Seismic waveforms and velocity model heterogeneity: towards full-waveform microseismic location algorithm

Seismic forward modeling is an integral component of microseismic location algorithms, yet there is generally no one correct approach, but rather a range of acceptable approaches that can be used. Since seismic signals are band limited, the length scale of heterogeneities can significantly influence the seismic wavefronts and waveforms. This can be especially important for borehole microseismic monitoring, where subsurface heterogeneity can be strong and/or vary on length scales equivalent to or less than the dominant source wavelength. In this paper, we show that ray-based approaches are not ubiquitously suitable for all borehole microseismic applications. For unconventional reservoir settings, ray-based algorithms may not be suitably accurate for advanced microseismic imaging. Here we focus on exploring the feasibility of using one-way wave equations as forward propagators for full waveform event location techniques. As a feasibility study, we implement an acoustic wide-angle wave equation and use a velocity model interpolation approach to explore the computational efficiency and accuracy of the solution. We compare the results with an exact solution to evaluate travel-time and amplitude errors. The results show that accurate travel-times can be predicted to within 2 ms of the true solution for modest velocity model interpolation. However, for accurate amplitude prediction or for higher dominant source frequencies, a larger number of velocity model interpolations is required

Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma

Objectives The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were >50 copies/mL in both compartments and bulk genotypic tests were realized. Results On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P = 0.0455) and T215Y (P = 0.0455). Conclusions In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performe

Analysis of fracture induced scattering of microseismic shear-waves

Fractures are pervasive features within the Earth’s crust and have a significant influence on the multi-physical response of the subsurface. The presence of coherent fracture sets often leads to observable seismic scattering enabling seismic techniques to remotely locate and characterise fracture systems. In this study, we confirm the general scale-dependence of seismic scattering and provide new results specific to shear-wave propagation. We do this by generating full waveform synthetics using finite-difference wave simulation within an isotropic background model containing explicit fractures. By considering a suite of fracture models having variable fracture density and fracture size, we examine the widening effect of wavelets due to scattering within a fractured medium by using several different approaches, such as root-mean-square envelope analysis, shear-wave polarisation distortion, differential attenuation analysis and peak frequency shifting. The analysis allows us to assess the scattering behavior of parametrised models in which the propagation direction is either normal or parallel to the fracture surfaces. The quantitative measures show strong observable deviations for fractures size on the order of or greater than the dominant seismic wavelength within the Mie and geometric scattering regime for both propagation normal and parallel to fracture strike. The results suggest that strong scattering is symptomatic of fractures having size on the same order of the probing seismic wave

Linking microseismic event observations with geomechanical models to minimise the risks of storing CO2 in geological formations

For carbon capture and storage (CCS) in geological formations to be scientifically viable, we must be able to model and monitor the effects of geomechanical deformation on the integrity of the caprock. Excess deformation may open fractures, providing pathways for CO2 leakage from the reservoir. An acceptable geomechanical model must provide a good match with field observations. Microseismic activity is a direct manifestation of mechanical deformation, so it can be used to constrain geomechanical models. The aim of this paper is to develop the concept of using observations of microseismic activity to help ground truth geomechanical models. Microseismic monitoring has been ongoing at the Weyburn CO2 Storage and Monitoring Project since 2003. We begin this paper by presenting these microseismic observations. Less than 100 events have been recorded, documenting a low rate of seismicity. Most of the events are located close to nearby producing wells rather than the injection well, a pattern that is difficult to interpret within the conventional framework for injection-induced seismicity. Many events are located in the overburden. Without geomechanical simulation it is difficult to assess what these observations mean for the integrity of the storage formation. To address these uncertainties we generate numerical geomechanical models to simulate the changes in stress induced by CO2 injection, and use these models to predict the generation of microseismic events and seismic anisotropy. The initial geomechanical model that we generate, using material properties based on laboratory core measurements, does not provide a good match with either event locations or S-wave splitting measurements made on the microseismic events. We find that an alternative model whose reservoir is an order of magnitude softer than lab core-sample measurements provides a much better match with observation, as it leads shear stresses to increase above the production wells, promoting microseismicity in these areas, and generates changes in effective horizontal stresses that match well with Swave splitting observations. This agreement between geophysical observations and a softer-than-labmeasurements reservoir model highlights the difficulties encountered in upscaling lab scale results. There is a strong need to link geomechanical models with observable manifestations of deformation in the field, such as induced seismicity, for calibration. Only then can we accurately assess the risks of leakage generated by mechanical deformation

Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia

Hypercapnia is clinically defined as an arterial blood partial pressure of CO2 of above 40 mmHg and is a feature of chronic lung disease. In previous studies we have demonstrated that hypercapnia modulates agonist-stimulated cAMP levels through effects on transmembrane adenylyl cyclase activity. In the airways, cAMP is known to regulate cystic fibrosis transmembrane conductance regulator (CFTR)-mediated anion and fluid secretion, which contributes to airway surface liquid homeostasis. The aim of the current work was to investigate if hypercapnia could modulate cAMP-regulated ion and fluid transport in human airway epithelial cells. We found that acute exposure to hypercapnia significantly reduced forskolin-stimulated elevations in intracellular cAMP as well as both adenosine and forskolin-stimulated increases in CFTR-dependent transepithelial short-circuit current, in polarised cultures of Calu-3 human airway cells. This CO2-induced reduction in anion secretion was not due to a decrease in HCO3− transport given that neither a change in CFTR-dependent HCO3− efflux, nor Na+/HCO3− cotransporter-dependent HCO3− influx were CO2-sensitive. Hypercapnia also reduced the volume of forskolin-stimulated fluid secretion over 24 h, yet had no effect on the HCO3− content of the secreted fluid. Our data reveal that hypercapnia reduces CFTR-dependent, electrogenic Cl− and fluid secretion, but not CFTR-dependent HCO3− secretion, which highlights a differential sensitivity of Cl− and HCO3− transporters to raised CO2 in Calu-3 cells. Hypercapnia also reduced forskolin-stimulated CFTR-dependent anion secretion in primary human airway epithelia. Based on current models of airways biology, a reduction in fluid secretion, associated with hypercapnia, would be predicted to have important consequences for airways hydration and the innate defence mechanisms of the lungs

Real-world 2-year weight changes among people with sustained HIV suppression: A multicenter French retrospective cohort study

Meeting abstract du "19th European AIDS Conference (#EACS2023)", 18-21 Octobre 2023, VarsovieInternational audienc

Community-acquired pneumonia. A prospective outpatient study.

We initiated a prospective study with a group of practitioners to assess the etiology, clinical presentation, and outcome of community-acquired pneumonia in patients diagnosed in the outpatient setting. All patients with signs and symptoms suggestive of pneumonia and an infiltrate on chest X-ray underwent an extensive standard workup and were followed over 4 weeks. Over a 4-year period, 184 patients were eligible, of whom 170 (age range, 15-96 yr; median, 43 yr) were included and analyzed. In 78 (46%), no etiologic agent could be demonstrated. In the remaining 92 patients, 107 etiologic agents were implicated: 43 were due to "pyogenic" bacteria (39 Streptococcus pneumoniae, 3 Haemophilus spp., 1 Streptococcus spp.), 39 were due to "atypical" bacteria (24 Mycoplasma pneumoniae, 9 Chlamydia pneumoniae, 4 Coxiella burnetii, 2 Legionella spp.), and 25 were due to viruses (20 influenza viruses and 5 other respiratory viruses). There were only a few statistically significant clinical differences between the different etiologic categories (higher age and comorbidities in viral or in episodes of undetermined etiology, higher neutrophil counts in "pyogenic" episodes, more frequent bilateral and interstitial infiltrates in viral episodes). There were 2 deaths, both in patients with advanced age (83 and 86 years old), and several comorbidities. Only 14 patients (8.2%) required hospitalization. In 6 patients (3.4%), the pneumonia episode uncovered a local neoplasia. This study shows that most cases of community-acquired pneumonia have a favorable outcome and can be successfully managed in an outpatient setting. Moreover, in the absence of rapid and reliable clinical or laboratory tests to establish a definite etiologic diagnosis at presentation, the spectrum of the etiologic agents suggest that initial antibiotic therapy should cover both S. pneumoniae and atypical bacteria, as well as possible influenza viruses during the epidemic season