1,520 research outputs found
Transdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trial
BACKGROUND
Comorbid anxiety in bipolar disorder (BD) is associated with greater illness severity, reduced treatment response, and greater impairment. Treating anxiety in the context of BD is crucial for improving illness course and outcomes. The current study examined the feasibility, acceptability and preliminary efficacy of the Unified Protocol (UP), a transdiagnostic cognitive behavioral therapy, as an adjunctive treatment to pharmacotherapy for BD and comorbid anxiety disorders.
METHODS
Twenty-nine patients with BD and at least one comorbid anxiety disorder were randomized to pharmacotherapy treatment-as-usual (TAU) or TAU with 18 sessions of the UP (UP+TAU). All patients completed assessments every four weeks to track symptoms, functioning, emotion regulation and temperament. Linear mixed-model regressions were conducted to track symptom changes over time and to examine the relationship between emotion-related variables and treatment response.
RESULTS
Satisfaction ratings were equivalent for both treatment groups. Patients in the UP+TAU group evidenced significantly greater reductions over time in anxiety and depression symptoms (Cohen's d's>0.80). Baseline levels of neuroticism, perceived affective control, and emotion regulation ability predicted magnitude of symptom change for the UP+TAU group only. Greater change in perceived control of emotions and emotion regulation skills predicted greater change in anxiety related symptoms.
LIMITATIONS
This was a pilot feasibility and acceptability trial; results should be interpreted with caution.
CONCLUSIONS
Treatment with the UP+TAU was rated high in patient satisfaction, and resulted in significantly greater improvement on indices of anxiety and depression relative to TAU. This suggests that the UP may be a feasible treatment approach for BD with comorbid anxiety.This work was supported by a Postdoctoral National Research Service Award from the National Institutes of Health [F32 MH098490] to K. Ellard. (F32 MH098490 - Postdoctoral National Research Service Award from the National Institutes of Health)Accepted manuscrip
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Nutrition, Exercise, and Wellness Treatment in bipolar disorder: proof of concept for a consolidated intervention
Background: This pilot study examines the proof of concept of a consolidated Nutrition, Exercise, and Wellness Treatment (NEW Tx) for overweight individuals with bipolar disorder. Findings: Five participants completed NEW Tx, a 20-week individual cognitive behavioral therapy-based treatment comprising three modules: Nutrition teaches appropriate serving sizes and balanced diet; Exercise emphasizes increasing weekly physical activity; Wellness focuses on skills for healthy decision-making. Participants attended most sessions and reported high satisfaction with the treatment. Participants’ weight, cholesterol and trigyclerides decreased over the study duration as well as number of daily calories and sugar intake. We found that weekly exercise duration more than tripled over the study duration and depressive symptoms and functioning have improved. Conclusions: These results offer proof of concept that consolidated NEW Tx is feasible and acceptable and has the potential to improve nutrition, exercise, wellness, and mood symptoms in bipolar disorder. Future iterations of NEW Tx will reflect the strengths and lessons learned from this study
N′-(4-Diethylamino-2-hydroxybenzylidene)-4-(dimethylamino)benzohydrazide methanol monosolvate
The title compound, C20H26N4O2·CH3OH, was prepared by the reaction of 4-diethylamino-2-hydroxybenzaldehyde with 4-(dimethylamino)benzohydrazide. The dihedral angle between the two benzene rings is 13.6 (3)° and an intramolecular O—H⋯N hydrogen bond generates an S(6) ring. In the crystal, the hydrazone and methanol molecules are linked through intermolecular O—H⋯O and N—H⋯O hydrogen bonds, forming chains along a
TileProbe: modeling tiling array probe effects using publicly available data
Motivation: Individual probes on an Affymetrix tiling array usually behave differently. Modeling and removing these probe effects are critical for detecting signals from the array data. Current data processing techniques either require control samples or use probe sequences to model probe-specific variability, such as with MAT. Although the MAT approach can be applied without control samples, residual probe effects continue to distort the true biological signals
Whole-genome analysis of histone H3 lysine 27 trimethylation in Arabidopsis
Trimethylation of histone H3 lysine 27 (H3K27me3) plays critical roles in regulating animal development, and in several cases, H3K27me3 is also required for the proper expression of developmentally important genes in plants. However, the extent to which H3K27me3 regulates plant genes on a genome-wide scale remains unknown. In addition, it is not clear whether the establishment and spreading of H3K27me3 occur through the same mechanisms in plants and animals. We identified regions containing H3K27me3 in the genome of the flowering plant Arabidopsis thaliana using a high-density whole-genome tiling microarray. The results suggest that H3K27me3 is a major silencing mechanism in plants that regulates an unexpectedly large number of genes in Arabidopsis (~4,400), and that the maintenance of H3K27me3 is largely independent of other epigenetic pathways, such as DNA methylation or RNA interference. Unlike in animals, where H3K27m3 occupies large genomic regions, in Arabidopsis, we found that H3K27m3 domains were largely restricted to the transcribed regions of single genes. Furthermore, unlike in animals systems, H3K27m3 domains were not preferentially associated with low-nucleosome density regions. The results suggest that different mechanisms may underlie the establishment and spreading of H3K27me3 in plants and animals
Direct Imaging in Reflected Light: Characterization of Older, Temperate Exoplanets With 30-m Telescopes
Direct detection, also known as direct imaging, is a method for discovering
and characterizing the atmospheres of planets at intermediate and wide
separations. It is the only means of obtaining spectra of non-transiting
exoplanets. Characterizing the atmospheres of planets in the <5 AU regime,
where RV surveys have revealed an abundance of other worlds, requires a
30-m-class aperture in combination with an advanced adaptive optics system,
coronagraph, and suite of spectrometers and imagers - this concept underlies
planned instruments for both TMT (the Planetary Systems Imager, or PSI) and the
GMT (GMagAO-X). These instruments could provide astrometry, photometry, and
spectroscopy of an unprecedented sample of rocky planets, ice giants, and gas
giants. For the first time habitable zone exoplanets will become accessible to
direct imaging, and these instruments have the potential to detect and
characterize the innermost regions of nearby M-dwarf planetary systems in
reflected light. High-resolution spectroscopy will not only illuminate the
physics and chemistry of exo-atmospheres, but may also probe rocky, temperate
worlds for signs of life in the form of atmospheric biomarkers (combinations of
water, oxygen and other molecular species). By completing the census of
non-transiting worlds at a range of separations from their host stars, these
instruments will provide the final pieces to the puzzle of planetary
demographics. This whitepaper explores the science goals of direct imaging on
30-m telescopes and the technology development needed to achieve them.Comment: (March 2018) Submitted to the Exoplanet Science Strategy committee of
the NA
R-process enrichment from a single event in an ancient dwarf galaxy
Elements heavier than zinc are synthesized through the (r)apid and (s)low
neutron-capture processes. The main site of production of the r-process
elements (such as europium) has been debated for nearly 60 years. Initial
studies of chemical abundance trends in old Milky Way halo stars suggested
continual r-process production, in sites like core-collapse supernovae. But
evidence from the local Universe favors r-process production mainly during rare
events, such as neutron star mergers. The appearance of a europium abundance
plateau in some dwarf spheroidal galaxies has been suggested as evidence for
rare r-process enrichment in the early Universe, but only under the assumption
of no gas accretion into the dwarf galaxies. Cosmologically motivated gas
accretion favors continual r-process enrichment in these systems. Furthermore,
the universal r-process pattern has not been cleanly identified in dwarf
spheroidals. The smaller, chemically simpler, and more ancient ultra-faint
dwarf galaxies assembled shortly after the first stars formed, and are ideal
systems with which to study nucleosynthesis events such as the r-process.
Reticulum II is one such galaxy. The abundances of non-neutron-capture elements
in this galaxy (and others like it) are similar to those of other old stars.
Here, we report that seven of nine stars in Reticulum II observed with
high-resolution spectroscopy show strong enhancements in heavy neutron-capture
elements, with abundances that follow the universal r-process pattern above
barium. The enhancement in this "r-process galaxy" is 2-3 orders of magnitude
higher than that detected in any other ultra-faint dwarf galaxy. This implies
that a single rare event produced the r-process material in Reticulum II. The
r-process yield and event rate are incompatible with ordinary core-collapse
supernovae, but consistent with other possible sites, such as neutron star
mergers.Comment: Published in Nature, 21 Mar 2016:
http://dx.doi.org/10.1038/nature1742
Fabrication and Operation of Magnetic Quantum-Dot Cellular Automata All Magnetic Logic
We report the fabrication of, and demonstrate logic functionality in, networks of magnetically-coupled, nanometer-scale magnets performing binary computation in a Magnetic Quantum-dot Cellular Automata (MQCA) system. MQCA is an all-magnetic logic that offers low power dissipation and high integration density of functional elements. Basic elements of MQCA architecture such as binary wire, three input majority logic gate, and a combination of the two logic elements are demonstrated at room temperature
Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals
Electron microscope studies have shown that the switched-off state of myosin II in muscle involves intramolecular interaction between the two heads of myosin and between one head and the tail. The interaction, seen in both myosin filaments and isolated molecules, inhibits activity by blocking actin-binding and ATPase sites on myosin. This interacting-heads motif is highly conserved, occurring in invertebrates and vertebrates, in striated, smooth, and nonmuscle myosin IIs, and in myosins regulated by both Ca(2+) binding and regulatory light-chain phosphorylation. Our goal was to determine how early this motif arose by studying the structure of inhibited myosin II molecules from primitive animals and from earlier, unicellular species that predate animals. Myosin II from Cnidaria (sea anemones, jellyfish), the most primitive animals with muscles, and Porifera (sponges), the most primitive of all animals (lacking muscle tissue) showed the same interacting-heads structure as myosins from higher animals, confirming the early origin of the motif. The social amoeba Dictyostelium discoideum showed a similar, but modified, version of the motif, while the amoeba Acanthamoeba castellanii and fission yeast (Schizosaccharomyces pombe) showed no head-head interaction, consistent with the different sequences and regulatory mechanisms of these myosins compared with animal myosin IIs. Our results suggest that head-head/head-tail interactions have been conserved, with slight modifications, as a mechanism for regulating myosin II activity from the emergence of the first animals and before. The early origins of these interactions highlight their importance in generating the inhibited (relaxed) state of myosin in muscle and nonmuscle cells
Early Spectra of the Gravitational Wave Source GW170817: Evolution of a Neutron Star Merger
On 2017 August 17, Swope Supernova Survey 2017a (SSS17a) was discovered as
the optical counterpart of the binary neutron star gravitational wave event
GW170817. We report time-series spectroscopy of SSS17a from 11.75 hours until
8.5 days after merger. Over the first hour of observations the ejecta rapidly
expanded and cooled. Applying blackbody fits to the spectra, we measure the
photosphere cooling from K to K,
and determine a photospheric velocity of roughly 30% of the speed of light. The
spectra of SSS17a begin displaying broad features after 1.46 days, and evolve
qualitatively over each subsequent day, with distinct blue (early-time) and red
(late-time) components. The late-time component is consistent with theoretical
models of r-process-enriched neutron star ejecta, whereas the blue component
requires high velocity, lanthanide-free material.Comment: 33 pages, 5 figures, 2 tables, Accepted to Scienc
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