83 research outputs found
Beautiful Mirrors at the LHC
We explore the "Beautiful Mirrors" model, which aims to explain the measured
value of , discrepant at the level. This scenario
introduces vector-like quarks which mix with the bottom, subtly affecting its
coupling to the . The spectrum of the new particles consists of two
bottom-like quarks and a charge -4/3 quark, all of which have electroweak
interactions with the third generation. We explore the phenomenology and
discovery reach for these new particles at the LHC, exploring single mirror
quark production modes whose rates are proportional to the same mixing
parameters which resolve the anomaly. We find that for mirror quark
masses is required to
reasonably establish the scenario and extract the relevant mixing parameters.Comment: version to be published in JHE
Covariant Description of Flavor Conversion in the LHC Era
A simple covariant formalism to describe flavor and CP violation in the
left-handed quark sector in a model independent way is provided. The
introduction of a covariant basis, which makes the standard model approximate
symmetry structure manifest, leads to a physical and transparent picture of
flavor conversion processes. Our method is particularly useful to derive robust
bounds on models with arbitrary mechanisms of alignment. Known constraints on
flavor violation in the K and D systems are reproduced in a straightforward
manner. Assumptions-free limits, based on top flavor violation at the LHC, are
then obtained. In the absence of signal, with 100 fb^{-1} of data, the LHC will
exclude weakly coupled (strongly coupled) new physics up to a scale of 0.6 TeV
(7.6 TeV), while at present no general constraint can be set related to Delta
t=1 processes. LHC data will constrain Delta F=2 contributions via same-sign
tops signal, with a model independent exclusion region of 0.08 TeV (1.0 TeV).
However, in this case, stronger bounds are found from the study of CP violation
in D-bar D mixing with a scale of 0.57 TeV (7.2 TeV). In addition, we apply our
analysis to models of supersymmetry and warped extra dimension. The minimal
flavor violation framework is also discussed, where the formalism allows to
distinguish between the linear and generic non-linear limits within this class
of models.Comment: 24 pages, 6 figures. Some corrections and clarifications; references
added. Matches published versio
Anomalous coupling effects in exclusive radiative B-meson decays
The top-quark FCNC processes will be searched for at the CERN LHC, which are
correlated with the B-meson decays. In this paper, we study the effects of
top-quark anomalous interactions in the exclusive radiative and decays. With the current experimental data of
the branching ratios, the direct CP and the isospin asymmetries, bounds on the
coupling from and
from decays are derived,
respectively. The bound on from is generally compatible with that from . However, the isospin asymmetry further
restrict the phase of , and the combined bound results
in the upper limit, , which is lower than the
CDF result. For real , the upper bound on is about of the same order as the discovery
potential of ATLAS with an integrated luminosity of . For
decays, the NP contribution is enhanced by a large CKM factor
, and the constraint on coupling is rather
restrictive, . With refined
measurements to be available at the LHCb and the future super-B factories, we
can get close correlations between and the rare
decays, which will be studied directly at the LHC ATLAS and CMS.Comment: 25 pages, 15 figures, pdflate
Genetic Polymorphisms and Drug Susceptibility in Four Isolates of Leishmania tropica Obtained from Canadian Soldiers Returning from Afghanistan
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease transmitted by the bite of sandflies, resulting in sores on the skin. No vaccines are available, and treatment relies on chemotherapy. CL has been frequently diagnosed in military personnel deployed to Afghanistan and returning from duty. The parasites isolated from Canadian soldiers were characterized by pulsed field gels and by sequencing conserved genes and were identified as Leishmania tropica. In contrast to other Leishmania species, high allelic polymorphisms were observed at several genetic loci for the L. tropica isolates that were characterized. In vitro susceptibility testing in macrophages showed that all isolates, despite their genetic heterogeneity, were sensitive to most antileishmanial drugs (antimonials, miltefosine, amphotericin B, paromomycin) but were insensitive to fluconazole. This study suggests a number of therapeutic regimens for treating cutaneous leishmaniasis caused by L. tropica among patients and soldiers returning from Afghanistan. Canadian soldiers from this study were successfully treated with miltefosine
Anomalous coupling effects in rare B- and K-meson decays
As a top-factory, the LHC is performing a direct study of top-quark anomalous
FCNC couplings, which are, however, correlated closely with the rare B- and
K-meson decays. In this paper, we study the effects of anomalous (with
) couplings in the rare decays , , , , and . With the up-to-date experimental bounds on the branching
ratios of these channels, constraints on the left-handed anomalous couplings
and are derived, respectively. With these low-energy
constraints taken into account, we find that, for real couplings and
, the indirect upper bounds on are much lower
than that from the D0 collaboration, but are still compatible with the
discovery potential of ATLAS with an integrated luminosity of . With refined measurements to be available at the LHCb, the
future super-B factories, the NA62 at CERN, and the KOTO at J-PARC, closer
correlations between the and the rare B- and K-meson decays are
expected in the near future, which will be helpful for the searches of the
top-quark FCNC decays at the LHC.Comment: 25 pages, 18 figures, 4 tables; More references added, version
published in JHE
Potential toxic elements in stream sediments, soils and waters in an abandoned radium mine (central Portugal)
The Alto da Vårzea radium mine (AV) exploited ore and U-bearing minerals, such as autunite and torbernite. The mine was exploited underground from 1911 to 1922, closed in 1946 without restoration, and actually a commercial area is deployed. Stream sediments, soils and water samples were collected between 2008 and 2009. Stream sediments are mainly contaminated in As, Th, U and W, which is related to the AV radium mine. The PTEs, As, Co, Cr, Sr, Th, U, W, Zn, and electrical conductivity reached the highest values in soils collected inside the mine influence. Soils are contaminated with As and U and must not be used for any purpose. Most waters have pH values ranging from 4.3 to 6.8 and are poorly mineralized (EC = 41-186 ”S/cm; TDS = 33-172 mg/L). Groundwater contains the highest Cu, Cr and Pb contents. Arsenic occurs predominantly as H2(AsO4)- and H(AsO4)2-. Waters are saturated in goethite, haematite and some of them also in lepidocrocite and ferrihydrite, which adsorbs As (V). Lead is divalent in waters collected during the warm season, being mobile in these waters. Thorium occurs mainly as Th(OH)3(CO3)-, Th(OH)2(CO3) and Th(OH)2(CO3) 22- , which increase water Th contents. Uranium occurs predominantly as UO2CO3, but CaUO2(CO3) 32- and CaUO2(CO3)3 also occur, decreasing its mobility in water. The waters are contaminated in NO2-, Mn, Cu, As, Pb and U and must not be used for human consumption and in agricultural activities. The water contamination is mainly associated with the old radium mine and human activities. A restoration of the mining area with PTE monitoring is necessary to avoid a public hazard.Thanks are due to Prof. Joao Coutinho for the determination of organic matter and cation exchange capacity in samples of stream sediments and soils and A. Rodrigues for the water analyses, EDM for some information on the Alto da Varzea mine area. This study had the support of Portuguese Fundacao para a Ciencia e Tecnologia (FCT), through the strategic projects UID/GEO/04035/2013 and UID/MAR/04292/2013 (MARE).info:eu-repo/semantics/publishedVersio
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Womenâs experiences of decision-making and informed choice about pregnancy and birth care: a systematic review and meta-synthesis of qualitative research
Background
The purpose of this systematic review (PROSPERO Ref: CRD42017053264) was to describe and interpret the qualitative research on parentâs decision-making and informed choice about their pregnancy and birth care. Given the growing evidence on the benefits of different models of maternity care and the prominence of informed choice in health policy, the review aimed to shed light on the research to date and what the findings indicate.
Methods
a systematic search and screening of qualitative research concerning parentsâ decision-making and informed choice experiences about pregnancy and birth care was conducted using PRISMA guidelines. A meta-synthesis approach was taken for the extraction and analysis of data and generation of the findings. Studies from 1990s onwards were included to reflect an era of policies promoting choice in maternity care in high-income countries.
Results
Thirty-seven original studies were included in the review. A multi-dimensional conceptual framework was developed, consisting of three analytical themes (âUncertaintyâ, âBodily autonomy and integrityâ and âPerforming good motherhoodâ) and three inter-linking actions (âInformation gathering,â âAligning with a birth philosophy,â and âBalancing aspects of a choiceâ).
Conclusions
Despite the increasing research on decision-making, informed choice is not often a primary research aim, and its development in literature published since the 1990s was difficult to ascertain. The meta-synthesis suggests that decision-making is a dynamic and temporal process, in that it is made within a defined period and invokes both the past, whether this is personal, familial, social or historical, and the future. Our findings also highlighted the importance of embodiment in maternal health experiences, particularly when it comes to decision-making about care. Policymakers and practitioners alike should examine critically current choice frameworks to ascertain whether they truly allow for flexibility in decision-making. Health systems should embrace more fluid, personalised models of care to augment service usersâ decision-making agency
Oxidative protein labeling in mass-spectrometry-based proteomics
Oxidation of proteins and peptides is a common phenomenon, and can be employed as a labeling technique for mass-spectrometry-based proteomics. Nonspecific oxidative labeling methods can modify almost any amino acid residue in a protein or only surface-exposed regions. Specific agents may label reactive functional groups in amino acids, primarily cysteine, methionine, tyrosine, and tryptophan. Nonspecific radical intermediates (reactive oxygen, nitrogen, or halogen species) can be produced by chemical, photochemical, electrochemical, or enzymatic methods. More targeted oxidation can be achieved by chemical reagents but also by direct electrochemical oxidation, which opens the way to instrumental labeling methods. Oxidative labeling of amino acids in the context of liquid chromatography(LC)âmass spectrometry (MS) based proteomics allows for differential LC separation, improved MS ionization, and label-specific fragmentation and detection. Oxidation of proteins can create new reactive groups which are useful for secondary, more conventional derivatization reactions with, e.g., fluorescent labels. This review summarizes reactions of oxidizing agents with peptides and proteins, the corresponding methodologies and instrumentation, and the major, innovative applications of oxidative protein labeling described in selected literature from the last decade
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