Splenotoxic Potentials of Chloroquine, Fansidar, Cotecxin and Amalar

The Histologic studies on the spleen was carried out with Chloroquine, Fansidar, Cotecxin and Amalar to observe any pathologic effect(s) on the tissue on comparative basis. The study revealed some degenerated white pulps and wider interstitial spaces with chloroquine drug not observed in control samples. Also animals with fansidar administration showed clumping of periateriolar lymphoid cells in the white pulp not shown in the control group without any drug. In the Amalar group the spleen showed sinuisoidal dilation in the red pulp with macrophages scattered around it but not in the form of activation. For cotecxin drug there was the degeneration of periarteriolar lymphoid sheaths with residue of the infiltrated cells in the arterioles. It is concluded that chloroquine, fansidar, cotecxin may induce jaundice and splenic disorders. Keywords: splenomegaly, splenic rupture, anti-malaria drugs

Assessment of Intracellular and Extracellular Fluids (Icf, Ecf) Compartments with Antimal, Chloroquine, Coartem, Fansidar and Malareich

Quantitative assay with spectrophotometer was used in the determination of plasma sodium, potassium and chloride concentration in the administration of antimal, chloroquine, coartem, fansidar and malareich antimalaria drugs. In the antimal group there was no significant difference in the sodium, potassium and chloride concentration in the plasma when compared with control (P>0.05). Also in the chloroquine group, the sodium and chloride concentrations were not significantly different from the control (P>0.05). However, there was low concentration of potassium which was significant when compared with control (P<0.05). In the Fansidar administration there was no significant difference in sodium, potassium and chloride concentration when compared with control, (P>0.05). Also in the malareich group, the sodium and chloride concentrations showed no significant difference with the control (P>0.05). But there was significant difference in potassium concentration when compared with control (P<0.05). The study observed that chloroquine and malareich therapy affect extracellular fluid compartment of the body and induced hypokalaemia which may result in deficit cell membrane potential and the related general body muscle weakness. Keyword: Hypokalaemia, antimalarials, ICF, ECF

Stomach Histopathologic and Ulcerogenic Potentials of Tea Beverage

Sixty four (64) albino rats were studied for possible histopathologic and ulcerogenic potentials of Lipton tea for the period of twenty eight days (28). The ulceration of the lumen of the stomach counted as ulcer points increased considerably within the 28 days duration, particularly 7-21 days. There were marked histologic changes as evidenced in the degeneration of gastric glands and cells due to loss of mucus such which were not found in the controls. Also the gastric pits were grossly dilated in 75% of the animals fed with Lipton tea while 15% had mild or no dilations of the gastric pits. Some of the dilated pits were filled with mucus absent in controls without Lipton tea. The oxyntic or parietal cells showed pale cytoplasm in contrast to eosinophilic staining affinity in controls. Particularly prominent was the decreases in the number of parietal cells, however such cells still maintained  normal large rounded morphology with round nuclei having nucleoli as in controls. Few mucus cells were observed in the clustered of mucus gland or mucuous neck cells as against many of such cells in controls. However the morphology and basal location of the cells nuclei and basophilic staining affinity were as in controls. It is concluded that Lipton tea has the tendency of inducing gastric ulcer, achlorhydria and pernicious anaemia. Keywords:  Lipton tea, Gastric, histopathology, ulcerogenic potentials

Categorisation of Ancillary Services for Providers

The focus of the work presented here is to raise awareness of how ancillary services within the NordPool area could be of value in supporting the future grid, and who could be the provider of these services. The ancillary services considered here are not limited to the current market, but also services for future market solutions as well as services for fulfilment of grid codes. The goal is to promote the development of existing and novel solutions to increase the utilisation and thus the value of equipment within the power system. The paper includes a techno-economical categorisation of ancillary services, from a provider\u27s perspective, presenting opportunities and competition. Furthermore, procurers of services could utilise this kind of categorisation to identify possible providers or partners. The analysis of the categorisation shows a broad range of possible providers for each service and a broad range of possible services from each provider

Real time response on dS_3: the Topological AdS Black Hole and the Bubble

We study real time correlators in strongly coupled N=4 supersymmetric Yang-Mills theory on dS_3 x S^1, with antiperiodic boundary conditions for fermions on the circle. When the circle radius is larger than a critical value, the dual geometry is the so-called "topological AdS_5 black hole". Applying the Son- Starinets recipe in this background we compute retarded glueball propagators which exhibit an infinite set of poles yielding the quasinormal frequencies of the topological black hole. The imaginary parts of the propagators exhibit thermal effects associated with the Gibbons-Hawking temperature due to the cosmological horizon of the de Sitter boundary. We also obtain R-current correlators and find that after accounting for a small subtlety, the Son-Starinets prescription yields the retarded Green's functions. The correlators do not display diffusive behaviour at late times. Below the critical value of the circle radius, the topological black hole decays to the AdS_5 "bubble of nothing". Using a high frequency WKB approximation, we show that glueball correlators in this phase exhibit poles on the real axis. The tunnelling from the black hole to the bubble is interpreted as a hadronization transition.Comment: 52 pages, 11 figures, typos corrected, references adde

1980: Abilene Christian College Bible Lectures - Full Text

UNTIL HE COMES Being the Abilene Christian University Annual Bible Lectures 1980 Published by Abilene Christian University Book Store ACU Station Abilene, Texas 7969

Vacuum Ambiguity in de Sitter Space at Strong Coupling

It is well known that in the weak coupling regime, quantum field theories in de Sitter space do not have a unique vacuum, but a class of vacua parametrized by a complex parameter $\alpha$, i.e., the so-called $\alpha$-vacua. In this article, using gauge/gravity duality, we calculate the symmetric two-point function of strongly coupled ${\cal N}=4$ supersymmetric Yang-Mills theory on $dS_3$. We find that there is a class of de Sitter invariant vacua, parametrized by a set of complex parameters $\{\alpha_{\nu}\}$.Comment: 17 pages in JHEP style, references adde

Assessment of a treatment guideline to improve home management of malaria in children in rural south-west Nigeria

<p>Abstract</p> <p>Background</p> <p>Many Nigerian children with malaria are treated at home. Treatments are mostly incorrect, due to caregivers' poor knowledge of appropriate and correct dose of drugs. A comparative study was carried out in two rural health districts in southwest Nigeria to determine the effectiveness of a guideline targeted at caregivers, in the treatment of febrile children using chloroquine.</p> <p>Methods</p> <p>Baseline and post intervention knowledge, attitude and practice household surveys were conducted. The intervention strategy consisted of training a core group of mothers ("mother trainers") in selected communities on the correct treatment of malaria and distributing a newly developed treatment guideline to each household. "Mother trainers" disseminated the educational messages about malaria and the use of the guideline to their communities.</p> <p>Results</p> <p>Knowledge of cause, prevention and treatment of malaria increased with the one-year intervention. Many, (70.4%) of the respondents stated that they used the guideline each time a child was treated for malaria. There was a significant increase in the correct use of chloroquine from 2.6% at baseline to 52.3% after intervention among those who treated children at home in the intervention arm compared with 4.2% to 12.7% in the control arm. The correctness of use was significantly associated with use of the guideline. The timeliness of commencing treatment was significantly earlier in those who treated febrile children at home using chloroquine than those who took their children to the chemist or health facility (p < 0.005). Mothers considered the guideline to be explicit and useful. Mother trainers were also considered to be effective and acceptable.</p> <p>Conclusion</p> <p>The use of the guideline with adequate training significantly improved correctness of malaria treatment with chloroquine at home. Adoption of this mode of intervention is recommended to improve compliance with drug use at home. The applicability for deploying artemisinin-based combination therapy at the community level needs to be investigated.</p

Primary processes: from atoms to diatomic molecules and clusters

International audienceThis article presents a short review of the main progresses achieved at the GANIL facilities during the last thirty years in the field of ion-atom and ion-diatomic molecule collisions. Thanks to the wide range of projectile energies and species available on the different beam lines of the facility, elementary processes such as electron capture, ionization and excitation have been extensively studied. Beside primary collision mechanisms, the relaxation processes of the collision partners after the collision have been another specific source of interest. Progresses on other fundamental processes such as Young type interferences induced by ion-molecule collisions or shake off ionization resulting from nuclear beta decay are also presented. 1. Introduction For the electronic structures of atoms and molecules, precise theoretical knowledge and high-resolution experimental data are available. But the complete understanding of dynamic processes in atomic collisions remains a challenge, due to large theoretical problems in describing time-dependent many-particle reactions, and to experimental difficulties in performing complete experiments in which all relevant quantities are accessible. Elementary collisions involving ions, atoms and molecules play an important role in many gaseous and plasma environments, where they provide both the heating and cooling mechanisms. The study of such collisions is thus not only of fundamental importance, it is also essential for the understanding of large-scale systems such as astrophysical plasmas, planetary atmospheres, gas discharge lasers, semiconductor processing plasmas, and fusion plasmas. Collisions between ions and atoms (or simple molecules) give also access to the elementary processes responsible for energy transfer in ion-matter and ion-biological molecule collisions. Complete knowledge of these elementary processes is thus of primordial importance for ion induced modification of materials as well as for radiolysis, radiotherapy and biological damages due to radiation exposure

Toward informatics-enabled preparedness for natural hazards to minimize health impacts of climate change

Natural hazards (NHs) associated with climate change have been increasing in frequency and intensity. These acute events impact humans both directly and through their effects on social and environmental determinants of health. Rather than relying on a fully reactive incident response disposition, it is crucial to ramp up preparedness initiatives for worsening case scenarios. In this perspective, we review the landscape of NH effects for human health and explore the potential of health informatics to address associated challenges, specifically from a preparedness angle. We outline important components in a health informatics agenda for hazard preparedness involving hazard-disease associations, social determinants of health, and hazard forecasting models, and call for novel methods to integrate them toward projecting healthcare needs in the wake of a hazard. We describe potential gaps and barriers in implementing these components and propose some high-level ideas to address them