(ONTO)2 Agent: an Ontology-based WWW broker to select ontologies

Knowledge reuse by means of ontologies now faces three important problems: (1) there are no standardized identifying features that characterize ontologies from the user point of view; (2) there are no web sites using the same logical organization, presenting relevant information about ontologies; and (3) the search for appropriate ontologies is hard, timeconsuming and usually fruitless. To solve the above problems, we present: (1) a living set of features that allow us to characterize ontologies from the user point of view and have the same logical organization; (2) a living domain ontology about ontologies (called Reference Ontology) that gathers, describes and has links to existing ontologies; and (3) (ONTO)2Agent, the ontology-based www broker about ontologies that uses the Reference Ontology as a source of its knowledge and retrieves descriptions of ontologies that satisfy a given set of constraints. (ONTO)2Agent is available at http://delicias.dia.fi.upm.es/REFERENCE_ONTOLOGY

Impacts of meteoric sulfur in the Earth's atmosphere

A meteoric sulfur input function and a sulfur ion chemistry scheme have been incorporated into a chemistry-climate model, in order to study the speciation of sulfur between the stratosphere and the thermosphere (~20 – 120 km), and the impact of the sulfur input from ablation of cosmic dust. The simulations have been compared to rocket observations of SO+ between 85 and 110 km, MIPAS observations of SO2 between 20 and 45 km, and stratospheric balloon-borne measurements of H2SO4 vapor and sulfate aerosol. These observations constrain the present day global flux of meteoric sulfur to ≤ 1.0 t S d-1, i.e. 2 orders of magnitude smaller than the flux of S into the stratosphere from OCS photo-oxidation and explosive volcanic SO2 injection. However, the meteoric sulfur flux is strongly focused into the polar vortices by the meridional circulation, and therefore the contribution of SO2 of meteoric origin to the polar upper stratosphere during winter is substantial (~ 30% at 50 km for a flux of 1.0 t S d-1). The Antarctic spring sulfate aerosol layer is found to be very sensitive to a moderate increase of the input rate of meteoric sulfur, showing a factor of 2 enhancement in total sulfate aerosol number density at 30 km for an input of 3.0 t S d-1. The input rate estimate of 1.0 t S d-1 suggests an enrichment of sodium relative to sulfur of 2.7 ± 1.5 and is consistent with a total cosmic dust input rate of 44 t d-1

Determination of the absorption cross sections of higher-order iodine oxides at 355 and 532 nm

Iodine oxides (IxOy) play an important role in the atmospheric chemistry of iodine. They are initiators of new particle formation events in the coastal and polar boundary layers and act as iodine reservoirs in tropospheric ozone-depleting chemical cycles. Despite the importance of the aforementioned processes, the photochemistry of these molecules has not been studied in detail previously. Here, we report the first determination of the absorption cross sections of IxOy, x=2, 3, 5, y=1–12 at λ=355 nm by combining pulsed laser photolysis of I2∕O3 gas mixtures in air with time-resolved photo-ionization time-of-flight mass spectrometry, using NO2 actinometry for signal calibration. The oxides selected for absorption cross-section determinations are those presenting the strongest signals in the mass spectra, where signals containing four iodine atoms are absent. The method is validated by measuring the absorption cross section of IO at 355 nm, σ355nm,IO=(1.2±0.1) ×10−18 cm2, which is found to be in good agreement with the most recent literature. The results obtained are σ355nm,I2O3<5×10−19 cm2 molec.−1, σ355nm,I2O4= (3.9±1.2)×10−18 cm2 molec.−1, σ355nm,I3O6= (6.1±1.6)×10−18 cm2 molec.−1, σ355nm,I3O7= (5.3±1.4)×10−18 cm2 molec.−1, and σ355nm,I5O12= (9.8±1.0)×10−18 cm2 molec.−1. Photodepletion at λ=532 nm was only observed for OIO, which enabled determination of upper limits for the absorption cross sections of IxOy at 532 nm using OIO as an actinometer. These measurements are supplemented with ab initio calculations of electronic spectra in order to estimate atmospheric photolysis rates J(IxOy). Our results confirm a high J(IxOy) scenario where IxOy is efficiently removed during daytime, implying enhanced iodine-driven ozone depletion and hindering iodine particle formation. Possible I2O3 and I2O4 photolysis products are discussed, including IO3, which may be a precursor to iodic acid (HIO3) in the presence of HO2

High efficiency and high linearity power amplifier design

The optimum high-frequency Class-F loading conditions are inferred, accounting for the effects of actual output device behavior, and deriving useful charts for an effective design. The important role of the biasing point selection is stressed, demonstrating that it must be different from the Class-B theoretical one to get the expected improvement. The IMD behavior of the Class-F amplifier is presented and the large-signal sweet-spot origin in the IMD output characteristics is discussed, together with possible strategies to improve intermodulation distortion performances. The control of the sweet spot position is demonstrated via proper terminating impedances, both at fundamental and harmonic frequencies and low frequencies

A laboratory characterisation of inorganic iodine emissions from the sea surface: dependence on oceanic variables and parameterisation for global modelling

Reactive iodine compounds play a significant role in the atmospheric chemistry of the oceanic boundary layer by influencing the oxidising capacity through catalytically removing O3 and altering the HOx and NOx balance. The sea-to-air flux of iodine over the open ocean is therefore an important quantity in assessing these impacts on a global scale. This paper examines the effect of a number of relevant environmental parameters, including water temperature, salinity and organic compounds, on the magnitude of the HOI and I2 fluxes produced from the uptake of O3 and its reaction with iodide ions in aqueous solution. The results of these laboratory experiments and those reported previously (Carpenter et al., 2013), along with sea surface iodide concentrations measured or inferred from measurements of dissolved total iodine and iodate reported in the literature, were then used to produce parameterised expressions for the HOI and I2 fluxes as a function of wind speed, sea-surface temperature and O3. These expressions were used in the Tropospheric HAlogen chemistry MOdel (THAMO) to compare with MAX-DOAS measurements of iodine monoxide (IO) performed during the HaloCAST-P cruise in the eastern Pacific ocean (Mahajan et al., 2012). The modelled IO agrees reasonably with the field observations, although significant discrepancies are found during a period of low wind speeds (< 3 m s&minus;1), when the model overpredicts IO by up to a factor of 3. The inorganic iodine flux contributions to IO are found to be comparable to, or even greater than, the contribution of organo-iodine compounds and therefore its inclusion in atmospheric models is important to improve predictions of the influence of halogen chemistry in the marine boundary layer

Oral pathology in the Iberian Neanderthals

In 1994, a series of human bones was found at the Sidrón cave in Borines (Concejo de Piloña, Asturias), Spain. Since the investigators suspected that they were dealing with human remains from the Spanish Civil War (1936-1939), the bones were collected by the Civil Guard, but were not subjected to archeological scrutiny. The finding was reported then to the corresponding authorities, who had them sent to the Laboratory of Forensic Anthropology of the Forensic Institute of Madrid (Spain), where an anthropological study was undertaken. This revealed the extraordinary palaeoanthropological and palaeopathological interest of the remains. The specimen studied herein, a mandible catalogued as SDR 7-8 (SIDRON 7-8) by the Forensic Laboratory in Madrid (Spain) and belonging to Homo neanderthalensis, with an age of 90,000 to 40,000 years BCE, showed special characteristics of oral pathology, making it a specimen of great palaeodontological interest.Key words: Mandible, Neanderthal, oral pathology, Sidrón, Asturias

Characteristic Evolution and Matching

I review the development of numerical evolution codes for general relativity based upon the characteristic initial value problem. Progress in characteristic evolution is traced from the early stage of 1D feasibility studies to 2D axisymmetric codes that accurately simulate the oscillations and gravitational collapse of relativistic stars and to current 3D codes that provide pieces of a binary black hole spacetime. Cauchy codes have now been successful at simulating all aspects of the binary black hole problem inside an artificially constructed outer boundary. A prime application of characteristic evolution is to extend such simulations to null infinity where the waveform from the binary inspiral and merger can be unambiguously computed. This has now been accomplished by Cauchy-characteristic extraction, where data for the characteristic evolution is supplied by Cauchy data on an extraction worldtube inside the artificial outer boundary. The ultimate application of characteristic evolution is to eliminate the role of this outer boundary by constructing a global solution via Cauchy-characteristic matching. Progress in this direction is discussed.Comment: New version to appear in Living Reviews 2012. arXiv admin note: updated version of arXiv:gr-qc/050809

A cost utility analysis alongside a cluster-randomised trial evaluating a minor ailment service compared to usual care in community pharmacy.

BACKGROUND: Minor ailments are "self-limiting conditions which may be diagnosed and managed without a medical intervention". A cluster randomised controlled trial (cRCT) was designed to evaluate the clinical, humanistic and economic outcomes of a Minor Ailment Service (MAS) in community pharmacy (CP) compared with usual care (UC). METHODS: The cRCT was conducted for 6 months from December 2017. The pharmacist-patient intervention consisted of a standardised face-to-face consultation on a web-based program using co-developed protocols, pharmacists' training, practice change facilitators and patients' educational material. Patients requesting a non-prescription medication (direct product request) or presenting minor ailments received MAS or UC and were followed-up by telephone 10-days after the consultation. The primary economic outcomes were incremental cost-utility ratio (ICUR) of the service and health related quality of life (HRQoL). Total costs included health system, CPs and patient direct costs: health professionals' consultation time, medication costs, pharmacists' training costs, investment of the pharmacy and consultation costs within the 10 days following the initial consultation. The HRQoL was obtained using the EuroQoL 5D-5L at the time of the consultation and at 10-days follow up. A sensitivity analysis was carried out using bootstrapping. There were two sub-group analyses undertaken, for symptom presentation and direct product requests, to evaluate possible differences. RESULTS: A total of 808 patients (323 MAS and 485 UC) were recruited in 27 CPs with 42 pharmacists (20 MAS and 22 UC). 64.7% (n = 523) of patients responded to follow-up after their consultation in CP. MAS patients gained an additional 0.0003 QALYs (p = 0.053). When considering only MAS patients presenting with symptoms, the ICUR was 24,733€/QALY with a 47.4% probability of cost-effectiveness (willingness to pay of 25,000€/QALY). Although when considering patients presenting for a direct product request, MAS was the dominant strategy with a 93.69% probability of cost-effectiveness. CONCLUSIONS: Expanding community pharmacists' scope through MAS may benefit health systems. To be fully cost effective, MAS should not only include consultations arising from symptom presentation but also include an oversight of self-selected products by patients. MAS increase patient safety through the appropriate use of non-prescription medication and through the direct referral of patients to GP. TRIAL REGISTRATION: ISRCTN, ISRCTN17235323 . Registered 07/05/2021 - Retrospectively registered

Meteor-ablated Aluminum in the Mesosphere-Lower Thermosphere

The first global atmospheric model (WACCM-Al) of meteor-ablated aluminum was constructed from three components: The Whole Atmospheric Community Climate Model (WACCM6); a meteoric input function for Al derived by coupling an astronomical model of dust sources in the solar system with a chemical meteoric ablation model; and a comprehensive set of neutral, ion-molecule and photochemical reactions relevant to the chemistry of Al in the upper atmosphere. The reaction kinetics of two important reactions that control the rate at which Al+ ions are neutralized were first studied using a fast flow tube with pulsed laser ablation of an Al target, yielding k(AlO+ + CO) = (3.7 ± 1.1) × 10−10 and k(AlO+ + O) = (1.7 ± 0.7) × 10−10 cm3 molecule−1 s−1 at 294 K. The first attempt to observe AlO by lidar was made by probing the bandhead of the B2Σ+(v′ = 0) ← X2Σ+(v″ = 0) transition at λair = 484.23 nm. An upper limit for AlO of 60 cm−3 was determined, which is consistent with a night-time concentration of ∼5 cm−3 estimated from the decay of AlO following rocket-borne grenade releases. WACCM-Al predicts the following: AlO, AlOH and Al+ are the three major species above 80 km; the AlO layer at mid-latitudes peaks at 89 km with a half-width of ∼5 km, and a peak density which increases from a night-time minimum of ∼10 cm−3 to a daytime maximum of ∼60 cm−3; and that the best opportunity for observing AlO is at high latitudes during equinoctial twilight