116 research outputs found
Detecting Ultra High Energy Neutrinos by Upward Tau Airshowers and Gamma Flashes
Tau Air-showers are the best trace of rarest Ultra High Energy neutrinos UHE
, and at PeV and higher energy.
Air-showers may generate billion times amplified signals by their
secondaries . Horizontal amplified air-showers by and UHE
at PeV emerging from mountain chain might be the most
power-full imprint. Upward UHE interaction on Earth crust at
horizontal edge and from below, their consequent UHE air-showers beaming
toward high mountains should flash ,,X and optical detectors on
the top.
Upward air-shower may hit nearby satellite flashing them by short,
hard, diluted burst at the edge of Gamma Ray Observatory BATSE
threshold. We identify these events with recent (1994) discovered upward
Terrestrial Gamma Flashes (TGF) and we probed their UHE - UHE
origin. From these TGF data approximated UHE flux and sever lower bound are derived. Partial TGF Galactic
signature is also manifest within known 47 TGF events clustered within three
degrees from the Galactic plane at probability. Well
known active galactic and extragalactic sources have
found probable counterpart in TGF arrival directions. Detection of elusive UHE
seem finally achieved.Comment: 8 pages,4 Figs, DARK 2000 Conference in UCL
Observations of the Askaryan Effect in Ice
We report on the first observations of the Askaryan effect in ice: coherent impulsive radio Cherenkov radiation from the charge asymmetry in an electromagnetic (EM) shower. Such radiation has been observed in silica sand and rock salt, but this is the first direct observation from an EM shower in ice. These measurements are important since the majority of experiments to date that rely on the effect for ultra-high energy neutrino detection are being performed using ice as the target medium. As part of the complete validation process for the Antarctic Impulsive Transient Antenna (ANITA) experiment, we performed an experiment at the Stanford Linear Accelerator Center (SLAC) in June 2006 using a 7.5 metric ton ice target, yielding results fully consistent with theoretical expectations
New Limits on the Ultra-high Energy Cosmic Neutrino Flux from the ANITA Experiment
We report initial results of the first flight of the Antarctic Impulsive
Transient Antenna (ANITA-1) 2006-2007 Long Duration Balloon flight, which
searched for evidence of a diffuse flux of cosmic neutrinos above energies of 3
EeV. ANITA-1 flew for 35 days looking for radio impulses due to the Askaryan
effect in neutrino-induced electromagnetic showers within the Antarctic ice
sheets. We report here on our initial analysis, which was performed as a blind
search of the data. No neutrino candidates are seen, with no detected physics
background. We set model-independent limits based on this result. Upper limits
derived from our analysis rule out the highest cosmogenic neutrino models. In a
background horizontal-polarization channel, we also detect six events
consistent with radio impulses from ultra-high energy extensive air showers.Comment: 4 pages, 2 table
High Energy Neutrino Astronomy: Towards Kilometer-Scale Detectors
Of all high-energy particles, only neutrinos can directly convey astronomical
information from the edge of the universe---and from deep inside the most
cataclysmic high-energy processes. Copiously produced in high-energy
collisions, travelling at the velocity of light, and not deflected by magnetic
fields, neutrinos meet the basic requirements for astronomy. Their unique
advantage arises from a fundamental property: they are affected only by the
weakest of nature's forces (but for gravity) and are therefore essentially
unabsorbed as they travel cosmological distances between their origin and us.
Many of the outstanding mysteries of astrophysics may be hidden from our sight
at all wavelengths of the electromagnetic spectrum because of absorption by
matter and radiation between us and the source. For example, the hot dense
regions that form the central engines of stars and galaxies are opaque to
photons. In other cases, such as supernova remnants, gamma ray bursters, and
active galaxies, all of which may involve compact objects or black holes at
their cores, the precise origin of the high-energy photons emerging from their
surface regions is uncertain. Therefore, data obtained through a variety of
observational windows---and especially through direct observations with
neutrinos---may be of cardinal importance. In this talk, the scientific goals
of high energy neutrino astronomy and the technical aspects of water and ice
Cherenkov detectors are examined, and future experimental possibilities,
including a kilometer-square deep ice neutrino telescope, are explored.Comment: 13 pages, Latex, 6 postscript figures, uses aipproc.sty and epsf.sty.
Talk presented at the International Symposium on High Energy Gamma Ray
Astronomy, Heidelberg, June 200
Ecological Niche and Geographic Distribution of Human Monkeypox in Africa
Monkeypox virus, a zoonotic member of the genus Orthopoxviridae, can cause a severe, smallpox-like illness in humans. Monkeypox virus is thought to be endemic to forested areas of western and Central Africa. Considerably more is known about human monkeypox disease occurrence than about natural sylvatic cycles of this virus in non-human animal hosts. We use human monkeypox case data from Africa for 1970–2003 in an ecological niche modeling framework to construct predictive models of the ecological requirements and geographic distribution of monkeypox virus across West and Central Africa. Tests of internal predictive ability using different subsets of input data show the model to be highly robust and suggest that the distinct phylogenetic lineages of monkeypox in West Africa and Central Africa occupy similar ecological niches. High mean annual precipitation and low elevations were shown to be highly correlated with human monkeypox disease occurrence. The synthetic picture of the potential geographic distribution of human monkeypox in Africa resulting from this study should support ongoing epidemiologic and ecological studies, as well as help to guide public health intervention strategies to areas at highest risk for human monkeypox
KamLAND Sensitivity to Neutrinos from Pre-Supernova Stars
In the late stages of nuclear burning for massive stars (M>8~M_{\sun}), the
production of neutrino-antineutrino pairs through various processes becomes the
dominant stellar cooling mechanism. As the star evolves, the energy of these
neutrinos increases and in the days preceding the supernova a significant
fraction of emitted electron anti-neutrinos exceeds the energy threshold for
inverse beta decay on free hydrogen. This is the golden channel for liquid
scintillator detectors because the coincidence signature allows for significant
reductions in background signals. We find that the kiloton-scale liquid
scintillator detector KamLAND can detect these pre-supernova neutrinos from a
star with a mass of 25~M_{\sun} at a distance less than 690~pc with 3
significance before the supernova. This limit is dependent on the neutrino mass
ordering and background levels. KamLAND takes data continuously and can provide
a supernova alert to the community.Comment: 19 pages, 6 figures, 1 tabl
Flavor conversion of cosmic neutrinos from hidden jets
High energy cosmic neutrino fluxes can be produced inside relativistic jets
under the envelopes of collapsing stars. In the energy range E ~ (0.3 - 1e5)
GeV, flavor conversion of these neutrinos is modified by various matter effects
inside the star and the Earth. We present a comprehensive (both analytic and
numerical) description of the flavor conversion of these neutrinos which
includes: (i) oscillations inside jets, (ii) flavor-to-mass state transitions
in an envelope, (iii) loss of coherence on the way to observer, and (iv)
oscillations of the mass states inside the Earth. We show that conversion has
several new features which are not realized in other objects, in particular
interference effects ("L- and H- wiggles") induced by the adiabaticity
violation. The neutrino-neutrino scattering inside jet and inelastic neutrino
interactions in the envelope may produce some additional features at E > 1e4
GeV. We study dependence of the probabilities and flavor ratios in the
matter-affected region on angles theta13 and theta23, on the CP-phase delta, as
well as on the initial flavor content and density profile of the star. We show
that measurements of the energy dependence of the flavor ratios will, in
principle, allow to determine independently the neutrino and astrophysical
parameters.Comment: 56 pages, 19 figures. Minor changes. Accepted by JHEP
Monkeypox Disease Transmission in an Experimental Setting: Prairie Dog Animal Model
Monkeypox virus (MPXV) is considered the most significant human public health threat in the genus Orthopoxvirus since the eradication of variola virus (the causative agent of smallpox). MPXV is a zoonotic agent endemic to forested areas of Central and Western Africa. In 2003, MPXV caused an outbreak in the United States due to the importation of infected African rodents, and subsequent sequential infection of North American prairie dogs (Cynomys ludovicianus) and humans. In previous studies, the prairie dog MPXV model has successfully shown to be very useful for understanding MPXV since the model emulates key characteristics of human monkeypox disease. In humans, percutaneous exposure to animals has been documented but the primary method of human-to-human MPXV transmission is postulated to be by respiratory route. Only a few animal model studies of MPXV transmission have been reported. Herein, we show that MPXV infected prairie dogs are able to transmit the virus to naive animals through multiple transmission routes. All secondarily exposed animals were infected with MPXV during the course of the study. Notably, animals secondarily exposed appeared to manifest more severe disease; however, the disease course was very similar to those of experimentally challenged animals including inappetence leading to weight loss, development of lesions, production of orthopoxvirus antibodies and shedding of similar levels or in some instances higher levels of MPXV from the oral cavity. Disease was transmitted via exposure to contaminated bedding, co-housing, or respiratory secretions/nasal mucous (we could not definitively say that transmission occurred via respiratory route exclusively). Future use of the model will allow us to evaluate infection control measures, vaccines and antiviral strategies to decrease disease transmission
Assessing the Effectiveness of a Community Intervention for Monkeypox Prevention in the Congo Basin
Human monkeypox is a potentially severe illness that begins with a high fever soon followed by the development of a smallpox-like rash. Both monkeypox and smallpox are caused by infection with viruses in the genus Orthopoxvirus. But smallpox, which only affected humans, has been eradicated, whereas monkeypox continues to occur when humans come into contact with infected animals. There are currently no drugs specifically available for the treatment of monkeypox, and the use of vaccines for prevention is limited due to safety concerns. Therefore, monkeypox prevention depends on diminishing human contact with infected animals and preventing person-to-person spread of the virus. The authors describe a film-based method for community outreach intended to increase monkeypox knowledge among residents of communities in the Republic of the Congo. Outreach was performed to ∼23,600 rural Congolese. The effectiveness of the outreach was evaluated using a sample of individuals who attended small-group sessions. The authors found that among the participants, the ability to recognize monkeypox symptoms and the willingness to take ill family members to the hospital was significantly increased after seeing the films. In contrast, the willingness to deter some high-risk behaviors, such as eating animal carcasses found in the forest, remained fundamentally unchanged
Inhibition of Monkeypox virus replication by RNA interference
The Orthopoxvirus genus of Poxviridae family is comprised of several human pathogens, including cowpox (CPXV), Vaccinia (VACV), monkeypox (MPV) and Variola (VARV) viruses. Species of this virus genus cause human diseases with various severities and outcome ranging from mild conditions to death in fulminating cases. Currently, vaccination is the only protective measure against infection with these viruses and no licensed antiviral drug therapy is available. In this study, we investigated the potential of RNA interference pathway (RNAi) as a therapeutic approach for orthopox virus infections using MPV as a model. Based on genome-wide expression studies and bioinformatic analysis, we selected 12 viral genes and targeted them by small interference RNA (siRNA). Forty-eight siRNA constructs were developed and evaluated in vitro for their ability to inhibit viral replication. Two genes, each targeted with four different siRNA constructs in one pool, were limiting to viral replication. Seven siRNA constructs from these two pools, targeting either an essential gene for viral replication (A6R) or an important gene in viral entry (E8L), inhibited viral replication in cell culture by 65-95% with no apparent cytotoxicity. Further analysis with wild-type and recombinant MPV expressing green fluorescence protein demonstrated that one of these constructs, siA6-a, was the most potent and inhibited viral replication for up to 7 days at a concentration of 10 nM. These results emphasis the essential role of A6R gene in viral replication, and demonstrate the potential of RNAi as a therapeutic approach for developing oligonucleotide-based drug therapy for MPV and other orthopox viruses
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