The Holocene Paleoecology of Jenny Lake Area, Southwest Yukon, and Its Implications for Prehistory

The pollen stratigraphy of a core extracted from Jenny Lake, southwest Yukon, in 1984 has marked archaeological significance. Five palynological zones are identified as follows: Zone JL1, the oldest (ca. 12,500-9,500 B.P.), is a Betula shrub tundra assemblage; Zone JL2 (ca. 9,500-8,500 B.P.) an Alnus shrub tundra; Zone JL3 (ca. 8,500-4,500 B.P.) a Picea forest; Zone JL4 (ca. 4,500-2,000 B.P.) a Picea-Alnus woodland; and JL5 (ca. 2,000 B.P.-present) a Picea forest. The widely held belief that the Kluane-Aishihik area of the SW Yukon was covered by extensive grasslands well into the Holocene period is not supported by the palynology of the Jenny Lake Core. Instead, palynological evidence suggests that the area, which initially was a Betula shrub tundra, then Alnus shrub tundra, became a Picea-dominated forest by approximately 8,500 B.P. and remained forested to the present. The hypothesis stating early prehistoric hunters and gatherers in the SW Yukon were adapted to extensive Holocene grasslands until ca. 3,300-2,600 B.P. will have to be modified in view of these findings.Key words: Yukon, paleoecology, palynology, archaeologyMots clés: Yukon, paléoécologie, palynologie, archéologi

Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency

YesChemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.EPSRC (EP/L019655/1)

Detection of Phosphorus and Nitrogen Deficiencies in Corn Using Spectral Radiance Measurements

Applications of remote sensing in crop production are becoming increasingly popular due in part to an increased concern with pollution of surface and ground waters due to over-fertilization of agricultural lands and the need to compensate for spatial variability in a field. Past research in this area has focused primarily on N stress in crops. Other stresses and the interactions have not been fully evaluated. A field experiment was conducted to determine wavelengths and/or combinations of wavelengths that are indicative of P and N deficiency and also the interaction between these in corn (Zea mays L.). The field experiment was a randomized complete block design with four replications using a factorial arrangement of treatments in an irrigated continuous corn system. The treatment included four N rates (0, 67, 134, and 269 kg N ha-1) and four P rates (0, 22, 45, and 67 kg P ha-1). Spectral radiance measurements were taken at various growth stages in increments from 350 to 1000 nm and correlated with plant N and P concentration, plant biomass, grain N and P concentration, and grain yield. Reflectance in the near-infrared (NIR) and blue regions was found to predict early season P stress between growth stages V6 and V8. Late season detection of P stress was not achieved. Plant N concentration was best predicted using reflectance in the red and green regions of the spectrum, while grain yield was estimated using reflectance in the NIR region, with the particular wavelengths of importance changing with growth stage

Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

YesA study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.D. L. B is grateful to the EPSRC for a First Grant (D. L. B. EP/P002951/1), CRD for a studentship award to J. L. H., Queen’s University Belfast for a Visiting Research Fellowship and the School of Chemistry at Cardiff University for generous support. S. L. J. is grateful to EPSRC for support (EP/L019655/1)

Predictors of short-term clinical response to cardiac resynchronization therapy

Aims: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with symptomatic heart failure and QRS prolongation but there is uncertainty about which patient characteristics predict short-term clinical response. Methods and results: In an individual patient meta-analysis of three double-blind, randomized trials, clinical composite score (CCS) at 6 months was compared in patients assigned to CRT programmed on or off. Treatment–covariate interactions were assessed to measure likelihood of improved CCS at 6 months. MIRACLE, MIRACLE ICD, and REVERSE trials contributed data for this analysis (n = 1591). Multivariable modelling identified QRS duration and left ventricular ejection fraction (LVEF) as predictors of CRT clinical response (P < 0.05). The odds ratio for a better CCS at 6 months increased by 3.7% for every 1% decrease in LVEF for patients assigned to CRT-on compared to CRT-off, and was greatest when QRS duration was between 160 and 180 ms. Conclusions: In symptomatic chronic heart failure patients (NYHA class II–IV), longer QRS duration and lower LVEF independently predict early clinical response to CRT

New supersymmetric solutions of N=2, D=5 gauged supergravity with hyperscalars

We construct new supersymmetric solutions, including AdS bubbles, in an N=2 truncation of five-dimensional N=8 gauged supergravity. This particular truncation is given by N=2 gauged supergravity coupled to two vector multiples and three incomplete hypermultiplets, and was originally investigated in the context of obtaining regular AdS bubble geometries with multiple active R-charges. We focus on cohomogeneity-one solutions corresponding to objects with two equal angular momenta and up to three independent R-charges. Curiously, we find a new set of zero and negative mass solitons asymptotic to AdS_5/Z_k, for k \ge 3, which are everywhere regular without closed timelike curves.Comment: Latex 3 times, 42 page

Generation of continuous variable squeezing and entanglement of trapped ions in time-varying potentials

We investigate the generation of squeezing and entanglement for the motional degrees of freedom of ions in linear traps, confined by time-varying and oscillating potentials, comprised of an DC and an AC component. We show that high degrees of squeezing and entanglement can be obtained by controlling either the DC or the AC trapping component (or both), and by exploiting transient dynamics in regions where the ions' motion is unstable, without any added optical control. Furthermore, we investigate the time-scales over which the potentials should be switched in order for the manipulations to be most effective.Comment: 10 pages, submitted to Quantum Information Processing (special issue on Quantum Decoherence and Entanglement

Antigenic Relationships among Human Pathogenic Orientia tsutsugamushi Isolates from Thailand

Scrub typhus is a common cause of undiagnosed febrile illness in certain tropical regions, but can be easily treated with antibiotics. The causative agent, Orientia tsutsugamushi, is antigenically variable which complicates diagnosis and efforts towards vaccine development. Methodology/Principal Findings: This study aimed to dissect the antigenic and genetic relatedness of O. tsutsugamushi strains and investigate sero-diagnostic reactivities by titrating individual patient sera against their O. tsutsugamushi isolates (whole-cell antigen preparation), in homologous and heterologous serum-isolate pairs from the same endemic region in NE Thailand. The indirect immunofluorescence assay was used to titrate Orientia tsutsugamushi isolates and human sera, and a mathematical technique, antigenic cartography, was applied to these data to visualise the antigenic differences and cross-reactivity between strains and sera. No functional or antigen-specific analyses were performed. The antigenic variation found in clinical isolates was much less pronounced than the genetic differences found in the 56kDa type-specific antigen genes. The Karp-like sera were more broadly reactive than the Gilliam-like sera. Conclusions/Significance: Antigenic cartography worked well with scrub typhus indirect immunofluorescence titres. The data from humoral responses suggest that a Karp-like strain would provide broader antibody cross-reactivity than a Gilliam-like strain. Although previous exposure to O. tsutsugamushi could not be ruled out, scrub typhus patient serum antibody responses were characterised by strong homologous, but weak heterologous antibody titres, with little evidence for cross-reactivity by Gilliam-like sera, but a broader response from some Karp-like sera. This work highlights the importance of antigenic variation in O. tsutsugamushi diagnosis and determination of new serotypes

Antigenic Relationships among Human Pathogenic Orientia tsutsugamushi Isolates from Thailand

Scrub typhus is a common cause of undiagnosed febrile illness in certain tropical regions, but can be easily treated with antibiotics. The causative agent, Orientia tsutsugamushi, is antigenically variable which complicates diagnosis and efforts towards vaccine development. Methodology/Principal Findings: This study aimed to dissect the antigenic and genetic relatedness of O. tsutsugamushi strains and investigate sero-diagnostic reactivities by titrating individual patient sera against their O. tsutsugamushi isolates (whole-cell antigen preparation), in homologous and heterologous serum-isolate pairs from the same endemic region in NE Thailand. The indirect immunofluorescence assay was used to titrate Orientia tsutsugamushi isolates and human sera, and a mathematical technique, antigenic cartography, was applied to these data to visualise the antigenic differences and cross-reactivity between strains and sera. No functional or antigen-specific analyses were performed. The antigenic variation found in clinical isolates was much less pronounced than the genetic differences found in the 56kDa type-specific antigen genes. The Karp-like sera were more broadly reactive than the Gilliam-like sera. Conclusions/Significance: Antigenic cartography worked well with scrub typhus indirect immunofluorescence titres. The data from humoral responses suggest that a Karp-like strain would provide broader antibody cross-reactivity than a Gilliam-like strain. Although previous exposure to O. tsutsugamushi could not be ruled out, scrub typhus patient serum antibody responses were characterised by strong homologous, but weak heterologous antibody titres, with little evidence for cross-reactivity by Gilliam-like sera, but a broader response from some Karp-like sera. This work highlights the importance of antigenic variation in O. tsutsugamushi diagnosis and determination of new serotypes

Near-horizon geometries of supersymmetric AdS(5) black holes

We provide a classification of near-horizon geometries of supersymmetric, asymptotically anti-de Sitter, black holes of five-dimensional U(1)^3-gauged supergravity which admit two rotational symmetries. We find three possibilities: a topologically spherical horizon, an S^1 \times S^2 horizon and a toroidal horizon. The near-horizon geometry of the topologically spherical case turns out to be that of the most general known supersymmetric, asymptotically anti-de Sitter, black hole of U(1)^3-gauged supergravity. The other two cases have constant scalars and only exist in particular regions of this moduli space -- in particular they do not exist within minimal gauged supergravity. We also find a solution corresponding to the near-horizon geometry of a three-charge supersymmetric black ring held in equilibrium by a conical singularity; when lifted to type IIB supergravity this solution can be made regular, resulting in a discrete family of warped AdS(3) geometries. Analogous results are presented in U(1)^n gauged supergravity.Comment: Latex, 29 pages. v2: minor improvements, references adde