F
- Brun P
- Bruno P
- Bulgarelli A
- Burton M
- Burtovoi A
- Buscemi M
- Cadena SH
- Cameron R
- Capasso M
- Caproni A
- Capuzzo-Dolcetta R
- Caraveo P
- Carosi A
- Carosi R
- Casanova S
- Cascone E
- Cassol F
- Catalani F
- Cauz D
- Cerruti M
- Chadwick P
- Chaty S
- Chen A
- Chernyakova M
- Chiaro G
- Chiavassa A
- Chikawa M
- Chudoba J
- Colak M
- Conforti V
- Coniglione R
- Conte F
- Contreras JL
- Coronado-Blazquez J
- Costa A
- Costantini H
- Cotter G
- Cristofari P
- D'Ai A
- D'Ammando A
- Dal Pino EMD
- Damone LA
- Daniel MK
- Dazzi F
- de Almeida RMN
- de Almeida UB
- De Angelis A
- De Caprio V
- De Lotto B
- De Martino D
- de Oliveira MAL
- De Palma F
- de Souza V
- Delgado C
- della Volpe D
- Depaoli D
- Di Girolamo T
- Di Pierro F
- Di Venere L
- Diebold S
- Dmytriiev A
- Dominguez A
- Donini A
- Doro M
- dos Anjos RD
- Ebr J
- Eckner C
- Edwards TDP
- Ekoume TRN
- Elsasser D
- Evoli C
- Falceta-Goncalves D
- Fedorova E
- Fegan S
- Feng Q
- Fernandez GR
- Ferrand G
- Ferrara G
- Fiandrini E
- Fiasson A
- Filipovic M
- Fioretti V
- Fiori M
- Foffano L
- Fontaine G
- Fornieri O
- Franco FJ
- Fukami S
- Fukui Y
- Gaggero D
- Galaz G
- Gammaldi V
- Garcia E
- Garczarczyk M
- Gascon D
- Gent A
- Ghalumyan A
- Gianotti F
- Giarrusso M
- Giavitto G
- Giglietto N
- Giler AGD
- Giordano F
- Giuliani A
- Glicenstein J
- Gnatyk R
- Goldoni P
- Gonzalez MM
- Gourgouliatos K
- Granot J
- Grasso D
- Green J
- Greus FS
- Grillo A
- Gueta O
- Gunji S
- Halim A
- Hassan T
- Hatlen ES
- Heller M
- Hiroshima N
- Hnatyk B
- Hofmann W
- Holder J
- Horan D
- Horandel J
- Horvath P
- Hovatta T
- Hrabovsky M
- Hrupec D
- Hughes G
- Humensky TB
- Hutten M
- Iarlori M
- Inada T
- Inoue S
- Iocco F
- Iori M
- Jamrozy M
- Janecek P
- Jin W
- Jouvin L
- Jurysek J
- Karukes E
- Katarzynski K
- Kazanas D
- Kerszberg D
- Kherlakian MC
- Kissmann R
- Knodlseder J
- Kobayashi Y
- Kohri K
- Komin N
- Kubo H
- Kushida J
- Lamanna G
- Lapington J
- Laporte P
- Larriva AB
- Lenain J
- Leone F
- Leto G
- Lindfors E
- Lohse T
- Lombardi S
- Longo F
- Lopez A
- Lopez M
- Lopez-Coto R
- Loporchio S
- Luque-Escamilla PL
- Mach E
- Maggio C
- Maier G
- Mallamaci M
- Mandat D
- Manganaro M
- Mangano S
- Manico G
- Marculewicz M
- Mariotti M
- Markoff S
- Marquez P
- Marti J
- Martinez G
- Martinez M
- Martinez O
- Martinez-Huerta H
- Martins VB
- Maurin G
- Mazin D
- Mbarubucyeye JD
- Meyer M
- Miceli M
- Miener T
- Minev M
- Miranda DM
- Miranda JM
- Mirzoyan R
- Mizuno T
- Mode B
- Moderski R
- Mohrmann L
- Molina E
- Montaruli T
- Moralejo A
- Morcuende-Parrilla D
- Morselli A
- Mukherjee R
- Mundell C
- Nagai A
- Nakamori T
- Nemmen R
- Niemiec J
- Nieto D
- Nikolajuk M
- Ninci D
- Noda K
- Nosek D
- Nozaki S
- Ohira Y
- Ohishi M
- Ohtani Y
- Oka T
- Okumura A
- Ong RA
- Orienti M
- Orito R
- Orlandini M
- Orlando E
- Orlando S
- Ostrowski M
- Oya I
- Pagano I
- Pagliaro A
- Palatiello M
- Pantaleo FR
- Paredes JM
- Pareschi G
- Parmiggiani N
- Patricelli B
- Pavletic L
- Pe'er A
- Pecimotika M
- Peixoto CJT
- Perez-Romero J
- Persic M
- Petruk O
- Pfrang K
- Piano G
- Piatteli P
- Pietropaolo E
- Pillera R
- Pilszyk B
- Pintore F
- Pohl M
- Poireau V
- Prado RR
- Prandini E
- Prast J
- Principe G
- Prokoph H
- Prouza M
- Przybilski H
- Puhlhofer G
- Pumo ML
- Queiroz F
- Quirrenbach A
- Raino S
- Ramirez JCR
- Rando R
- Razzaque S
- Recchia S
- Reimer O
- Reisenegger A
- Renier Y
- Rhode W
- Ribeiro D
- Ribo M
- Richtler T
- Rico J
- Rieger F
- Rinchiuso L
- Rizi V
- Rodriguez J
- Rojas G
- Romano P
- Romeo G
- Rosado J
- Rowell G
- Rudak B
- Russo F
- Sadeh I
- Safi-Harb S
- Salina G
- Sanchez D
- Sanchez-Conde M
- Sangiorgi P
- Sano H
- Santander M
- Santos EM
- Santos-Lima R
- Sanuy A
- Sarkar S
- Saturni FG
- Sawangwit U
- Schussler F
- Schwanke U
- Sciacca E
- Scuderi S
- Seglar-Arroyo M
- Sergijenko O
- Servillat M
- Seweryn K
- Shalchi A
- Sharma P
- Shellard RC
- Siejkowski H
- Silk J
- Siqueira C
- Sliusar V
- Sokolenko A
- Sol H
- Spencer S
- Stamerra A
- Stanic S
- Starling R
- Stolarczyk T
- Straumann U
- Striskovic J
- Suda Y
- Suomijarvi T
- Swierk P
- Tavecchio F
- Taylor L
- Tejedor LA
- Teshima M
- Testa V
- Tibaldo L
- Tjus JB
- Tokanai F
- Tonev D
- Tosti G
- Tosti L
- Tothill N
- Travnicek P
- Truzzi S
- Vagelli V
- Vallage B
- Vallania P
- van Eldik C
- Vandenbroucke J
- Varner GS
- Vassiliev V
- Vecchi M
- Ventura S
- Vercellone S
- Vergani S
- Verna G
- Viana A
- Vigorito CF
- Vink J
- Vitale V
- Vorobiov S
- Vovk I
- Vuillaume T
- Wagner SJ
- Walter R
- Watson J
- Weniger C
- White M
- White R
- Wiemann R
- Wierzcholska A
- Wilhelmi ED
- Will M
- Williams DA
- Wischnewski R
- Yanagita S
- Yang L
- Yoshikoshi T
- Zacharias M
- Zaharijas G
- Zakaria AA
- Zampieri L
- Zanin R
- Zaric D
- Zavrtanik D
- Zavrtanik M
- Zdziarski AA
- Zech A
- Zechlin H
- Zhdanov VI
- Zivec M
- Publication venue
- 'IOP Publishing'
- Publication date
- 28/10/2022
- Field of study
We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies
Measurement of the Higgs boson width and evidence of its off-shell contributions to ZZ production
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams MR
- Adams T
- Adan DP
- Addesa FM
- Adloff C
- Adzic P
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- Aime C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrecht S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Almond J
- Alpana A
- Alvarez Fernandez A
- Alvarez Gonzalez B
- Alverson G
- Alves BAFS
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amarilo KM
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Anampa KH
- Andrea J
- Andreassi G
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Anguiano J
- Antchev G
- Antequera JB
- Anthony D
- Antunovic Z
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar M
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakshi AS
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Banos LIE
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrera CB
- Barria P
- Barrio Luna M
- Bartek R
- Bartok M
- Bartosik N
- Bartschi P
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
- Bayatmakou M
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerra DAS
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- Yuldashev BS
- Yumiceva F
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
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- Zhizhin I
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- Zorbakir IS
- Zorbilmez C
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- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Since the discovery of the Higgs boson in 2012, detailed studies of its properties have been ongoing. Besides its mass, its width—related to its lifetime—is an important parameter. One way to determine this quantity is to measure its off-shell production, where the Higgs boson mass is far away from its nominal value, and relating it to its on-shell production, where the mass is close to the nominal value. Here we report evidence for such off-shell contributions to the production cross-section of two Z bosons with data from the CMS experiment at the CERN Large Hadron Collider. We constrain the total rate of the off-shell Higgs boson contribution beyond the Z boson pair production threshold, relative to its standard model expectation, to the interval [0.0061, 2.0] at the 95% confidence level. The scenario with no off-shell contribution is excluded at a p-value of 0.0003 (3.6 standard deviations). We measure the width of the Higgs boson as ΓH=3.2+2.4−1.7MeV, in agreement with the standard model expectation of 4.1 MeV. In addition, we set constraints on anomalous Higgs boson couplings to W and Z boson pairs
Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease
- Author
- A Gorog D
- Abadier R
- Acheatel R
- Al-Joundi B
- Albert M
- Albirini A
- Albisu Di Gennaro J
- Alcocer Gamba M
- Alexandersen P
- Alexeeva N
- Almassi H
- Altunkeser B
- Amerena J
- Amin J
- Ando K
- Apostolova E
- Appel Kf
- Appel M
- Ardissino D
- Arif I
- Armstrong P
- Asbill B
- Aslam A
- Aviles R
- Azocar J
- Bacon J
- Baden M
- Bakbak A
- Bakhai A
- Ballantyne C
- Bang L
- Barbarash O
- Barr C
- Barter Philip J.
- Basson M
- Batchelor W
- Beaudry Y
- Benatar J
- Benton R
- Bernhardi D
- Berrouschot J
- Betteridge J
- Bhagwat R
- Bhargava A
- Bhargava R
- Bhatia P
- Binder R
- Bitzur R
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- Bourhaial H
- Brautigam D
- Brewer H. Bryan
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- Broncel M
- Bronzwaer P
- Brown K
- Bruckert E
- Brunskill J
- Brønnum-Schou J
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- Bugan W
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- Caccavo A
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- Castano L
- Cecil J
- Chan K
- Chandler G
- Chandrika Parameswaran A
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- Chehayeb R
- Chen J
- Cheng S
- Chenier M
- Chiang Ce
- Chizhov P
- Cho B
- Chorin E
- Cinteza M
- Claudio J
- Cohen K
- Cohn J
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- Conde Diego
- Constantinescu M
- Cooke D
- Copaci I
- Coste P
- Cottin Y
- Coulson W
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- Fernandez-Ortiz A
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- Georgeson S
- Gergel V
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- Gibson C. Michael
- Gilchrist I
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- Granger Christopher
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- Yeung V
- Young C
- Younis L
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- Zhu J
- Ziada K
- Zrazhevsky K
- Zólyomi S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease.
METHODS:
In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Patients were randomly assigned to receive either evacetrapib at a dose of 130 mg or matching placebo, administered daily, in addition to standard medical therapy. The primary efficacy end point was the first occurrence of any component of the composite of death from cardiovascular causes, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina.
RESULTS:
At 3 months, a 31.1% decrease in the mean LDL cholesterol level was observed with evacetrapib versus a 6.0% increase with placebo, and a 133.2% increase in the mean HDL cholesterol level was seen with evacetrapib versus a 1.6% increase with placebo. After 1363 of the planned 1670 primary end-point events had occurred, the data and safety monitoring board recommended that the trial be terminated early because of a lack of efficacy. After a median of 26 months of evacetrapib or placebo, a primary end-point event occurred in 12.9% of the patients in the evacetrapib group and in 12.8% of those in the placebo group (hazard ratio, 1.01; 95% confidence interval, 0.91 to 1.11; P=0.91).
CONCLUSIONS:
Although the cholesteryl ester transfer protein inhibitor evacetrapib had favorable effects on established lipid biomarkers, treatment with evacetrapib did not result in a lower rate of cardiovascular events than placebo among patients with high-risk vascular disease. (Funded by Eli Lilly; ACCELERATE ClinicalTrials.gov number, NCT01687998 .)
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