259 research outputs found
Molecular dynamics study of accelerated ion-induced shock waves in biological media
We present a molecular dynamics study of the effects of carbon- and iron-ion induced shock waves in DNA duplexes in liquid water. We use the CHARMM force field implemented within the MBN Explorer simulation package to optimize and equilibrate DNA duplexes in liquid water boxes of different sizes and shapes. The translational and vibrational degrees of freedom of water molecules are excited according to the energy deposited by the ions and the subsequent shock waves in liquid water are simulated. The pressure waves generated are studied and compared with an analytical hydrodynamics model which serves as a benchmark for evaluating the suitability of the simulation boxes. The energy deposition in the DNA backbone bonds is also monitored as an estimation of biological damage, something which is not possible with the analytical model
Charge-Symmetry Violation in Pion Scattering from Three-Body Nuclei
We discuss the experimental and theoretical status of charge-symmetry
violation (CSV) in the elastic scattering of pi+ and pi- on 3H and 3He.
Analysis of the experimental data for the ratios r1, r2, and R at Tpi = 142,
180, 220, and 256 MeV provides evidence for the presence of CSV. We describe
pion scattering from the three-nucleon system in terms of single- and
double-scattering amplitudes. External and internal Coulomb interactions as
well as the Delta-mass splitting are taken into account as sources of CSV.
Reasonable agreement between our theoretical calculations and the experimental
data is obtained for Tpi = 180, 220, and 256 MeV. For these energies, it is
found that the Delta-mass splitting and the internal Coulomb interaction are
the most important contributions for CSV in the three-nucleon system. The CSV
effects are rather sensitive to the choice of pion-nuclear scattering
mechanisms, but at the same time, our theoretical predictions are much less
sensitive to the choice of the nuclear wave function. It is found, however,
that data for r2 and R at Tpi = 142 MeV do not agree with the predictions of
our model, which may indicate that there are additional mechanisms for CSV
which are important only at lower energies.Comment: 26 pages of RevTeX, 16 postscript figure
Discrete molecular dynamics simulations of peptide aggregation
We study the aggregation of peptides using the discrete molecular dynamics
simulations. At temperatures above the alpha-helix melting temperature of a
single peptide, the model peptides aggregate into a multi-layer parallel
beta-sheet structure. This structure has an inter-strand distance of 0.48 nm
and an inter-sheet distance of 1.0 nm, which agree with experimental
observations. In this model, the hydrogen bond interactions give rise to the
inter-strand spacing in beta-sheets, while the Go interactions among side
chains make beta-strands parallel to each other and allow beta-sheets to pack
into layers. The aggregates also contain free edges which may allow for further
aggregation of model peptides to form elongated fibrils.Comment: 15 pages, 8 figure
Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong
Human metapneumovirus (HMPV) is a newly discovered pathogen thought to be associated with respiratory disease. We report the results of a study of 587 children hospitalized with respiratory infection over a 13-month period. HMPV was detected in the nasopharyngeal aspirates from 32 (5.5%) children by reverse transcription-polymerase chain reaction. HMPV infection was associated with clinical diagnoses of pneumonia (36%), asthma exacerbation (23%), or acute bronchiolitis (10%). When compared to those with respiratory syncytial virus infection, children with HMPV infection were older, and wheezing was more likely to represent asthma exacerbation rather than acute bronchiolitis. HMPV viral activity peaked during the spring-summer period in Hong Kong. Phylogenetically, all HMPV virus strains from Hong Kong belonged to one of the two genetic lineages previously described. HMPV contributed to 441.6 hospital admissions per 100,000 population <6 years of age
Ecological Invasion, Roughened Fronts, and a Competitor's Extreme Advance: Integrating Stochastic Spatial-Growth Models
Both community ecology and conservation biology seek further understanding of
factors governing the advance of an invasive species. We model biological
invasion as an individual-based, stochastic process on a two-dimensional
landscape. An ecologically superior invader and a resident species compete for
space preemptively. Our general model includes the basic contact process and a
variant of the Eden model as special cases. We employ the concept of a
"roughened" front to quantify effects of discreteness and stochasticity on
invasion; we emphasize the probability distribution of the front-runner's
relative position. That is, we analyze the location of the most advanced
invader as the extreme deviation about the front's mean position. We find that
a class of models with different assumptions about neighborhood interactions
exhibit universal characteristics. That is, key features of the invasion
dynamics span a class of models, independently of locally detailed demographic
rules. Our results integrate theories of invasive spatial growth and generate
novel hypotheses linking habitat or landscape size (length of the invading
front) to invasion velocity, and to the relative position of the most advanced
invader.Comment: The original publication is available at
www.springerlink.com/content/8528v8563r7u2742
Simulations of the Static Friction Due to Adsorbed Molecules
The static friction between crystalline surfaces separated by a molecularly
thin layer of adsorbed molecules is calculated using molecular dynamics
simulations. These molecules naturally lead to a finite static friction that is
consistent with macroscopic friction laws. Crystalline alignment, sliding
direction, and the number of adsorbed molecules are not controlled in most
experiments and are shown to have little effect on the friction. Temperature,
molecular geometry and interaction potentials can have larger effects on
friction. The observed trends in friction can be understood in terms of a
simple hard sphere model.Comment: 13 pages, 13 figure
Geometric Spin Hall Effect of Light at Polarizing Interfaces
The geometric Spin Hall Effect of Light (geometric SHEL) amounts to a
polarization-dependent positional shift when a light beam is observed from a
reference frame tilted with respect to its direction of propagation. Motivated
by this intriguing phenomenon, the energy density of the light beam is
decomposed into its Cartesian components in the tilted reference frame. This
illustrates the occurrence of the characteristic shift and the significance of
the effective response function of the detector.
We introduce the concept of a tilted polarizing interface and provide a
scheme for its experimental implementation. A light beam passing through such
an interface undergoes a shift resembling the original geometric SHEL in a
tilted reference frame. This displacement is generated at the polarizer and its
occurrence does not depend on the properties of the detection system. We give
explicit results for this novel type of geometric SHEL and show that at grazing
incidence this effect amounts to a displacement of multiple wavelengths, a
shift larger than the one introduced by Goos-H\"anchen and Imbert-Fedorov
effects.Comment: 6 pages, 4 figure
Prostate cancer and Hedgehog signalling pathway
[Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates. In some contexts, Hh signals act as morphogens in the dose-dependent induction of distinct cell fates within a target field, in others as mitogens in the regulation of cell proliferation or as inducing factors controlling the form of a developing organ. These diverse functions of Hh proteins raise many intriguing questions about their mode of action. Various studies have now demonstrated the function of Hh signalling in the control of cell proliferation, especially for stem cells and stem-like progenitors. Abnormal activation of the Hh pathway has been demonstrated in a variety of human tumours. Hh pathway activity in these tumours is required for cancer cell proliferation and tumour growth. Recent studies have uncovered the role for Hh signalling in advanced prostate cancer and demonstrated that autocrine signalling by tumour cells is required for proliferation, viability and invasive behaviour. Thus, Hh signalling represents a novel pathway in prostate cancer that offers opportunities for prognostic biomarker development, drug targeting and therapeutic response monitoring
Before and After: Comparison of Legacy and Harmonized TCGA Genomic Data Commons’ Data
We present a systematic analysis of the effects of synchronizing a large-scale, deeply characterized, multi-omic dataset to the current human reference genome, using updated software, pipelines, and annotations. For each of 5 molecular data platforms in The Cancer Genome Atlas (TCGA)—mRNA and miRNA expression, single nucleotide variants, DNA methylation and copy number alterations—comprehensive sample, gene, and probe-level studies were performed, towards quantifying the degree of similarity between the ‘legacy’ GRCh37 (hg19) TCGA data and its GRCh38 (hg38) version as ‘harmonized’ by the Genomic Data Commons. We offer gene lists to elucidate differences that remained after controlling for confounders, and strategies to mitigate their impact on biological interpretation. Our results demonstrate that the hg19 and hg38 TCGA datasets are very highly concordant, promote informed use of either legacy or harmonized omics data, and provide a rubric that encourages similar comparisons as new data emerge and reference data evolve. Gao et al. performed a systematic analysis of the effects of synchronizing the large-scale, widely used, multi-omic dataset of The Cancer Genome Atlas to the current human reference genome. For each of the five molecular data platforms assessed, they demonstrated a very high concordance between the ‘legacy’ GRCh37 (hg19) TCGA data and its GRCh38 (hg38) version as ‘harmonized’ by the Genomic Data Commons
One-loop corrections to omega photoproduction near threshold
One-loop corrections to photoproduction near threshold have been
investigated by using the approximation that all relevant transition amplitudes
are calculated from the tree diagrams of effective Lagrangians. With the
parameters constrained by the data of , , and reactions, it is found that the one-loop effects
due to the intermediate and states can significantly change
the differential cross sections and spin observables. The results from this
exploratory investigation suggest strongly that the coupled-channel effects
should be taken into account in extracting reliable resonance parameters from
the data of vector meson photoproduction in the resonance region.Comment: 19 pages, REVTeX, 14 figures, title changed, revised version to
appear in Phys. Rev.
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