A dimensão poética no contexto hegemônico da técnica

This paper presents the concepts of measure, identity and representation as principles, that is, as conditions of possibility for the trajectory of the Occidental Culture to have showed itself as a culture that agrees to be understood as a culture where there is a hegemony of the technical aspect. Otherwise, is showed the poetics as a original and constituent principle for all the humans beings

Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity

OBJECTIVES: This study evaluated the resistance to antimicrobials of aerobes and facultative anaerobes isolated from patients wearing complete dentures, patients with gingivitis and periodontitis, and periodontally health subjects. MATERIAL AND METHODS: Three hundred and four isolates were tested. The minimal inhibitory concentrations of the drugs were evaluated through the agar dilution method using Mueller-Hinton agar. RESULTS: The most active antimicrobial drugs were the carbapenems (meropenem and imipenem), and resistance to these drugs was restrict to 1.6-2.3% of the isolates, as well as ciprofloxacin and rifampin. Microbial resistance to ampicillin, amoxicillin/clavulanic acid, cefoxitin, cephalothin, amikacin, chloramphenicol and nalidixic acid was particularly high. In most cases, the resistance to β-lactams was mediated by the production of hydrolytic enzymes, especially in gram-negative enteric rods, while enterococci did not evidence production of these enzymes. The association amoxicillin/clavulanic acid was not effective in 28.3% of the tested isolates. CONCLUSIONS: The results of this investigation confirmed that the oral cavity of patients with periodontitis and gingivitis, and particularly edentulous patients wearing complete dentures could harbor microorganisms with several antimicrobial resistance markers, and these microorganisms are frequently implicated in multiresistant, systemic, oral or nosocomial infections

Práticas do ator: uma ciência do corpo sutil - Brasil e America Latina

praticas do ator uma ciencia do corpo sutil Braisl e America Latin

Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies

This study was designed to determine the effects of phlebotomy on iron body contents and coagulation tests of COPD patients with polycythemia secondary to hypoxemia. Seventeen patients with COPD and hematocrits higher than 54 percent (mean Hct: 57 ± 0.49 percent ), who had not received anti-inflammatory or antiplatelet aggregation agents recently. Their mean forced expiratory volume at 1 second (FEV1) was 0.92 ± 0.11 L. Intervention: Blood work was collected to evaluate the following: serum iron and ferritin levels, total iron binding capacity, transferrin saturation index, fibrinogen plasma levels, activated partial thromboplastin time, platelet count, platelet aggregation measurements, and thromboelastography coagulation parameters. The blood samples were obtained before and about 7 days after the hematocrit correction by 300-400 ml phlebotomies done every other day. The mean number of phlebotomies done for each patient was 4.4. Postphlebotomy iron serum levels decreased from 90.1 ± 14.8 to 59.7 ± 9.9 mg/dl and the ferritin serum levels from 133.8 ± 37.9 to 70.8 ± 32.7 ng/ml (p< 0.05). Regarding the coagulation studies, there were significant increases in the platelet count, from 227,300 ± 13,900 to 312,500 ± 30,200 per mm³, and in the maximum clot amplitude (a) obtained by thromboelastography ( from 53.6 ± 1.4 percent to 60.4 ± 1.1 percent). The coagulation time (k) of the thromboelastography also decreased significantly, from 7.5 ± 0.7mm prephlebotomy to 4.5 ± 0.3mm postphlebotomy. Although the coagulation changes were small amount, the observed significant decrease in iron contents may have important clinical implications.Determinar os efeitos das sangrias nas reservas corporais de ferro e em testes da coagulação sanguínea de pacientes com policitemia secundária a hipoxemia por doença pulmonar obstrutiva crônica (DPOC). Dezesete pacientes portadores de DPOC, com hematócritos superiores a 54%, ( Hct médio: 57± 0,49%) que não tinham feito uso recente de agentes antinflamatórios ou antiadesivos plaquetários, e cujo volume expirado forçado no primeiro segundo (VEF1), médio foi de 0,92 ± 0,11 L. Determinação dos níveis de ferro, ferritina, capacidade de ligação do ferro, índice de saturação da transferrina, fibrinogênio, tempo de tromboplastina parcial ativada, número de plaquetas, agregação plaquetária e de parâmetros da coagulação medidos pela tromboelastografia. Tais dosagens foram realizadas antes e em torno de sete dias após a normalização dos hematócritos através de sangrias de 300-400ml cada, realizadas em dias alternados, resultando num número médio de 4,4 sangrias por paciente. Com as sangrias os níveis séricos do ferro caíram de 90,1± 14,8 mg/dl a 59,7 ± 9,9 mg/dl, e os níveis da ferritina sérica de 133,8 ± 37,9 ng/ml a 70,8 ± 32,7 ng/ml (p<0.05). Em relação aos estudos da coagulação, houve um aumento significante na contagem plaquetária de 227.300 ± 13.900 a 312.500 ± 30,200 elementos/mm³, e na amplitude máxima do coágulo obtida pela tromboelastografia (a), de 53,6 ± 1,4% para 60,4 1 ± 1,1%. O tempo de coagulação (k) da tromboelastografia, também diminuiu significantemente de 7,5 ± 0,7 mm pré-flebotomias para 4,5 ± 0,3 mm pós-flebotomias. Os autores concluem que embora as alterações da coagulação tenham sido de pequena monta, os decréscimos nas reservas de ferro foram significantes podendo ter implicações clínicas importantes.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Respiratory and Hematology DivisionsUNIFESP, EPM, Respiratory and Hematology DivisionsSciEL

Evaluation of the population based cancer registry of the municipality of Goiânia, Goiás state, Brazil

Os Registros de Câncer de Base Populacional (RCBP) constituem uma reconhecida ferramenta para vigilância e monitoramento das neoplasias, exercendo um papel fundamental para a Saúde Pública. Aplicar uma metodologia de avaliação permitirá dispor de informações relevantes quanto à qualidade e utilidade desses registros. A metodologia de avaliação aplicada foi baseada nas seguintes publicações: “Diretrizes para Avaliação de Sistemas de Vigilância”, dos Centers for Disease Control and Prevention (CDC) dos Estados Unidos da América; “Registros de Câncer: Princípios e Métodos” (manuais) e “Comparabilidade e Controle de Qualidade nos Registros de Câncer”, ambas da Agência Internacional para Pesquisa sobre o Câncer (IACR)/Organização Mundial da Saúde (OMS); e “Manual de Rotinas e Procedimentos para Registros de Câncer de Base Populacional”, do Instituto Nacional do Câncer do Ministério da Saúde (Inca/MS). O RCBP do Município de Goiânia, Estado de Goiás, Brasil, mostrou-se complexo em sua operacionalização, porém flexível, oportuno, útil e representativo. Os indicadores de qualidade aferidos validam a importância e o papel das informações geradas pelos RCBP enquanto subsídios à implementação de políticas públicas de prevenção e controle do câncer. _______________________________________________________________________________________ ABSTRACTPopulation Based Cancer Registries (RCBP) constitute a recognized tool for cancer surveillance and monitoring, and have a fundamental role in Public Health. The application of an evaluation methodology will generate valuable information with respect to the quality and usefulness of the registries. The applied evaluation methodology was based on the following publications: “Guidelines for Evaluating Surveillance Systems”, of the Centers for Disease Control and Prevention (CDC) of the United States of America; “Cancer Registry: Principles and Methods” (manuals), and the “Comparability and Quality Control of Cancer Registry”, both of the International Agency for Cancer Research (IACR)/World Health Organization (WHO); and “Routines and Procedures for Population-based Cancer Registrees”, of the National Institute of Cancer of the Ministry of Health of Brazil (Inca/MS). The RCBP of the Municipality of Goiânia, Goiás State, Brazil, showed to be complex in its operationalization, but flexible, timely, useful and representative. The measured quality indicators validate the importance and the role of the information generated by the registry as subsidies for implementation of public prevention and cancer control policies

Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis

Objective: To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis.Methodology: Samples of mucus were collected, from 21 volunteers presenting no lung disease who had undergone surgery, from 10 patients presenting chronic COPD, and from 16 patients with bronchiectasis. Mucociliary transport (MCT), transport by cough (SCM), and contact angle (CAM) were evaluated.Results: MCT was found to be greater in healthy individuals (1.0 +/- 0.19) than in COPD (0.91 +/- 0.17) and bronchiectasis (0.76 +/- 0.23) patients (p < 0.05), whereas SCM was greater in COPD patients (16.31 +/- 7.35 cm) than in patients with bronchiectasis (12.16 +/- 6.64 cm) and healthy individuals (10.50 +/- 25.8 cm) (p < 0.05). No significant differences were observed between the groups regarding CAM.Conclusion: Mucus from healthy individuals allows better mucociliary transport compared to that from patients with lung diseases. However, the mucus from COPD patients allows a better transport by coughing, demonstrating that these individuals have adapted to a defence mechanism compared to patients with bronchiectasis, who have impairment in their ciliary and cough transport mechanisms. (c) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.Ctr Univ Tridngulo, Dept Fisioterapia, Uberlandia, MG, BrazilFac Med Ribeirao Preto, Dept Fisioterapia, Ribeirao Preto, BrazilUniversidade Federal de São Paulo, Dept Pneumol, São Paulo, BrazilFac Med Ribeirao Preto, Dept Pneumol, Ribeirao Preto, BrazilUniversidade Federal de São Paulo, Dept Pneumol, São Paulo, BrazilWeb of Scienc

Avaliação dos problemas cognitivos em pacientes psquiátricos Pós-COVID-19: Evaluation of cognitive problems in Post-COVID-19 pschiatric patients

Popularmente conhecido como coronavírus, o Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) teve sua primeira ocorrência identificada no final de dezembro do ano de 2019 na China, a partir disso alcançou uma contaminação desenfreada e foi responsável por um colapso mundial dos sistemas de saúde, ocasionando centenas de repercussões. Dentre essas implicações, tem-se uma imprecisão de funções cognitivas, caracterizando um déficit conhecido como problemas cognitivos, principalmente associado a memória e atenção. Sendo assim, o presente trabalho visa correlacionar as alterações cognitivas de 100 (cem) pacientes psiquiátricos do centro de Atenção Psicossocial Álcool e Drogas II, no consultório psiquiátrico Dr. Marcos Hering, ambos em Caçador-SC e na Clínica Psiquiátrica em Santa Cecília-SC, através da aplicação de um questionário elaborado e do teste do miniexame do estado mental (MEEM). Os resultados não obtiveram alterações significativas para um comprometimento cognitivo presente, mas um número considerável sobre alteração na memória recente dentro do exame analisado foi evidente. Portanto, mais estudos direcionados a alteração da memória de curto prazo dos infectados pelo vírus é de suma importância

Contact Failure Identification in Multilayered Media via Artificial Neural Networks and Autoencoders

The estimation of defects positioning occurring in the interface between different materials is performed by using an artificial neural network modeled as an inverse heat conduction problem. Identifying contact failures in the bonding process of different materials is crucial in many engineering applications, ranging from manufacturing, preventive inspection and even failure diagnosis. This can be modeled as an inverse heat conduction problem in multilayered media, where thermography temperature measurements from an exposed surface of the media are available. This work solves this inverse problem with an artificial neural network that receives these experimental data as input and outputs the thermalphysical properties of the adhesive layer, where defects can occur. An autoencoder is used to reduce the dimension of the transient 1D thermography data, where its latent space represents the experimental data in a lower dimension, then these reduced data are used as input to a fully connected multilayer perceptron network. Results indicate that this is a promising approach due to the good accuracy and low computational cost observed. In addition, by including different noise levels within a defined range in the training process, the network can generalize the experimental data input and estimate the positioning of defects with similar quality.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Finance Code 001), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Grant CAPES/PrInt No. 88887.469279/2019-00PID2020-112754 GB-I00 (Spanish Ministry of Economy and Competitiveness and funds from the European Regional Developement Fund, ERDF)B-TIC-640-UGR20 (Regional Govern of Andalusia, Spain

Oxygen and Ventilatory Output during Several Activities of Daily Living Performed by COPD Patients Stratified According to Disease Severity

Objectives: To measure the oxygen and ventilatory output across all COPD stages performing 18 common ADL and identify the activities that present the highest metabolic and ventilatory output as well as to compare the energy expenditure within each disease severity.Materials and Methods: Metabolic (VO2 and VCO2), ventilatory (f and V-E), cardiovascular (HR) and dyspnea (Borg score) variables were assessed in one hundred COPD patients during the completion of eighteen ADL grouped into four activities domains: rest, personal care, labor activities and efforts.Results: the activities with the highest proportional metabolic and ventilatory output (VO2/VO(2)max and VE/MVV) were walking with 2.5 Kg in each hand and walking with 5.0 Kg in one hand. Very severe patients presented the highest metabolic, ventilatory output and dyspnea than mild patients (p<0.05).Conclusions: COPD patients present an increased proportion of energy expenditure while performing activities of daily living. the activities that developed the highest metabolic and ventilatory output are the ones associated to upper and lower limbs movements combined. Very severe patients present the highest proportional estimated metabolic and ventilatory output and dyspnea. Activities of daily living are mainly limited by COPD's reduced ventilatory reserve.Fed Univ São Paulo Unifesp, Pulm Rehabil Ctr, São Paulo, BrazilFed Univ Pampa Unipampa, Uruguaiana, RS, BrazilAdventist Univ, São Paulo, BrazilNove de Julho Univ, São Paulo, BrazilPulm Rehabil Ctr Unifesp, São Paulo, BrazilUniversidade Federal de São Paulo, Pulm Rehabil Ctr, São Paulo, BrazilFed Univ São Paulo Unifesp, Pulm Rehabil Ctr, São Paulo, BrazilPulm Rehabil Ctr Unifesp, São Paulo, BrazilUniversidade Federal de São Paulo, Pulm Rehabil Ctr, São Paulo, BrazilWeb of Scienc

Specific discrimination between Taenia saginata and Taenia solium by one step PCR assay and duplex-PCR

Este estudo teve como objetivo a padronização de protocolos e a seleção de novos primers para a identificação espécie-específica de Taenia saginata e Taenia solium através da reação em cadeia da polimerase (PCR) e duplex-PCR. Inicialmente, foram recuperadas seqüências depositadas no GenBank (acesso n° AB020399 para T. saginata e n° AB020395 para T. solium) referentes ao gene da subunidade maior do ribossomo (LSU RNAr) de tenídeos. A partir do alinhamento das seqüências, um primer genérico denominado TBR-3 (5’- ggcttgtttgaatggtttgacg- 3’) foi selecionado de região conservada e, de diferentes regiões semi-conservadas, os primers específicos TBR-4 para T. saginata (5’-cgactcatgaagataaacaaggt-3’) e TBR- 5 (5’-cggtcgaacagaccataaatct-3’) e TBR-6 (5’- gctactacacctaaattctaacc- 3’) para T. solium. Os primers foram avaliados quanto à especificidade através da PCR empregandose DNA total (DNAt) de amostras de cisticercos e proglotes dos parasitos, previamente identificadas por critérios morfológicos. O par de primers TBR-3/TBR-4 permitiu a amplificação específica do fragmento esperado de 328 pb a partir do DNAt de T. saginata. Os pares TBR-3/TBR-5 e TBR-3/TBR-6 permitiram a amplificação, respectivamente, dos fragmentos específicos de 310pb e 286pb a partir do DNAt de T. solium. A identidade dos produtos de PCR foi comprovada comparando-se a seqüência dos amplicons obtidos às seqüências de referência do gene LSU RNAr registrado no GenBank (n° AB020399 e n° AB020395). As reações apresentaram sensibilidade para detecção de até 1fg do DNAt de T. solium e 0,2fg do DNAt de T. saginata. A combinação dos primers TBR-3/TBR-4 e TBR3/TBR-6 e o tamanho dos fragmentos gênicos obtidos permitiram o estabelecimento de ensaios de duplex-PCR, eficaz na detecção simultânea do DNA de T. saginata e T. solium em sistema único de reação. Os primers utilizados não geraram qualquer produto de amplificação cruzada quando testados com DNAt de Taenia hydatigena, Taenia taeniaeformis, Hymenolepis diminuta, Anoplocephala magna, Paranoplocephala mamillana e Moniezia expansa, nem frente ao DNAt dos hospedeiros Homo sapiens, Bos taurus e Sus scrofa.This study was conducted to evaluate a protocol and to select novel primers for the species-specific identification of Taenia saginata and Taenia solium by PCR and duplex- PCR assays. Sequences of the LSU rRNA gene of taenids were obtained from the GenBank (T. saginata access n° AB020399 and T. solium access n° AB020395). The sequences were aligned and then used for primer design. The generic primer TBR3 (5’- ggcttgtttgaatggtttgacg- 3’) was selected from a conserved region. The T. saginata specific primer TBR-4 (5’- cgactcatgaagataaacaaggt-3’) as well as T. solium specific primers TBR-5 (5’-cggtcgaacagaccataaatct-3’) and TBR-6 (5’- gctactacacctaaattctaacc- 3’) were selected from different semiconserved regions. The selected sequences were examined in for similarities with other organisms through the GenBank Blast procedure and experimentally by PCR using total DNA (tDNA)extracted from cysticerci and proglottids from both parasites. The primer pair TBR-3/TBR-4 amplified specific fragments of 328 bp from T. saginata tDNA. The pairs TBR-3/TBR5 and TBR-3/TBR-6 amplified, respectively, the expected and specific fragments of 310bp and 286bp from the T. solium tDNA. Sequencing of the amplicons followed by comparison to GenBank reference sequences confirmed the identities of the PCR products. The detection sensitivity was equivalent to 1fg of T. solium tDNA and 0,2fg of T. saginata tDNA. The combination of primers TBR-3/TBR-4 and TBR3/TBR-6 and the size of amplicons allowed the establishment of a duplex-PCR assay to detect T. saginata and T. solium DNA. No cross reaction was observed with any combination of primers in reactions with tDNA of the parasites Taenia hydatigena, Taenia taeniaeformis, Hymenolepis diminuta, Anoplocephala magna, Paranoplocephala mamillana and Moniezia expansa, nether from the hosts tDNA Homo sapiens, Bos taurus nor Sus scrofa