29 research outputs found

    Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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    Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

    One man,s journey through the years when ecology came of age

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    Erster Hauptsatz

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    The Size and Depth of Layered Boolean Circuits

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    Abstract. We consider the relationship between size and depth for layered Boolean circuits, synchronous circuits and planar circuits as well as classes of circuits with small separators. In particular, we show that every layered Boolean circuit of size s can be simulated by a layered Boolean circuit of depth O ( √ s log s). For planar circuits and synchronous circuits of size s, we obtain simulations of depth O ( √ s). The best known result so far was by Paterson and Valiant [16], and Dymond and Tompa [6], which holds for general Boolean circuits and states that D(f) = O(C(f) / log C(f)), where C(f) and D(f) are the minimum size and depth, respectively, of Boolean circuits computing f. The proof of our main result uses an adaptive strategy based on the two-person pebble game introduced by Dymond and Tompa [6]. Improving any of our results by polylog factors would immediately improve the bounds for general circuits. Key words: Boolean circuits, circuit size, circuit depth, pebble games
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