Association Between Alpha 1 Antitrypsin Deficiency And Cystic Fibrosis Severity

Objective: To ascertain the distribution of alpha 1 antitrypsin genotypes and correlate it with the severity of pulmonary disease in patients with cystic fibrosis. Method: A clinical and laboratory cross sectional study of 70 patients at the Universidade Estadual de Campinas teaching hospital. Cystic fibrosis diagnoses was confirmed by both clinical and laboratory methods. The severity of cystic fibrosis was evaluated by Shwachman score. All the patients were tested for the presence of S and Z alleles for alpha 1 antitrypsin deficiency using polymerase chain reaction. Results: Nine (12.8%) patients were heterozygous for S or Z alleles or the heterozygote compound (SZ). No significant differences were found in clinical severity of Cystic fibrosis between genotypes of alpha 1 antitrypsin. No significant differences were found when the patients were divided according to the presence or absence of the DF508 mutation. Conclusion: In this study, the first undertaken in Brazil into the association of alpha 1 antitrypsin deficiency and cystic fibrosis, we did not find an association between the deficiency and cystic fibrosis severity. 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PROMOÇÃO DA SAÚDE E PREVENÇÃO DE DOENÇAS: RESPONSABILIDADE INDIVIDUAL OU RESPONSABILIDADE SOCIAL

No presente artigo aborda-se alguns pressupostos teóricos que têm norteado a promoção da saúde. Alguns questionamentos são apontados quanto as intervenções profissionais que preconizam a promoção da saúde como responsabilidade individual Sugere-se o enfoque em que as mudanças sociais sejam alcançadas através da conscientização profissional quanto aos aspectos sociais, políticos, econômicos e comportamentais que exercem influência na saúde da população e a incorporação dos mesmos na interação enfermeira(o)-cliente

a longitudinal analysis using data from Brazil

The Brazilian Unified Health System was created in the late 1980s to ensure free universal access to health care and was funded by taxes and social contributions. The persistent inequity in access to health services in favour of richer individuals in Brazil has been observed in the literature. However, to the best of our knowledge, no measurement of inequality in medicine use or private health insurance (PHI) among children has been performed with longitudinal data. This paper uses inequality indices and their decompositions to analyse the income-related inequalities/inequities in children's health care in the city of Pelotas, Brazil, using longitudinal data following children from 12 to 72 months of age. Our sample with data in all waves has between 1877 and 2638 children (varying according to outcome). We seek to answer three questions: i) How does the inequality/inequity in health care evolve as children grow up? ii) What are the main factors associated with inequality in children's health care? iii) How much of the change in inequality/inequity is explained by mobility in children's health care and income mobility? We found that inequities in health care have their beginnings in early childhood but that there was a reduction in inequity at 72 months of age. Ownership of children's PHI was associated with greater pro-rich inequity in health care. The reduction in inequality/inequity was linked to mobility in the sense that initially poorer children had greater gains in health care (a greater increase in PHI ownership and a lower reduction in medicine use). Despite this improvement among the poorest, apparently, the Brazilian public health service seems to fail to ensure equity in health care use among children, with possible long-term consequences on inequalities in health.publishersversionpublishe

The effect of methylphenidate and rearing environment on behavioral inhibition in adult male rats

The effect of the type of CNT (functionalized and non-functionalized) on the dielectric relaxation phenomena and conductivity of MWCNT/chitosan (MWCNT/CS) was investigated. Composites were prepared by the solvent cast method by homogeneously dispersing CNT into a CS matrix. FTIR analysis suggests the formation of hydrogen bonding in functionalized-MWCNT/CS whereas the CS remains unaffected in non-functionalized films. In the low conductivity region, the ?-relaxation process associated with a glass transition in CS is affected by the MWCNT; the Vogel temperature increases due to a decrease of the water content. The ?-relaxation exhibits a typical Arrhenius-type temperature dependence that is independent on the moisture content. Strong interfacial interactions of functionalized-MWCNT with the CS matrix are responsible for high values of the contact resistance Rc between individual CNT. Conversely, non-functionalized MWCNTs exhibit a typical 3D percolation threshold at ca. 4 wt %. " 2015 Elsevier B.V. All rights reserved.",,,,,,"10.1016/j.matchemphys.2015.02.041",,,"http://hdl.handle.net/20.500.12104/45086","http://www.scopus.com/inward/record.url?eid=2-s2.0-84924626391&partnerID=40&md5=2077a8248f1178527deca8ec39ee5bde",,,,,,,,"Materials Chemistry and Physics",,"25