63 research outputs found
Ludzie starzy a ich jakość życia – wyzwania dla geografii
W artykule podjęto problem badawczy dotyczący jakości życia ludzi starych. Zwrócono uwagę na istotę tego zagadnienia i możliwe drogi podjęcia tego tematu w geografii społecznej. Waga problemu jakości życia ludzi w podeszłym wieku nie jest wynikiem tylko uwarunkowań demograficznych związanych z powiększaniem się tej grupy osób, ale dotyczy także rozmiaru zadań w zakresie opieki nad osobami starszymi i starymi. Przy opisie jakości życia ludzi starych należy odnieść się do czterech podstawowych kategorii: komunikacji (społecznej), zdrowia, autonomii i korzystania z usług instytucji.
Podejmowane badania nad jakością życia seniorów przez różne dyscypliny naukowe przyczyniają się do poszerzenia wiedzy na ten temat i ujmowania tych zagadnień pod różnym kątem w zależności od swoistego charakteru badań przynależnego danej dyscyplinie naukowej. Autorzy opracowania zwracają uwagę na rolę geografii społecznej w tej dziedzinie i to nie tylko przy wyjaśnianiu aspektów przestrzennych zjawiska jakości życia ludzi starych.The article raises the issue of the quality of life of elderly people. It focuses on the significance of the phenomenon and possible routes for approaching it within the framework of social geography. The importance of the problem of the quality of life of the elderly is not only a result of demographic conditions related to the increase in the size of this group, but it is also related to the scope of care over elderly people. When describing the quality of life of the elderly, one must refer to four basic categories: (social) communication, health, autonomy and utilisation of institutional services. Studies into the quality of life of the elderly conducted by various scientists help expand the knowledge on this subject and approach these matters from different angles depending on the specific character of each study related to a different area of science. The authors of the study emphasise the role of social geography in this area, not only for explaining the spatial aspects of the phenomenon of the quality of life of elderly people
Molecular diagnostics of families with long-QT syndrome
The Department of Pediatric Cardiology, Medical University of Silesia in Katowice-Ligota,
studied 24 patients with clinically diagnosed (using ECG) long-QT syndrome (LQTS) in 18 cases.
Nine patients were diagnosed with LQT1 and nine with LQT2. The other six individuals were
healthy, with no symptoms characteristic for prolonged QT syndrome, but came from families
with confirmed disease occurrence. The study was conducted on members of four families. In
order to search for mutations (using mSSCP and sequencing), genomic DNA was obtained
from patients to determine the expression levels of the genes KCNQ1 and KCNH2 (HERG),
involved in the occurrence of clinical signs of disease. Total RNA was extracted from peripheral
blood. Consent to the use of blood samples of patients had been given by the Bioethics
Commission of the Medical University of Silesia.
mSSCP analysis and sequencing did not confirm the occurrence of mutations in KCNQ1 and
HERG associated with the occurrence of LQTS. Analysis of gene expression profile of KCNQ1
and HERG confirmed the presence of disease in people with a known clinical diagnosis.
Overexpression, as well as reduced expression, was observed for the examined genes. KCNQ1
was inhibited in two families, whereas HERG was reduced in one and overexpressed in the
other. Gene expression profile analysis showed abnormal expressions of KCNQ1 and HERG
in healthy subjects, which may be a sign of predisposition to develop the disease. The novelty of
our study involved the use of total mRNA isolated from human peripheral blood, and the very
limited evidence in the literature to date regarding the assessment of gene expression profile of
HERG and KCNQ1 in relation to the presence of prolonged QT syndrome. (Cardiol J 2012;
19, 2: 159–167
Church in a Local Community
The Catholic Church is a global and universal (unified) formation, which has adapted
itself to the needs and expectations of the regions in a flexible way. Similarly to other great
religious institutions, it also participates in changes of the late modernity period. The faithful
were also participated in these changes, in both secular and religious aspects of their lives
Wybrane aspekty demograficzne pandemii COVID-19 w polskich regionach a reaktywne działania polityki zdrowotnej
The main purpose of the article is to juxtapose the demographic impact of the pandemic and the real-time actions and health policies that were remodeled as a result of the outbreak. The subject of interest of the Authors is Poland. However, a broader European background is outlined when discussing the actions of international institutions. In addition to the cognitive dimension of the article, the Authors wanted to draw attention to methodological problems. It seems that one more effect of the pandemic is to expose the methodological inconsistency at the national and European levels when it comes to issues of medical statistics and quality of life more broadly. The analysis of statistical materials carried out clearly showed that in the overwhelming number of administrative units (provinces/counties) there were recorded, very unfavorable phenomena from the demographic point of view. The pandemic definitely worsened the situation in the level of health, as evidenced by the increase in deaths, especially excess deaths, unrelated to COVID-19. As a consequence of these events, an increase in health debt was observed, which is the result of the obstruction of the public health system, making it difficult for citizens to access effective medical care and treatment.
The negative changes brought about by the pandemic require government intervention in social policy, including health policy. Undoubtedly, in the near term, measures should be taken to improve the level of health of the Polish population. Given the narrowed reproduction (as a result of the increase in COVID-19 and excess deaths), the second important area of intervention is fertility. But since the demographic transition is a complex and long-term process, it is important to be aware that the interventions undertaken (even if effective) have limited power of impact, and their effects will be deferred over time.Głównym celem artykułu jest określenie wybranych demograficznych skutków pandemii i działań podejmowanych w czasie rzeczywistym oraz polityk zdrowia, które przemodelowane były na skutek jej wybuchu. Podmiotem zainteresowania autorek jest Polska, a jednostkami odniesienia były województwa i powiaty. Zarysowano jednak szersze, europejskie tło podczas omawiania działań instytucji międzynarodowych. Materiał źródłowy pochodzi z baz danych Głównego Urzędu Statystycznego i Ministerstwa Zdrowia. Oprócz poznawczego wymiaru artykułu autorki chciały zwrócić uwagę na problemy metodologiczne. Wydaje się, że jeszcze jednym ze skutków pandemii jest obnażenie braku spójności metodologicznej na poziomie krajowym i europejskim, gdy chodzi o kwestie statystyki medycznej i szerzej jakości życia.
Analiza materiałów statystycznych jednoznacznie wykazała, że w przeważającej liczbie jednostek administracyjnych (województw/powiatów) odnotowano wzrost liczby zgonów (covidowych i noncovidowych), który wpłynął na powiększenie się ubytku naturalnego w Polsce. Pandemia zdecydowanie pogorszyła sytuację w poziomie zdrowotności, o czym świadczy wzrost zgonów, w tym szczególnie nadmiarowych, niezwiązanych z COVID-19. W konsekwencji tych wydarzeń zaobserwowano powiększenie się długu zdrowotnego, który jest efektem niedrożności publicznego systemu zdrowia, utrudniającym obywatelom dostęp do efektywnej opieki medycznej i leczenia
Evaluation of the textural parameters of zeolite beta in LDPE catalytic degradation : thermogravimetric analysis coupled with FTIR operando studies
The performance of triglyceride to high-density lipoprotein cholesterol ratio in acute coronary syndromes using a diagnostic decision tree
Background. Modern modeling techniques, including decision trees, may potentially provide accurate prediction and classification of outcomes, and support the process of clinical decision making. The objective of our study was to evaluate the performance of triglyceride to high-density lipoprotein (TG:HDL-C) ratio in acute coronary syndromes (ACS) presented using a decision tree analysis. Methods. The initial study group consisted of 220 consecutive patients admitted to hospital within the first 6 hours from the onset of chest pain. All these patients met clinical criteria of ACS and were compared with 116 healthy volunteers in a case-control study. Serum was assayed on admission for cardiac troponin I, C-reactive protein, apolipoproteins ApoAI and ApoB, and lipid parameters. Atherogenic lipid ratios: TC:HDL:C, LDL-C:HDL:C and TG:HDL-C were calculated. Results. ACS patients showed almost twice as high median values of TG:HDL-C as controls [2.77 (1.88–4.08) vs. 1.47 (0.99–2.08); p < 0.0001]. The TG:HDL-C ratio was significantly related to the positive history of coronary artery disease, age and lipid parameters, except for LDL-C. The TG:HDL-C ratio was, after age, the most powerful independent predictor and classifier of the occurrence of ACS with the optimal cutoff being 2.28. The performance of TG:HDL-C was superior to other lipid parameters and ratios, and enabled identification of the additional 6 subjects with ACS. Conclusion. The TG:HDL-C ratio is a useful risk marker of the ACS occurrence. Further prospective studies are needed to confirm our findings and clarify the interaction between TG and HDL-C concentrations in ACS patients
ARCHITECT STAT High Sensitive Troponin I Familiarization Study (FAM) in the Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University in Bydgoszcz, Poland
Background. International guidelines recommend the use of cardiac troponin assays for early detection of acute myocardial infarction. New high-sensitivity assays along with improved precision and sensitivity, are now widely available, accelerating patient’s diagnosis, treatment and invasive therapy. In this study we evaluated analytical performance of the Abbott ARCHITECT STAT high-sensitive troponin-I immunoassay and its 99th percentile upper reference limit.
Methods. We performed the analytical evaluation of the hs-cTnI assay using Abbott ARCHITECT i2000SR immunoanalyzers. Features of the assay including imprecision, detection limits, linearity of dilution, interferences and method comparisons were assessed, as well as the 99th percentile upper reference limits in a cohort of 427 presumably healthy individuals were established.
Results. Total imprecision ranged from 3.1% to 4.7% and was lowest for the medium controls. The observed limit of blank, limit of detection and limit of quantitation assumed values of 0.1, 1.5 and 4.8 ng/L, respectively. Common interferences, sample dilution and carry over did not affect the hs-cTnI results. Hs-cTnI was detectable in 98% of presumably healthy individuals. The 99th percentile values were age and sex dependent in the presumably healthy, but not in the healthy individuals.
Conclusion. The new high-sensitivity troponin-I assay has improved analytical features and may be a valuable diagnostic tool.
Opinion of nurses of surgical departments on musculoskeletal pain
Introduction
Musculoskeletal pains have been around for a long time but in recent years the frequency of their occurrence has increased significantly. It is a problem that occurs in an increasingly larger and younger part of society. The aim of the study was to find out the opinions of nurses of surgical departments on the occurrence of musculoskeletal pains.
Data and process
The research was conducted in a group of 100 people in surgical departments, in 4 hospitals in Lublin in 2016. The study involved both the author's questionnaire, which included questions allowing to determine the specificity of the work, and the Nordic questionnaire, which allowed to determine the place and frequency of pain, and the scale of Vas.
Findings
Nurses working in surgical departments are a group exposed to musculoskeletal pain. The specificity of work related to the necessity to perform specific tasks: care, transport, instrumental, and external load are most often the cause of pain. Demographic variables have a significant impact on the ailments experienced
Conclusions
Age, work experience , number of worksites and BMI are the variables that determine pain incidence in 91% of respondents. The most common pain conditions are chronic and the average pain is determined at the level of 4. 64 on a 10-point scale
Catalytic properties of metallosilicates
Metallosilicates with MFI structure containing metal atoms such as Ni, Co, Cu, Zn-Cu and Zn in framework have been synthesized with various metal/silicone (Me/Si) ratios (up to 0.1). The acidities of H-form metallosilicates were evaluated by some acid-catalyzed reactions (decomposition of 2-propanol, cracking of cumene and isomerization of 1-butene). The Zn-Si catalyst showed the highest acidities among various metallosilicates. In the metallosilicates-supported noble metal catalysts, 5%Pt/Zn-Si and 0.1%Pd/Cu-Si catalysts showed the highest activities for hydrodesulfurization of thiophene and hydrodechlorination of chlorobenzene, respectively.研究報
Wrodzony zespół wydłuzonego QT - aspekty diagnostyczne
Zespół wydłużonego QT charakteryzuje się zaburzeniami repolaryzacji z wydłużeniem czasu
trwania odstępu QT w zapisie EKG i predyspozycją do groźnych komorowych arytmii (torsade
de pointes) prowadzących do omdleń i nagłych zgonów. Na podstawie badań molekularnych
za przyczynę zaburzeń elektrofizjologicznych występujących w tym zespole uznano defekty
w białkach kanałów jonowych (potasowych i sodowych) błony komórkowej komórek mięśnia sercowego. Dziedziczony autosomalnie dominująco, bez wrodzonej głuchoty zespół Romano-
-Warda jest zbiorem co najmniej 6 genotypów, z których najczęściej występują 3 pierwsze
postacie LQTS1, LQTS2 i LQTS3. W zależności od położenia zmutowanego genu na chromosomie
11 (IKs), 7 (IKr) lub 3 (INa) te 3 genotypy różnią się między sobą zaburzeniami okresu
repolaryzacji ze zmienną morfologią załamka T w zapisach elektrokardiograficznych oraz
czynnikami wyzwalającymi objawową arytmię komorową. W obrazie klinicznym dominują
nawracające utraty przytomności, które w LQTS1 i LQTS2 są najczęściej wywołane stymulacją
układu adrenergicznego (wysiłek, emocje, przestrach, nagły bodziec dźwiękowy). W genotypie
LQTS3 objawowa arytmia komorowa najczęściej występuje w spoczynku lub we śnie.
U 40% pacjentów z wrodzonym zespołem wydłużonego QT przebieg kliniczny jest bezobjawowy.
W postaciach LQTS klinicznie utajonych — wydłużenie odstępu QT, zmiany załamka T oraz
komorowe zaburzenia rytmu serca — mogą występować napadowo, co można zaobserwować
w zapisie Holtera lub w teście wysiłkowym. Często u pozornie zdrowych dzieci i młodzieży
pierwszym objawem może być zatrzymanie krążenia lub nagły zgon. Młodzi pacjenci bez
objawów powinni być objęci leczeniem profilaktycznym ze względu na możliwość występowania
u nich epizodów nagłego zatrzymania krążenia, bez objawów poprzedzających. (Folia
Cardiol. 2005; 12: 403–411
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