2,700 research outputs found
Accurate Atmospheric Parameters at Moderate Resolution Using Spectral Indices: Preliminary Application to the MARVELS Survey
Studies of Galactic chemical and dynamical evolution in the solar
neighborhood depend on the availability of precise atmospheric parameters
(Teff, [Fe/H] and log g) for solar-type stars. Many large-scale spectroscopic
surveys operate at low to moderate spectral resolution for efficiency in
observing large samples, which makes the stellar characterization difficult due
to the high degree of blending of spectral features. While most surveys use
spectral synthesis, in this work we employ an alternative method based on
spectral indices to determine the atmospheric parameters of a sample of nearby
FGK dwarfs and subgiants observed by the MARVELS survey at moderate resolving
power (R~12,000). We have developed three codes to automatically normalize the
observed spectra, measure the equivalent widths of the indices and, through the
comparison of those with values calculated with pre-determined calibrations,
derive the atmospheric parameters of the stars. The calibrations were built
using a sample of 309 stars with precise stellar parameters obtained from the
analysis of high-resolution FEROS spectra. A validation test of the method was
conducted with a sample of 30 MARVELS targets that also have reliable
atmospheric parameters from high-resolution spectroscopic analysis. Our
approach was able to recover the parameters within 80 K for Teff, 0.05 dex for
[Fe/H] and 0.15 dex for log g, values that are lower or equal to the typical
external uncertainties found between different high-resolution analyzes. An
additional test was performed with a subsample of 138 stars from the ELODIE
stellar library and the literature atmospheric parameters were recovered within
125 K for Teff, 0.10 dex for [Fe/H] and 0.29 dex for log g. These results show
that the spectral indices are a competitive tool to characterize stars with the
intermediate resolution spectra.Comment: Accepted for publication in AJ. Abstract edited to comply with arXiv
standards regarding the number of character
Polymorphous low-grade adenocarcinoma of the tongue: a case report
<p>Abstract</p> <p>Introduction</p> <p>Polymorphous low-grade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and non-luminal tumor cells admixed in varying proportions. Its resemblance to lobular carcinoma of the breast had led to its earlier nomenclature of 'terminal duct carcinoma'. Most patients present with an asymptomatic mass in the hard palate. In rare cases, the mass can also occur in the tongue. We report an unusual case of polymorphous low-grade adenocarcinoma at the base of tongue.</p> <p>Case presentation</p> <p>A 47-year-old Asian Caucasian woman presented with a painless swelling at the right lateral border of the tongue with an intact overlying mucosa. There were no other associated complaints. The lesion was excised and subjected to histopathological examination that revealed an interesting and unusual morphology of polymorphous low-grade adenocarcinoma.</p> <p>Conclusion</p> <p>Polymorphous low-grade adenocarcinoma is a well-defined entity in the minor salivary glands. Its occurrence in the tongue is rare with very few cases reported in the literature. It is a malignant neoplasm with low aggressiveness and it is thus important to identify and treat it accordingly.</p
Cosmological reconstruction of realistic modified F(R) gravities
The cosmological reconstruction scheme for modified gravity is
developed in terms of e-folding (or, redshift). It is demonstrated how any FRW
cosmology may emerge from specific theory. The specific examples of
well-known cosmological evolution are reconstructed, including CDM
cosmology, deceleration with transition to phantom superacceleration era which
may develop singularity or be transient. The application of this scheme to
viable gravities unifying inflation with dark energy era is proposed.
The additional reconstruction of such models leads to non-leading gravitational
correction mainly relevant at the early/late universe and helping to pass the
cosmological bounds (if necessary). It is also shown how cosmological
reconstruction scheme may be generalized in the presence of scalar field.Comment: LaTex 11 page
Menstrual And Reproductive Factors, Hormone Use, And Risk Of Pancreatic Cancer: Analysis From The International Pancreatic Cancer Case-control Consortium (Panc4)
Objectives: We aimed to evaluate the relation between menstrual and reproductive factors, exogenous hormones, and risk of pancreatic cancer (PC). Methods: Eleven case-control studies within the International Pancreatic Cancer Case-control Consortium took part in the present study, including in total 2838 case and 4748 control women. Pooled estimates of odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a 2-step logistic regression model and adjusting for relevant covariates. Results: An inverse OR was observed in women who reported having had hysterectomy (ORyesvs.no, 0.78; 95% CI, 0.67-0.91), remaining significant in postmenopausal women and never-smoking women, adjusted for potential PC confounders. A mutually adjusted model with the joint effect for hormone replacement therapy (HRT) and hysterectomy showed significant inverse associations with PC in women who reported having had hysterectomy with HRT use (OR, 0.64; 95% CI, 0.48-0.84). Conclusions: Our large pooled analysis suggests that women who have had a hysterectomy may have reduced risk of PC. However, we cannot rule out that the reduced risk could be due to factors or indications for having had a hysterectomy. Further investigation of risk according to HRT use and reason for hysterectomy may be necessary
The Pioneer Anomaly
Radio-metric Doppler tracking data received from the Pioneer 10 and 11
spacecraft from heliocentric distances of 20-70 AU has consistently indicated
the presence of a small, anomalous, blue-shifted frequency drift uniformly
changing with a rate of ~6 x 10^{-9} Hz/s. Ultimately, the drift was
interpreted as a constant sunward deceleration of each particular spacecraft at
the level of a_P = (8.74 +/- 1.33) x 10^{-10} m/s^2. This apparent violation of
the Newton's gravitational inverse-square law has become known as the Pioneer
anomaly; the nature of this anomaly remains unexplained. In this review, we
summarize the current knowledge of the physical properties of the anomaly and
the conditions that led to its detection and characterization. We review
various mechanisms proposed to explain the anomaly and discuss the current
state of efforts to determine its nature. A comprehensive new investigation of
the anomalous behavior of the two Pioneers has begun recently. The new efforts
rely on the much-extended set of radio-metric Doppler data for both spacecraft
in conjunction with the newly available complete record of their telemetry
files and a large archive of original project documentation. As the new study
is yet to report its findings, this review provides the necessary background
for the new results to appear in the near future. In particular, we provide a
significant amount of information on the design, operations and behavior of the
two Pioneers during their entire missions, including descriptions of various
data formats and techniques used for their navigation and radio-science data
analysis. As most of this information was recovered relatively recently, it was
not used in the previous studies of the Pioneer anomaly, but it is critical for
the new investigation.Comment: 165 pages, 40 figures, 16 tables; accepted for publication in Living
Reviews in Relativit
Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
Data from multiple sclerosis (MS) and the MS rodent model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy at the basis of the neurodegenerative damage causing irreversible disability in these disorders. This synaptopathy is characterized by an imbalance between glutamatergic and GABAergic transmission and has been proposed to be a potential therapeutic target. Siponimod (BAF312), a selective sphingosine 1-phosphate1,5 receptor modulator, is currently under investigation in a clinical trial in secondary progressive MS patients. We investigated whether siponimod, in addition to its peripheral immune modulation, may exert direct neuroprotective effects in the central nervous system (CNS) of mice with chronic progressive EAE
Btk regulates macrophage polarization in response to lipopolysaccharide
Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer downstream of TLR4, we investigated its role in M1/M2 induction. In Btk deficient (Btk (−\−)) mice we observed markedly reduced recruitment of M1 macrophages following intraperitoneal administration of LPS. Ex vivo analysis demonstrated an impaired ability of Btk(−/−) macrophages to polarize into M1 macrophages, instead showing enhanced induction of immunosuppressive M2-associated markers in response to M1 polarizing stimuli, a finding accompanied by reduced phosphorylation of STAT1 and enhanced STAT6 phosphorylation. In addition to STAT activation, M1 and M2 polarizing signals modulate the expression of inflammatory genes via differential activation of transcription factors and regulatory proteins, including NF-κB and SHIP1. In keeping with a critical role for Btk in macrophage polarization, we observed reduced levels of NF-κB p65 and Akt phosphorylation, as well as reduced induction of the M1 associated marker iNOS in Btk(−/−) macrophages in response to M1 polarizing stimuli. Additionally enhanced expression of SHIP1, a key negative regulator of macrophage polarisation, was observed in Btk(−/−) macrophages in response to M2 polarizing stimuli. Employing classic models of allergic M2 inflammation, treatment of Btk (−/−) mice with either Schistosoma mansoni eggs or chitin resulted in increased recruitment of M2 macrophages and induction of M2-associated genes. This demonstrates an enhanced M2 skew in the absence of Btk, thus promoting the development of allergic inflammation
- …