Congenital Linear Streaks on the Face and Neck and Microphthalmia in an Infant Girl

Peer reviewe

Geographical distribution and epidemiological features of Old World Leishmania infantum and Leishmania donovani foci, based on the isoenzyme analysis of 2277 strains

A series of 2277 Leishmania strains from Old World visceral leishmaniasis foci, isolated between 1973 and 2008, were studied by isoenzyme analysis. The strains were obtained from humans, domestic and wild carnivores, rodents and phlebotomine sandflies, and came from 36 countries. In all, 60 different zymodemes were identified and clustered by a phenetic analysis into 3 different groups corresponding to the typically visceralizing species L. donovani (20 zymodemes, 169 strains), L. archibaldi (3 zymodemes, 46 strains) and L. infantum (37 zymodemes, 2,062 strains). The taxonomic position of these isoenzymatic groups is discussed in view of contradictory results obtained from recent molecular studie

Multifaceted Population Structure and Reproductive Strategy in Leishmania donovani Complex in One Sudanese Village

Leishmania species of the subgenus Leishmania and especially L. donovani are responsible for a large proportion of visceral leishmaniasis cases. The debate on the mode of reproduction and population structure of Leishmania parasites remains opened. It has been suggested that Leishmania parasites could alternate different modes of reproduction, more particularly clonality and frequent recombinations either between related individuals (endogamy) or between unrelated individuals (outcrossing) within strongly isolated subpopulations. To determine whether this assumption is generalized to other species, a population genetics analysis within Leishmania donovani complex strains was conducted within a single village. The results suggest that a mixed-mating reproduction system exists, an important heterogeneity of subsamples and the coexistence of several genetic entities in Sudanese L. donovani. Indeed, results showed significant genetic differentiation between the three taxa (L. donovani, L. infantum and L. archibaldi) and between the human or canine strains of such taxa, suggesting that there may be different imbricated transmission cycles involving either dogs or humans. Results also are in agreement with an almost strict specificity of L. donovani stricto sensu to human hosts. This empirical study demonstrates the complexity of population structure in the genus Leishmania and the need to pursue such kind of analyses at the smallest possible spatio-temporal and ecological scales

Étude des gènes suppresseurs de tumeurs et gouvernant l'apoptose dans les lymphomes cutanés T épidermotropes

MONTPELLIER-BU Médecine (341722104) / SudocMONTPELLIER-BU Médecine UPM (341722108) / SudocPARIS-BIUM (751062103) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Risk zones of human Leishmaniases in the Western Mediterranean basin. Correlations between vector sand flies, bioclimatology and phytosociology

Correspondence analysis was applied to sand fly sampling in 865 stations from the Western Mediterranean basin. The position of each of 24 species was determined with respect to the bioclimatic belts. Thus, the multidimensional analyses manifest clear correlations between bioclimatic belts and their expression in the area, the phytosociological groupings, and vector species of visceral and cutaneous leishmaniases. The transfer of these data to usual maps allows to delimit the geographical distribution of these diseases in the Western Mediterranean basin and contributes to the determination, in a rational manner, of the high risk zones

Friction induced vibration for an aircraft brake system--Part 2: Non-linear dynamics

International audienceNon-linear dynamics due to friction induced vibrations in a complex aircraft brake model are investigated. This paper outlines a non-linear strategy, based on the center manifold concept and the rational in order to evaluate the non-linear dynamical behaviour of a system in the neighbourhood of a critical steady-state equilibrium point. In order to obtain time-history responses, the complete set of non-linear dynamic equations may be integrated numerically. But this procedure is both time consuming and costly to perform when parametric design studies are needed. So it is necessary to use non-linear analysis: the center manifold approach and the rational approximants are used to obtain the limit cycle of the non-linear system and to study the behaviour of the system in the unstable region. Results from these non-linear methods are compared with results obtained by integrating the full original system. These non-linear methods appear very interesting in regard to computational time and also necessitate very few computer resources

Friction-induced vibration for an aircraft brake system--Part 1: Experimental approach and stability analysis

International audienceFriction-induced vibrations are a major concern in a wide variety of mechanical systems. This is especially the case in aircraft braking systems where the problem of unstable vibrations in disk brakes has been studied by a number of researchers. Solving potential vibration problems requires experimental and theoretical approaches. A non-linear model for the analysis of mode aircraft brake whirl is presented and developed based on experimental observations. The non-linear contact between the rotors and the stators, and mechanisms between components of the brake system are considered. Stability is analyzed by determining the eigenvalues of the Jacobian matrix of the linearized system at the equilibrium point. Linear stability theory is applied in order to determine the effect of system parameters on stability